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Antonio Bianco

InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Antonio Bianco is a physician-scientist working in the thyroid field. His studies have focused on how the systemic hormone T3 initiates or terminates critical biological steps while maintaining relatively stable levels in the circulation. As a graduate student, he discovered the molecular link between deiodination and thermogenesis, specifically that the UCP-1 gene, key for brown adipose tissue thermogenesis, is transcriptionally stimulated by T3. This finding inspired further research on how deiodinases can modify intracellular T3 levels and signaling without antecedent changes in plasma TH levels. Over the years, the work in his lab has established the importance of “local” control of TH metabolism provided by deiodinases. From a broad perspective, this work has inspired the modern paradigm that deiodinases regulate thyroid hormone signaling on a tissue-specific basis, playing critical roles in human health and disease. He also served in different administrative capacities and as President of the American Thyroid Association (2015-16).
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    Collapse Biography 
    Collapse education and training
    Santa Casa School of Medicine, Sao Paulo, BrazilM.D.12/1983Medicine
    University of Sao Paulo, Sao Paulo, BrazilPh.D.12/1988Human Physiology
    Collapse awards and honors
    1983Manuel de Abreu Prize, Santa Casa School of Medicine
    2000LATS Prize, Latin American Thyroid Society
    2004Van Meter Award, American Thyroid Association
    2013Rosalind Pitt-Rivers Medal, British Thyroid Association
    2005Membership, American Society for Clinical Investigation
    2010Membership, Association of American Physicians
    2015 - 2016President, American Thyroid Association

    Collapse Research 
    Collapse research activities and funding
    R56DK058538     (BIANCO, ANTONIO C.)Sep 17, 2019 - Aug 31, 2020
    Selenodeidinase Processing by the Proteasome System
    Role: Principal Investigator

    R01DK078620     (BIANCO, ANTONIO C)Jul 20, 2009 - Jun 30, 2012
    Characterization of TGR5-D2-WSB1 signaling in metabolic homeostasis in vivo
    Role: Principal Investigator

    R01DK077148     (BIANCO, ANTONIO C.)Jan 1, 2007 - Jun 30, 2017
    Metabolic and Xenobiotic Control of Thyroid Hormone Metabolism
    Role: Principal Investigator

    R03TW006467     (BIANCO, ANTONIO C)Sep 1, 2003 - Aug 31, 2007
    Selenodeiodinase processing by the proteasome system
    Role: Principal Investigator

    R01DK065055     (BIANCO, ANTONIO C)Jul 1, 2003 - Jul 31, 2022
    Thyroid-adrenergic synergism and adaptive thermogenesis
    Role: Principal Investigator

    R01DK058538     (BIANCO, ANTONIO C ;GEREBEN, BALÁZS)Feb 1, 2001 - Mar 31, 2025
    Selenodeidinase Processing by the Proteasome System
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Penna GC, Bensenor IM, Bianco AC, Ettleson MD. Thyroid hormone homeostasis in levothyroxine-treated patients: Findings from ELSA-Brasil. J Clin Endocrinol Metab. 2024 Mar 20. PMID: 38506164.
      Citations:    Fields:    
    2. Salas-Lucia F, Escamilla S, Bianco AC, Dumitrescu A, Refetoff S. Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie Allan-Herndon-Dudley syndrome. JCI Insight. 2024 Feb 20; 9(7). PMID: 38376950.
      Citations:    Fields:    
    3. Penna GC, Bianco AC, Ettleson MD. A Cross-Sectional Analysis of Cardiovascular and Bone Health Care Utilization During Treatment With Thyroid Hormone. J Clin Endocrinol Metab. 2024 Feb 20; 109(3):e1143-e1150. PMID: 37878964; PMCID: PMC10876406.
      Citations:    Fields:    Translation:Humans
    4. Bianco AC, Dayan CM, Jonklaas J. Editorial: (Re)defining hypothyroidism: the key to patient-centered treatment. Front Endocrinol (Lausanne). 2024; 15:1369723. PMID: 38379867; PMCID: PMC10877014.
      Citations:    Fields:    Translation:Humans
    5. Hidalgo-Álvarez J, Salas-Lucia F, Vera Cruz D, Fonseca TL, Bianco AC. Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids. JCI Insight. 2023 Dec 08; 8(23). PMID: 37856222; PMCID: PMC10795825.
      Citations:    Fields:    Translation:HumansCells
    6. Ettleson MD, Ibarra S, Wan W, Peterson S, Laiteerapong N, Bianco AC. Demographic, Healthcare Access, and Dietary Factors Associated With Thyroid Hormone Treatments for Hypothyroidism. J Clin Endocrinol Metab. 2023 Nov 17; 108(12):e1614-e1623. PMID: 37327351; PMCID: PMC10655529.
      Citations: 3     Fields:    Translation:Humans
    7. Batistuzzo A, Salas-Lucia F, Gereben B, Ribeiro MO, Bianco AC. Sustained Pituitary T3 Production Explains the T4-mediated TSH Feedback Mechanism. Endocrinology. 2023 11 02; 164(12). PMID: 37864846; PMCID: PMC10637099.
      Citations: 1     Fields:    Translation:HumansAnimals
    8. Penna GC, Salas-Lucia F, Ribeiro MO, Bianco AC. Gene polymorphisms and thyroid hormone signaling: implication for the treatment of hypothyroidism. Endocrine. 2023 Sep 23. PMID: 37740833; PMCID: PMC10959761.
      Citations:    Fields:    
    9. Bianco AC. Emerging Therapies in Hypothyroidism. Annu Rev Med. 2024 Jan 29; 75:307-319. PMID: 37738506; PMCID: PMC10843736.
      Citations:    Fields:    Translation:HumansAnimals
    10. Zhu K, Mukherjee K, Wei C, Hayek SS, Collins A, Gu C, Corapi K, Altintas MM, Wang Y, Waikar SS, Bianco AC, Koch A, Tacke F, Reiser J, Sever S. The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes and kidney disease. Sci Transl Med. 2023 09 20; 15(714):eabq6492. PMID: 37729431.
      Citations:    Fields:    Translation:HumansAnimals
    11. Jiang C, Wolf K, Kaakati R, Oh J, Yip AT, Jonklaas J, Bianco AC, Laiteerapong N, Ettleson MD. The Effects of Patient Characteristics on the Management of Subclinical Hypothyroidism: A Survey of Faculty and Trainees. Endocr Pract. 2023 Oct; 29(10):787-793. PMID: 37549880; PMCID: PMC10592164.
      Citations:    Fields:    Translation:Humans
    12. Bianco AC, Bao Y, Antunez Flores O, Halpern R, Le L, Stackland S, Frieze T. Levothyroxine Treatment Adequacy and Formulation Changes in Patients with Hypothyroidism: A Retrospective Study of Real-World Data from the United States. Thyroid. 2023 08; 33(8):940-949. PMID: 37335236.
      Citations:    Fields:    Translation:Humans
    13. Casula S, Ettleson MD, Bianco AC. Are We Restoring Thyroid Hormone Signaling in Levothyroxine-Treated Patients With Residual Symptoms of Hypothyroidism? Endocr Pract. 2023 Jul; 29(7):581-588. PMID: 37419565.
      Citations: 2     Fields:    Translation:Humans
    14. Fekete C, Ruska Y, Egri P, Rada K, Salas-Lucia F, Sinkó R, Gereben B, Bianco AC. Axonal T3 uptake and transport can trigger thyroid hormone signaling in the brain. Elife. 2023 05 19; 12. PMID: 37204837; PMCID: PMC10241515.
      Citations: 2     Fields:    Translation:AnimalsCells
    15. Ettleson MD, Prieto WH, Russo PST, de Sa J, Wan W, Laiteerapong N, Maciel RMB, Bianco AC. Serum Thyrotropin and Triiodothyronine Levels in Levothyroxine-treated Patients. J Clin Endocrinol Metab. 2023 05 17; 108(6):e258-e266. PMID: 36515655; PMCID: PMC10413428.
      Citations: 5     Fields:    Translation:Humans
    16. Penksza V, Fonseca TL, Bianco AC, Fekete C, Sinkó R, Mohácsik P, Kovári D, Wittmann G, Mácsai L, Gereben B. Different Hypothalamic Mechanisms Control Decreased Circulating Thyroid Hormone Levels in Infection and Fasting-Induced Non-Thyroidal Illness Syndrome in Male Thyroid Hormone Action Indicator Mice. Thyroid. 2023 01; 33(1):109-118. PMID: 36322711; PMCID: PMC9885537.
      Citations: 4     Fields:    Translation:Animals
    17. Salas-Lucia F, Bianco AC. T3 levels and thyroid hormone signaling. Front Endocrinol (Lausanne). 2022; 13:1044691. PMID: 36387853; PMCID: PMC9646642.
      Citations: 10     Fields:    Translation:HumansAnimals
    18. Jonklaas J, Bianco AC. Enhancing the Patient Voice: Quality of Life, Satisfaction, and Preference During Treatment of Hypothyroidism. Thyroid. 2022 Oct; 32(10):1139-1141. PMID: 36136911; PMCID: PMC9836669.
      Citations:    Fields:    Translation:Humans
    19. Batistuzzo A, de Almeida GG, Zucato VP, Arnold AJT, Sato JM, Dias E, Lorena FB, do Nascimento BPP, Bianco AC, Ribeiro MO, Brás TS, Giannocco G, Yamanouchi LM. Multisensory Stimulation Improves Cognition and Behavior in Adult Male Rats Born to LT4-treated Thyroidectomized Dams. Endocrinology. 2022 09 01; 163(9). PMID: 35914267; PMCID: PMC9354969.
      Citations: 1     Fields:    Translation:Animals
    20. Ettleson MD, Bianco AC, Wan W, Laiteerapong N. Suboptimal Thyroid Hormone Replacement Is Associated With Worse Hospital Outcomes. J Clin Endocrinol Metab. 2022 07 14; 107(8):e3411-e3419. PMID: 35472082; PMCID: PMC9282363.
      Citations:    Fields:    Translation:Humans
    21. Lorena FB, Sato JM, Coviello BM, Arnold AJT, Batistuzzo A, Dias Junior E, do Nascimento BPP, Fonseca TL, Bianco AC, Ribeiro MO, Yamanouchi LM. Age Worsens the Cognitive Phenotype in Mice Carrying the Thr92Ala-DIO2 Polymorphism. Metabolites. 2022 Jul 08; 12(7). PMID: 35888752; PMCID: PMC9319877.
