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Evgeny Izumchenko

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Hematology and Oncology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Dr. Izumchenko received his Bachelor of Laboratory Medicine (B.Med.Lab.) and Master degree in Clinical Biochemistry (M.Med.Sc.) from Ben-Gurion University (BGU) School of Medicine, Israel, where he graduated summa cum laude from the Faculty of Health Sciences. He received his Ph.D. from Ben-Gurion University via the BGU/Fox Chase Cancer Center Partnership Graduate Research Program. He has performed thesis work in the laboratory of Dr. Erica Golemis, an internationally recognized cancer biologist, and his studies provided some of the earliest insights on the role of NEDD9 in the early stages of cancer development. He completed his first postdoctoral training with Dr. Kevin Brown and Dr. Stratford May at the University of Florida, with an NIH postdoctoral fellowship supporting his research. His studies described a novel mechanism by which dysregulation of genomic stability drives cancer development. Dr. Izumchenko joined the lab of Dr. David Sidransky at Johns Hopkins University in 2012, where he carried out seminal work in defining the clonal evolution and heterogeneity in several solid tumor types, at both the genetic and epigenetic levels. Based on his record of research accomplishments, he was invited to join the Department of Otolaryngology as an Instructor in 2016, and subsequently was promoted to the rank of Assistant Professor in May, 2017. Dr. Izumchenko joined the Department of Medicine at the University of Chicago in 2019. His research focus is on understanding the complex interplay between the genetic and epigenetic alterations in carcinogenesis and disease progression, and on exploiting this understanding for developing novel biomarkers for diagnosis and risk stratification as well as in identifying targets for therapeutic intervention. Specifically, he is interested in defining the drivers underlying the premalignant progression and early immune evasion. Dr. Izumchenko has focused his research on cancers of upper aerodigestive tract, which is a very challenging area of oncology. He is actively engaged in partnering with researchers and oncologists in academia and pharmaceutical industry worldwide, to advance discovery of biomarkers for early cancer detection and risk assessment, personalized therapy, and novel anti-cancer interventions.

    Collapse Biography 
    Collapse education and training
    Ben-Gurion University, Dept of Clinical Biochemistry and Pharmacology, IsraelM.Med.Sc.2005Clinical Biochemistry and Pharmacology
    Ben-Gurion University, School of Medicine, IsraelPh.D.2010Cancer Research
    University of Florida, Department of Biochemistry and Molecular Biology, Gainesville, FLPostdoctoral Fellow2012Cancer Research
    Johns Hopkins University, Baltimore, MDPostdoctoral Fellow2016Cancer Research
    Collapse awards and honors
    2005Dean Award and Prize for Academic Achievements , Ben-Gurion University
    2005American Associates, Ben-Gurion University of the Negev (AABGU) research fellowship, Ben-Gurion University
    2007The Kreitman Foundation Ph.D. Fellowship, Ben-Gurion University
    2008Fox Chase Cancer Center Postdoctoral and Graduate Student Research Award , Fox Chase Cancer Center
    2015The most cited manuscript in Cancer Prevention Research journal, Johns Hopkins University
    2016Head and Neck Cancer Specialized Program of Research Excellence Pilot Grant Award , Johns Hopkins University
    2016Career Development Award (Head and Neck SPORE), Johns Hopkins University
    20172017 ALCF-IASLC Fellowship Award for the Early Detection of Lung Cancer, Johns Hopkins University
    2019Janet D. Rowley Discovery Award, University of Chicago
    20192019 Cancer Spotlights Award , University of Chicago
    2020Adenoid Cystic Carcinoma Research Foundation (ACCRF) Award, University of Chicago
    2020The U.S.-Israel Binational Science Foundation Award, University of Chicago
    2020University of Chicago Comprehensive Cancer Center Pilot Project Award, University of Chicago
    2021AbbVie-UChicago Collaboration Award, University of Chicago
    2022Provost’s Global Faculty Award - India and South Asia , University of Chicago
    2022First Place Prize ay the 26th Edward L. Kaplan, '71, New Venture Challenge (NVC) Competition, University of Chicago Booth School of Business
    2022George Shultz Innovation Fund (GSIF) early-stage tech venture Award , University of Chicago
    2022V Foundation for Cancer Research Award , University of Chicago
    2022Janet D. Rowley Discovery Award , University of Chicago
    2023Institute for Translational Medicine (ITM) Pilot Award , University of Chicago
    2023Cancer Research Foundation Breakthrough Award , University of Chicago
    2023Janet Rowley Research Day Poster Awards (Winner) , University of Chicago
    2023Department of Defense Idea Award, University of Chicago
    2024UCCCC Program Pilot Project Grant, University of Chicago
    2024UCCCC Cancer Immunotherapy Team Science Award, University of Chicago

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cyberski TF, Singh A, Korzinkin M, Mishra V, Pun F, Shen L, Wing C, Cheng X, Baird B, Miao Y, Elkabets M, Kochanny S, Guo W, Dyer E, Pearson AT, Juloori A, Lingen M, Cole G, Zhavoronkov A, Agrawal N, Izumchenko E, Rosenberg AJ. Acquired resistance to immunotherapy and chemoradiation in MYC amplified head and neck cancer. NPJ Precis Oncol. 2024 May 23; 8(1):114. PMID: 38783041; PMCID: PMC11116544.
    2. Ren F, Aliper A, Chen J, Zhao H, Rao S, Kuppe C, Ozerov IV, Zhang M, Witte K, Kruse C, Aladinskiy V, Ivanenkov Y, Polykovskiy D, Fu Y, Babin E, Qiao J, Liang X, Mou Z, Wang H, Pun FW, Ayuso PT, Veviorskiy A, Song D, Liu S, Zhang B, Naumov V, Ding X, Kukharenko A, Izumchenko E, Zhavoronkov A. A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models. Nat Biotechnol. 2024 Mar 08. PMID: 38459338.
