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Roizman, Bernard
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overview Herpes simplex viruses cause two kinds of infections. On initial infection at the portal of entry into the body, the virus replicates and kills the infected cell (lytic infection). In the course of its replication, the virus infects nerve endings and is transported retrograde to neuronal nuclei of peripheral ganglia where it remains latent (silent) and does not harm the neuron. In some individuals the virus periodically reactivates, and is transported anterograde to a site near the portal of entry where it can cause recurrent lesions. The focus of the research conducted in this laboratory is on the mechanism by which herpes simplex virus with less than 100 genes takes over a human cell with more than 20,000 genes in both lytic and latent infection.
One or more keywords matched the following items that are connected to Roizman, Bernard
Item TypeName
Concept Amino Acid Sequence
Concept Base Sequence
Concept Gene Expression Regulation
Concept Genes, Viral
Concept Molecular Sequence Data
Concept Nucleic Acid Conformation
Concept Genes, ras
Concept Genes, Essential
Concept Genome, Viral
Concept Gene Expression
Concept Genes, Immediate-Early
Concept Genes, Reporter
Concept Gene Transfer Techniques
Concept Gene Deletion
Concept Interferon-Stimulated Gene Factor 3
Concept Interferon-Stimulated Gene Factor 3, gamma Subunit
Concept Gene Regulatory Networks
Concept Gene Knockout Techniques
Concept Gene Expression Profiling
Concept Open Reading Frames
Concept Gene Expression Regulation, Viral
Concept Genes, fos
Concept Gene Silencing
Concept Gene Expression Regulation, Neoplastic
Concept Nuclear Export Signals
Academic Article The essential protein encoded by the UL31 gene of herpes simplex virus 1 depends for its stability on the presence of UL34 protein.
Academic Article Redefining virology.
Academic Article Molecular targeting of gene therapy and radiotherapy.
Academic Article An early regulatory function required in a cell type-dependent manner is expressed by the genomic but not the cDNA copy of the herpes simplex virus 1 gene encoding infected cell protein 0.
Academic Article Of the three tegument proteins that package mRNA in herpes simplex virions, one (VP22) transports the mRNA to uninfected cells for expression prior to viral infection.
Academic Article Herpes simplex virus 1 open reading frames O and P are not necessary for establishment of latent infection in mice.
Academic Article The domains of glycoprotein D required to block apoptosis depend on whether glycoprotein D is present in the virions carrying herpes simplex virus 1 genome lacking the gene encoding the glycoprotein.
Academic Article RNAs extracted from herpes simplex virus 1 virions: apparent selectivity of viral but not cellular RNAs packaged in virions.
Academic Article Dose-dependent and independent temporal patterns of gene responses to ionizing radiation in normal and tumor cells and tumor xenografts.
Academic Article The role of cdc2 in the expression of herpes simplex virus genes.
Academic Article The use of a genetically engineered herpes simplex virus (R7020) with ionizing radiation for experimental hepatoma.
Academic Article Herpes simplex virus 1 activates cdc2 to recruit topoisomerase II alpha for post-DNA synthesis expression of late genes.
Academic Article U(S)3 protein kinase of herpes simplex virus 1 blocks caspase 3 activation induced by the products of U(S)1.5 and U(L)13 genes and modulates expression of transduced U(S)1.5 open reading frame in a cell type-specific manner.
Academic Article Promyelocytic leukemia protein mediates interferon-based anti-herpes simplex virus 1 effects.
Academic Article Cell surface major histocompatibility complex class II proteins are regulated by the products of the gamma(1)34.5 and U(L)41 genes of herpes simplex virus 1.
Academic Article Requirements for the nuclear-cytoplasmic translocation of infected-cell protein 0 of herpes simplex virus 1.
Academic Article Herpes simplex virus 1 gene expression is accelerated by inhibitors of histone deacetylases in rabbit skin cells infected with a mutant carrying a cDNA copy of the infected-cell protein no. 0.
Academic Article Activation of NF-kappaB in cells productively infected with HSV-1 depends on activated protein kinase R and plays no apparent role in blocking apoptosis.
Academic Article The herpes simplex virus 1 UL41 gene-dependent destabilization of cellular RNAs is selective and may be sequence-specific.
