 Interleukin-4
"Interleukin-4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
| Descriptor ID |
D015847
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| MeSH Number(s) |
D12.644.276.374.465.504 D12.776.467.374.465.504 D23.529.374.465.504
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| Concept/Terms |
Interleukin-4- Interleukin-4
- Interleukin 4
- B-Cell Growth Factor-1
- B Cell Growth Factor 1
- B-Cell Growth Factor-I
- B Cell Growth Factor I
- B-Cell Proliferating Factor
- B Cell Proliferating Factor
- B-Cell Stimulating Factor-1
- B Cell Stimulating Factor 1
- B-Cell Stimulatory Factor 1
- B-Cell Stimulatory Factor-1
- BCGF-1
- Binetrakin
- BSF-1
- IL-4
- IL4
- Mast Cell Growth Factor-2
- Mast Cell Growth Factor 2
- MCGF-2
- B Cell Stimulatory Factor-1
- B Cell Stimulatory Factor 1
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Below are MeSH descriptors whose meaning is more general than "Interleukin-4".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-4".
This graph shows the total number of publications written about "Interleukin-4" by people in this website by year, and whether "Interleukin-4" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1981 | 0 | 1 | 1 | | 1984 | 0 | 1 | 1 | | 1988 | 0 | 2 | 2 | | 1989 | 0 | 3 | 3 | | 1990 | 2 | 1 | 3 | | 1991 | 0 | 2 | 2 | | 1992 | 2 | 0 | 2 | | 1993 | 2 | 5 | 7 | | 1994 | 2 | 3 | 5 | | 1995 | 2 | 1 | 3 | | 1996 | 2 | 1 | 3 | | 1997 | 2 | 5 | 7 | | 1998 | 1 | 4 | 5 | | 1999 | 0 | 6 | 6 | | 2001 | 1 | 0 | 1 | | 2002 | 1 | 4 | 5 | | 2003 | 0 | 4 | 4 | | 2004 | 1 | 3 | 4 | | 2005 | 1 | 1 | 2 | | 2006 | 1 | 2 | 3 | | 2007 | 1 | 4 | 5 | | 2008 | 0 | 4 | 4 | | 2009 | 2 | 2 | 4 | | 2010 | 0 | 3 | 3 | | 2011 | 0 | 4 | 4 | | 2012 | 1 | 2 | 3 | | 2013 | 1 | 1 | 2 | | 2014 | 1 | 1 | 2 | | 2015 | 0 | 2 | 2 | | 2016 | 2 | 1 | 3 | | 2017 | 3 | 2 | 5 | | 2018 | 1 | 1 | 2 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Interleukin-4" by people in Profiles.
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Calderon D, Nguyen MLT, Mezger A, Kathiria A, Müller F, Nguyen V, Lescano N, Wu B, Trombetta J, Ribado JV, Knowles DA, Gao Z, Blaeschke F, Parent AV, Burt TD, Anderson MS, Criswell LA, Greenleaf WJ, Marson A, Pritchard JK. Landscape of stimulation-responsive chromatin across diverse human immune cells. Nat Genet. 2019 10; 51(10):1494-1505.
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Bao L, Chau C, Bao J, Tsoukas MM, Chan LS. IL-4 dysregulates microRNAs involved in inflammation, angiogenesis and apoptosis in epidermal keratinocytes. Microbiol Immunol. 2018 Nov; 62(11):732-736.
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Cho S, Lee HM, Yu IS, Choi YS, Huang HY, Hashemifar SS, Lin LL, Chen MC, Afanasiev ND, Khan AA, Lin SW, Rudensky AY, Crotty S, Lu LF. Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b. Nat Commun. 2018 07 16; 9(1):2757.
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McKnight CG, Morris SC, Perkins C, Zhu Z, Hildeman DA, Bendelac A, Finkelman FD. NKT cells contribute to basal IL-4 production but are not required to induce experimental asthma. PLoS One. 2017; 12(11):e0188221.
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Seo GY, Lee JM, Jang YS, Kang SG, Yoon SI, Ko HJ, Lee GS, Park SR, Nagler CR, Kim PH. Mechanism underlying the suppressor activity of retinoic acid on IL4-induced IgE synthesis and its physiological implication. Cell Immunol. 2017 Dec; 322:49-55.
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Liu H, Antony S, Roy K, Juhasz A, Wu Y, Lu J, Meitzler JL, Jiang G, Polley E, Doroshow JH. Interleukin-4 and interleukin-13 increase NADPH oxidase 1-related proliferation of human colon cancer cells. Oncotarget. 2017 Jun 13; 8(24):38113-38135.
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Willson TJ, Naclerio RM, Lee SE. Monoclonal Antibodies for the Treatment of Nasal Polyps. Immunol Allergy Clin North Am. 2017 05; 37(2):357-367.
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Verykokakis M, Kee BL. Applying the TOR(C)QUE in iNKT cells: A new twist in an old tale. Eur J Immunol. 2017 03; 47(3):454-457.
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Eskalli Z, Achouri Y, Hahn S, Many MC, Craps J, Refetoff S, Liao XH, Dumont JE, Van Sande J, Corvilain B, Miot F, De Deken X. Overexpression of Interleukin-4 in the Thyroid of Transgenic Mice Upregulates the Expression of Duox1 and the Anion Transporter Pendrin. Thyroid. 2016 10; 26(10):1499-1512.
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Chan PY, Carrera Silva EA, De Kouchkovsky D, Joannas LD, Hao L, Hu D, Huntsman S, Eng C, Licona-Limón P, Weinstein JS, Herbert DR, Craft JE, Flavell RA, Repetto S, Correale J, Burchard EG, Torgerson DG, Ghosh S, Rothlin CV. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science. 2016 Apr 01; 352(6281):99-103.
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