      Citations: 2     Fields:    
    3. Jagadeeshan S, Suryamohan K, Shin N, Mathukkada S, Boyko A, Melikhova D, Tsareva A, Yunusova L, Pravdivtseva E, Stupichev D, Shaposhnikov K, Peterson A, Bednyagin L, Shugaev-Mendosa E, Kessler L, Burrows F, Ho AL, Agrawal N, Pearson AT, Izumchenko E, Cole G, Elkabets M, Rosenberg AJ. Evolutionary dynamics of tipifarnib in HRAS mutated head and neck squamous cell carcinoma. Oral Oncol. 2024 Feb; 149:106688. PMID: 38219706.
      Citations:    Fields:    Translation:HumansCells
    4. Pun FW, Leung GHD, Leung HW, Rice J, Schmauck-Medina T, Lautrup S, Long X, Liu BHM, Wong CW, Ozerov IV, Aliper A, Ren F, Rosenberg AJ, Agrawal N, Izumchenko E, Fang EF, Zhavoronkov A. A comprehensive AI-driven analysis of large-scale omic datasets reveals novel dual-purpose targets for the treatment of cancer and aging. Aging Cell. 2023 Dec; 22(12):e14017. PMID: 37888486; PMCID: PMC10726874.
      Citations: 1     Fields:    Translation:HumansAnimals
    5. Izumchenko E, Vokes EE. Epstein-Barr Virus DNA Screening in Asymptomatic People without Known Nasopharyngeal Cancer. NEJM Evid. 2023 Jul; 2(7):EVIDe2300077. PMID: 38320171.
      Citations:    Translation:HumansCells
    6. Peace DJ, Izumchenko E, Sidransky D. Unexpected heterogeneity in oropharyngeal squamous cell tumors. Nat Genet. 2023 04; 55(4):534-535. PMID: 37016098.
      Citations:    Fields:    Translation:Humans
    7. Yan K, Auger S, Diaz A, Naman J, Vemulapalli R, Hasina R, Izumchenko E, Shogan B, Agrawal N. Microbial Changes Associated With Oral Cavity Cancer Progression. Otolaryngol Head Neck Surg. 2023 06; 168(6):1443-1452. PMID: 36939272; PMCID: PMC10213157.
      Citations:    Fields:    Translation:HumansCells
    8. Goldberg M, Manzi A, Birdi A, Laporte B, Conway P, Cantin S, Mishra V, Singh A, Pearson AT, Goldberg ER, Goldberger S, Flaum B, Hasina R, London NR, Gallia GL, Bettegowda C, Young S, Sandulache V, Melville J, Shun J, O'Neill SE, Aydin E, Zhavoronkov A, Vidal A, Soto A, Alonso MJ, Rosenberg AJ, Lingen MW, D'Cruz A, Agrawal N, Izumchenko E. Author Correction: A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer. Nat Commun. 2022 Dec 21; 13(1):7865. PMID: 36543765.
      Citations:    Fields:    
    9. Mkrtchyan GV, Veviorskiy A, Izumchenko E, Shneyderman A, Pun FW, Ozerov IV, Aliper A, Zhavoronkov A, Scheibye-Knudsen M. High-confidence cancer patient stratification through multiomics investigation of DNA repair disorders. Cell Death Dis. 2022 Nov 26; 13(11):999. PMID: 36435816; PMCID: PMC9701218.
      Citations: 3     Fields:    Translation:HumansCells
    10. Matthews JM, Schuster B, Kashaf SS, Liu P, Ben-Yishay R, Ishay-Ronen D, Izumchenko E, Shen L, Weber CR, Bielski M, Kupfer SS, Bilgic M, Rzhetsky A, Tay S. OrganoID: A versatile deep learning platform for tracking and analysis of single-organoid dynamics. PLoS Comput Biol. 2022 11; 18(11):e1010584. PMID: 36350878; PMCID: PMC9645660.
      Citations: 13     Fields:    
    11. Goldberg M, Manzi A, Birdi A, Laporte B, Conway P, Cantin S, Mishra V, Singh A, Pearson AT, Goldberg ER, Goldberger S, Flaum B, Hasina R, London NR, Gallia GL, Bettegowda C, Young S, Sandulache V, Melville J, Shum J, O'Neill SE, Aydin E, Zhavoronkov A, Vidal A, Soto A, Alonso MJ, Rosenberg AJ, Lingen MW, D'Cruz A, Agrawal N, Izumchenko E. A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer. Nat Commun. 2022 08 17; 13(1):4829. PMID: 35977936; PMCID: PMC9385702.
      Citations: 9     Fields:    Translation:Animals
    12. Rosenberg AJ, Agrawal N, Pearson AT, Gooi Z, Blair E, Portugal L, Cursio JF, Juloori A, Chin J, Rouse K, Villaflor VM, Seiwert TY, Izumchenko E, Lingen MW, Haraf DJ, Vokes EE. Phase I study of nab-paclitaxel-based induction followed by nab-paclitaxel-based concurrent chemotherapy and re-irradiation in previously treated head and neck squamous cell carcinoma. Br J Cancer. 2022 11; 127(8):1497-1506. PMID: 35945244; PMCID: PMC9553920.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    13. Ferrarotto R, Mishra V, Herz E, Yaacov A, Solomon O, Rauch R, Mondshine A, Motin M, Leibovich-Rivkin T, Davis M, Kaye J, Weber CR, Shen L, Pearson AT, Rosenberg AJ, Chen X, Singh A, Aster JC, Agrawal N, Izumchenko E. AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling. Cell Death Dis. 2022 08 05; 13(8):678. PMID: 35931701; PMCID: PMC9355983.