      Citations: 1     
    22. Boucai L, Salas-Lucia F, Krishnamoorthy GP, Sherman E, Rudin CM, Drilon A, Bianco AC, Fagin JA. Selpercatinib-Induced Hypothyroidism Through Off-Target Inhibition of Type 2 Iodothyronine Deiodinase. JCO Precis Oncol. 2022 06; 6:e2100496. PMID: 35704797; PMCID: PMC9384953.
      Citations: 5     Fields:    Translation:Humans
    23. de Souza Braga Filho J, de Brito Oliveira J, de Jesus JDS, Dos Santos Silva H, Teixeira HMP, Rodrigues JL, de Figueiredo CAV, Dos Santos Costa R, Hecht F, Bianco AC, Ramos HE, de Lima Beltrão FE, de Almeida Beltrão DC, Carvalhal G, de Lima Beltrão FE, Machado GJR, da Conceição Rodrigues Gonçalves M. Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19. J Clin Endocrinol Metab. 2022 05 17; 107(6):e2488-e2501. PMID: 35137147; PMCID: PMC8903419.
      Citations: 4     Fields:    Translation:Humans
    24. Fonseca TL, Russo SC, Luongo C, Salvatore D, Bianco AC. Inactivation of Type 3 Deiodinase Results in Life-long Changes in the Brown Adipose Tissue Transcriptome in the Male Mouse. Endocrinology. 2022 05 01; 163(5). PMID: 35238380; PMCID: PMC8988869.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    25. Salvatore D, Porcelli T, Ettleson MD, Bianco AC. The relevance of T3 in the management of hypothyroidism. Lancet Diabetes Endocrinol. 2022 05; 10(5):366-372. PMID: 35240052; PMCID: PMC9987447.
      Citations: 9     Fields:    Translation:Humans
    26. Shakir MKM, Brooks DI, McAninch EA, Fonseca TL, Mai VQ, Bianco AC, Hoang TD. Response to Letter to the Editor From Bonnema et al: "Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine + Liothyronine in Hypothyroidism". J Clin Endocrinol Metab. 2022 02 17; 107(3):e1327-e1328. PMID: 34718640; PMCID: PMC8852202.
      Citations: 1     Fields:    Translation:Humans
    27. Bianco AC, Jonklaas J, Pearce SH, Weetman AP, Perros P, Hegedüs L. Primary hypothyroidism and quality of life. Nat Rev Endocrinol. 2022 04; 18(4):230-242. PMID: 35042968; PMCID: PMC8930682.
      Citations: 30     Fields:    Translation:Humans
    28. Dumitrescu AM, Hanlon EC, Arosemena M, Duchon O, Ettleson M, Giurcanu M, Bianco AC. Extended Absorption of Liothyronine from Poly-Zinc-Liothyronine: Results from a Phase 1, Double-Blind, Randomized, and Controlled Study in Humans. Thyroid. 2022 02; 32(2):196-205. PMID: 34641706; PMCID: PMC8861912.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    29. Ettleson MD, Raine A, Batistuzzo A, Batista SP, McAninch E, Teixeira MCTV, Jonklaas J, Laiteerapong N, Ribeiro MO, Bianco AC. Brain Fog in Hypothyroidism: Understanding the Patient's Perspective. Endocr Pract. 2022 Mar; 28(3):257-264. PMID: 34890786; PMCID: PMC8901556.
      Citations: 13     Fields:    Translation:Humans
    30. Shakir MKM, Brooks DI, McAninch EA, Fonseca TL, Mai VQ, Bianco AC, Hoang TD. Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism. J Clin Endocrinol Metab. 2021 10 21; 106(11):e4400-e4413. PMID: 34185829; PMCID: PMC8530721.
      Citations: 24     Fields:    Translation:HumansCells
    31. Agarwal S, Koh KH, Tardi NJ, Chen C, Dande RR, WerneckdeCastro JP, Sudhini YR, Luongo C, Salvatore D, Samelko B, Altintas MM, Mangos S, Bianco A, Reiser J. Deiodinase-3 is a thyrostat to regulate podocyte homeostasis. EBioMedicine. 2021 Oct; 72:103617. PMID: 34649077; PMCID: PMC8517284.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    32. Carvalhal G, Bastos IHA, Hecht F, Bianco AC, Ramos HE, Beltrão FEL, Beltrão DCA, Beltrão FEL, Brito ADS, Capistrano KHRD, Daltro CHDC, Gonçalves MDCR. Thyroid Hormone Levels During Hospital Admission Inform Disease Severity and Mortality in COVID-19 Patients. Thyroid. 2021 11; 31(11):1639-1649. PMID: 34314259.
      Citations: 20     Fields:    Translation:HumansCells
    33. Idrees T, Bianco AC. Letter to the Editor from Idrees and Bianco: "Treatment of Thyroid Dysfunction and Serum Lipids: A Systematic Review and Meta-analysis". J Clin Endocrinol Metab. 2021 08 18; 106(9):e3785-e3786. PMID: 33837396; PMCID: PMC9633326.
      Citations:    Fields:    Translation:Humans
    34. Russo SC, Salas-Lucia F, Bianco AC. Deiodinases and the Metabolic Code for Thyroid Hormone Action. Endocrinology. 2021 08 01; 162(8). PMID: 33720335; PMCID: PMC8237994.
      Citations: 19     Fields:    Translation:HumansAnimals
    35. Fonseca TL, Garcia T, Fernandes GW, Nair TM, Bianco AC. Neonatal thyroxine activation modifies epigenetic programming of the liver. Nat Commun. 2021 07 21; 12(1):4446. PMID: 34290257; PMCID: PMC8295303.
      Citations: 8     Fields:    Translation:AnimalsCells
    36. Butterfield NC, Curry KF, Dewhurst H, Komla-Ebri D, Mannan NS, Adoum AT, Leitch VD, Logan JG, Waung JA, Ghirardello E, Youlten SE, Wilkinson JM, McAninch EA, Vancollie VE, Kussy F, White JK, Lelliott CJ, Adams DJ, Jacques R, Bianco AC, Boyde A, Croucher PI, Williams GR, Bassett JHD, Steinberg J, Southam L, Zeggini E. Publisher Correction: Accelerating functional gene discovery in osteoarthritis. Nat Commun. 2021 May 28; 12(1):3302. PMID: 34050183; PMCID: PMC8163861.
      Citations: 4     Fields:    
    37. Ettleson MD, Bianco AC, Zhu M, Laiteerapong N. Sociodemographic Disparities in the Treatment of Hypothyroidism: NHANES 2007-2012. J Endocr Soc. 2021 Jul 01; 5(7):bvab041. PMID: 34104843; PMCID: PMC8156978.
      Citations: 7     
    38. Idrees T, Prieto WH, Casula S, Ajith A, Ettleson M, Narchi FAA, Russo PST, Fernandes F, Johnson J, Mayampurath A, Maciel RMB, Bianco AC. Use of Statins Among Patients Taking Levothyroxine: an Observational Drug Utilization Study Across Sites. J Endocr Soc. 2021 Jul 01; 5(7):bvab038. PMID: 34141994; PMCID: PMC8204793.
      Citations: 8     
    39. Jonklaas J, Bianco AC, Cappola AR, Celi FS, Fliers E, Heuer H, McAninch EA, Moeller LC, Nygaard B, Sawka AM, Watt T, Dayan CM. Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document. Eur Thyroid J. 2021 Mar; 10(1):10-38. PMID: 33777817; PMCID: PMC7983670.
      Citations: 21     
    40. Jonklaas J, Bianco AC, Cappola AR, Celi FS, Fliers E, Heuer H, McAninch EA, Moeller LC, Nygaard B, Sawka AM, Watt T, Dayan CM. Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document. Thyroid. 2021 02; 31(2):156-182. PMID: 33276704; PMCID: PMC8035928.
      Citations: 38     Fields:    Translation:Humans
    41. Butterfield NC, Curry KF, Dewhurst H, Komla-Ebri D, Mannan NS, Adoum AT, Leitch VD, Logan JG, Waung JA, Ghirardello E, Youlten SE, Wilkinson JM, McAninch EA, Vancollie VE, Kussy F, White JK, Lelliott CJ, Adams DJ, Jacques R, Bianco AC, Boyde A, Croucher PI, Williams GR, Bassett JHD, Steinberg J, Southam L, Zeggini E. Accelerating functional gene discovery in osteoarthritis. Nat Commun. 2021 01 20; 12(1):467. PMID: 33473114; PMCID: PMC7817695.
      Citations: 22     Fields:    Translation:AnimalsCells
    42. Bianco AC, E Marcondes AA, Gomez TGB, Ravache TT, Batistuzzo A, Lorena FB, de Paula CS, Lowenthal R, Ribeiro MO. Assessment of children in the autistic spectrum disorder that carry the Thr92Ala-DIO2 polymorphism. J Endocrinol Invest. 2021 Aug; 44(8):1775-1782. PMID: 33449341; PMCID: PMC8693502.
      Citations: 3     Fields:    Translation:Humans
    43. Bocco BMLC, Fernandes GW, Fonseca TL, Bianco AC. Iodine Deficiency Increases Fat Contribution to Energy Expenditure in Male Mice. Endocrinology. 2020 12 01; 161(12). PMID: 33091112; PMCID: PMC7707619.
      Citations: 3     Fields:    Translation:AnimalsCells
    44. Sawka AM, Alexander EK, Bianco AC, Chou R, Haugen BR, Kopp PA, Pearce EN, Ross DS, Smallridge RC, Jonklaas J. Challenges in Developing Recommendations Based on Low-Quality Evidence in Thyroid Guidelines. Thyroid. 2021 01; 31(1):3-7. PMID: 32900277.
      Citations: 2     Fields:    Translation:Humans
    45. German A, Fernandes GW, Liao XH, Bianco AC, Refetoff S, Dumitrescu AM, França MM. Human Type 1 Iodothyronine Deiodinase (DIO1) Mutations Cause Abnormal Thyroid Hormone Metabolism. Thyroid. 2021 02; 31(2):202-207. PMID: 32718224; PMCID: PMC7891200.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    46. McAninch EA, Fernandes GW, Bocco BMLC, Ribeiro MO, Bianco AC, Marcelino CP. Temporal Pole Responds to Subtle Changes in Local Thyroid Hormone Signaling. J Endocr Soc. 2020 Nov 01; 4(11):bvaa136. PMID: 33123655; PMCID: PMC7575126.
      Citations: 6     
    47. Ettleson MD, Bianco AC. Individualized Therapy for Hypothyroidism: Is T4 Enough for Everyone? J Clin Endocrinol Metab. 2020 09 01; 105(9). PMID: 32614450; PMCID: PMC7382053.
