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Demet Arac-Ozkan

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentBiochemistry and Molecular Biology
AddressChicago IL 60637
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    PI last name in publications: ARAÇ

    ARAÇ LAB RESEARCH
    Cells in multicellular organisms have the extraordinary ability of adhering to each other and exchanging information. Cellular adhesion and communication is essential for the development of all organs such as the brain, and is a key phenomenon that is disrupted in many human diseases. The Araç Lab is interested in understanding cellular communication with a special focus on the cell-surface receptors that mediate intercellular adhesion and communication. Genetic studies revealed critical roles for these surface proteins in embryonic development (especially of the brain and the heart), and in neurobiology (especially in synaptogenesis, axon pathfinding, axon-dendrite partner marching and wiring the brain); and link them to numerous diseases including neurological disorders, developmental impairments, multiple types of cancers (such as glioblastoma and ovarian cancer) and congenital general anosmia (the inability to smell). Considering that many drugs target the extracellular regions of membrane receptors to regulate receptor function, and have excellent therapeutic benefits, these proteins may be promising targets for drugs to treat numerous diseases once mechanistic details about the components that regulate their functions are understood. However, in spite of the recent exciting advances, their mechanisms of action, high-resolution structures in isolation or in complex with their ligands, and how they can mediate such broad range of functions remain majorly unknown. Our lab’s ultimate goal is to understand the mechanisms by which cell-adhesion receptors mediate communication between cells.

    Collapse Biography 
    Collapse education and training
    Stanford University, Stanford, CAPostdoctoral2013Structural and Cellular Biology
    UT Southwestern Med. Center, Dallas, TXPhD2006Molecular Biophysics
    Bilkent University, Ankara, Turkey BS1999Molecular Biology and Genetics
    Collapse awards and honors
    2014 - 2015Fay/Frank Seed Grant, Brain Research Foundation
    2014 - 2015Big Ideas Generator , University of Chicago
    2007 - 2010Life Sciences Research Foundation Postdoctoral Fellowship, Howard Hughes Medical Center
    1999 - 2000Chancellor’s Distinguished Fellowship, University of California, Riverside

    Collapse Research 
    Collapse research activities and funding
    R35GM148412     (ARAC-OZKAN, DEMET)Feb 1, 2023 - Jan 31, 2028
    NIH
    Structural and Functional Studies of Cell-Adhesion Receptors
    Role: Principal Investigator

    T32GM144292     (MUNRO, EDWIN MARSHALL)Jul 1, 2022 - Jun 30, 2027
    NIH
    Molecular and Cellular Biology Training Program
    Role: Co-Principal Investigator

    R01GM134035     (ARAC-OZKAN, DEMET)Sep 1, 2019 - Aug 31, 2023
    NIH
    Structural and Functional Studies of Teneurins: A bacterial toxin homolog in human
    Role: Principal Investigator

    R03MH122261     (ARAC-OZKAN, DEMET)Sep 1, 2019 - Aug 31, 2020
    NIH
    Structural and Functional Studies of Brain Angiogenesis Inhibitors (BAIs/ADGRBs)
    Role: Principal Investigator