      Citations: 6     Fields:    Translation:HumansCells
    14. Pun FW, Liu BHM, Long X, Leung HW, Leung GHD, Mewborne QT, Gao J, Shneyderman A, Ozerov IV, Wang J, Ren F, Aliper A, Bischof E, Izumchenko E, Guan X, Zhang K, Lu B, Rothstein JD, Cudkowicz ME, Zhavoronkov A. Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics - An AI-Enabled Biological Target Discovery Platform. Front Aging Neurosci. 2022; 14:914017. PMID: 35837482; PMCID: PMC9273868.
      Citations: 13     
    15. Topchu I, Pangeni RP, Bychkov I, Miller SA, Izumchenko E, Yu J, Golemis E, Karanicolas J, Boumber Y. The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors. Cell Mol Life Sci. 2022 May 09; 79(6):285. PMID: 35532818; PMCID: PMC9520630.
      Citations: 7     Fields:    Translation:Humans
    16. Nair V, Auger S, Kochanny S, Howard FM, Ginat D, Pasternak-Wise O, Juloori A, Koshy M, Izumchenko E, Agrawal N, Rosenberg A, Vokes EE, Skandari MR, Pearson AT. Development and Validation of a Decision Analytical Model for Posttreatment Surveillance for Patients With Oropharyngeal Carcinoma. JAMA Netw Open. 2022 04 01; 5(4):e227240. PMID: 35416988; PMCID: PMC9008506.
      Citations: 1     Fields:    Translation:HumansCells
    17. Pun FW, Leung GHD, Leung HW, Liu BHM, Long X, Ozerov IV, Wang J, Ren F, Aliper A, Izumchenko E, Moskalev A, Zhavoronkov A, de Magalhães JP. Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine. Aging (Albany NY). 2022 03 29; 14(6):2475-2506. PMID: 35347083; PMCID: PMC9004567.
      Citations: 17     Fields:    
    18. Uddin S, Singh A, Mishra V, Agrawal N, Gooi Z, Izumchenko E. Molecular drivers of oral cavity squamous cell carcinoma in non-smoking and non-drinking patients: what do we know so far? Oncol Rev. 2022 Feb 22; 16(1):549. PMID: 35340886; PMCID: PMC8941340.
      Citations: 4     
    19. Rosenberg AJ, Izumchenko E, Pearson A, Gooi Z, Blair E, Karrison T, Juloori A, Ginat D, Cipriani N, Lingen M, Sloane H, Edelstein DL, Keyser K, Fredebohm J, Holtrup F, Jones FS, Haraf D, Agrawal N, Vokes EE. Prospective study evaluating dynamic changes of cell-free HPV DNA in locoregional viral-associated oropharyngeal cancer treated with induction chemotherapy and response-adaptive treatment. BMC Cancer. 2022 Jan 03; 22(1):17. PMID: 34980038; PMCID: PMC8722316.
      Citations: 2     Fields:    Translation:CTClinical Trials
    20. Mishra V, Singh A, Chen X, Rosenberg AJ, Pearson AT, Zhavoronkov A, Savage PA, Lingen MW, Agrawal N, Izumchenko E. Application of liquid biopsy as multi-functional biomarkers in head and neck cancer. Br J Cancer. 2022 02; 126(3):361-370. PMID: 34876674; PMCID: PMC8810877.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    21. Rouhani SJ, Trujillo JA, Pyzer AR, Yu J, Fessler J, Cabanov A, Higgs EF, Cron KR, Zha Y, Lu Y, Bloodworth JC, Abasiyanik MF, Okrah S, Flood BA, Hatogai K, Leung MY, Pezeshk A, Kozloff L, Reschke R, Strohbehn GW, Chervin CS, Kumar M, Schrantz S, Madariaga ML, Beavis KG, Yeo KJ, Sweis RF, Segal J, Tay S, Izumchenko E, Mueller J, Chen LS, Gajewski TF. Severe COVID-19 infection is associated with aberrant cytokine production by infected lung epithelial cells rather than by systemic immune dysfunction. Res Sq. 2021 Nov 24. PMID: 34845442; PMCID: PMC8629200.
      Citations: 3     
    22. Rosenberg AJ, Agrawal N, Pearson A, Gooi Z, Blair E, Cursio J, Juloori A, Ginat D, Howard A, Chin J, Kochanny S, Foster C, Cipriani N, Lingen M, Izumchenko E, Seiwert TY, Haraf D, Vokes EE. Risk and response adapted de-intensified treatment for HPV-associated oropharyngeal cancer: Optima paradigm expanded experience. Oral Oncol. 2021 11; 122:105566. PMID: 34662771; PMCID: PMC9295443.
      Citations: 5     Fields:    Translation:HumansCellsCTClinical Trials
    23. Ghantous Y, Omar M, Broner EC, Agrawal N, Pearson AT, Rosenberg AJ, Mishra V, Singh A, El-Naaj IA, Savage PA, Sidransky D, Marchionni L, Izumchenko E. A robust and interpretable gene signature for predicting the lymph node status of primary T1/T2 oral cavity squamous cell carcinoma. Int J Cancer. 2022 02 01; 150(3):450-460. PMID: 34569064; PMCID: PMC8760163.
      Citations: 3     Fields:    Translation:HumansCells
    24. Solanki HS, Raja R, Zhavoronkov A, Ozerov IV, Artemov AV, Advani J, Radhakrishnan A, Babu N, Puttamallesh VN, Syed N, Nanjappa V, Subbannayya T, Sahasrabuddhe NA, Patil AH, Prasad TSK, Gaykalova D, Chang X, Sathyendran R, Mathur PP, Rangarajan A, Sidransky D, Pandey A, Izumchenko E, Gowda H, Chatterjee A. Correction: Targeting focal adhesion kinase overcomes erlotinib resistance in smoke induced lung cancer by altering phosphorylation of epidermal growth factor receptor. Oncoscience. 2021; 8:108-109. PMID: 34589558; PMCID: PMC8460121.
