Platelet Activating Factor
"Platelet Activating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.
| Descriptor ID |
D010972
|
| MeSH Number(s) |
D02.033.100.291.211.500 D02.092.063.291.211.500 D02.092.877.883.333.710 D02.675.276.232.710 D10.570.755.375.760.400.985.910 D23.119.865 D23.469.050.600
|
| Concept/Terms |
Platelet Activating Factor- Platelet Activating Factor
- Factor, Platelet Activating
- Phosphorylcholine, Acetyl Glyceryl Ether
- Platelet Aggregating Factor
- Aggregating Factor, Platelet
- Platelet Aggregation Enhancing Factor
- AGEPC
- Thrombocyte Aggregating Activity
- 1-Alkyl-2-acetyl-sn-glycerophosphocholine
- 1 Alkyl 2 acetyl sn glycerophosphocholine
- Acetyl Glyceryl Ether Phosphorylcholine
- PAF-Acether
- PAF Acether
- Platelet-Activating Substance
- Platelet Activating Substance
|
Below are MeSH descriptors whose meaning is more general than "Platelet Activating Factor".
Below are MeSH descriptors whose meaning is more specific than "Platelet Activating Factor".
This graph shows the total number of publications written about "Platelet Activating Factor" by people in this website by year, and whether "Platelet Activating Factor" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 2 | 1 | 3 |
| 1994 | 4 | 1 | 5 |
| 1995 | 1 | 1 | 2 |
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 2 | 3 |
| 1998 | 1 | 1 | 2 |
| 2000 | 1 | 1 | 2 |
| 2001 | 0 | 2 | 2 |
| 2002 | 1 | 0 | 1 |
| 2003 | 3 | 0 | 3 |
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2008 | 2 | 1 | 3 |
| 2010 | 1 | 1 | 2 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Platelet Activating Factor" by people in Profiles.
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Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation. Mol Cell. 2022 06 02; 82(11):1992-2005.e9.
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The Effects of Platelet-Activating Factor on Uterine Contractility, Perfusion, Hypoxia, and Pain in Mice. Reprod Sci. 2018 03; 25(3):384-394.
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Attenuated Reactive Gliosis and Enhanced Functional Recovery Following Spinal Cord Injury in Null Mutant Mice of Platelet-Activating Factor Receptor. Mol Neurobiol. 2016 07; 53(5):3448-3461.
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Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice. Biol Reprod. 2014 Nov; 91(5):119.
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Necrotizing enterocolitis: pathophysiology, platelet-activating factor, and probiotics. Semin Pediatr Surg. 2013 May; 22(2):88-93.
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The significance of endothelin in platelet-activating factor-induced fetal growth restriction. Reprod Sci. 2012 Nov; 19(11):1175-80.
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Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis. PLoS One. 2010 Oct 15; 5(10):e15044.
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Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis. Pediatr Res. 2010 Sep; 68(3):225-30.
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The importance of pro-inflammatory signaling in neonatal necrotizing enterocolitis. Semin Perinatol. 2008 Apr; 32(2):100-6.
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Polyunsaturated fatty acids block platelet-activating factor-induced phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2008 May; 294(5):G1181-90.