"Proteolysis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cleavage of proteins into smaller peptides or amino acids either by PROTEASES or non-enzymatically (e.g., Hydrolysis). It does not include Protein Processing, Post-Translational.
| Descriptor ID |
D059748
|
| MeSH Number(s) |
G02.111.720 G03.812
|
| Concept/Terms |
Proteolysis- Proteolysis
- Proteolyses
- Protein Degradation
- Degradation, Protein
- Degradations, Protein
- Protein Degradations
Protein Digestion- Protein Digestion
- Digestion, Protein
- Digestions, Protein
- Protein Digestions
|
Below are MeSH descriptors whose meaning is more general than "Proteolysis".
Below are MeSH descriptors whose meaning is more specific than "Proteolysis".
This graph shows the total number of publications written about "Proteolysis" by people in this website by year, and whether "Proteolysis" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 6 | 6 |
| 2012 | 1 | 9 | 10 |
| 2013 | 3 | 4 | 7 |
| 2014 | 4 | 9 | 13 |
| 2015 | 2 | 5 | 7 |
| 2016 | 3 | 6 | 9 |
| 2017 | 3 | 4 | 7 |
| 2018 | 1 | 3 | 4 |
| 2019 | 1 | 8 | 9 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 6 | 7 |
| 2022 | 1 | 2 | 3 |
| 2023 | 1 | 2 | 3 |
| 2024 | 3 | 2 | 5 |
| 2025 | 1 | 4 | 5 |
| 2026 | 0 | 2 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Proteolysis" by people in Profiles.
-
Tet Trim-Away: a conditional rapid protein degradation system for Tetrahymena thermophila. Mol Biol Cell. 2026 Sep; 37(9):mr9.
-
A Rapid Binder Discovery Workflow for Engineering Mini-Protein Degraders. J Am Chem Soc. 2026 06 03; 148(21):21444-21456.
-
A light-induced microprotein triggers regulated intramembrane proteolysis to promote photo-sensing in a pathogenic bacterium. Nat Commun. 2025 Dec 06; 17(1):182.
-
Myristoylation of TMEM106B by NMT1/2 regulates TMEM106B trafficking and turnover. J Biol Chem. 2025 07; 301(7):110322.
-
Telomerase reverse transcriptase degradation via a rationally designed covalent proteolysis targeting chimera. Bioorg Med Chem Lett. 2025 Sep 01; 125-126:130286.
-
Loss of DRD5P2 in hypoxia attenuates Rock2 degradation to promote EMT and gastric cancer metastasis. Biochim Biophys Acta Mol Basis Dis. 2025 Aug; 1871(6):167858.
-
Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC). J Med Chem. 2025 Feb 27; 68(4):4961-4987.
-
Targeting DTX2/UFD1-mediated FTO degradation to regulate antitumor immunity. Proc Natl Acad Sci U S A. 2024 12 17; 121(51):e2407910121.
-
Novel mechanism of cyclic nucleotide crosstalk mediated by PKG-dependent proteasomal degradation of the Hsp90 client protein phosphodiesterase 3A. J Biol Chem. 2024 10; 300(10):107723.
-
Proteolytic degradation of atrial sarcomere proteins underlies contractile defects in atrial fibrillation. Am J Physiol Heart Circ Physiol. 2024 08 01; 327(2):H460-H472.