    R01GM120322     (ARAC-OZKAN, DEMET)Sep 15, 2016 - May 31, 2021
    NIH
    Structural and Functional Studies of Adhesion GPCRs
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Li J, Araç D. Teneurins and latrophilins: two giants meet at the synapse. Curr Opin Struct Biol. 2019 02; 54:141-151. PMID: 30952063; PMCID: PMC6677252.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    2. Nazarko O, Kibrom A, Leon K, Stoveken H, Salzman G, Merdas K, Lu Y, Narkhede P, Tall G, Winkler J, Prömel S, Araç D. A Comprehensive Mutagenesis Screen of the Adhesion GPCR Latrophilin-1/ADGRL1. iScience. 2018 May 25; 3:264-278. PMID: 30428326; PMCID: PMC6137404.
      Citations: 23     
    3. Li J, Shalev-Benami M, Sando R, Jiang X, Kibrom A, Wang J, Leon K, Katanski C, Nazarko O, Lu YC, Skiniotis G, Südhof TC, Araç D. Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse. Cell. 2018 04 19; 173(3):735-748.e15. PMID: 29677516; PMCID: PMC5912346.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    4. Bowler MW, Correia AR, Hoelz A, Larsen S, Leonard GA, McCarthy AA, McSweeney S, Mueller-Dieckmann C, Otten H, Salzman G, Pannu NS, Skubák P, Araç D. A new MR-SAD algorithm for the automatic building of protein models from low-resolution X-ray data and a poor starting model. IUCrJ. 2018 Mar 01; 5(Pt 2):166-171. PMID: 29765606; PMCID: PMC5947721.
      Citations: 18     Fields:    
    5. Salzman GS, Zhang S, Gupta A, Koide A, Koide S, Araç D. Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region. Proc Natl Acad Sci U S A. 2017 09 19; 114(38):10095-10100. PMID: 28874577; PMCID: PMC5617296.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    6. Salzman GS, Ackerman SD, Ding C, Koide A, Leon K, Luo R, Stoveken HM, Fernandez CG, Tall GG, Piao X, Monk KR, Koide S, Araç D. Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains. Neuron. 2016 Sep 21; 91(6):1292-1304. PMID: 27657451; PMCID: PMC5036532.
      Citations: 50     Fields:    Translation:HumansCells
    7. Seiradake E, Araç D, Sträter N. Understanding the Structural Basis of Adhesion GPCR Functions. Handb Exp Pharmacol. 2016; 234:67-82. PMID: 27832484.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    8. Lu YC, Nazarko OV, Sando R, Salzman GS, Li NS, Südhof TC, Araç D. Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structure. 2015 Sep 01; 23(9):1678-1691. PMID: 26235030; PMCID: PMC4851429.
      Citations: 67     Fields:    Translation:HumansCells
    9. Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Pharmacol Rev. 2015; 67(2):338-67. PMID: 25713288; PMCID: PMC4394687.
      Citations: 211     Fields:    Translation:HumansAnimalsCells
    10. Liebscher I, Ackley B, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Hall RA, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Ressl S, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X, Araç D, Goffinet AM, Hamann J, Prömel S, Schiöth HB, Sigoillot SM. New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2014 Dec; 1333:43-64. PMID: 25424900; PMCID: PMC4278406.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    11. Tsetsenis T, Boucard AA, Brunger AT, Araç D, Südhof TC. Direct visualization of trans-synaptic neurexin-neuroligin interactions during synapse formation. J Neurosci. 2014 Nov 05; 34(45):15083-96. PMID: 25378172; PMCID: PMC4220035.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    12. Luo R, Jeong SJ, Yang A, Wen M, Saslowsky DE, Lencer WI, Piao X, Araç D. Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation. PLoS One. 2014; 9(6):e100043. PMID: 24949629; PMCID: PMC4065004.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    13. Langenhan T, Prömel S, Araç D. Matching structure with function: the GAIN domain of adhesion-GPCR and PKD1-like proteins. Trends Pharmacol Sci. 2013 Aug; 34(8):470-8. PMID: 23850273.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    14. Aust G, Calebiro D, Engel FB, Formstone C, Kittel RJ, Liebscher I, Lin HH, Monk KR, Petrenko A, Piao X, Schwartz TW, Stacey M, Ushkaryov YA, Wobus M, Wolfrum U, Xu L, Langenhan T, Araç D, Goffinet A, Hamann J, Prömel S, Schiöth HB. Dissecting signaling and functions of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2012 Dec; 1276:1-25. PMID: 23215895.
      Citations: 22     Fields:    Translation:HumansCells
    15. Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Brunger AT, Araç D, Südhof TC. A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis. EMBO J. 2012 Mar 21; 31(6):1364-78. PMID: 22333914; PMCID: PMC3321182.
      Citations: 208     Fields:    Translation:HumansAnimalsCells
    16. Zhang C, Atasoy D, Yang X, Fucillo MV, Robison AJ, Ko J, Brunger AT, Araç D, Südhof TC. Neurexins physically and functionally interact with GABA(A) receptors. Neuron. 2010 May 13; 66(3):403-16. PMID: 20471353; PMCID: PMC3243752.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    17. Ko J, Zhang C, Arac D, Boucard AA, Brunger AT, Südhof TC. Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. EMBO J. 2009 Oct 21; 28(20):3244-55. PMID: 19730411; PMCID: PMC2771087.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    18. Zuniga JE, Schmidt JJ, Fenn T, Burnett JC, Gussio R, Stafford RG, Badie SS, Bavari S, Brunger AT, Araç D. A potent peptidomimetic inhibitor of botulinum neurotoxin serotype A has a very different conformation than SNAP-25 substrate. Structure. 2008 Oct 08; 16(10):1588-97. PMID: 18940613; PMCID: PMC2716802.
