Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling.

Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling. Biochem J. 1999 Dec 15; 344 Pt 3:649-58.

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subject areas

Adaptor Proteins, Signal Transducing
Adaptor Proteins, Vesicular Transport
Animals
Cell Division
Cell Line
DNA-Binding Proteins
Glucose
GRB2 Adaptor Protein
Growth Hormone
Insulin Receptor Substrate Proteins
Insulin-Like Growth Factor I
Intracellular Signaling Peptides and Proteins
Islets of Langerhans
Janus Kinase 2
Milk Proteins
Mitogen-Activated Protein Kinases
Phosphoproteins
Phosphorylation
Proteins
Protein-Tyrosine Kinases
Proto-Oncogene Proteins
Rats
Ribosomal Protein S6 Kinases
Shc Signaling Adaptor Proteins
Signal Transduction
Son of Sevenless Protein, Drosophila
Src Homology 2 Domain-Containing, Transforming Protein 1
STAT5 Transcription Factor
Trans-Activators

authors with profiles

Christopher J. Rhodes