"Dichloroacetic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A derivative of ACETIC ACID that contains two CHLORINE atoms attached to its methyl group.
| Descriptor ID |
D003999
|
| MeSH Number(s) |
D02.241.081.018.214.500 D02.455.526.439.196.500
|
| Concept/Terms |
Dichloroacetic Acid- Dichloroacetic Acid
- Acid, Dichloroacetic
- Bichloroacetic Acid
- Acid, Bichloroacetic
|
Below are MeSH descriptors whose meaning is more general than "Dichloroacetic Acid".
Below are MeSH descriptors whose meaning is more specific than "Dichloroacetic Acid".
This graph shows the total number of publications written about "Dichloroacetic Acid" by people in this website by year, and whether "Dichloroacetic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dichloroacetic Acid" by people in Profiles.
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Enhanced pyruvate dehydrogenase activity improves cardiac outcomes in a murine model of cardiac arrest. PLoS One. 2017; 12(9):e0185046.
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FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate. J Mol Med (Berl). 2013 Mar; 91(3):333-46.
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Therapeutic targets in pulmonary arterial hypertension. Pharmacol Ther. 2009 Jan; 121(1):69-88.
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A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell. 2007 Jan; 11(1):37-51.
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An evidence-based approach to the management of pulmonary arterial hypertension. Curr Opin Cardiol. 2006 Jul; 21(4):385-92.
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An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation. 2006 Jun 06; 113(22):2630-41.
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The NO - K+ channel axis in pulmonary arterial hypertension. Activation by experimental oral therapies. Adv Exp Med Biol. 2003; 543:293-322.
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Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels. Circulation. 2002 Jan 15; 105(2):244-50.
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Glycolysis vs. respiration as ATP source for the shape of quiescent cardiomyocytes. Respir Physiol. 1994 Jul; 97(2):213-23.