      Citations: 24     Fields:    Translation:Humans
    48. Idrees T, Palmer S, Maciel RMB, Bianco AC. Liothyronine and Desiccated Thyroid Extract in the Treatment of Hypothyroidism. Thyroid. 2020 10; 30(10):1399-1413. PMID: 32279609; PMCID: PMC7640752.
      Citations: 16     Fields:    Translation:Humans
    49. Bianco AC. We All Know We Need Them, We Hope They Are Coming, But When? Thyroid. 2020 06; 30(6):791-793. PMID: 32228170; PMCID: PMC7307695.
      Citations: 2     Fields:    Translation:Humans
    50. Bianco AC, Taylor P. Levothyroxine treatment and cholesterol in hypothyroidism. Nat Rev Endocrinol. 2020 04; 16(4):193-194. PMID: 32005968.
      Citations: 4     Fields:    Translation:HumansAnimals
    51. McKeever L, Peterson SJ, Lateef O, Freels S, Fonseca TL, Bocco BMLC, Fernandes GW, Roehl K, Nowak K, Mozer M, Bianco AC, Braunschweig CA. Higher Caloric Exposure in Critically Ill Patients Transiently Accelerates Thyroid Hormone Activation. J Clin Endocrinol Metab. 2020 02 01; 105(2). PMID: 31581295; PMCID: PMC9633328.
      Citations: 6     Fields:    Translation:Humans
    52. Sawka AM, Cappola AR, Peeters RP, Kopp PA, Bianco AC, Jonklaas J. Patient Context and Thyrotropin Levels Are Important When Considering Treatment of Subclinical Hypothyroidism. Thyroid. 2019 10; 29(10):1359-1363. PMID: 31489828.
      Citations: 7     Fields:    Translation:Humans
    53. Taylor P, Bianco AC. Urgent need for further research in subclinical hypothyroidism. Nat Rev Endocrinol. 2019 09; 15(9):503-504. PMID: 31300726; PMCID: PMC7309559.
      Citations: 9     Fields:    Translation:Humans
    54. Idrees T, Price JD, Piccariello T, Bianco AC. Sustained Release T3 Therapy: Animal Models and Translational Applications. Front Endocrinol (Lausanne). 2019; 10:544. PMID: 31456749; PMCID: PMC6700330.
      Citations: 9     Fields:    
    55. Bianco AC, Dumitrescu A, Fonseca TL, Fernandes GW, Bocco BMLC, Gereben B, Ribeiro MO. Paradigms of Dynamic Control of Thyroid Hormone Signaling. Endocr Rev. 2019 08 01; 40(4):1000-1047. PMID: 31033998; PMCID: PMC6596318.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    56. McAninch EA, Bianco AC. The Swinging Pendulum in Treatment for Hypothyroidism: From (and Toward?) Combination Therapy. Front Endocrinol (Lausanne). 2019; 10:446. PMID: 31354624; PMCID: PMC6629976.
      Citations: 10     Fields:    
    57. Keshavarzian A, Jakate S, Donohue TM, Fonseca TL, Fernandes GW, Bocco BMLC, Gereben B, Bianco AC. Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis. Alcohol Clin Exp Res. 2019 07; 43(7):1376-1383. PMID: 30908637; PMCID: PMC6602874.
      Citations: 6     Fields:    Translation:Animals
    58. Jo S, Fonseca TL, Bocco BMLC, Fernandes GW, McAninch EA, Bolin AP, Werneck-de-Castro JP, Ignacio DL, Fekete C, Leitch VD, Mannan NS, Curry KF, Butterfield NC, Bassett JHD, Williams GR, Bianco AC, Da Conceição RR, Egri P, Németh D, Bernardi MM, Gereben B, Ribeiro MO. Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain. J Clin Invest. 2019 01 02; 129(1):230-245. PMID: 30352046; PMCID: PMC6307951.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    59. Fernandes GW, Fonseca TL, Bocco BMLC, Bianco AC, Da Conceição RR. Metal Coordinated Poly-Zinc-Liothyronine Provides Stable Circulating Triiodothyronine Levels in Hypothyroid Rats. Thyroid. 2018 11; 28(11):1425-1433. PMID: 30301431; PMCID: PMC7207055.
      Citations: 13     Fields:    Translation:Animals
    60. Bianco AC, Kim BS. Pathophysiological relevance of deiodinase polymorphism. Curr Opin Endocrinol Diabetes Obes. 2018 10; 25(5):341-346. PMID: 30063552; PMCID: PMC6571023.
      Citations: 24     Fields:    Translation:Humans
    61. Trohman RG, Sharma PS, McAninch EA, Bianco AC. Amiodarone and thyroid physiology, pathophysiology, diagnosis and management. Trends Cardiovasc Med. 2019 07; 29(5):285-295. PMID: 30309693; PMCID: PMC6661016.
      Citations: 21     Fields:    Translation:HumansAnimals
    62. McAninch EA, Rajan KB, Miller CH, Bianco AC. Systemic Thyroid Hormone Status During Levothyroxine Therapy In Hypothyroidism: A Systematic Review and Meta-Analysis. J Clin Endocrinol Metab. 2018 Aug 15. PMID: 30124904; PMCID: PMC6226605.
      Citations: 37     Fields:    
    63. Bocco BMLC, Fernandes GW, Fonseca TL, McAninch EA, Bianco AC, Nascimento BPP, Cardoso CV, Bondan EF, Nassif RJ, Cysneiros RM, Ribeiro MO. Induction of Type 2 Iodothyronine Deiodinase After Status Epilepticus Modifies Hippocampal Gene Expression in Male Mice. Endocrinology. 2018 08 01; 159(8):3090-3104. PMID: 29905787; PMCID: PMC6669821.
      Citations: 7     Fields:    Translation:AnimalsCells
    64. McAninch EA, Glueck JS, Bianco AC. Does Sex Bias Play a Role for Dissatisfied Patients With Hypothyroidism? J Endocr Soc. 2018 Aug 01; 2(8):970-973. PMID: 30094410; PMCID: PMC6077803.
      Citations: 2     
    65. McAninch EA, Rajan KB, Evans DA, Jo S, Chaker L, Peeters RP, Bennett DA, Mash DC, Bianco AC. A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans. J Clin Endocrinol Metab. 2018 05 01; 103(5):1818-1826. PMID: 29481662; PMCID: PMC6276710.
      Citations: 21     Fields:    Translation:Humans
    66. Peterson SJ, Cappola AR, Castro MR, Dayan CM, Farwell AP, Hennessey JV, Kopp PA, Ross DS, Samuels MH, Sawka AM, Taylor PN, Jonklaas J, Bianco AC. An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction. Thyroid. 2018 06; 28(6):707-721. PMID: 29620972; PMCID: PMC6916129.
      Citations: 85     Fields:    Translation:Humans
    67. Lechan RM, Bianco AC, Fekete C, Mohácsik P, Erdélyi F, Baranyi M, Botz B, Szabó G, Tóth M, Haltrich I, Helyes Z, Sperlágh B, Tóth Z, Sinkó R, Gereben B. A Transgenic Mouse Model for Detection of Tissue-Specific Thyroid Hormone Action. Endocrinology. 2018 02 01; 159(2):1159-1171. PMID: 29253128; PMCID: PMC6283413.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    68. Fernandes GW, Bocco BMLC, Fonseca TL, McAninch EA, Jo S, Lartey LJ, O-Sullivan I, Unterman TG, Preite NZ, Voigt RM, Forsyth CB, Keshavarzian A, Goldfine AB, Patti ME, Ribeiro MO, Bianco AC, Sinkó R, Gereben B. The Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia. Cell Rep. 2018 01 09; 22(2):523-534. PMID: 29320745; PMCID: PMC6474669.
      Citations: 16     Fields:    Translation:Animals
    69. Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism and hypertension: fact or myth? - Authors' reply. Lancet. 2018 01 06; 391(10115):30. PMID: 29323655.
      Citations: 3     Fields:    Translation:Humans
    70. Bianco AC, da Conceição RR. The Deiodinase Trio and Thyroid Hormone Signaling. Methods Mol Biol. 2018; 1801:67-83. PMID: 29892818; PMCID: PMC6668716.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    71. Yu G, Tzouvelekis A, Wang R, Herazo-Maya JD, Ibarra GH, Srivastava A, de Castro JPW, DeIuliis G, Ahangari F, Woolard T, Aurelien N, Arrojo E Drigo R, Gan Y, Graham M, Liu X, Homer RJ, Scanlan TS, Mannam P, Lee PJ, Herzog EL, Bianco AC, Kaminski N. Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. Nat Med. 2018 01; 24(1):39-49. PMID: 29200204; PMCID: PMC5760280.
      Citations: 144     Fields:    Translation:HumansAnimalsCells
    72. Preite NZ, Bianco AC, Paolino BS, Pomerantzeff PM, Dallan LAO, Gaiotto FA, Latrônico AC, Nicolau JC, Giraldez RRCV. Myocardial Inactivation of Thyroid Hormones in Patients with Aortic Stenosis. Thyroid. 2017 05; 27(5):738-745. PMID: 28095748; PMCID: PMC5749598.
      Citations: 6     Fields:    Translation:Humans
    73. Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism. Lancet. 2017 Sep 23; 390(10101):1550-1562. PMID: 28336049; PMCID: PMC6619426.
      Citations: 321     Fields:    
    74. Ignacio DL, Silvestre DH, Anne-Palmer E, Bocco BM, Fonseca TL, Bianco AC, Werneck-de-Castro JP, Ribeiro MO, Gereben B. Early Developmental Disruption of Type 2 Deiodinase Pathway in Mouse Skeletal Muscle Does Not Impair Muscle Function. Thyroid. 2017 04; 27(4):577-586. PMID: 27967605; PMCID: PMC5385430.
      Citations: 6     Fields:    Translation:AnimalsCells
    75. Peterson SJ, McAninch EA, Bianco AC. Is a Normal TSH Synonymous With "Euthyroidism" in Levothyroxine Monotherapy? J Clin Endocrinol Metab. 2016 12; 101(12):4964-4973. PMID: 27700539; PMCID: PMC6287526.
      Citations: 73     Fields:    Translation:Humans
    76. Preite NZ, Nascimento BP, Muller CR, Higa TS, Evangelista FS, Henriques FS, Batista ML, Bianco AC, Ribeiro MO, Américo AL, Lancellotti CL. Disruption of beta3 adrenergic receptor increases susceptibility to DIO in mouse. J Endocrinol. 2016 12; 231(3):259-269. PMID: 27672060; PMCID: PMC5609459.
      Citations: 19     Fields:    Translation:AnimalsCells
    77. Rajan KB, Arvanitakis Z, Lynch EB, McAninch EA, Wilson RS, Weuve J, Barnes LL, Bianco AC, Evans DA. Cognitive decline following incident and preexisting diabetes mellitus in a population sample. Neurology. 2016 Oct 18; 87(16):1681-1687. PMID: 27655734; PMCID: PMC5085078.