      Citations: 1     
    25. Chao JL, Korzinkin M, Zhavoronkov A, Ozerov IV, Walker MT, Higgins K, Lingen MW, Izumchenko E, Savage PA. Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma. Cell Rep Med. 2021 09 21; 2(9):100399. PMID: 34622236; PMCID: PMC8484691.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    26. Broner EC, Trujillo JA, Korzinkin M, Subbannayya T, Agrawal N, Ozerov IV, Zhavoronkov A, Rooper L, Kotlov N, Shen L, Pearson AT, Rosenberg AJ, Savage PA, Mishra V, Chatterjee A, Sidransky D, Izumchenko E. Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma. Front Oncol. 2021; 11:677051. PMID: 34336664; PMCID: PMC8323482.
      Citations: 10     
    27. Naumov V, Putin E, Pushkov S, Kozlova E, Romantsov K, Kalashnikov A, Galkin F, Tihonova N, Shneyderman A, Galkin E, Zinkevich A, Cope SM, Sethuraman R, Oprea TI, Pearson AT, Tay S, Agrawal N, Dubovenko A, Vanhaelen Q, Ozerov I, Aliper A, Izumchenko E, Zhavoronkov A. COVIDomic: A multi-modal cloud-based platform for identification of risk factors associated with COVID-19 severity. PLoS Comput Biol. 2021 07; 17(7):e1009183. PMID: 34260589; PMCID: PMC8312936.
      Citations: 3     Fields:    Translation:HumansCells
    28. Abasiyanik MF, Flood B, Lin J, Ozcan S, Rouhani SJ, Pyzer A, Trujillo J, Zhen C, Wu P, Jumic S, Wang A, Gajewski TF, Wang P, Hartley M, Ameti B, Niemiec R, Fernando M, Mishra V, Savage P, Aydogan B, Bethel C, Matushek S, Beavis KG, Agrawal N, Segal J, Tay S, Izumchenko E. Sensitive detection and quantification of SARS-CoV-2 in saliva. Sci Rep. 2021 06 14; 11(1):12425. PMID: 34127708; PMCID: PMC8203799.
      Citations: 19     Fields:    Translation:HumansCells
    29. Rosenberg AJ, Izumchenko E. Neoantigen evolution in head and neck cancer progression: where do we go from here? Oncotarget. 2021 Jun 08; 12(12):1124-1125. PMID: 34136081; PMCID: PMC8202774.
      Citations:    Fields:    
    30. Kaur RP, Izumchenko E, Blakaj DM, Mladkova N, Lechner M, Beaumont TL, Floudas CS, Gallia GL, London NR. The genomics and epigenetics of olfactory neuroblastoma: A?systematic review. Laryngoscope Investig Otolaryngol. 2021 Aug; 6(4):721-728. PMID: 34401496; PMCID: PMC8356883.
      Citations: 7     
    31. Shanmugam A, Hariharan AK, Hasina R, Nair JR, Katragadda S, Irusappan S, Ravichandran A, Veeramachaneni V, Bettadapura R, Bhati M, Ramaswamy V, Rao VUS, Bagadia RK, Manjunath A, Manjunath NML, Solomon MC, Maji S, Bahadur U, Bettegowda C, Papadopoulos N, Lingen MW, Hariharan R, Gupta V, Agrawal N, Izumchenko E. Ultrasensitive detection of tumor-specific mutations in saliva of patients with oral cavity squamous cell carcinoma. Cancer. 2021 05 15; 127(10):1576-1589. PMID: 33405231; PMCID: PMC8084899.
      Citations: 12     Fields:    Translation:Humans
    32. Abasiyanik MF, Flood B, Lin J, Ozcan S, Rouhani SJ, Pyzer A, Trujillo J, Zhen C, Wu P, Jumic S, Wang A, Gajewski TF, Wang P, Hartley M, Ameti B, Niemiec R, Fernando M, Aydogan B, Bethel C, Matushek S, Beavis KG, Agrawal N, Segal J, Tay S, Izumchenko E. Sensitive detection and quantification of SARS-CoV-2 in saliva. medRxiv. 2020 Dec 07. PMID: 33330880; PMCID: PMC7743089.
      Citations: 6     
    33. Zhou H, Lei M, Wang W, Guo M, Wang J, Zhang H, Qiao L, Feng H, Liu Z, Chen L, Hou J, Wang X, Gu C, Zhao B, Izumchenko E, Yang Y, Zhu Y. In vitro and in vivo efficacy of the novel oral proteasome inhibitor NNU546 in multiple myeloma. Aging (Albany NY). 2020 11 16; 12(22):22949-22974. PMID: 33203800; PMCID: PMC7746380.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    34. Sacconi A, Donzelli S, Pulito C, Ferrero S, Spinella F, Morrone A, Rigoni M, Pimpinelli F, Ensoli F, Sanguineti G, Pellini R, Agrawal N, Izumchenko E, Ciliberto G, Muti P, Strano S, Blandino G, Giannì A. TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients. J Exp Clin Cancer Res. 2020 Sep 23; 39(1):200. PMID: 32967703; PMCID: PMC7510014.
      Citations: 21     Fields:    Translation:HumansCellsPHPublic Health
    35. Shibata M, Ooki A, Inokawa Y, Sadhukhan P, Ugurlu MT, Izumchenko E, Munari E, Bogina G, Rudin CM, Gabrielson E, Singh A, Hoque MO. Concurrent Targeting of Potential Cancer Stem Cells Regulating Pathways Sensitizes Lung Adenocarcinoma to Standard Chemotherapy. Mol Cancer Ther. 2020 10; 19(10):2175-2185. PMID: 32847981; PMCID: PMC7541748.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    36. Hayashi M, Guida E, Inokawa Y, Goldberg R, Reis LO, Ooki A, Pilli M, Sadhukhan P, Woo J, Choi W, Izumchenko E, Gonzalez LM, Marchionni L, Zhavoronkov A, Brait M, Bivalacqua T, Baras A, Netto GJ, Koch W, Singh A, Hoque MO. GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma. Sci Signal. 2020 08 18; 13(645). PMID: 32817372.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    37. Saloura V, Vougiouklakis T, Bao R, Kim S, Baek S, Zewde M, Bernard B, Burkitt K, Nigam N, Izumchenko E, Dohmae N, Hamamoto R, Nakamura Y. WHSC1 monomethylates histone H1 and induces stem-cell like features in squamous cell carcinoma of the head and neck. Neoplasia. 2020 08; 22(8):283-293. PMID: 32497898; PMCID: PMC7265065.
