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Jueqi Chen

TitleAssistant Professor
InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Inflammasomes are multi-protein complexes that are responsible for the induction of proinflammatory cytokines and inflammatory cell death. They are unique in innate immune signaling because they can be triggered by a plethora of diverse signals from both pathogens and environmental danger. The research in our lab focuses on dissecting the molecular mechanisms of inflammasome pathways and studying how their dysfunction leads to defective host defense against various pathogenic microorganisms, as well as the impact on autoimmune diseases, neurodegeneration and metabolic syndromes.

    Our lab utilizes diverse and complementary approaches, including biochemical assays, confocal fluorescence imaging, CRISPR knockout/rescue and animal models. Our recent study has uncovered the unexpected role of trans-Golgi network dispersion in inflammasome activation, and we are currently interested in studying how pathogens are able to evade or hijack these cellular signals to counter the host defense. We believe that these studies will unveil potential therapeutic targets for infectious diseases and many other human health problems.
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    UT Southwestern Medical Center, Dallas, TXPostdoctoral Researcher06/2019Immunology & Microbiology
    UT Southwestern Medical Center, Dallas, TXPh.D.12/2014Biomedical Science
    Zhejiang University, Hangzhou, ChinaB.S.06/2009Biotechnology

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chen J, Chen ZJ. PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation. Nature. 2018 12; 564(7734):71-76. PMID: 30487600; PMCID: PMC9402428.
      Citations: 254     Fields:    Translation:HumansAnimalsCells
    2. Tan X, Sun L, Chen J, Chen ZJ. Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids. Annu Rev Microbiol. 2018 Sep 08; 72:447-478. PMID: 30200854.
      Citations: 179     Fields:    Translation:Cells
    3. Cai X, Chen J, Xu H, Liu S, Jiang QX, Halfmann R, Chen ZJ. Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation. Cell. 2014 Mar 13; 156(6):1207-1222. PMID: 24630723; PMCID: PMC4034535.
      Citations: 301     Fields:    Translation:HumansAnimalsCells
    4. Liu S, Chen J, Cai X, Wu J, Chen X, Wu YT, Sun L, Chen ZJ. MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades. Elife. 2013 Aug 14; 2:e00785. PMID: 23951545; PMCID: PMC3743401.
      Citations: 187     Fields:    Translation:HumansAnimalsCells
    5. Chen J, Chen ZJ. Regulation of NF-?B by ubiquitination. Curr Opin Immunol. 2013 Feb; 25(1):4-12. PMID: 23312890; PMCID: PMC3594545.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    6. Skaug B, Chen J, Du F, He J, Ma A, Chen ZJ. Direct, noncatalytic mechanism of IKK inhibition by A20. Mol Cell. 2011 Nov 18; 44(4):559-71. PMID: 22099304; PMCID: PMC3237303.
      Citations: 131     Fields:    Translation:HumansCells
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