 Pyruvate Kinase
"Pyruvate Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the presence of ATP. It has four isozymes (L, R, M1, and M2). Deficiency of the enzyme results in hemolytic anemia. EC 2.7.1.40.
| Descriptor ID |
D011770
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| MeSH Number(s) |
D08.811.913.696.620.695
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| Concept/Terms |
Pyruvate Kinase L- Pyruvate Kinase L
- L-Type Pyruvate Kinase
- L Type Pyruvate Kinase
- Pyruvate Kinase, L-Type
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Below are MeSH descriptors whose meaning is more general than "Pyruvate Kinase".
Below are MeSH descriptors whose meaning is more specific than "Pyruvate Kinase".
This graph shows the total number of publications written about "Pyruvate Kinase" by people in this website by year, and whether "Pyruvate Kinase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pyruvate Kinase" by people in Profiles.
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Xiong PY, Motamed M, Chen KH, Dasgupta A, Potus F, Tian L, Martin A, Mewburn J, Jones O, Thébaud A, Archer SL. Inhibiting pyruvate kinase muscle isoform 2 regresses group 2 pulmonary hypertension induced by supra-coronary aortic banding. Acta Physiol (Oxf). 2022 02; 234(2):e13764.
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Cereghetti G, Wilson-Zbinden C, Kissling VM, Diether M, Arm A, Yoo H, Piazza I, Saad S, Picotti P, Drummond DA, Sauer U, Dechant R, Peter M. Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly. Nat Cell Biol. 2021 10; 23(10):1085-1094.
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McGee JP, Melani RD, Goodwin M, McAlister G, Huguet R, Senko MW, Compton PD, Kelleher NL. Voltage Rollercoaster Filtering of Low-Mass Contaminants During Native Protein Analysis. J Am Soc Mass Spectrom. 2020 Mar 04; 31(3):763-767.
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Schachner LF, Ives AN, McGee JP, Melani RD, Kafader JO, Compton PD, Patrie SM, Kelleher NL. Standard Proteoforms and Their Complexes for Native Mass Spectrometry. J Am Soc Mass Spectrom. 2019 Jul; 30(7):1190-1198.
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Archer SL. Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension: Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension. Circulation. 2017 12 19; 136(25):2486-2490.
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Nassin ML, Lapping-Carr G, de Jong JL. Anemia in the Neonate: The Differential Diagnosis and Treatment. Pediatr Ann. 2015 Jul; 44(7):e159-63.
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Hamanaka RB, Chandel NS. Cell biology. Warburg effect and redox balance. Science. 2011 Dec 02; 334(6060):1219-20.
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Zhou G, Doçi CL, Lingen MW. Identification and functional analysis of NOL7 nuclear and nucleolar localization signals. BMC Cell Biol. 2010 Sep 27; 11:74.
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Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ, Xie J, Gu TL, Polakiewicz RD, Roesel JL, Boggon TJ, Khuri FR, Gilliland DG, Cantley LC, Kaufman J, Chen J. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci Signal. 2009 Nov 17; 2(97):ra73.
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Griffiths JS, Cheriyan M, Corbell JB, Pocivavsek L, Fierke CA, Toone EJ. A bacterial selection for the directed evolution of pyruvate aldolases. Bioorg Med Chem. 2004 Aug 01; 12(15):4067-74.
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