"Receptors, Somatotropin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cell surface proteins that bind GROWTH HORMONE with high affinity and trigger intracellular changes influencing the behavior of cells. Activation of growth hormone receptors regulates amino acid transport through cell membranes, RNA translation to protein, DNA transcription, and protein and amino acid catabolism in many cell types. Many of these effects are mediated indirectly through stimulation of the release of somatomedins.
| Descriptor ID |
D011986
|
| MeSH Number(s) |
D12.776.543.750.750.555.770 D12.776.543.750.750.660.750
|
| Concept/Terms |
Receptors, Somatotropin- Receptors, Somatotropin
- Receptor, Growth Hormone
- Somatotropin Receptors
- Receptors, Growth Hormone
- Somatotropin Receptor
- Growth Hormone Receptor
- Hormone Receptor, Growth
- Growth Hormone Receptors
- Hormone Receptors, Growth
|
Below are MeSH descriptors whose meaning is more general than "Receptors, Somatotropin".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Somatotropin".
This graph shows the total number of publications written about "Receptors, Somatotropin" by people in this website by year, and whether "Receptors, Somatotropin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 |
| 1994 | 1 | 1 | 2 |
| 1995 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2002 | 2 | 0 | 2 |
| 2003 | 0 | 2 | 2 |
| 2004 | 2 | 0 | 2 |
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptors, Somatotropin" by people in Profiles.
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Cell biology. New tricks for an old dimer. Science. 2014 May 16; 344(6185):703-4.
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Diversification and biogeography of the Neotropical caviomorph lineage Octodontoidea (Rodentia: Hystricognathi). Mol Phylogenet Evol. 2012 May; 63(2):417-29.
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Exogenous growth hormone attenuates cognitive deficits induced by intermittent hypoxia in rats. Neuroscience. 2011 Nov 24; 196:237-50.
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Crystal structure and site 1 binding energetics of human placental lactogen. J Mol Biol. 2006 May 05; 358(3):773-84.
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Shotgun alanine scanning shows that growth hormone can bind productively to its receptor through a drastically minimized interface. J Biol Chem. 2005 Jul 08; 280(27):25524-32.
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The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled. Proc Natl Acad Sci U S A. 2004 Dec 07; 101(49):17078-83.
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The structural basis for biological signaling, regulation, and specificity in the growth hormone-prolactin system of hormones and receptors. Adv Protein Chem. 2004; 68:147-69.
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The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity. J Mol Biol. 2003 Sep 05; 332(1):195-204.
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Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):952-7.
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Functional promiscuity of squirrel monkey growth hormone receptor toward both primate and nonprimate growth hormones. Mol Biol Evol. 2002 Jul; 19(7):1083-92.