Ubiquitin-Protein Ligases
"Ubiquitin-Protein Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.
| Descriptor ID |
D044767
|
| MeSH Number(s) |
D08.811.464.938.750
|
| Concept/Terms |
Ubiquitin-Protein Ligases- Ubiquitin-Protein Ligases
- Ligases, Ubiquitin-Protein
- Ubiquitin Protein Ligases
- E3 Ubiquitin Ligase
- Ligase, E3 Ubiquitin
- Ubiquitin Ligase, E3
- Ubiquitin-Protein Ligase E3
- Ligase E3, Ubiquitin-Protein
- Ubiquitin Protein Ligase E3
- Ubiquitin Ligase E3
- Ligase E3, Ubiquitin
- Ubiquitin-Protein Ligase
- Ligase, Ubiquitin-Protein
- Ubiquitin Protein Ligase
- E3 Ligase
- Ligase, E3
|
Below are MeSH descriptors whose meaning is more general than "Ubiquitin-Protein Ligases".
Below are MeSH descriptors whose meaning is more specific than "Ubiquitin-Protein Ligases".
This graph shows the total number of publications written about "Ubiquitin-Protein Ligases" by people in this website by year, and whether "Ubiquitin-Protein Ligases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 2 | 1 | 3 |
| 1997 | 6 | 0 | 6 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 3 | 4 |
| 2001 | 0 | 7 | 7 |
| 2002 | 2 | 4 | 6 |
| 2003 | 4 | 3 | 7 |
| 2004 | 1 | 7 | 8 |
| 2005 | 3 | 5 | 8 |
| 2006 | 4 | 2 | 6 |
| 2007 | 3 | 2 | 5 |
| 2008 | 3 | 2 | 5 |
| 2009 | 5 | 5 | 10 |
| 2010 | 5 | 0 | 5 |
| 2011 | 5 | 4 | 9 |
| 2012 | 5 | 3 | 8 |
| 2013 | 3 | 2 | 5 |
| 2014 | 4 | 3 | 7 |
| 2015 | 0 | 2 | 2 |
| 2016 | 2 | 2 | 4 |
| 2017 | 2 | 1 | 3 |
| 2018 | 1 | 1 | 2 |
| 2019 | 2 | 0 | 2 |
| 2020 | 2 | 0 | 2 |
| 2021 | 3 | 2 | 5 |
| 2022 | 0 | 3 | 3 |
| 2023 | 1 | 2 | 3 |
| 2024 | 2 | 1 | 3 |
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Below are the most recent publications written about "Ubiquitin-Protein Ligases" by people in Profiles.
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Targeting DTX2/UFD1-mediated FTO degradation to regulate antitumor immunity. Proc Natl Acad Sci U S A. 2024 Dec 17; 121(51):e2407910121.
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Identification of RNF213 as a Potential Suppressor of Local Invasion in Intrahepatic Cholangiocarcinoma. Lab Invest. 2024 07; 104(7):102074.
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Discovery of LLC0424 as a Potent and Selective in Vivo NSD2 PROTAC Degrader. J Med Chem. 2024 May 09; 67(9):6938-6951.
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Vasovagal Responses to Human Monomorphic Ventricular Tachycardia: Hemodynamic Implications From Sinus Rate Analysis. J Am Coll Cardiol. 2023 09 12; 82(11):1096-1105.
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SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck. Cell Rep. 2023 07 25; 42(7):112823.
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CAND1 orchestrates CRLs through rock and roll. Cell. 2023 04 27; 186(9):1817-1818.
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Cross-Regulation of F-Box Protein FBXL2 with T-bet and TNF-a during Acute and Chronic Lung Allograft Rejection. J Immunol. 2022 11 01; 209(9):1788-1795.
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LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2205629119.
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The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity. J Cell Biol. 2022 04 04; 221(4).
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H5N1 infection impairs the alveolar epithelial barrier through intercellular junction proteins via Itch-mediated proteasomal degradation. Commun Biol. 2022 03 01; 5(1):186.