      Citations: 5     Fields:    Translation:HumansCells
    38. Hsu PJ, Yan K, Shi H, Izumchenko E, Agrawal N. Molecular biology of oral cavity squamous cell carcinoma. Oral Oncol. 2020 03; 102:104552. PMID: 31918173; PMCID: PMC7659372.
      Citations: 12     Fields:    Translation:Humans
    39. Schubert AD, Channah Broner E, Agrawal N, London N, Pearson A, Gupta A, Wali N, Seiwert TY, Wheelan S, Lingen M, Macleod K, Allen H, Chatterjee A, Vassiliki S, Gaykalova D, Hoque MO, Sidransky D, Suresh K, Izumchenko E. Somatic mitochondrial mutation discovery using ultra-deep sequencing of the mitochondrial genome reveals spatial tumor heterogeneity in head and neck squamous cell carcinoma. Cancer Lett. 2020 02 28; 471:49-60. PMID: 31830557; PMCID: PMC6980748.
      Citations: 9     Fields:    Translation:Humans
    40. London NR, Rooper LM, Bishop JA, Xu H, Bernhardt LJ, Ishii M, Hann CL, Taube JM, Izumchenko E, Gaykalova DA, Gallia GL. Expression of Programmed Cell Death Ligand 1 and Associated Lymphocyte Infiltration in Olfactory Neuroblastoma. World Neurosurg. 2020 Mar; 135:e187-e193. PMID: 31785431.
      Citations: 13     Fields:    Translation:HumansCells
    41. Saloura V, Izumchenko E, Zuo Z, Bao R, Korzinkin M, Ozerov I, Zhavoronkov A, Sidransky D, Bedi A, Hoque MO, Koeppen H, Keck MK, Khattri A, London N, Kotlov N, Fatima A, Vougiouklakis T, Nakamura Y, Lingen M, Agrawal N, Savage PA, Kron S, Kline J, Kowanetz M, Seiwert TY. Immune profiles in primary squamous cell carcinoma of the head and neck. Oral Oncol. 2019 09; 96:77-88. PMID: 31422218; PMCID: PMC7893610.
      Citations: 37     Fields:    Translation:Humans
    42. Subbannayya T, Leal-Rojas P, Zhavoronkov A, Ozerov IV, Korzinkin M, Babu N, Radhakrishnan A, Chavan S, Raja R, Pinto SM, Patil AH, Barbhuiya MA, Kumar P, Guerrero-Preston R, Navani S, Tiwari PK, Kumar RV, Prasad TSK, Pandey A, Sidransky D, Gowda H, Izumchenko E, Chatterjee A, Roa JC. PIM1 kinase promotes gallbladder cancer cell proliferation via inhibition of proline-rich Akt substrate of 40 kDa (PRAS40). J Cell Commun Signal. 2019 Jun; 13(2):163-177. PMID: 30666556; PMCID: PMC6498269.
      Citations: 7     
    43. Izumchenko E, Shavit Grievink L, Rosenbaum E, Hoque MO. GSTP1 as a Potential Marker of Early Chemotherapy Response for Noninvasive Detection. Eur Urol. 2019 09; 76(3):313-314. PMID: 30642610.
      Citations:    Fields:    Translation:Humans
    44. Maldonado L, Brait M, Izumchenko E, Begum S, Chatterjee A, Sen T, Loyo M, Barbosa A, Poeta ML, Makarev E, Zhavoronkov A, Fazio VM, Angioli R, Rabitti C, Ongenaert M, Van Criekinge W, Noordhuis MG, de Graeff P, Wisman GBA, van der Zee AGJ, Hoque MO. Integrated transcriptomic and epigenomic analysis of ovarian cancer reveals epigenetically silenced GULP1. Cancer Lett. 2018 10 01; 433:242-251. PMID: 29964205.
      Citations: 10     Fields:    Translation:HumansCells
    45. Stein-O'Brien G, Kagohara LT, Li S, Thakar M, Ranaweera R, Ozawa H, Cheng H, Considine M, Schmitz S, Favorov AV, Danilova LV, Califano JA, Izumchenko E, Gaykalova DA, Chung CH, Fertig EJ. Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance. Genome Med. 2018 05 23; 10(1):37. PMID: 29792227; PMCID: PMC5966898.
      Citations: 16     Fields:    Translation:HumansCells
    46. Solanki HS, Raja R, Zhavoronkov A, Ozerov IV, Artemov AV, Advani J, Radhakrishnan A, Babu N, Puttamallesh VN, Syed N, Nanjappa V, Subbannayya T, Sahasrabuddhe NA, Patil AH, Prasad TSK, Gaykalova D, Chang X, Sathyendran R, Mathur PP, Rangarajan A, Sidransky D, Pandey A, Izumchenko E, Gowda H, Chatterjee A. Targeting focal adhesion kinase overcomes erlotinib resistance in smoke induced lung cancer by altering phosphorylation of epidermal growth factor receptor. Oncoscience. 2018 Jan; 5(1-2):21-38. PMID: 29556515; PMCID: PMC5854290.