      Citations: 27     Fields:    Translation:Cells
    19. Boucard AA, Ozkan E, Strop P, Newell E, Brunger AT, Araç D, Südhof TC. Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron. 2007 Dec 20; 56(6):992-1003. PMID: 18093522.
      Citations: 109     Fields:    Translation:AnimalsCells
    20. Dai H, Shen N, Rizo J, Araç D. A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release. J Mol Biol. 2007 Mar 30; 367(3):848-63. PMID: 17320903; PMCID: PMC1855161.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    21. Rizo J, Chen X, Araç D. Unraveling the mechanisms of synaptotagmin and SNARE function in neurotransmitter release. Trends Cell Biol. 2006 Jul; 16(7):339-50. PMID: 16698267.
      Citations: 114     Fields:    Translation:AnimalsCells
    22. Li L, Shin OH, Rhee JS, Rah JC, Rizo J, Rosenmund C, Araç D, Südhof T. Phosphatidylinositol phosphates as co-activators of Ca2+ binding to C2 domains of synaptotagmin 1. J Biol Chem. 2006 Jun 09; 281(23):15845-52. PMID: 16595652.
      Citations: 63     Fields:    Translation:AnimalsCells
    23. Chen X, Khant HA, Ubach J, Ludtke SJ, Kikkawa M, Johnson AE, Chiu W, Rizo J, Araç D, Südhof TC. Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nat Struct Mol Biol. 2006 Mar; 13(3):209-17. PMID: 16491093.
      Citations: 140     Fields:    Translation:AnimalsCells
    24. Chen X, Wang TM, Gilpin CJ, Zimmerberg J, Rizo J, Araç D. SNARE-mediated lipid mixing depends on the physical state of the vesicles. Biophys J. 2006 Mar 15; 90(6):2062-74. PMID: 16361343; PMCID: PMC1386784.
      Citations: 70     Fields:    Translation:HumansCells
    25. Ferguson AD, Labunskyy VM, Fomenko DE, Chelliah Y, Amezcua CA, Rizo J, Gladyshev VN, Deisenhofer J, Araç D. NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family. J Biol Chem. 2006 Feb 10; 281(6):3536-43. PMID: 16319061.
      Citations: 77     Fields:    Translation:AnimalsCells
    26. Dulubova I, Pei J, Huryeva I, Grishin NV, Rizo J, Araç D. Three-dimensional structure of the rSly1 N-terminal domain reveals a conformational change induced by binding to syntaxin 5. J Mol Biol. 2005 Feb 18; 346(2):589-601. PMID: 15670607.
      Citations: 15     Fields:    Translation:AnimalsCells
    27. Jarousse N, Wilson JD, Arac D, Rizo J, Kelly RB. Endocytosis of synaptotagmin 1 is mediated by a novel, tryptophan-containing motif. Traffic. 2003 Jul; 4(7):468-78. PMID: 12795692.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    28. Murphy T, Rizo J, Araç D. Facile detection of protein-protein interactions by one-dimensional NMR spectroscopy. Biochemistry. 2003 Mar 18; 42(10):2774-80. PMID: 12627942.
      Citations: 29     Fields:    Translation:Cells
    29. Dulubova I, Yamaguchi T, Arac D, Li H, Huryeva I, Min SW, Rizo J, Sudhof TC. Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):32-7. PMID: 12506202; PMCID: PMC140874.
      Citations: 44     Fields:    Translation:AnimalsCells
    30. Kulik V, Weyand M, Seidel R, Niks D, Arac D, Dunn MF, Schlichting I, Kulik V, Weyand M, Seidel R, Niks D, Arac D, Dunn MF, Schlichting I. On the role of alphaThr183 in the allosteric regulation and catalytic mechanism of tryptophan synthase. J Mol Biol. 2002 Dec 06; 324(4):677-90. PMID: 12460570.
      Citations: 20     Fields:    Translation:Cells
    31. Dulubova I, Arac D, Pabst S, Plitzner J, Rizo J, Jahn R, Antonin W. The N-terminal domains of syntaxin 7 and vti1b form three-helix bundles that differ in their ability to regulate SNARE complex assembly. J Biol Chem. 2002 Sep 27; 277(39):36449-56. PMID: 12114520.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    32. Hafezparast M, Ball S, Nicholson SJ, Witherden A, Arac D, Broadway N, Saggerson D, Cooper E, Naase M, Gokhale S, Quant P, Lascelles C, Nickols C, Baker CS, Peters J, Martin JE, Fisher EM. A new mouse mutant, skijumper. Mamm Genome. 2002 Jul; 13(7):359-364. PMID: 12152619.
      Citations:    Fields:    Translation:AnimalsCells
    33. Chen X, Tomchick DR, Kovrigin E, Machius M, Rizo J, Chen X, Tomchick DR, Kovrigin E, Machius M, Rizo J. Three-dimensional structure of the complexin/SNARE complex. Neuron. 2002 Jan 31; 33(3):397-409. PMID: 11832227.
      Citations: 200     Fields:    Translation:Cells
    34. Witherden AS, Hafezparast M, Nicholson SJ, Ahmad-Annuar A, Bermingham N, Arac D, Rankin J, Iravani M, Ball S, Peters J, Martin JE, Huntley D, Hummerich H, Sergot M, Fisher EM. An integrated genetic, radiation hybrid, physical and transcription map of a region of distal mouse chromosome 12, including an imprinted locus and the 'Legs at odd angles' (Loa) mutation. Gene. 2002 Jan 23; 283(1-2):71-82. PMID: 11867214.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    35. Fernandez I, Ubach J, Gerber SH, Shin O, Gao Y, Anderson RG, Rizo J, Araç D, Südhof TC. Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine. Neuron. 2001 Dec 20; 32(6):1057-69. PMID: 11754837.
      Citations: 185     Fields:    Translation:AnimalsCells
    36. Ubach J, Lao Y, Fernandez I, Arac D, Rizo J, Südhof TC. The C2B domain of synaptotagmin I is a Ca2+-binding module. Biochemistry. 2001 May 22; 40(20):5854-60. PMID: 11352720.
      Citations: 51     Fields:    Translation:AnimalsCellsPHPublic Health
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