 Drug Tolerance
"Drug Tolerance" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
| Descriptor ID |
D004361
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| MeSH Number(s) |
G07.690.812.260 G07.700.680.260
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| Concept/Terms |
Drug Tolerance- Drug Tolerance
- Drug Tolerances
- Tolerance, Drug
- Tolerances, Drug
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Below are MeSH descriptors whose meaning is more general than "Drug Tolerance".
Below are MeSH descriptors whose meaning is more specific than "Drug Tolerance".
This graph shows the total number of publications written about "Drug Tolerance" by people in this website by year, and whether "Drug Tolerance" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 0 | 1 | 1 | | 1984 | 0 | 2 | 2 | | 1985 | 0 | 1 | 1 | | 1987 | 0 | 1 | 1 | | 1990 | 0 | 1 | 1 | | 1991 | 0 | 3 | 3 | | 1992 | 0 | 1 | 1 | | 1993 | 0 | 1 | 1 | | 1994 | 0 | 5 | 5 | | 1995 | 0 | 2 | 2 | | 1996 | 1 | 5 | 6 | | 1997 | 0 | 2 | 2 | | 1999 | 0 | 2 | 2 | | 2002 | 1 | 0 | 1 | | 2004 | 0 | 2 | 2 | | 2006 | 1 | 1 | 2 | | 2007 | 1 | 1 | 2 | | 2008 | 0 | 2 | 2 | | 2010 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 | | 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "Drug Tolerance" by people in Profiles.
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Yi H, Kim HS. Antibiotic Scars Left on the Gut Microbiota from the Stringent Response. Trends Microbiol. 2018 09; 26(9):735-737.
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Yi H, Lee H, Cho KH, Kim HS. Mutations in MetG (methionyl-tRNA synthetase) and TrmD [tRNA (guanine-N1)-methyltransferase] conferring meropenem tolerance in Burkholderia thailandensis. J Antimicrob Chemother. 2018 02 01; 73(2):332-338.
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Abburi C, Wolfman SL, Metz RA, Kamber R, McGehee DS, McDaid J. Tolerance to Ethanol or Nicotine Results in Increased Ethanol Self-Administration and Long-Term Depression in the Dorsolateral Striatum. eNeuro. 2016 Jul-Aug; 3(4).
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Wardle MC, Marcus BA, de Wit H. A Preliminary Investigation of Individual Differences in Subjective Responses to D-Amphetamine, Alcohol, and Delta-9-Tetrahydrocannabinol Using a Within-Subjects Randomized Trial. PLoS One. 2015; 10(10):e0140501.
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Kinder JM, Then JE, Hansel PM, Molinero LL, Bruns HA. Long-term repeated daily use of intragastric gavage hinders induction of oral tolerance to ovalbumin in mice. Comp Med. 2014 Oct; 64(5):369-76.
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Kim JH, O'Brien KM, Sharma R, Boshoff HI, Rehren G, Chakraborty S, Wallach JB, Monteleone M, Wilson DJ, Aldrich CC, Barry CE, Rhee KY, Ehrt S, Schnappinger D. A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19095-100.
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Jagannath S, Vij R, Stewart AK, Trudel S, Jakubowiak AJ, Reiman T, Somlo G, Bahlis N, Lonial S, Kunkel LA, Wong A, Orlowski RZ, Siegel DS. An open-label single-arm pilot phase II study (PX-171-003-A0) of low-dose, single-agent carfilzomib in patients with relapsed and refractory multiple myeloma. Clin Lymphoma Myeloma Leuk. 2012 Oct; 12(5):310-8.
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Fillmore MT, Weafer J. Acute tolerance to alcohol in at-risk binge drinkers. Psychol Addict Behav. 2012 Dec; 26(4):693-702.
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Weafer J, Fillmore MT. Acute tolerance to alcohol impairment of behavioral and cognitive mechanisms related to driving: drinking and driving on the descending limb. Psychopharmacology (Berl). 2012 Apr; 220(4):697-706.
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Mechlin C, Kalorin C, Asplin J, White M. Splenda® improves tolerance of oral potassium citrate supplementation for prevention of stone formation: results of a randomized double-blind trial. J Endourol. 2011 Sep; 25(9):1541-5.
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