      Citations: 8     
    47. Ravi R, Noonan KA, Pham V, Bedi R, Zhavoronkov A, Ozerov IV, Makarev E, V Artemov A, Wysocki PT, Mehra R, Nimmagadda S, Marchionni L, Sidransky D, Borrello IM, Izumchenko E, Bedi A. Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFß enhance the efficacy of cancer immunotherapy. Nat Commun. 2018 02 21; 9(1):741. PMID: 29467463; PMCID: PMC5821872.
      Citations: 160     Fields:    Translation:HumansAnimalsCells
    48. Cortese F, Klokov D, Osipov A, Stefaniak J, Moskalev A, Schastnaya J, Cantor C, Aliper A, Mamoshina P, Ushakov I, Sapetsky A, Vanhaelen Q, Alchinova I, Karganov M, Kovalchuk O, Wilkins R, Shtemberg A, Izumchenko E, Artemov AV, Costes SV, Beheshti A, Mao XW, Pecaut MJ, Kaminskiy D, Ozerov IV, Scheibye-Knudsen M, Zhavoronkov A, Moreels M, Baatout S, de Magalhães JP. Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization. Oncotarget. 2018 Mar 06; 9(18):14692-14722. PMID: 29581875; PMCID: PMC5865701.
      Citations: 25     Fields:    
    49. West MD, Labat I, Sternberg H, Larocca D, Nasonkin I, Chapman KB, Singh R, Makarev E, Aliper A, Kazennov A, Alekseenko A, Shuvalov N, Cheskidova E, Alekseev A, Artemov A, Putin E, Mamoshina P, Pryanichnikov N, Larocca J, Copeland K, Izumchenko E, Korzinkin M, Zhavoronkov A. Use of deep neural network ensembles to identify embryonic-fetal transition markers: repression of COX7A1 in embryonic and cancer cells. Oncotarget. 2018 Jan 30; 9(8):7796-7811. PMID: 29487692; PMCID: PMC5814259.
      Citations: 16     Fields:    
    50. Peri S, Izumchenko E, Schubert AD, Slifker MJ, Ruth K, Serebriiskii IG, Guo T, Burtness BA, Mehra R, Ross EA, Sidransky D, Golemis EA. NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis. Nat Commun. 2017 11 24; 8(1):1772. PMID: 29176703; PMCID: PMC5701248.
      Citations: 27     Fields:    Translation:Humans
    51. Pustovalova M, Grekhova A, Vorobyeva N, Tsvetkova A, Blokhina T, Nikitina V, Suchkova Y, Usupzhanova D, Brunchukov V, Kobzeva I, Ozerov IV, Samoylov A, Bushmanov A, Leonov S, Izumchenko E, Zhavoronkov A, Klokov D, Osipov AN, Astrelina ?A, Karaseva ?. Residual ?H2AX foci induced by low dose x-ray radiation in bone marrow mesenchymal stem cells do not cause accelerated senescence in the progeny of irradiated cells. Aging (Albany NY). 2017 11 21; 9(11):2397-2410. PMID: 29165316; PMCID: PMC5723693.
      Citations: 12     Fields:    Translation:HumansCells
    52. Mamoshina P, Ojomoko L, Yanovich Y, Ostrovski A, Botezatu A, Prikhodko P, Izumchenko E, Aliper A, Romantsov K, Zhebrak A, Ogu IO, Zhavoronkov A. Converging blockchain and next-generation artificial intelligence technologies to decentralize and accelerate biomedical research and healthcare. Oncotarget. 2018 Jan 19; 9(5):5665-5690. PMID: 29464026; PMCID: PMC5814166.
      Citations: 48     Fields:    
    53. Izumchenko E, Paz K, Ciznadija D, Sloma I, Katz A, Vasquez-Dunddel D, Ben-Zvi I, Stebbing J, McGuire W, Harris W, Maki R, Gaya A, Bedi A, Zacharoulis S, Ravi R, Wexler LH, Hoque MO, Rodriguez-Galindo C, Pass H, Peled N, Davies A, Morris R, Hidalgo M, Sidransky D. Patient-derived xenografts effectively capture responses to oncology therapy in a heterogeneous cohort of patients with solid tumors. Ann Oncol. 2017 Oct 01; 28(10):2595-2605. PMID: 28945830; PMCID: PMC5834154.
      Citations: 146     Fields:    Translation:HumansAnimals
    54. Kelley DZ, Flam EL, Izumchenko E, Danilova LV, Wulf HA, Guo T, Singman DA, Afsari B, Skaist AM, Considine M, Welch JA, Stavrovskaya E, Bishop JA, Westra WH, Khan Z, Koch WM, Sidransky D, Wheelan SJ, Califano JA, Favorov AV, Fertig EJ, Gaykalova DA. Integrated Analysis of Whole-Genome ChIP-Seq and RNA-Seq Data of Primary Head and Neck Tumor Samples Associates HPV Integration Sites with Open Chromatin Marks. Cancer Res. 2017 12 01; 77(23):6538-6550. PMID: 28947419; PMCID: PMC6029614.
      Citations: 30     Fields:    Translation:HumansCells
    55. Nam HS, Izumchenko E, Dasgupta S, Hoque MO. Mitochondria in chronic obstructive pulmonary disease and lung cancer: where are we now? Biomark Med. 2017 May; 11(6):475-489. PMID: 28598223; PMCID: PMC5618933.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    56. Makarev E, Schubert AD, Kanherkar RR, London N, Teka M, Ozerov I, Lezhnina K, Bedi A, Ravi R, Mehra R, Hoque MO, Sloma I, Gaykalova DA, Csoka AB, Sidransky D, Zhavoronkov A, Izumchenko E. In silico analysis of pathways activation landscape in oral squamous cell carcinoma and oral leukoplakia. Cell Death Discov. 2017; 3:17022. PMID: 28580171; PMCID: PMC5439156.