Academic Article Expression of interleukin-4 but not of interleukin-10 from a replicative herpes simplex virus type 1 viral vector precludes experimental allergic encephalomyelitis.
Academic Article Role of ICP0 in the strategy of conquest of the host cell by herpes simplex virus 1.
Academic Article Herpes simplex virus 1 mutant in which the ICP0 HUL-1 E3 ubiquitin ligase site is disrupted stabilizes cdc34 but degrades D-type cyclins and exhibits diminished neurotoxicity.
Academic Article Prevention of restenosis by a herpes simplex virus mutant capable of controlled long-term expression in vascular tissue in vivo.
Academic Article Herpes simplex virus 1 gene products occlude the interferon signaling pathway at multiple sites.
Academic Article The UL41 protein of herpes simplex virus mediates selective stabilization or degradation of cellular mRNAs.
Academic Article The carboxyl-terminal domain of RNA polymerase II is phosphorylated by a complex containing cdk9 and infected-cell protein 22 of herpes simplex virus 1.
Academic Article The patterns of accumulation of cellular RNAs in cells infected with a wild-type and a mutant herpes simplex virus 1 lacking the virion host shutoff gene.
Academic Article The stress-inducible immediate-early responsive gene IEX-1 is activated in cells infected with herpes simplex virus 1, but several viral mechanisms, including 3' degradation of its RNA, preclude expression of the gene.
Academic Article The first 30 minutes in the life of a virus: unREST in the nucleus.
Academic Article Herpes simplex virus 1 recombinant virions exhibiting the amino terminal fragment of urokinase-type plasminogen activator can enter cells via the cognate receptor.
Academic Article Herpes simplex virus 1 infected cell protein 0 forms a complex with CIN85 and Cbl and mediates the degradation of EGF receptor from cell surfaces.
Academic Article Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1.
Academic Article Ionizing radiation activates late herpes simplex virus 1 promoters via the p38 pathway in tumors treated with oncolytic viruses.
Academic Article State and role of SRC family kinases in replication of herpes simplex virus 1.
Academic Article Glycoprotein M of herpes simplex virus 1 is incorporated into virions during budding at the inner nuclear membrane.
Academic Article Temperature-sensitive mutations in the putative herpes simplex virus type 1 terminase subunits pUL15 and pUL33 preclude viral DNA cleavage/packaging and interaction with pUL28 at the nonpermissive temperature.
Academic Article Expression of gamma interferon-dependent genes is blocked independently by virion host shutoff RNase and by US3 protein kinase.
Academic Article Replication-competent herpes simplex virus 1 isolates selected from cells transfected with a bacterial artificial chromosome DNA lacking only the UL49 gene vary with respect to the defect in the UL41 gene encoding host shutoff RNase.
Academic Article An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer.
Academic Article Role of cdk9 in the optimization of expression of the genes regulated by ICP22 of herpes simplex virus 1.
Academic Article Translocation and colocalization of ICP4 and ICP0 in cells infected with herpes simplex virus 1 mutants lacking glycoprotein E, glycoprotein I, or the virion host shutoff product of the UL41 gene.
Academic Article Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells.
Academic Article Radioresistance of Stat1 over-expressing tumour cells is associated with suppressed apoptotic response to cytotoxic agents and increased IL6-IL8 signalling.
Academic Article Role of herpes simplex virus ICP27 in the degradation of mRNA by virion host shutoff RNase.
Academic Article Interwoven roles of cyclin D3 and cdk4 recruited by ICP0 and ICP4 in the expression of herpes simplex virus genes.
Academic Article Systemic delivery of (gamma1)34.5-deleted herpes simplex virus-1 selectively targets and treats distant human xenograft tumors that express high MEK activity.
Academic Article The CoREST/REST repressor is both necessary and inimical for expression of herpes simplex virus genes.
Academic Article Antisense RNA directed to the human papillomavirus type 16 E7 mRNA from herpes simplex virus type 1 derived vectors is expressed in CaSki cells and downregulates E7 mRNA.
Academic Article Interaction of herpes simplex virus RNase with VP16 and VP22 is required for the accumulation of the protein but not for accumulation of mRNA.
Academic Article Increased oncolytic efficacy for high-grade gliomas by optimal integration of ionizing radiation into the replicative cycle of HSV-1.
