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Jueqi Chen

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMicrobiology
AddressChicago IL 60637
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    Collapse Overview 
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    Inflammasomes are multi-protein complexes that are responsible for the induction of proinflammatory cytokines and inflammatory cell death. They are unique in innate immune signaling because they can be triggered by a plethora of diverse signals from both pathogens and environmental danger. The research in our lab focuses on dissecting the molecular mechanisms of inflammasome pathways and studying how their dysfunction leads to defective host defense against various pathogenic microorganisms, as well as the impact on autoimmune diseases, neurodegeneration and metabolic syndromes.

    Our lab utilizes diverse and complementary approaches, including biochemical assays, confocal fluorescence imaging, CRISPR knockout/rescue and animal models. Our recent study has uncovered the unexpected role of trans-Golgi network dispersion in inflammasome activation, and we are currently interested in studying how pathogens are able to evade or hijack these cellular signals to counter the host defense. We believe that these studies will unveil potential therapeutic targets for infectious diseases and many other human health problems.


    Collapse Biography 
    Collapse education and training
    UT Southwestern Medical Center, Dallas, TXPostdoctoral Researcher06/2019Immunology & Microbiology
    UT Southwestern Medical Center, Dallas, TXPh.D.12/2014Biomedical Science
    Zhejiang University, Hangzhou, ChinaB.S.06/2009Biotechnology

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chen J, Chen ZJ. PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation. Nature. 2018 12; 564(7734):71-76. PMID: 30487600.
      View in: PubMed
    2. Tan X, Sun L, Chen J, Chen ZJ. Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids. Annu Rev Microbiol. 2018 Sep 08; 72:447-478. PMID: 30200854.
      View in: PubMed
    3. Cai X, Chen J, Xu H, Liu S, Jiang QX, Halfmann R, Chen ZJ. Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation. Cell. 2014 Mar 13; 156(6):1207-1222. PMID: 24630723.
      View in: PubMed
    4. Liu S, Chen J, Cai X, Wu J, Chen X, Wu YT, Sun L, Chen ZJ. MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades. Elife. 2013 Aug 14; 2:e00785. PMID: 23951545.
      View in: PubMed
    5. Chen J, Chen ZJ. Regulation of NF-?B by ubiquitination. Curr Opin Immunol. 2013 Feb; 25(1):4-12. PMID: 23312890.
      View in: PubMed
    6. Skaug B, Chen J, Du F, He J, Ma A, Chen ZJ. Direct, noncatalytic mechanism of IKK inhibition by A20. Mol Cell. 2011 Nov 18; 44(4):559-71. PMID: 22099304.
      View in: PubMed
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