      Citations: 13     
    57. Ozawa H, Ranaweera RS, Izumchenko E, Makarev E, Zhavoronkov A, Fertig EJ, Howard JD, Markovic A, Bedi A, Ravi R, Perez J, Le QT, Kong CS, Jordan RC, Wang H, Kang H, Quon H, Sidransky D, Chung CH. SMAD4 Loss Is Associated with Cetuximab Resistance and Induction of MAPK/JNK Activation in Head and Neck Cancer Cells. Clin Cancer Res. 2017 Sep 01; 23(17):5162-5175. PMID: 28522603; PMCID: PMC6078415.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    58. Brait M, Banerjee M, Maldonado L, Ooki A, Loyo M, Guida E, Izumchenko E, Mangold L, Humphreys E, Rosenbaum E, Partin A, Sidransky D, Hoque MO. Promoter methylation of MCAM, ERa and ERß in serum of early stage prostate cancer patients. Oncotarget. 2017 Feb 28; 8(9):15431-15440. PMID: 28147335; PMCID: PMC5362497.
      Citations: 15     Fields:    Translation:HumansCells
    59. Brait M, Izumchenko E, Kagohara LT, Long S, Wysocki PT, Faherty B, Fertig EJ, Khor TO, Bruckheimer E, Baia G, Ciznadija D, Sloma I, Ben-Zvi I, Paz K, Sidransky D. Comparative mutational landscape analysis of patient-derived tumour xenografts. Br J Cancer. 2017 Feb 14; 116(4):515-523. PMID: 28118322; PMCID: PMC5318980.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    60. Ozerov IV, Lezhnina KV, Izumchenko E, Artemov AV, Medintsev S, Vanhaelen Q, Aliper A, Vijg J, Osipov AN, Labat I, West MD, Buzdin A, Cantor CR, Nikolsky Y, Borisov N, Khokhlovich E, Sidransky D, Camargo ML, Zhavoronkov A, Irincheeva I. In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development. Nat Commun. 2016 11 16; 7:13427. PMID: 27848968; PMCID: PMC5116087.
      Citations: 60     Fields:    Translation:HumansCells
    61. Wysocki PT, Izumchenko E, Meir J, Ha PK, Sidransky D, Brait M. Adenoid cystic carcinoma: emerging role of translocations and gene fusions. Oncotarget. 2016 Oct 04; 7(40):66239-66254. PMID: 27533466; PMCID: PMC5323230.
      Citations: 26     Fields:    Translation:Humans
    62. Raja R, Sahasrabuddhe NA, Radhakrishnan A, Syed N, Solanki HS, Puttamallesh VN, Balaji SA, Nanjappa V, Datta KK, Babu N, Renuse S, Patil AH, Izumchenko E, Prasad TS, Chang X, Rangarajan A, Sidransky D, Pandey A, Gowda H, Chatterjee A. Chronic exposure to cigarette smoke leads to activation of p21 (RAC1)-activated kinase 6 (PAK6) in non-small cell lung cancer cells. Oncotarget. 2016 Sep 20; 7(38):61229-61245. PMID: 27542207; PMCID: PMC5308647.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    63. Zhavoronkov A, Izumchenko E, Kanherkar RR, Teka M, Cantor C, Manaye K, Sidransky D, West MD, Makarev E, Csoka AB. Pro-fibrotic pathway activation in trabecular meshwork and lamina cribrosa is the main driving force of glaucoma. Cell Cycle. 2016 06 17; 15(12):1643-52. PMID: 27229292; PMCID: PMC4934076.
      Citations: 26     Fields:    Translation:HumansCells
    64. Makarev E, Izumchenko E, Aihara F, Wysocki PT, Zhu Q, Buzdin A, Sidransky D, Zhavoronkov A, Atala A. Common pathway signature in lung and liver fibrosis. Cell Cycle. 2016 07 02; 15(13):1667-73. PMID: 27267766; PMCID: PMC4957589.
      Citations: 24     Fields:    Translation:HumansCells
    65. Izumchenko E, Meir J, Bedi A, Wysocki PT, Hoque MO, Sidransky D. Patient-derived xenografts as tools in pharmaceutical development. Clin Pharmacol Ther. 2016 Jun; 99(6):612-21. PMID: 26874468.
      Citations: 32     Fields:    Translation:HumansAnimals
    66. Izumchenko E, Chang X, Brait M, Fertig E, Kagohara LT, Bedi A, Marchionni L, Agrawal N, Ravi R, Jones S, Hoque MO, Westra WH, Sidransky D. Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA. Nat Commun. 2015 Sep 16; 6:8258. PMID: 26374070; PMCID: PMC4595648.
      Citations: 80     Fields:    Translation:HumansCells
    67. Begum S, Hayashi M, Ogawa T, Jabboure FJ, Brait M, Izumchenko E, Tabak S, Ahrendt SA, Westra WH, Koch W, Sidransky D, Hoque MO. An integrated genome-wide approach to discover deregulated microRNAs in non-small cell lung cancer: Clinical significance of miR-23b-3p deregulation. Sci Rep. 2015 Aug 28; 5:13236. PMID: 26314549; PMCID: PMC4551983.
      Citations: 17     Fields:    Translation:HumansCells
    68. Izumchenko E, Sidransky D. Understanding the MIG6-EGFR Signaling Axis in Lung Tumorigenesis. Cancer Discov. 2015 May; 5(5):472-4. PMID: 25941338.
      Citations: 3     Fields:    Translation:HumansAnimals
    69. Zhu Q, Izumchenko E, Aliper AM, Makarev E, Paz K, Buzdin AA, Zhavoronkov AA, Sidransky D. Pathway activation strength is a novel independent prognostic biomarker for cetuximab sensitivity in colorectal cancer patients. Hum Genome Var. 2015; 2:15009. PMID: 27081524; PMCID: PMC4785572.
