"Factor XII" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.
- Factor XII
- Factor Twelve
- Hageman Factor
- Factor 12
- Coagulation Factor XII
Below are MeSH descriptors whose meaning is more general than "Factor XII".
Below are MeSH descriptors whose meaning is more specific than "Factor XII".
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Below are the most recent publications written about "Factor XII" by people in Profiles.
Aptamers influence the hemostatic system by activating the intrinsic coagulation pathway in an in vitro Chandler-Loop model. Clin Appl Thromb Hemost. 2010 Apr; 16(2):161-9.
Hematologic changes following burns. J Surg Res. 1977 Jun; 22(6):626-35.
Contact activation of heparinized plasma. Thromb Res. 1974 Sep; 5(3):379-400.