      Citations: 17     Fields:    Translation:Humans
    78. Lowe K, Bianco AC, Canar J, Kasdorf K, Mantei B, Smith BT. The Relationship Between Work Relative Value Unit Awareness and Work Relative Value Unit Accumulation Among Physicians. J Med Pract Manage. 2016 09; 32(2):86-91. PMID: 29944795.
      Citations:    Fields:    Translation:Humans
    79. Bocco BM, Louzada RA, Silvestre DH, Santos MC, Anne-Palmer E, Rangel IF, Abdalla S, Ferreira AC, Ribeiro MO, Carvalho DP, Bianco AC, Gereben B, Werneck-de-Castro JP. Thyroid hormone activation by type 2 deiodinase mediates exercise-induced peroxisome proliferator-activated receptor-? coactivator-1a expression in skeletal muscle. J Physiol. 2016 09 15; 594(18):5255-69. PMID: 27302464; PMCID: PMC5023700.
      Citations: 23     Fields:    Translation:AnimalsCells
    80. Bocco BM, Oliveira KC, Fernandes GW, Fonseca TL, Nascimento BP, McAninch EA, Ricci E, Fekete C, Bernardi MM, Bianco AC, Ribeiro MO, Werneck-de-Castro JP, Kvárta-Papp Z, Gereben B. Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice. Endocrinology. 2016 09; 157(9):3682-95. PMID: 27501182; PMCID: PMC5007895.
      Citations: 33     Fields:    Translation:AnimalsCells
    81. Bianco AC, Bocco BM, Fernandes GW, Lorena FB, Cysneiros RM, Christoffolete MA, Grecco SS, Lancellotti CL, Romoff P, Lago JH, Ribeiro MO. Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice. Braz J Med Biol Res. 2016 Mar; 49(3). PMID: 26840707; PMCID: PMC4763817.
      Citations: 7     Fields:    Translation:Animals
    82. McAninch EA, Bianco AC. The History and Future of Treatment of Hypothyroidism. Ann Intern Med. 2016 Jan 05; 164(1):50-6. PMID: 26747302; PMCID: PMC4980994.
      Citations: 50     Fields:    Translation:HumansCells
    83. McAninch EA, Bianco AC. Of rats and men: thyroid homeostasis in rodents and human beings - Authors' reply. Lancet Diabetes Endocrinol. 2015 Dec; 3(12):933. PMID: 26590685.
      Citations:    Fields:    Translation:HumansAnimals
    84. Fonseca TL, McAninch EA, Abdalla SM, Fekete C, Li D, Xing X, Wang T, Bianco AC, Fernandes GW, Bocco BM, Ribeiro MO, Mohácsik P, Gereben B. Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):14018-23. PMID: 26508642; PMCID: PMC4653175.
      Citations: 23     Fields:    Translation:AnimalsCells
    85. Lartey LJ, O-Sullivan I, Unterman TG, Bianco AC, Werneck-de-Castro JP. Coupling between Nutrient Availability and Thyroid Hormone Activation. J Biol Chem. 2015 Dec 18; 290(51):30551-61. PMID: 26499800; PMCID: PMC4683275.
      Citations: 22     Fields:    Translation:AnimalsCells
    86. McAninch EA, Bianco AC, Gereben B, Ribeiro MO. Scope and limitations of iodothyronine deiodinases in hypothyroidism. Nat Rev Endocrinol. 2015 Nov; 11(11):642-652. PMID: 26416219; PMCID: PMC5003781.
      Citations: 61     Fields:    Translation:HumansAnimals
    87. McAninch EA, Bianco AC. New insights into the variable effectiveness of levothyroxine monotherapy for hypothyroidism. Lancet Diabetes Endocrinol. 2015 Oct; 3(10):756-8. PMID: 26362364; PMCID: PMC5006060.
      Citations: 18     Fields:    Translation:HumansAnimals
    88. Werneck-de-Castro JP, Fonseca TL, Ignacio DL, Fernandes GW, Andrade-Feraud CM, Lartey LJ, Ribeiro MB, Ribeiro MO, Gereben B, Bianco AC. Thyroid Hormone Signaling in Male Mouse Skeletal Muscle Is Largely Independent of D2 in Myocytes. Endocrinology. 2015 Oct; 156(10):3842-52. PMID: 26214036; PMCID: PMC4588812.
      Citations: 15     Fields:    Translation:AnimalsCells
    89. Fliers E, Bianco AC, Langouche L, Boelen A. Thyroid function in critically ill patients. Lancet Diabetes Endocrinol. 2015 Oct; 3(10):816-25. PMID: 26071885; PMCID: PMC4979220.
      Citations: 140     Fields:    Translation:Humans
    90. Roberts SC, Bianco AC, Stapleton HM. Disruption of type 2 iodothyronine deiodinase activity in cultured human glial cells by polybrominated diphenyl ethers. Chem Res Toxicol. 2015 Jun 15; 28(6):1265-74. PMID: 26004626; PMCID: PMC4827872.
      Citations: 16     Fields:    Translation:HumansCells
    91. McAninch EA, Fonseca TL, Poggioli R, Panos AL, Salerno TA, Deng Y, Li Y, Bianco AC, Iacobellis G. Epicardial adipose tissue has a unique transcriptome modified in severe coronary artery disease. Obesity (Silver Spring). 2015 Jun; 23(6):1267-78. PMID: 25959145; PMCID: PMC5003780.
      Citations: 47     Fields:    Translation:HumansCells
    92. Cao Y, Gomes SA, Rangel EB, Paulino EC, Fonseca TL, Li J, Teixeira MB, Gouveia CH, Bianco AC, Kapiloff MS, Balkan W, Hare JM. S-nitrosoglutathione reductase-dependent PPAR? denitrosylation participates in MSC-derived adipogenesis and osteogenesis. J Clin Invest. 2015 Apr; 125(4):1679-91. PMID: 25798618; PMCID: PMC4396480.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    93. Jo S, Preite NZ, Fekete C, Li Y, Deng Y, Patti ME, Zevenbergen C, Peeters RP, Mash DC, Bianco AC, McAninch EA, Farkas E, Mohácsik P, Egri P, Gereben B. Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes. J Clin Endocrinol Metab. 2015 Mar; 100(3):920-33. PMID: 25569702; PMCID: PMC4333048.
      Citations: 37     Fields:    Translation:HumansCells
    94. Werneck de Castro JP, Fonseca TL, Ueta CB, McAninch EA, Abdalla S, Wittmann G, Lechan RM, Gereben B, Bianco AC. Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine. J Clin Invest. 2015 Feb; 125(2):769-81. PMID: 25555216; PMCID: PMC4319436.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    95. Jonklaas J, Bianco AC, Bauer AJ, Burman KD, Cappola AR, Celi FS, Cooper DS, Kim BW, Peeters RP, Rosenthal MS, Sawka AM, American Thyroid Association Task Force on Thyroid Hormone Replacement. Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid. 2014 Dec; 24(12):1670-751. PMID: 25266247; PMCID: PMC4267409.
      Citations: 520     Fields:    Translation:Humans
    96. Abdalla SM, Bianco AC. Defending plasma T3 is a biological priority. Clin Endocrinol (Oxf). 2014 Nov; 81(5):633-41. PMID: 25040645; PMCID: PMC4699302.
      Citations: 55     Fields:    Translation:Humans
    97. Medina MC, Fonesca TL, Molina J, Fachado A, Castillo M, Dong L, Soares R, Caicedo A, Bianco AC, Hernández A. Maternal inheritance of an inactive type III deiodinase gene allele affects mouse pancreatic ß-cells and disrupts glucose homeostasis. Endocrinology. 2014 Aug; 155(8):3160-71. PMID: 24885572; PMCID: PMC4097999.
      Citations: 9     Fields:    Translation:AnimalsCells
    98. Fernandes GW, Ueta CB, Fonseca TL, Gouveia CH, Lancellotti CL, Brum PC, Christoffolete MA, Bianco AC, Ribeiro MO. Inactivation of the adrenergic receptor ß2 disrupts glucose homeostasis in mice. J Endocrinol. 2014 Jun; 221(3):381-90. PMID: 24868110; PMCID: PMC4976625.
      Citations: 17     Fields:    Translation:Animals
    99. McAninch EA, Bianco AC. Thyroid hormone signaling in energy homeostasis and energy metabolism. Ann N Y Acad Sci. 2014 Apr; 1311:77-87. PMID: 24697152; PMCID: PMC4451242.
      Citations: 73     Fields:    Translation:HumansAnimals
    100. Leiva AG, Chen AL, Devarajan P, Chen Z, Damanpour S, Hall JA, Bianco AC, Li J, Badiavas EV, Zaias J, Miteva M, Romanelli P, Nouri K, Cao Wikramanayake T. Loss of Mpzl3 function causes various skin abnormalities and greatly reduced adipose depots. J Invest Dermatol. 2014 Jul; 134(7):1817-1827. PMID: 24531688; PMCID: PMC4057944.
      Citations: 10     Fields:    Translation:AnimalsCells
    101. Fonseca TL, Werneck-De-Castro JP, Castillo M, Bocco BM, Fernandes GW, McAninch EA, Ignacio DL, Moises CC, Ferreira AR, Ferreira A, Bianco AC, Gereben B. Tissue-specific inactivation of type 2 deiodinase reveals multilevel control of fatty acid oxidation by thyroid hormone in the mouse. Diabetes. 2014 May; 63(5):1594-604. PMID: 24487027; PMCID: PMC3994955.
      Citations: 32     Fields:    Translation:AnimalsCells
    102. Bianco AC, Anderson G, Forrest D, Galton VA, Kim BW, Kopp PA, Liao XH, Obregon MJ, Peeters RP, Refetoff S, Sharlin DS, Simonides WS, Weiss RE, Williams GR, American Thyroid Association Task Force on Approaches and Strategies to Investigate Thyroid Hormone , Gereben B. American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models. Thyroid. 2014 Jan; 24(1):88-168. PMID: 24001133; PMCID: PMC3887458.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    103. Arrojo E Drigo R, Jo S, Bianco AC, Egri P, Gereben B. The type II deiodinase is retrotranslocated to the cytoplasm and proteasomes via p97/Atx3 complex. Mol Endocrinol. 2013 Dec; 27(12):2105-15. PMID: 24196352; PMCID: PMC3857201.
