"Genes, Tumor Suppressor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
| Descriptor ID |
D016147
|
| MeSH Number(s) |
G05.360.340.024.340.375.249 G05.360.340.024.340.415.400
|
| Concept/Terms |
Genes, Tumor Suppressor- Genes, Tumor Suppressor
- Gene, Tumor Suppressor
- Tumor Suppressor Gene
- Antioncogenes
- Antioncogene
- Emerogenes
- Emerogene
- Genes, Onco-Suppressor
- Gene, Onco-Suppressor
- Genes, Onco Suppressor
- Onco-Suppressor Gene
- Onco-Suppressor Genes
- Cancer Suppressor Genes
- Cancer Suppressor Gene
- Gene, Cancer Suppressor
- Suppressor Gene, Cancer
- Suppressor Genes, Cancer
- Oncogenes, Recessive
- Oncogene, Recessive
- Recessive Oncogene
- Recessive Oncogenes
- Anti-Oncogenes
- Anti Oncogenes
- Anti-Oncogene
- Tumor Suppressing Genes
- Gene, Tumor Suppressing
- Genes, Tumor Suppressing
- Tumor Suppressing Gene
- Genes, Cancer Suppressor
- Tumor Suppressor Genes
Metastasis Suppressor Genes- Metastasis Suppressor Genes
- Gene, Metastasis Suppressor
- Metastasis Suppressor Gene
- Suppressor Gene, Metastasis
- Suppressor Genes, Metastasis
- Genes, Metastasis Suppressor
Growth Suppressor Genes- Growth Suppressor Genes
- Gene, Growth Suppressor
- Growth Suppressor Gene
- Suppressor Gene, Growth
- Suppressor Genes, Growth
- Genes, Growth Suppressor
|
Below are MeSH descriptors whose meaning is more general than "Genes, Tumor Suppressor".
Below are MeSH descriptors whose meaning is more specific than "Genes, Tumor Suppressor".
- Genes, Tumor Suppressor
- Genes, APC
- Genes, BRCA1
- Genes, BRCA2
- Genes, DCC
- Genes, MCC
- Genes, Neurofibromatosis 1
- Genes, Neurofibromatosis 2
- Genes, p16
- Genes, p53
- Genes, Retinoblastoma
- Genes, Wilms Tumor
This graph shows the total number of publications written about "Genes, Tumor Suppressor" by people in this website by year, and whether "Genes, Tumor Suppressor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 3 | 2 | 5 |
| 1995 | 5 | 3 | 8 |
| 1996 | 4 | 1 | 5 |
| 1997 | 1 | 1 | 2 |
| 1998 | 4 | 3 | 7 |
| 1999 | 4 | 5 | 9 |
| 2000 | 6 | 3 | 9 |
| 2001 | 3 | 4 | 7 |
| 2002 | 2 | 4 | 6 |
| 2003 | 1 | 5 | 6 |
| 2004 | 4 | 4 | 8 |
| 2005 | 1 | 2 | 3 |
| 2006 | 2 | 2 | 4 |
| 2007 | 0 | 3 | 3 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 5 | 1 | 6 |
| 2012 | 0 | 3 | 3 |
| 2013 | 1 | 2 | 3 |
| 2014 | 4 | 1 | 5 |
| 2015 | 0 | 3 | 3 |
| 2016 | 2 | 2 | 4 |
| 2018 | 0 | 1 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 1 | 3 | 4 |
| 2022 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Genes, Tumor Suppressor" by people in Profiles.
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CRISPR screening in human hematopoietic stem and progenitor cells reveals an enrichment for tumor suppressor genes within chromosome 7 commonly deleted regions. Leukemia. 2022 05; 36(5):1421-1425.
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Integrated genomic analyses of cutaneous T-cell lymphomas reveal the molecular bases for disease heterogeneity. Blood. 2021 10 07; 138(14):1225-1236.
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METTL14 facilitates global genome repair and suppresses skin tumorigenesis. Proc Natl Acad Sci U S A. 2021 08 31; 118(35).
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Loss-of-Function Variants in the Tumor-Suppressor Gene PTPN14 Confer Increased Cancer Risk. Cancer Res. 2021 04 15; 81(8):1954-1964.
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LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms. Cancer Discov. 2021 06; 11(6):1398-1410.
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Molecular correlates and therapeutic targets in T cell-inflamed versus non-T cell-inflamed tumors across cancer types. Genome Med. 2020 10 27; 12(1):90.
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Therapeutic targeting of miRNA-216b in cancer. Cancer Lett. 2020 08 01; 484:16-28.
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The evolutionary history of 2,658 cancers. Nature. 2020 02; 578(7793):122-128.
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Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma. Cancer Res. 2018 05 15; 78(10):2747-2759.
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Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors. Nat Commun. 2017 10 31; 8(1):1221.