 Tachykinins
"Tachykinins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of biologically active peptides sharing a common conserved C-terminal sequence, -Phe-X-Gly-Leu-Met-NH2, where X is either an aromatic or a branched aliphatic amino acid. Members of this family have been found in mammals, amphibians, and mollusks. Tachykinins have diverse pharmacological actions in the central nervous system and the cardiovascular, genitourinary, respiratory, and gastrointestinal systems, as well as in glandular tissues. This diversity of activity is due to the existence of three or more subtypes of tachykinin receptors.
| Descriptor ID |
D015320
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| MeSH Number(s) |
D12.644.276.812.900 D12.644.400.800 D12.644.456.800 D12.776.467.812.900 D12.776.641.650.800 D23.469.050.375.850 D23.529.812.900
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Tachykinins".
Below are MeSH descriptors whose meaning is more specific than "Tachykinins".
This graph shows the total number of publications written about "Tachykinins" by people in this website by year, and whether "Tachykinins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1991 | 1 | 2 | 3 | | 1993 | 1 | 0 | 1 | | 1994 | 1 | 0 | 1 | | 1995 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2003 | 1 | 1 | 2 | | 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "Tachykinins" by people in Profiles.
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Tran AH, Berger A, Wu GE, Kee BL, Paige CJ. Early B-cell factor regulates the expression of Hemokinin-1 in the olfactory epithelium and differentiating B lymphocytes. J Neuroimmunol. 2011 Mar; 232(1-2):41-50.
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Winston JH, Toma H, Shenoy M, He ZJ, Zou L, Xiao SY, Micci MA, Pasricha PJ. Acute pancreatitis results in referred mechanical hypersensitivity and neuropeptide up-regulation that can be suppressed by the protein kinase inhibitor k252a. J Pain. 2003 Aug; 4(6):329-37.
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Kumar GK, Prabhakar NR. Tachykinins in the control of breathing by hypoxia: pre- and post-genomic era. Respir Physiol Neurobiol. 2003 May 30; 135(2-3):145-54.
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Telgkamp P, Cao YQ, Basbaum AI, Ramirez JM. Long-term deprivation of substance P in PPT-A mutant mice alters the anoxic response of the isolated respiratory network. J Neurophysiol. 2002 Jul; 88(1):206-13.
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Kim JS, Rabe KF, Magnussen H, Green JM, White SR. Migration and proliferation of guinea pig and human airway epithelial cells in response to tachykinins. Am J Physiol. 1995 Jul; 269(1 Pt 1):L119-26.
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Cragg PA, Runold M, Kou YR, Prabhakar NR. Tachykinin antagonists in carotid body responses to hypoxia and substance P in the rat. Respir Physiol. 1994 Mar; 95(3):295-310.
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Solway J, Kao BM, Jordan JE, Gitter B, Rodger IW, Howbert JJ, Alger LE, Necheles J, Leff AR, Garland A. Tachykinin receptor antagonists inhibit hyperpnea-induced bronchoconstriction in guinea pigs. J Clin Invest. 1993 Jul; 92(1):315-23.
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Solway J, Leff AR. Sensory neuropeptides and airway function. J Appl Physiol (1985). 1991 Dec; 71(6):2077-87.
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Garland A, Ray DW, Doerschuk CM, Alger L, Eappon S, Hernandez C, Jackson M, Solway J. Role of tachykinins in hyperpnea-induced bronchovascular hyperpermeability in guinea pigs. J Appl Physiol (1985). 1991 Jan; 70(1):27-35.
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Lagercrantz H, Srinivasan M, Yamamoto Y, Prabhakar N. Functional role of substance P for respiratory control during development. Ann N Y Acad Sci. 1991; 632:48-52.
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