 Glutamine
"Glutamine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.
| Descriptor ID |
D005973
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| MeSH Number(s) |
D12.125.068.330 D12.125.095.461 D12.125.154.424
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Glutamine".
Below are MeSH descriptors whose meaning is more specific than "Glutamine".
This graph shows the total number of publications written about "Glutamine" by people in this website by year, and whether "Glutamine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 0 | 1 | 1 | | 1982 | 1 | 0 | 1 | | 1987 | 0 | 1 | 1 | | 1988 | 1 | 0 | 1 | | 1989 | 1 | 1 | 2 | | 1990 | 1 | 1 | 2 | | 1991 | 0 | 2 | 2 | | 1992 | 0 | 1 | 1 | | 1996 | 1 | 1 | 2 | | 1997 | 1 | 0 | 1 | | 1998 | 1 | 1 | 2 | | 1999 | 1 | 0 | 1 | | 2001 | 3 | 0 | 3 | | 2002 | 0 | 1 | 1 | | 2003 | 3 | 1 | 4 | | 2005 | 2 | 1 | 3 | | 2006 | 1 | 0 | 1 | | 2007 | 5 | 0 | 5 | | 2008 | 1 | 1 | 2 | | 2009 | 1 | 1 | 2 | | 2010 | 0 | 1 | 1 | | 2011 | 1 | 1 | 2 | | 2012 | 0 | 1 | 1 | | 2013 | 3 | 0 | 3 | | 2014 | 0 | 1 | 1 | | 2015 | 1 | 1 | 2 | | 2016 | 0 | 2 | 2 | | 2017 | 1 | 1 | 2 | | 2018 | 0 | 1 | 1 | | 2019 | 1 | 3 | 4 | | 2020 | 1 | 0 | 1 | | 2021 | 0 | 2 | 2 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Glutamine" by people in Profiles.
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Zhang R, Chen D, Fan H, Wu R, Tu J, Zhang FQ, Wang M, Zheng H, Qu CK, Elf SE, Faubert B, He YY, Bissonnette MB, Gao X, DeBerardinis RJ, Chen J. Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells. Cell Chem Biol. 2022 07 21; 29(7):1200-1208.e6.
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Schwörer S, Pavlova NN, Cimino FV, King B, Cai X, Sizemore GM, Thompson CB. Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment. Nat Metab. 2021 11; 3(11):1484-1499.
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Reinfeld BI, Madden MZ, Wolf MM, Chytil A, Bader JE, Patterson AR, Sugiura A, Cohen AS, Ali A, Do BT, Muir A, Lewis CA, Hongo RA, Young KL, Brown RE, Todd VM, Huffstater T, Abraham A, O'Neil RT, Wilson MH, Xin F, Tantawy MN, Merryman WD, Johnson RW, Williams CS, Mason EF, Mason FM, Beckermann KE, Vander Heiden MG, Manning HC, Rathmell JC, Rathmell WK. Cell-programmed nutrient partitioning in the tumour microenvironment. Nature. 2021 05; 593(7858):282-288.
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Schwörer S, Berisa M, Violante S, Qin W, Zhu J, Hendrickson RC, Cross JR, Thompson CB. Proline biosynthesis is a vent for TGFß-induced mitochondrial redox stress. EMBO J. 2020 04 15; 39(8):e103334.
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Hamanaka RB, O'Leary EM, Witt LJ, Tian Y, Gökalp GA, Meliton AY, Dulin NO, Mutlu GM. Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts. Am J Respir Cell Mol Biol. 2019 11; 61(5):597-606.
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Chen PH, Cai L, Huffman K, Yang C, Kim J, Faubert B, Boroughs L, Ko B, Sudderth J, McMillan EA, Girard L, Chen D, Peyton M, Shields MD, Yao B, Shames DS, Kim HS, Timmons B, Sekine I, Britt R, Weber S, Byers LA, Heymach JV, Chen J, White MA, Minna JD, Xiao G, DeBerardinis RJ. Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells. Mol Cell. 2019 12 05; 76(5):838-851.e5.
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Ni M, Solmonson A, Pan C, Yang C, Li D, Notzon A, Cai L, Guevara G, Zacharias LG, Faubert B, Vu HS, Jiang L, Ko B, Morales NM, Pei J, Vale G, Rakheja D, Grishin NV, McDonald JG, Gotway GK, McNutt MC, Pascual JM, DeBerardinis RJ. Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans. Cell Rep. 2019 04 30; 27(5):1376-1386.e6.
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Efimova EV, Appelbe OK, Ricco N, Lee SS, Liu Y, Wolfgeher DJ, Collins TN, Flor AC, Ramamurthy A, Warrington S, Bindokas VP, Kron SJ. O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors. Mol Cancer Res. 2019 06; 17(6):1338-1350.
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Wu D, Woods PS, Duong HT, Mutlu GM. Role of Cellular Metabolism in Pulmonary Diseases. Am J Respir Cell Mol Biol. 2018 07; 59(1):127-129.
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Muir A, Danai LV, Gui DY, Waingarten CY, Lewis CA, Vander Heiden MG. Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition. Elife. 2017 08 15; 6.
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