      Citations: 17     Fields:    Translation:HumansCells
    104. Vose LR, Vinukonda G, Jo S, Miry O, Diamond D, Korumilli R, Arshad A, Zia MT, Hu F, Kayton RJ, La Gamma EF, Bansal R, Bianco AC, Ballabh P. Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage. J Neurosci. 2013 Oct 30; 33(44):17232-46. PMID: 24174657; PMCID: PMC3812500.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    105. Bianco AC, McAninch EA. The role of thyroid hormone and brown adipose tissue in energy homoeostasis. Lancet Diabetes Endocrinol. 2013 Nov; 1(3):250-8. PMID: 24622373; PMCID: PMC4976626.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    106. Poggioli R, Ueta CB, Drigo RA, Castillo M, Fonseca TL, Bianco AC. Dexamethasone reduces energy expenditure and increases susceptibility to diet-induced obesity in mice. Obesity (Silver Spring). 2013 Sep; 21(9):E415-20. PMID: 23408649; PMCID: PMC4451231.
      Citations: 29     Fields:    Translation:Animals
    107. Hong EG, Kim BW, Jung DY, Kim JH, Yu T, Seixas Da Silva W, Friedline RH, Bianco SD, Seslar SP, Wakimoto H, Berul CI, Russell KS, Lee KW, Larsen PR, Bianco AC, Kim JK. Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice. Endocrinology. 2013 Oct; 154(10):3937-46. PMID: 23861374; PMCID: PMC4411365.
      Citations: 14     Fields:    Translation:HumansAnimals
    108. Jonklaas J, Burman KD, Bianco AC, American Thyroid Association Spring 2013 Program Committee. Treatment of hypothyroidism: possibilities on the horizon. Thyroid. 2013 Apr; 23(4):ix-xi. PMID: 23521210.
      Citations: 3     Fields:    Translation:Humans
    109. Fonseca TL, Correa-Medina M, Campos MP, Wittmann G, Werneck-de-Castro JP, Arrojo e Drigo R, Mora-Garzon M, Ueta CB, Caicedo A, Fekete C, Gereben B, Lechan RM, Bianco AC. Coordination of hypothalamic and pituitary T3 production regulates TSH expression. J Clin Invest. 2013 Apr; 123(4):1492-500. PMID: 23524969; PMCID: PMC3613903.
      Citations: 67     Fields:    Translation:AnimalsCells
    110. Bianco AC. Cracking the code for thyroid hormone signaling. Trans Am Clin Climatol Assoc. 2013; 124:26-35. PMID: 23874007; PMCID: PMC3715916.
      Citations: 4     Fields:    Translation:AnimalsCells
    111. Arrojo E Drigo R, Fonseca TL, Werneck-de-Castro JP, Bianco AC. Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling. Biochim Biophys Acta. 2013 Jul; 1830(7):3956-64. PMID: 22967761; PMCID: PMC4979226.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    112. Bianco AC, Casula S. Thyroid hormone replacement therapy: three 'simple' questions, complex answers. Eur Thyroid J. 2012 Jul; 1(2):88-98. PMID: 24783002; PMCID: PMC3821470.
      Citations: 14     
    113. Fernandes GW, Capelo LP, Fonseca TL, Gouveia CH, Christoffolete MA, Aoki MS, Lancellotti CL, Kim B, Bianco AC, Ribeiro MO, Ueta CB, Maculan FD, Brum PC. ß(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice. J Endocrinol. 2012 Sep; 214(3):359-65. PMID: 22728333; PMCID: PMC4977996.
      Citations: 50     Fields:    Translation:AnimalsCells
    114. Jo S, Arrojo e Drigo R, Liposits Z, Oliva A, Lemmon VP, Bixby JL, Bianco AC, Kalló I, Bardóczi Z, Zeöld A, Gereben B. Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism. J Neurosci. 2012 Jun 20; 32(25):8491-500. PMID: 22723689; PMCID: PMC3752066.
      Citations: 35     Fields:    Translation:AnimalsCells
    115. Vida B, Zavacki AM, Hrabovszky E, Arrojo E Drigo R, Dong L, Lechan RM, Bianco AC, Liposits Z, Fekete C, Kalló I, Mohácsik P, Zeöld A, Bardóczi Z, Farkas E, Kádár A, Barna L, Palkovits M, Borsay BA, Herczeg L, Gereben B. A novel pathway regulates thyroid hormone availability in rat and human hypothalamic neurosecretory neurons. PLoS One. 2012; 7(6):e37860. PMID: 22719854; PMCID: PMC3377717.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    116. Casula S, Bianco AC. Thyroid hormone deiodinases and cancer. Front Endocrinol (Lausanne). 2012; 3:74. PMID: 22675319; PMCID: PMC3365412.
      Citations: 15     Fields:    
    117. Ueta CB, Oskouei BN, Olivares EL, Pinto JR, Correa MM, Simovic G, Simonides WS, Hare JM, Bianco AC. Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice. Mol Endocrinol. 2012 May; 26(5):809-18. PMID: 22403173; PMCID: PMC3355550.
      Citations: 20     Fields:    Translation:Animals
    118. Arrojo E Drigo R, Fonseca TL, Castillo M, Salathe M, Simovic G, Gereben B, Bianco AC, Mohácsik P. Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis. Mol Endocrinol. 2011 Dec; 25(12):2065-75. PMID: 22053000; PMCID: PMC3231828.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    119. Bianco AC, Mohácsik P, Zeöld A, Gereben B. Thyroid hormone and the neuroglia: both source and target. J Thyroid Res. 2011; 2011:215718. PMID: 21876836; PMCID: PMC3163027.
      Citations: 22     
    120. Iacobellis G, Bianco AC. Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features. Trends Endocrinol Metab. 2011 Nov; 22(11):450-7. PMID: 21852149; PMCID: PMC4978122.
      Citations: 182     Fields:    Translation:HumansAnimals
    121. Medina MC, Molina J, Gadea Y, Fachado A, Murillo M, Simovic G, Pileggi A, Edlund H, Bianco AC, Hernández A. The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion. Endocrinology. 2011 Oct; 152(10):3717-27. PMID: 21828183; PMCID: PMC3176649.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    122. Ueta CB, Olivares EL, Bianco AC. Responsiveness to thyroid hormone and to ambient temperature underlies differences between brown adipose tissue and skeletal muscle thermogenesis in a mouse model of diet-induced obesity. Endocrinology. 2011 Sep; 152(9):3571-81. PMID: 21771890; PMCID: PMC3159782.
      Citations: 21     Fields:    Translation:Animals
    123. Bianco AC. Minireview: cracking the metabolic code for thyroid hormone signaling. Endocrinology. 2011 Sep; 152(9):3306-11. PMID: 21712363; PMCID: PMC3159779.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    124. Arrojo E Drigo R, Bianco AC. Type 2 deiodinase at the crossroads of thyroid hormone action. Int J Biochem Cell Biol. 2011 Oct; 43(10):1432-41. PMID: 21679772; PMCID: PMC3163779.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    125. Ribeiro MO, Bianco AC. Crossing the hurdles of thyroid hormone receptor-a activation. Endocrinology. 2011 Mar; 152(3):745-7. PMID: 21339380; PMCID: PMC5393282.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    126. Castillo M, Hall JA, Correa-Medina M, Ueta C, Kang HW, Cohen DE, Bianco AC. Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality. Diabetes. 2011 Apr; 60(4):1082-9. PMID: 21335378; PMCID: PMC3064082.
      Citations: 80     Fields:    Translation:Animals
    127. da-Silva WS, Ribich S, Arrojo e Drigo R, Castillo M, Patti ME, Bianco AC. The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure. FEBS Lett. 2011 Feb 04; 585(3):539-44. PMID: 21237159; PMCID: PMC3133948.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    128. Rosene ML, Arrojo e Drigo R, Singru PS, Lechan RM, Bianco AC, Wittmann G. Inhibition of the type 2 iodothyronine deiodinase underlies the elevated plasma TSH associated with amiodarone treatment. Endocrinology. 2010 Dec; 151(12):5961-70. PMID: 20926587; PMCID: PMC2999495.
      Citations: 30     Fields:    Translation:AnimalsCells
    129. Hall JA, Ribich S, Christoffolete MA, Simovic G, Correa-Medina M, Patti ME, Bianco AC. Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis. Endocrinology. 2010 Sep; 151(9):4573-82. PMID: 20660060; PMCID: PMC2940501.
      Citations: 54     Fields:    Translation:AnimalsCells
    130. Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ. Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev. 2010 Jul 15; 24(14):1507-18. PMID: 20634317; PMCID: PMC2904941.
      Citations: 136     Fields:    Translation:HumansAnimalsCells
    131. Acosta BM, Bianco AC. New insights into thyroid hormone replacement therapy. F1000 Med Rep. 2010 May 11; 2. PMID: 20948851; PMCID: PMC2950057.
      Citations: 3     
    132. Castillo M, Liposits Z, Zavacki AM, Maciel RM, Jo S, Singru P, Sanchez E, Lechan RM, Bianco AC, Freitas BC, Gereben B, Kalló I, Zeöld A, Egri P. Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells. J Clin Invest. 2010 Jun; 120(6):2206-17. PMID: 20458138; PMCID: PMC2877954.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    133. Castillo M, Freitas BC, Rosene ML, Drigo RA, Grozovsky R, Maciel RM, Patti ME, Ribeiro MO, Bianco AC. Impaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity. Thyroid. 2010 May; 20(5):545-53. PMID: 20406106; PMCID: PMC2941403.
      Citations: 16     Fields:    Translation:AnimalsCells
    134. Christoffolete MA, Liposits Z, Zavacki AM, Bianco AC, Doleschall M, Egri P, Gereben B. Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway. J Endocrinol. 2010 May; 205(2):179-86. PMID: 20176747; PMCID: PMC3133926.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    135. Ribeiro MO, Bianco SD, Kaneshige M, Schultz JJ, Cheng SY, Bianco AC, Brent GA. Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis. Endocrinology. 2010 Jan; 151(1):432-40. PMID: 19906816; PMCID: PMC2817565.
      Citations: 52     Fields:    Translation:AnimalsCells
    136. Bianco AC, Gereben B. Covering the base-pairs in iodothyronine deiodinase-1 biology: holes remain in the lineup. Thyroid. 2009 Oct; 19(10):1027-9. PMID: 19803788.
      Citations: 2     Fields:    Translation:HumansCells
    137. Ueta CB, Freitas BC, Nassif RJ, Christoffolete MA, Moriscot AS, Lancelloti CL, Barbeiro HV, de Souza HP, Catanozi S, Passarelli M, Aoki MS, Bianco AC, Ribeiro MO, Amorim BS, Gouveia CH, Llimona F. A TRbeta-selective agonist confers resistance to diet-induced obesity. J Endocrinol. 2009 Nov; 203(2):291-9. PMID: 19713219; PMCID: PMC3133532.
