"Proteolysis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cleavage of proteins into smaller peptides or amino acids either by PROTEASES or non-enzymatically (e.g., Hydrolysis). It does not include Protein Processing, Post-Translational.
| Descriptor ID |
D059748
|
| MeSH Number(s) |
G02.111.720 G03.812
|
| Concept/Terms |
Proteolysis- Proteolysis
- Proteolyses
- Protein Degradation
- Degradation, Protein
- Degradations, Protein
- Protein Degradations
Protein Digestion- Protein Digestion
- Digestion, Protein
- Digestions, Protein
- Protein Digestions
|
Below are MeSH descriptors whose meaning is more general than "Proteolysis".
Below are MeSH descriptors whose meaning is more specific than "Proteolysis".
This graph shows the total number of publications written about "Proteolysis" by people in this website by year, and whether "Proteolysis" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 6 | 6 |
| 2012 | 1 | 8 | 9 |
| 2013 | 3 | 4 | 7 |
| 2014 | 3 | 9 | 12 |
| 2015 | 2 | 5 | 7 |
| 2016 | 3 | 6 | 9 |
| 2017 | 2 | 4 | 6 |
| 2018 | 1 | 3 | 4 |
| 2019 | 1 | 8 | 9 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 7 | 8 |
| 2022 | 1 | 2 | 3 |
| 2023 | 1 | 2 | 3 |
| 2024 | 2 | 2 | 4 |
| 2025 | 1 | 2 | 3 |
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Below are the most recent publications written about "Proteolysis" by people in Profiles.
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Telomerase reverse transcriptase degradation via a rationally designed covalent proteolysis targeting chimera. Bioorg Med Chem Lett. 2025 Sep 01; 125-126:130286.
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Loss of DRD5P2 in hypoxia attenuates Rock2 degradation to promote EMT and gastric cancer metastasis. Biochim Biophys Acta Mol Basis Dis. 2025 Aug; 1871(6):167858.
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Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC). J Med Chem. 2025 Feb 27; 68(4):4961-4987.
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Targeting DTX2/UFD1-mediated FTO degradation to regulate antitumor immunity. Proc Natl Acad Sci U S A. 2024 Dec 17; 121(51):e2407910121.
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Proteolytic degradation of atrial sarcomere proteins underlies contractile defects in atrial fibrillation. Am J Physiol Heart Circ Physiol. 2024 08 01; 327(2):H460-H472.
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Protocol for auxin-inducible protein degradation in C. elegans using different auxins and TIR1-expressing strains. STAR Protoc. 2024 09 20; 5(3):103133.
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Discovery of LLC0424 as a Potent and Selective in Vivo NSD2 PROTAC Degrader. J Med Chem. 2024 05 09; 67(9):6938-6951.
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Cortical tension promotes Kibra degradation via Par-1. Mol Biol Cell. 2024 Jan 01; 35(1):ar2.
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CAND1 orchestrates CRLs through rock and roll. Cell. 2023 04 27; 186(9):1817-1818.
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Microbiota-dependent proteolysis of gluten subverts diet-mediated protection against type 1 diabetes. Cell Host Microbe. 2023 02 08; 31(2):213-227.e9.