      Citations: 30     
    70. Rettig EM, Chung CH, Bishop JA, Howard JD, Sharma R, Li RJ, Douville C, Karchin R, Izumchenko E, Sidransky D, Koch W, Califano J, Agrawal N, Fakhry C. Cleaved NOTCH1 Expression Pattern in Head and Neck Squamous Cell Carcinoma Is Associated with NOTCH1 Mutation, HPV Status, and High-Risk Features. Cancer Prev Res (Phila). 2015 Apr; 8(4):287-95. PMID: 25633867; PMCID: PMC4383699.
      Citations: 22     Fields:    Translation:HumansCells
    71. Michailidi C, Hayashi M, Datta S, Sen T, Zenner K, Oladeru O, Brait M, Izumchenko E, Baras A, VandenBussche C, Argos M, Bivalacqua TJ, Ahsan H, Hahn NM, Netto GJ, Sidransky D, Hoque MO. Involvement of epigenetics and EMT-related miRNA in arsenic-induced neoplastic transformation and their potential clinical use. Cancer Prev Res (Phila). 2015 Mar; 8(3):208-21. PMID: 25586904; PMCID: PMC4355280.
      Citations: 30     Fields:    Translation:HumansCells
    72. Izumchenko E, Sun K, Jones S, Brait M, Agrawal N, Koch W, McCord CL, Riley DR, Angiuoli SV, Velculescu VE, Jiang WW, Sidransky D. Notch1 mutations are drivers of oral tumorigenesis. Cancer Prev Res (Phila). 2015 Apr; 8(4):277-286. PMID: 25406187; PMCID: PMC4383685.
      Citations: 32     Fields:    Translation:Humans
    73. Izumchenko E, Chang X, Michailidi C, Kagohara L, Ravi R, Paz K, Brait M, Hoque MO, Ling S, Bedi A, Sidransky D. The TGFß-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors. Cancer Res. 2014 Jul 15; 74(14):3995-4005. PMID: 24830724; PMCID: PMC4122100.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    74. Chang X, Izumchenko E, Solis LM, Kim MS, Chatterjee A, Ling S, Monitto CL, Harari PM, Hidalgo M, Goodman SN, Wistuba II, Bedi A, Sidransky D. The relative expression of Mig6 and EGFR is associated with resistance to EGFR kinase inhibitors. PLoS One. 2013; 8(7):e68966. PMID: 23935914; PMCID: PMC3729565.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    75. Little JL, Serzhanova V, Izumchenko E, Egleston BL, Parise E, Klein-Szanto AJ, Loudon G, Shubina M, Seo S, Kurokawa M, Ochs MF, Golemis EA. A requirement for Nedd9 in luminal progenitor cells prior to mammary tumorigenesis in MMTV-HER2/ErbB2 mice. Oncogene. 2014 Jan 23; 33(4):411-20. PMID: 23318423; PMCID: PMC3628996.
      Citations: 19     Fields:    Translation:AnimalsCells
    76. Izumchenko E, Saydi J, Brown KD. Exonuclease 1 (Exo1) is required for activating response to S(N)1 DNA methylating agents. DNA Repair (Amst). 2012 Dec 01; 11(12):951-64. PMID: 23062884; PMCID: PMC3505598.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    77. Delmas AL, Riggs BM, Pardo CE, Dyer LM, Darst RP, Izumchenko EG, Hakam A, Kladde MP, Siegel EM, Brown KD, Monroe M. WIF1 is a frequent target for epigenetic silencing in squamous cell carcinoma of the cervix. Carcinogenesis. 2011 Nov; 32(11):1625-33. PMID: 21873353; PMCID: PMC3204350.
      Citations: 20     Fields:    Translation:HumansCells
    78. Singh MK, Izumchenko E, Klein-Szanto AJ, Egleston BL, Wolfson M, Golemis EA. Enhanced genetic instability and dasatinib sensitivity in mammary tumor cells lacking NEDD9. Cancer Res. 2010 Nov 01; 70(21):8907-16. PMID: 20940402; PMCID: PMC2970659.
      Citations: 22     Fields:    Translation:AnimalsCells
    79. Izumchenko E, Singh MK, Plotnikova OV, Tikhmyanova N, Little JL, Serebriiskii IG, Seo S, Kurokawa M, Egleston BL, Klein-Szanto A, Pugacheva EN, Hardy RR, Wolfson M, Connolly DC, Golemis EA. NEDD9 promotes oncogenic signaling in mammary tumor development. Cancer Res. 2009 Sep 15; 69(18):7198-206. PMID: 19738060; PMCID: PMC2758619.
      Citations: 80     Fields:    Translation:AnimalsCells
    80. Tikhmyanova NY, Izumchenko EA, Serebriiskii IG, Golemis EA. A bacterial/yeast merged two-hybrid system: protocol for yeast screening with single or parallel baits. Methods Mol Biol. 2007; 408:257-90. PMID: 18314588.
      Citations:    Fields:    Translation:AnimalsCells
    81. Sharabani H, Izumchenko E, Wang Q, Kreinin R, Steiner M, Barvish Z, Kafka M, Sharoni Y, Levy J, Uskokovic M, Studzinski GP, Danilenko M. Cooperative antitumor effects of vitamin D3 derivatives and rosemary preparations in a mouse model of myeloid leukemia. Int J Cancer. 2006 Jun 15; 118(12):3012-21. PMID: 16395705; PMCID: PMC2824511.
      Citations: 28     Fields:    Translation:AnimalsCells
    82. Sharoni Y, Agbaria R, Amir H, Ben-Dor A, Bobilev I, Doubi N, Giat Y, Hirsh K, Izumchenko G, Khanin M, Kirilov E, Krimer R, Nahum A, Steiner M, Walfisch Y, Walfisch S, Zango G, Danilenko M, Levy J. Modulation of transcriptional activity by antioxidant carotenoids. Mol Aspects Med. 2003 Dec; 24(6):371-84. PMID: 14585308.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
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