 Leupeptins
"Leupeptins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of acylated oligopeptides produced by Actinomycetes that function as protease inhibitors. They have been known to inhibit to varying degrees trypsin, plasmin, KALLIKREINS, papain and the cathepsins.
| Descriptor ID |
D007976
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| MeSH Number(s) |
D12.644.456.580
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Leupeptins".
Below are MeSH descriptors whose meaning is more specific than "Leupeptins".
This graph shows the total number of publications written about "Leupeptins" by people in this website by year, and whether "Leupeptins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 1 | 2 | | 1995 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2001 | 0 | 4 | 4 | | 2002 | 0 | 2 | 2 | | 2006 | 0 | 2 | 2 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2010 | 1 | 2 | 3 | | 2011 | 1 | 1 | 2 | | 2012 | 1 | 0 | 1 |
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Below are the most recent publications written about "Leupeptins" by people in Profiles.
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Mao J, Tessanne K, Whitworth KM, Spate LD, Walters EM, Samuel MS, Murphy CN, Tracy L, Zhao J, Prather RS. Effects of combined treatment of MG132 and scriptaid on early and term development of porcine somatic cell nuclear transfer embryos. Cell Reprogram. 2012 Oct; 14(5):385-9.
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Ishida M, El-Mounayri O, Kattman S, Zandstra P, Sakamoto H, Ogawa M, Keller G, Husain M. Regulated expression and role of c-Myb in the cardiovascular-directed differentiation of mouse embryonic stem cells. Circ Res. 2012 Jan 20; 110(2):253-64.
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David J, Melamud A, Kesner L, Roth S, Rosenbaum PS, Barone FC, Popp S, Hassen GW, Stracher A, Rosenbaum DM. A novel calpain inhibitor for treatment of transient retinal ischemia in the rat. Neuroreport. 2011 Sep 14; 22(13):633-6.
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Dawson G, Qin J. Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants. Biochem Biophys Res Commun. 2011 Jan 07; 404(1):321-3.
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Sengupta S, Nandi S, Hindi ES, Wainwright DA, Han Y, Lesniak MS. Short hairpin RNA-mediated fibronectin knockdown delays tumor growth in a mouse glioma model. Neoplasia. 2010 Oct; 12(10):837-47.
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Selsby J, Pendrak K, Zadel M, Tian Z, Pham J, Carver T, Acosta P, Barton E, Sweeney HL. Leupeptin-based inhibitors do not improve the mdx phenotype. Am J Physiol Regul Integr Comp Physiol. 2010 Nov; 299(5):R1192-201.
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Salabat MR, Melstrom LG, Strouch MJ, Ding XZ, Milam BM, Ujiki MB, Chen C, Pelling JC, Rao S, Grippo PJ, McGarry TJ, Bentrem DJ. Geminin is overexpressed in human pancreatic cancer and downregulated by the bioflavanoid apigenin in pancreatic cancer cell lines. Mol Carcinog. 2008 Nov; 47(11):835-44.
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Lange Y, Ory DS, Ye J, Lanier MH, Hsu FF, Steck TL. Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase. J Biol Chem. 2008 Jan 18; 283(3):1445-1455.
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Norstrom EM, Ciaccio MF, Rassbach B, Wollmann R, Mastrianni JA. Cytosolic prion protein toxicity is independent of cellular prion protein expression and prion propagation. J Virol. 2007 Mar; 81(6):2831-7.
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Poon AP, Benetti L, Roizman B. U(S)3 and U(S)3.5 protein kinases of herpes simplex virus 1 differ with respect to their functions in blocking apoptosis and in virion maturation and egress. J Virol. 2006 Apr; 80(8):3752-64.
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