"Cardiac Glycosides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
- Cardiac Glycosides
- Glycosides, Cardiac
- Cardiotonic Steroids
- Steroids, Cardiotonic
Below are MeSH descriptors whose meaning is more general than "Cardiac Glycosides".
Below are MeSH descriptors whose meaning is more specific than "Cardiac Glycosides".
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Below are the most recent publications written about "Cardiac Glycosides" by people in Profiles.
Identification of a Cardiac Glycoside Exhibiting Favorable Brain Bioavailability and Potency for Reducing Levels of the Cellular Prion Protein. Int J Mol Sci. 2022 Nov 26; 23(23).
Regulation of myofibroblast differentiation by cardiac glycosides. Am J Physiol Lung Cell Mol Physiol. 2016 05 01; 310(9):L815-23.
Biphasic effect of cardiac glycosides on action potential duration in isolated Purkinje fibers. Pharmacol Toxicol. 2001 Sep; 89(3):145-8.
Congestive heart failure in the infant. Heart Lung. 1976 Jan-Feb; 5(1):63-70.