      Citations: 27     Fields:    Translation:Animals
    138. Zavacki AM, Arrojo E Drigo R, Freitas BC, Chung M, Harney JW, Fekete C, Bianco AC, Egri P, Wittmann G, Gereben B. The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase. Mol Cell Biol. 2009 Oct; 29(19):5339-47. PMID: 19651899; PMCID: PMC2747977.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    139. Boes T, Kim EY, Dearie F, Kim BW, Schroeder J, Mun E, Nasser I, Park PJ, Bianco AC, Goldfine AB, Patti ME, Pihlajamäki J. Thyroid hormone-related regulation of gene expression in human fatty liver. J Clin Endocrinol Metab. 2009 Sep; 94(9):3521-9. PMID: 19549744; PMCID: PMC2741713.
      Citations: 85     Fields:    Translation:HumansAnimals
    140. Kang HW, Ribich S, Kim BW, Hagen SJ, Bianco AC, Cohen DE. Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue. J Lipid Res. 2009 Nov; 50(11):2212-21. PMID: 19502644; PMCID: PMC2759827.
      Citations: 18     Fields:    Translation:AnimalsCells
    141. Hall JA, Bianco AC. Triumphs of the thyroid despite lesser conversion. Endocrinology. 2009 Jun; 150(6):2502-4. PMID: 19458245; PMCID: PMC5393300.
      Citations: 2     Fields:    Translation:Animals
    142. Kim BW, Bianco AC. For some, L-thyroxine replacement might not be enough: a genetic rationale. J Clin Endocrinol Metab. 2009 May; 94(5):1521-3. PMID: 19420275.
      Citations: 5     Fields:    Translation:Humans
    143. Patti ME, Houten SM, Bianco AC, Bernier R, Larsen PR, Holst JJ, Badman MK, Maratos-Flier E, Mun EC, Pihlajamaki J, Auwerx J, Goldfine AB. Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring). 2009 Sep; 17(9):1671-7. PMID: 19360006; PMCID: PMC4683159.
      Citations: 279     Fields:    Translation:HumansCells
    144. Streijger F, Pluk H, Oerlemans F, Beckers G, Bianco AC, Ribeiro MO, Van der Zee CE, Wieringa B. Mice lacking brain-type creatine kinase activity show defective thermoregulation. Physiol Behav. 2009 Apr 20; 97(1):76-86. PMID: 19419668; PMCID: PMC3133955.
      Citations: 15     Fields:    Translation:AnimalsCells
    145. Grozovsky R, Ribich S, Rosene ML, Mulcahey MA, Huang SA, Patti ME, Bianco AC, Kim BW. Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes. Endocrinology. 2009 Apr; 150(4):1976-83. PMID: 19036883; PMCID: PMC2659265.
      Citations: 41     Fields:    Translation:AnimalsCells
    146. Zavacki AM, Ribich S, Kim BW, Huang SA, Simonides WS, Bianco AC, Gereben B, Zeöld A. Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr Rev. 2008 Dec; 29(7):898-938. PMID: 18815314; PMCID: PMC2647704.
      Citations: 294     Fields:    Translation:HumansAnimalsCells
    147. Capelo LP, Beber EH, Huang SA, Zorn TM, Bianco AC, Gouveia CH. Deiodinase-mediated thyroid hormone inactivation minimizes thyroid hormone signaling in the early development of fetal skeleton. Bone. 2008 Nov; 43(5):921-30. PMID: 18682303; PMCID: PMC4683160.
      Citations: 21     Fields:    Translation:AnimalsCells
    148. Singru PS, Acharya R, Bodria M, Fekete C, Zavacki AM, Bianco AC, Lechan RM, Sánchez E. Differential effects of refeeding on melanocortin-responsive neurons in the hypothalamic paraventricular nucleus. Endocrinology. 2008 Sep; 149(9):4329-35. PMID: 18467436; PMCID: PMC2553369.
      Citations: 8     Fields:    Translation:AnimalsCells
    149. Sagar GD, Callebaut I, Mornon JP, Curcio-Morelli C, Harney JW, Luongo C, Mulcahey MA, Larsen PR, Huang SA, Bianco AC, Gereben B, Zeöld A. The thyroid hormone-inactivating deiodinase functions as a homodimer. Mol Endocrinol. 2008 Jun; 22(6):1382-93. PMID: 18356288; PMCID: PMC2422829.
      Citations: 25     Fields:    Translation:HumansCells
    150. Simonides WS, Mulcahey MA, Redout EM, Muller A, Zuidwijk MJ, Visser TJ, Wassen FW, Crescenzi A, da-Silva WS, Harney J, Engel FB, Larsen PR, Bianco AC, Huang SA, Obregon MJ. Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats. J Clin Invest. 2008 Mar; 118(3):975-83. PMID: 18259611; PMCID: PMC2230657.
      Citations: 111     Fields:    Translation:AnimalsCells
    151. Bianco AC. Metabolic effects of thyroid hormones-beyond traditional prospects. Thyroid. 2008 Feb; 18(2):99-100. PMID: 18279009.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    152. Gereben B, Dentice M, Salvatore D, Bianco AC, Zeöld A. Activation and inactivation of thyroid hormone by deiodinases: local action with general consequences. Cell Mol Life Sci. 2008 Feb; 65(4):570-90. PMID: 17989921.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    153. Huang SA, Bianco AC. Reawakened interest in type III iodothyronine deiodinase in critical illness and injury. Nat Clin Pract Endocrinol Metab. 2008 Mar; 4(3):148-55. PMID: 18212764; PMCID: PMC3133953.
      Citations: 41     Fields:    Translation:HumansAnimals
    154. Adams BA, Gray SL, Isaac ER, Bianco AC, Vidal-Puig AJ, Sherwood NM. Feeding and metabolism in mice lacking pituitary adenylate cyclase-activating polypeptide. Endocrinology. 2008 Apr; 149(4):1571-80. PMID: 18162530; PMCID: PMC2276722.
      Citations: 22     Fields:    Translation:Animals
    155. Dentice M, Luongo C, Huang S, Ambrosio R, Elefante A, Mirebeau-Prunier D, Zavacki AM, Fenzi G, Grachtchouk M, Hutchin M, Dlugosz AA, Bianco AC, Missero C, Larsen PR, Salvatore D. Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes. Proc Natl Acad Sci U S A. 2007 Sep 04; 104(36):14466-71. PMID: 17720805; PMCID: PMC1964817.
      Citations: 77     Fields:    Translation:AnimalsCells
    156. Marassi MP, Fortunato RS, da Silva AC, Costa-e-Sousa RH, Mattos EC, Masuda MO, Mulcahey MA, Huang SA, Bianco AC, Carvalho DP, Olivares EL, Araújo IG. Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study. Endocrinology. 2007 Oct; 148(10):4786-92. PMID: 17628010.
      Citations: 66     Fields:    Translation:Animals
    157. Fekete C, Freitas BC, Liposits Z, Christoffolete MA, Singru P, Lechan RM, Bianco AC, Zeöld A, Wittmann G, Kádár A, Gereben B. Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain. Endocrinology. 2007 Oct; 148(10):4865-74. PMID: 17628004.
      Citations: 19     Fields:    Translation:AnimalsCells
    158. Melo RC, Parreira GG, Bianco AC, Fekete C, Sanchez E, Lechan RM, Maia AL, Wajner SM, dos Santos Wagner M, Chiarini-Garcia H. Type 2 iodothyronine deiodinase is highly expressed in germ cells of adult rat testis. J Endocrinol. 2007 Jul; 194(1):47-54. PMID: 17592020.
      Citations: 11     Fields:    Translation:AnimalsCells
    159. Bianco AC, Ribich S, Kim BW. An inside job. Endocrinology. 2007 Jul; 148(7):3077-9. PMID: 17575061.
      Citations: 1     Fields:    Translation:Animals
    160. Sagar GD, Callebaut I, Mornon JP, da Silva WS, Luongo C, Dentice M, Tente SM, Freitas BC, Harney JW, Zavacki AM, Bianco AC, Gereben B, Zeöld A. Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity. Mol Cell Biol. 2007 Jul; 27(13):4774-83. PMID: 17452445; PMCID: PMC1951476.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    161. Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, Patti ME. Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. J Biol Chem. 2007 May 25; 282(21):15439-50. PMID: 17416903.
      Citations: 99     Fields:    Translation:AnimalsCells
    162. Freitas FR, Aoki MS, Scanlan TS, Moriscot AS, Ribeiro MO, Bianco AC, Villicev CM, Taffarel C, Gouveia CH. Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. J Endocrinol. 2007 Apr; 193(1):21-9. PMID: 17400799.
      Citations: 39     Fields:    Translation:Animals
    163. Souza SC, Christoffolete MA, Ribeiro MO, Miyoshi H, Strissel KJ, Stancheva ZS, Rogers NH, D'Eon TM, Perfield JW, Imachi H, Obin MS, Bianco AC, Greenberg AS. Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue. J Lipid Res. 2007 Jun; 48(6):1273-9. PMID: 17401109.
      Citations: 23     Fields:    Translation:AnimalsCells
    164. da-Silva WS, Harney JW, Kim BW, Li J, Bianco SD, Crescenzi A, Christoffolete MA, Huang SA, Bianco AC. The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation. Diabetes. 2007 Mar; 56(3):767-76. PMID: 17327447.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    165. Christoffolete MA, Arrojo e Drigo R, Gazoni F, Tente SM, Goncalves V, Amorim BS, Larsen PR, Bianco AC, Zavacki AM. Mice with impaired extrathyroidal thyroxine to 3,5,3'-triiodothyronine conversion maintain normal serum 3,5,3'-triiodothyronine concentrations. Endocrinology. 2007 Mar; 148(3):954-60. PMID: 17138654.
      Citations: 36     Fields:    Translation:Animals
    166. Bianco AC, Kim BW. Deiodinases: implications of the local control of thyroid hormone action. J Clin Invest. 2006 Oct; 116(10):2571-9. PMID: 17016550; PMCID: PMC1578599.
      Citations: 246     Fields:    Translation:HumansAnimalsCells
    167. Dentice M, Harney JW, Curcio-Morelli C, Tente SM, Bianco AC, Zeöld A, Pormüller L, Gereben B. Metabolic instability of type 2 deiodinase is transferable to stable proteins independently of subcellular localization. J Biol Chem. 2006 Oct 20; 281(42):31538-43. PMID: 16928685.