Academic Article Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complex.
Academic Article The checkpoints of viral gene expression in productive and latent infection: the role of the HDAC/CoREST/LSD1/REST repressor complex.
Academic Article Characterization of a recombinant herpes simplex virus 1 designed to enter cells via the IL13Ralpha2 receptor of malignant glioma cells.
Academic Article Checkpoints in productive and latent infections with herpes simplex virus 1: conceptualization of the issues.
Academic Article HSV-1 gene expression from reactivated ganglia is disordered and concurrent with suppression of latency-associated transcript and miRNAs.
Academic Article Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expression.
Academic Article Overexpression of the ubiquitin-specific protease 7 resulting from transfection or mutations in the ICP0 binding site accelerates rather than depresses herpes simplex virus 1 gene expression.
Academic Article Induction of apoptosis accelerates reactivation of latent HSV-1 in ganglionic organ cultures and replication in cell cultures.
Academic Article Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells.
Academic Article Role of cellular phosphatase cdc25C in herpes simplex virus 1 replication.
Academic Article The disappearance of cyclins A and B and the increase in activity of the G(2)/M-phase cellular kinase cdc2 in herpes simplex virus 1-infected cells require expression of the alpha22/U(S)1.5 and U(L)13 viral genes.
Academic Article Identification of a novel expressed open reading frame situated between genes U(L)20 and U(L)21 of the herpes simplex virus 1 genome.
Academic Article Glycoprotein D or J delivered in trans blocks apoptosis in SK-N-SH cells induced by a herpes simplex virus 1 mutant lacking intact genes expressing both glycoproteins.
Academic Article Cation-independent mannose 6-phosphate receptor blocks apoptosis induced by herpes simplex virus 1 mutants lacking glycoprotein D and is likely the target of antiapoptotic activity of the glycoprotein.
Academic Article Friendly fire: redirecting herpes simplex virus-1 for therapeutic applications.
Academic Article Oct-1 is posttranslationally modified and exhibits reduced capacity to bind cognate sites at late times after infection with herpes simplex virus 1.
Academic Article Post-transcriptional processing of cellular RNAs in herpes simplex virus-infected cells.
Academic Article Construction and properties of a herpes simplex virus 1 designed to enter cells solely via the IL-13alpha2 receptor.
Academic Article ICP0 and the US3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression.
Academic Article Herpes simplex virus 1 precludes replenishment of the short-lived receptor of tumor necrosis factor alpha by virion host shutoff-dependent degradation of its mRNA.
Academic Article Role of herpes simplex virus ICP0 in the transactivation of genes introduced by infection or transfection: a reappraisal.
Academic Article HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST is suppressed.
Academic Article Use of biotinylated plasmid DNA as a surrogate for HSV DNA to identify proteins that repress or activate viral gene expression.
Academic Article Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein.
Academic Article The 3 facets of regulation of herpes simplex virus gene expression: A critical inquiry.
Academic Article miRNAs Targeting ICP4 and Delivered to Susceptible Cells in Exosomes Block HSV-1 Replication in a Dose-Dependent Manner.
Academic Article Innate responses to gene knockouts impact overlapping gene networks and vary with respect to resistance to viral infection.
Academic Article PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2.
Academic Article GADD45? Activated Early in the Course of Herpes Simplex Virus 1 Infection Suppresses the Activation of a Network of Innate Immunity Genes.
Grant MOLECULAR BIOLOGY OF HERPES SIMPLEX VIRUSES
Grant Engineered HSV For Treatment of Malignant Glioma
Grant DISSECTION OF THE FUNCTIONS OF HERPES SIMPLEX VIRUS ICPO
Grant FUNCTIONS FOR HERPES SIMPLEX VIRUS ICP22 AND US1.5
Grant Selective Degradation of mRNA by Herpes Simplex Virus 1
Grant The functions of the US3 protein kinase of herpes simplex virus
Grant Dissection of the Functions of Herpes Simplex Virus ICPO
Grant MECHANISMS OF VIRAL INFECTION IN RELATION TO CANCER
Grant UCCRC: VIRAL ONCOLOGY PROGRAM
Grant MECHANISMS OF VIRAL INFECTION IN RELATION TO CANCER
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  • Genes