      Citations: 25     Fields:    Translation:HumansCells
    168. Haffner MC, Capelo LP, Liposits Z, da Silva WS, Bianco AC, Kacskovics I, Fekete C, Zeöld A, Doleschall M, Menyhért J, Gereben B. Characterization of the nuclear factor-kappa B responsiveness of the human dio2 gene. Endocrinology. 2006 Sep; 147(9):4419-29. PMID: 16728495.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    169. Miyoshi H, Souza SC, Zhang HH, Strissel KJ, Christoffolete MA, Kovsan J, Rudich A, Kraemer FB, Bianco AC, Obin MS, Greenberg AS. Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms. J Biol Chem. 2006 Jun 09; 281(23):15837-44. PMID: 16595669.
      Citations: 124     Fields:    Translation:AnimalsCells
    170. Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J, Watanabe M. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature. 2006 Jan 26; 439(7075):484-9. PMID: 16400329.
      Citations: 832     Fields:    Translation:HumansAnimalsCells
    171. Christoffolete MA, Singru P, Fekete C, da Silva WS, Gordon DF, Huang SA, Crescenzi A, Harney JW, Ridgway EC, Larsen PR, Lechan RM, Bianco AC, Ribeiro R. Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism. Endocrinology. 2006 Apr; 147(4):1735-43. PMID: 16396983.
      Citations: 60     Fields:    Translation:AnimalsCells
    172. Sharma V, Hays WR, Wood WM, Pugazhenthi U, St Germain DL, Bianco AC, Krezel W, Chambon P, Haugen BR. Effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis. Endocrinology. 2006 Mar; 147(3):1438-51. PMID: 16306084.
      Citations: 13     Fields:    Translation:AnimalsCells
    173. Fekete C, Singru PS, Sanchez E, Sarkar S, Christoffolete MA, Riberio RS, Rand WM, Emerson CH, Bianco AC, Lechan RM. Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus. Endocrinology. 2006 Jan; 147(1):520-9. PMID: 16210367.
      Citations: 24     Fields:    Translation:AnimalsCells
    174. Fekete C, Sarkar S, Christoffolete MA, Emerson CH, Bianco AC, Lechan RM. Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels. Brain Res. 2005 Sep 14; 1056(1):97-9. PMID: 16095572.
      Citations: 22     Fields:    Translation:AnimalsCells
    175. Zyngier S, Kimura ET, Bianco AC, Monte O. [Dopaminergic and somatostatinergic pathways decrease serum thyrotropin in rats bearing the 256-Walker mammary carcinoma]. Arq Bras Endocrinol Metabol. 2005 Apr; 49(2):253-64. PMID: 16184254.
      Citations:    Fields:    Translation:Animals
    176. Bianco AC, Larsen PR. Cellular and structural biology of the deiodinases. Thyroid. 2005 Aug; 15(8):777-86. PMID: 16131321.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    177. Dentice M, Bandyopadhyay A, Callebaut I, Christoffolete MA, Kim BW, Nissim S, Mornon JP, Zavacki AM, Capelo LP, Curcio-Morelli C, Harney JW, Tabin CJ, Bianco AC, Gereben B, Zeöld A, Ribeiro R. The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. Nat Cell Biol. 2005 Jul; 7(7):698-705. PMID: 15965468; PMCID: PMC1761694.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
    178. Bianco AC, Maia AL, da Silva WS, Christoffolete MA. Adaptive activation of thyroid hormone and energy expenditure. Biosci Rep. 2005 Jun-Aug; 25(3-4):191-208. PMID: 16283553.
      Citations: 49     Fields:    Translation:HumansAnimals
    179. Kalaany NY, Gauthier KC, Zavacki AM, Mammen PP, Kitazume T, Peterson JA, Horton JD, Garry DJ, Bianco AC, Mangelsdorf DJ. LXRs regulate the balance between fat storage and oxidation. Cell Metab. 2005 Apr; 1(4):231-44. PMID: 16054068.
      Citations: 144     Fields:    Translation:AnimalsCells
    180. Capp C, Meyer EL, Harney JW, Larsen PR, Gross JL, Bianco AC, Maia AL, Canani LH, Dora JM, Wagner MS. The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2005 Jun; 90(6):3472-8. PMID: 15797963.
      Citations: 76     Fields:    Translation:Humans
    181. Zavacki AM, Ying H, Christoffolete MA, Aerts G, So E, Harney JW, Cheng SY, Larsen PR, Bianco AC. Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse. Endocrinology. 2005 Mar; 146(3):1568-75. PMID: 15591136.
      Citations: 59     Fields:    Translation:Animals
    182. Gouveia CH, Christoffolete MA, Zaitune CR, Harney JW, Maia AL, Bianco AC, Dora JM. Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation. Endocrinology. 2005 Jan; 146(1):195-200. PMID: 15471965.
      Citations: 24     Fields:    Translation:AnimalsCells
    183. Bianco AC. Triplets! Unexpected structural similarity among the three enzymes that catalyze initiation and termination of thyroid hormone effects. Arq Bras Endocrinol Metabol. 2004 Feb; 48(1):16-24. PMID: 15611815.
      Citations:    Fields:    Translation:HumansAnimalsCells
    184. Carvalho-Bianco SD, Kim BW, Zhang JX, Harney JW, Gereben B, Bianco AC, Mende U, Larsen PR, Ribeiro RS. Chronic cardiac-specific thyrotoxicosis increases myocardial beta-adrenergic responsiveness. Mol Endocrinol. 2004 Jul; 18(7):1840-9. PMID: 15131256.
      Citations: 15     Fields:    Translation:AnimalsCells
    185. Christoffolete MA, Linardi CC, de Jesus L, Ebina KN, Carvalho SD, Ribeiro MO, Rabelo R, Curcio C, Martins L, Kimura ET, Bianco AC. Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis. Diabetes. 2004 Mar; 53(3):577-84. PMID: 14988240.
      Citations: 99     Fields:    Translation:AnimalsCells
    186. Fekete C, Harney JW, Dora JM, Bianco AC, Sarkar S, Liposits Z, Rand W, Emerson C, Kacskovics I, Larsen PR, Lechan RM, Gereben B, Doleschall M. Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome. Endocrinology. 2004 Apr; 145(4):1649-55. PMID: 14684601.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    187. Freitas FR, Moriscot AS, Jorgetti V, Soares AG, Passarelli M, Scanlan TS, Brent GA, Bianco AC, Gouveia CH. Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1. Am J Physiol Endocrinol Metab. 2003 Nov; 285(5):E1135-41. PMID: 12965872.
      Citations: 22     Fields:    Translation:Animals
    188. Kim BW, Zavacki AM, Curcio-Morelli C, Dentice M, Harney JW, Larsen PR, Bianco AC. Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2. Mol Endocrinol. 2003 Dec; 17(12):2603-12. PMID: 12933904.
      Citations: 26     Fields:    Translation:HumansCells
    189. Curcio-Morelli C, Mornon JP, Gereben B, Buettner C, Huang S, Castro B, Fonseca TL, Harney JW, Larsen PR, Bianco AC, Callebaut I. The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure. J Biol Chem. 2003 Sep 19; 278(38):36887-96. PMID: 12847093.
      Citations: 59     Fields:    Translation:HumansCells
    190. Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC. Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. J Clin Invest. 2003 Jul; 112(2):189-96. PMID: 12865408; PMCID: PMC164294.
      Citations: 59     Fields:    Translation:HumansCells
    191. Curcio-Morelli C, Gereben B, Zavacki AM, Kim BW, Huang S, Harney JW, Larsen PR, Bianco AC. In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases. Endocrinology. 2003 Mar; 144(3):937-46. PMID: 12586771.
      Citations: 36     Fields:    Translation:HumansCells
    192. Nakayama A, Bianco AC, Zhang CY, Lowell BB, Frangioni JV. Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging. Mol Imaging. 2003 01; 2(1):37-49. PMID: 12926236.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    193. Fekete C, Sarkar S, Rand WM, Harney JW, Emerson CH, Bianco AC, Beck-Sickinger A, Lechan RM, Fekete C, Sarkar S, Rand WM, Harney JW, Emerson CH, Bianco AC, Beck-Sickinger A, Lechan RM. Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis. Endocrinology. 2002 Dec; 143(12):4513-9. PMID: 12446577.
      Citations: 23     Fields:    Translation:Animals
    194. Baqui M, Botero D, Gereben B, Curcio C, Harney JW, Salvatore D, Sorimachi K, Larsen PR, Bianco AC, Baqui M, Botero D, Gereben B, Curcio C, Harney JW, Salvatore D, Sorimachi K, Larsen PR, Bianco AC. Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes. J Biol Chem. 2003 Jan 10; 278(2):1206-11. PMID: 12419801.
      Citations: 47     Fields:    Translation:HumansCells
    195. Fekete C, Sarkar S, Rand WM, Harney JW, Emerson CH, Bianco AC, Lechan RM. Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis. Endocrinology. 2002 Oct; 143(10):3846-53. PMID: 12239096.
      Citations: 38     Fields:    Translation:Animals
    196. Botero D, Gereben B, Goncalves C, De Jesus LA, Harney JW, Bianco AC. Ubc6p and ubc7p are required for normal and substrate-induced endoplasmic reticulum-associated degradation of the human selenoprotein type 2 iodothyronine monodeiodinase. Mol Endocrinol. 2002 Sep; 16(9):1999-2007. PMID: 12198238.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    197. Bachman ES, Dhillon H, Zhang CY, Cinti S, Bianco AC, Kobilka BK, Lowell BB. betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science. 2002 Aug 02; 297(5582):843-5. PMID: 12161655.
      Citations: 311     Fields:    Translation:AnimalsCells
    198. Bianco AC, Bicudo JE, Vianna CR. Adaptive thermogenesis in hummingbirds. J Exp Biol. 2002 Aug; 205(Pt 15):2267-73. PMID: 12110660.
      Citations: 10     Fields:    Translation:AnimalsCells
    199. Bianco AC, Salvatore D, Berry MJ, Larsen PR, Bianco AC, Salvatore D, Berry MJ, Larsen PR. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev. 2002 Feb; 23(1):38-89. PMID: 11844744.
      Citations: 466     Fields:    Translation:HumansAnimalsCells
    200. Bisi H, Bianco AC, Bloise W, Bisi H, Bianco AC, Bloise W. Severe and mild neonatal hypothyroidism mediate opposite effects on Leydig cells of rats. Thyroid. 2002 Jan; 12(1):13-8. PMID: 11838725.
      Citations: 5     Fields:    Translation:AnimalsCells
    201. de Jesus LA, Carvalho SD, Ribeiro MO, Schneider M, Kim SW, Harney JW, Larsen PR, Bianco AC. The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J Clin Invest. 2001 Nov; 108(9):1379-85. PMID: 11696583; PMCID: PMC209445.
      Citations: 228     Fields:    Translation:AnimalsCells
    202. Gouveia CH, Schultz JJ, Bianco AC, Brent GA, Gouveia CH, Schultz JJ, Bianco AC, Brent GA. Thyroid hormone stimulation of osteocalcin gene expression in ROS 17/2.8 cells is mediated by transcriptional and post-transcriptional mechanisms. J Endocrinol. 2001 Sep; 170(3):667-75. PMID: 11524248.
      Citations: 15     Fields:    Translation:AnimalsCells
    203. Peeters R, Fekete C, Goncalves C, Legradi G, Tu HM, Harney JW, Bianco AC, Lechan RM, Larsen PR, Peeters R, Fekete C, Goncalves C, Legradi G, Tu HM, Harney JW, Bianco AC, Lechan RM, Larsen PR. Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency. Am J Physiol Endocrinol Metab. 2001 Jul; 281(1):E54-61. PMID: 11404222.
      Citations: 33     Fields:    Translation:Animals
    204. Ribeiro MO, Carvalho SD, Schultz JJ, Chiellini G, Scanlan TS, Bianco AC, Brent GA. Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specific. J Clin Invest. 2001 Jul; 108(1):97-105. PMID: 11435461; PMCID: PMC209342.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    205. Curcio C, Baqui MM, Salvatore D, Rihn BH, Mohr S, Harney JW, Larsen PR, Bianco AC. The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line. J Biol Chem. 2001 Aug 10; 276(32):30183-7. PMID: 11425850.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    206. Hagen T, Zhang CY, Bachman E, Boss O, Gereben B, Moriscot AS, Lowell BB, Bicudo JE, Bianco AC, Vianna CR. Cloning and functional characterization of an uncoupling protein homolog in hummingbirds. Physiol Genomics. 2001 Apr 02; 5(3):137-45. PMID: 11285367.
      Citations: 17     Fields:    Translation:AnimalsCells
    207. Gereben B, Goncalves C, Harney JW, Larsen PR, Bianco AC. Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation. Mol Endocrinol. 2000 Nov; 14(11):1697-708. PMID: 11075806.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    208. Baqui MM, Gereben B, Harney JW, Larsen PR, Bianco AC. Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy. Endocrinology. 2000 Nov; 141(11):4309-12. PMID: 11089566.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    209. Lebrun FL, Christoffolete MA, Branco M, Crescenzi A, Carvalho SD, Bianco AC, Ribeiro MO, Negrão N. Evidence of UCP1-independent regulation of norepinephrine-induced thermogenesis in brown fat. Am J Physiol Endocrinol Metab. 2000 Aug; 279(2):E314-22. PMID: 10913031.
      Citations: 22     Fields:    Translation:AnimalsCells
    210. Steinsapir J, Bianco AC, Buettner C, Harney J, Larsen PR. Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center. Endocrinology. 2000 Mar; 141(3):1127-35. PMID: 10698189.
      Citations: 35     Fields:    Translation:HumansCells
    211. Lopes AM, Ribeiro MO, Francoso OA, Carvalho SD, Lima FB, Bicudo JE, Bianco AC, Curcio C. Development of compensatory thermogenesis in response to overfeeding in hypothyroid rats. Endocrinology. 1999 Aug; 140(8):3438-43. PMID: 10433198.
      Citations: 13     Fields:    Translation:Animals
    212. Ribeiro M, Bianco AC, Branco M, Negrão N. 3,5,3'-Triiodothyronine actively stimulates UCP in brown fat under minimal sympathetic activity. Am J Physiol. 1999 01; 276(1):E179-87. PMID: 9886965.
      Citations: 23     Fields:    Translation:AnimalsCells
    213. Carvalho SD, Carvalho CR, Rabelo R, Moriscot AS, Bianco AC. Thyroxine 5'-deiodination mediates norepinephrine-induced lipogenesis in dispersed brown adipocytes. Endocrinology. 1998 Feb; 139(2):571-8. PMID: 9449627.
      Citations: 20     Fields:    Translation:AnimalsCells
    214. Jorgetti V, Bianco AC, Gouveia CH. Effects of thyroid hormone administration and estrogen deficiency on bone mass of female rats. J Bone Miner Res. 1997 Dec; 12(12):2098-107. PMID: 9421243.
      Citations: 9     Fields:    Translation:Animals
    215. Carvalho SD, Bianco AC, Silva JE. Effects of hypothyroidism on brown adipose tissue adenylyl cyclase activity. Endocrinology. 1996 Dec; 137(12):5519-29. PMID: 8940379.
      Citations: 11     Fields:    Translation:AnimalsCells
    216. Bianco AC, Bartolini P, Ribela MT. The use of recombinant human thyrotropin produced by Chinese hamster ovary cells for the preparation of immunoassay reagents. J Clin Endocrinol Metab. 1996 Jan; 81(1):249-56. PMID: 8550760.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    217. Latronico AC, Bianco AC, Villares SM, Lucon MA, Nicolau W, Wajchenberg BL, Mendonça BB. Calcium-dependent protein kinase-C activity in human adrenocortical neoplasms, hyperplastic adrenals, and normal adrenocortical tissue. J Clin Endocrinol Metab. 1994 Sep; 79(3):736-9. PMID: 7521351.
      Citations:    Fields:    Translation:HumansCells
    218. Rabelo R, Bianco AC, Moriscot A. Corticosterone inhibits uncoupling protein gene expression in brown adipose tissue. Am J Physiol. 1993 Jul; 265(1 Pt 1):E81-7. PMID: 8338156.
      Citations: 20     Fields:    Translation:AnimalsCells
    219. Bianco AC, Carvalho SD, Negrão N. Hormonal regulation of malic enzyme and glucose-6-phosphate dehydrogenase in brown adipose tissue. Am J Physiol. 1993 Jun; 264(6 Pt 1):E874-81. PMID: 8333512.
      Citations: 18     Fields:    Translation:Animals
    220. Bianco AC, Kieffer JD, Silva JE. Adenosine 3',5'-monophosphate and thyroid hormone control of uncoupling protein messenger ribonucleic acid in freshly dispersed brown adipocytes. Endocrinology. 1992 May; 130(5):2625-33. PMID: 1374009.
      Citations: 19     Fields:    Translation:AnimalsCells
    221. Rehnmark S, Bianco AC, Kieffer JD, Silva JE. Transcriptional and posttranscriptional mechanisms in uncoupling protein mRNA response to cold. Am J Physiol. 1992 Jan; 262(1 Pt 1):E58-67. PMID: 1733251.
      Citations: 13     Fields:    Translation:AnimalsCells
    222. Carvalho SD, Kimura ET, Bianco AC, Silva JE. Central role of brown adipose tissue thyroxine 5'-deiodinase on thyroid hormone-dependent thermogenic response to cold. Endocrinology. 1991 Apr; 128(4):2149-59. PMID: 2004619.
      Citations: 24     Fields:    Translation:AnimalsCells
    223. Scalissi NM, Marone MM, Correa PH, Bianco AC, Dias Júnior AA. [Basedow-Graves' disease: analysis of various parameters in the prognosis of remission after clinical treatment]. Rev Paul Med. 1989 Mar-Apr; 107(2):69-74. PMID: 2629056.
      Citations:    Fields:    Translation:Humans
    224. Bianco AC, Sheng XY, Silva JE. Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis. J Biol Chem. 1988 Dec 05; 263(34):18168-75. PMID: 3192531.
      Citations: 52     Fields:    Translation:AnimalsCells
    225. Bianco AC, Silva JE. Cold exposure rapidly induces virtual saturation of brown adipose tissue nuclear T3 receptors. Am J Physiol. 1988 Oct; 255(4 Pt 1):E496-503. PMID: 3177636.
      Citations: 35     Fields:    Translation:AnimalsCells
    226. Bianco AC, Silva JE. Optimal response of key enzymes and uncoupling protein to cold in BAT depends on local T3 generation. Am J Physiol. 1987 Sep; 253(3 Pt 1):E255-63. PMID: 3631256.
      Citations: 30     Fields:    Translation:Animals
    227. Bianco AC, Nunes MT, Hell NS, Maciel RM. The role of glucocorticoids in the stress-induced reduction of extrathyroidal 3,5,3'-triiodothyronine generation in rats. Endocrinology. 1987 Mar; 120(3):1033-8. PMID: 3803308.
      Citations: 21     Fields:    Translation:Animals
    228. Bianco AC, Silva JE. Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue. J Clin Invest. 1987 Jan; 79(1):295-300. PMID: 3793928; PMCID: PMC424048.
      Citations: 81     Fields:    Translation:Animals
    229. Bianco AC, Silva JE. Nuclear 3,5,3'-triiodothyronine (T3) in brown adipose tissue: receptor occupancy and sources of T3 as determined by in vivo techniques. Endocrinology. 1987 Jan; 120(1):55-62. PMID: 3780570.
      Citations: 27     Fields:    Translation:AnimalsCells
    230. Nunes MT, Bianco AC. Extrathyroidal conversion of thyroxine to 3,5,3'-triiodothyronine in cold-acclimated thyroxine-maintained thyroidectomized rats. Braz J Med Biol Res. 1986; 19(2):311-8. PMID: 3828577.
      Citations: 2     Fields:    Translation:Animals
    231. Nunes MT, Bianco AC, Migala A, Agostini B, Hasselbach W. Thyroxine induced transformation in sarcoplasmic reticulum of rabbit soleus and psoas muscles. Z Naturforsch C Biosci. 1985 Sep-Oct; 40(9-10):726-34. PMID: 2934902.
      Citations: 9     Fields:    Translation:AnimalsCells
    232. Bianco AC, Nunes MT, Marone MS, Correa PH. Conversion of thyroxine (T4) to T3 and rT3 in human leucocyte suspension: its application to clinical investigation. Endocrinol Exp. 1985 Mar; 19(1):53-61. PMID: 3921342.
      Citations: 1     Fields:    Translation:HumansCells
    233. Bianco AC, Nunes MT, Marone MM, Scalissi NM, Correa PH, Douglas CR. [Thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3,3',5'-triiodothyronine (reverse T3) conversion in human leukocyte suspensions. Study in hyper and hypothyroidism states]. Rev Paul Med. 1984 Mar-Apr; 102(2):61-4. PMID: 6474031.
      Citations:    Fields:    Translation:HumansCells
    234. Bianco AC, Nunes MT, Martins O, Roesner I, Douglas RA, Pereira RC, Douglas CR. Possible mechanism of action of cholesterol enriched diet on the thyroid. Endocrinol Exp. 1981 Dec; 15(4):277-85. PMID: 6976263.
      Citations:    Fields:    Translation:Animals
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