 Interleukin-10
"Interleukin-10" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein.
| Descriptor ID |
D016753
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| MeSH Number(s) |
D12.644.276.374.465.510 D12.776.467.374.465.510 D23.529.374.465.510
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| Concept/Terms |
Interleukin-10- Interleukin-10
- Interleukin 10
- IL10
- IL-10
- CSIF-10
- Cytokine Synthesis Inhibitory Factor
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Below are MeSH descriptors whose meaning is more general than "Interleukin-10".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-10".
This graph shows the total number of publications written about "Interleukin-10" by people in this website by year, and whether "Interleukin-10" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 2 | 3 | | 1995 | 2 | 1 | 3 | | 1996 | 1 | 1 | 2 | | 1997 | 1 | 2 | 3 | | 1998 | 2 | 3 | 5 | | 1999 | 2 | 1 | 3 | | 2000 | 2 | 1 | 3 | | 2001 | 1 | 1 | 2 | | 2002 | 1 | 4 | 5 | | 2003 | 1 | 4 | 5 | | 2004 | 0 | 5 | 5 | | 2005 | 0 | 2 | 2 | | 2006 | 0 | 1 | 1 | | 2007 | 2 | 3 | 5 | | 2008 | 0 | 2 | 2 | | 2009 | 2 | 2 | 4 | | 2010 | 2 | 1 | 3 | | 2011 | 0 | 6 | 6 | | 2012 | 4 | 4 | 8 | | 2013 | 3 | 2 | 5 | | 2014 | 1 | 3 | 4 | | 2015 | 4 | 6 | 10 | | 2016 | 1 | 3 | 4 | | 2017 | 2 | 2 | 4 | | 2018 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 | | 2020 | 2 | 2 | 4 | | 2021 | 3 | 2 | 5 |
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Below are the most recent publications written about "Interleukin-10" by people in Profiles.
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Chugh RM, Park HS, El Andaloussi A, Elsharoud A, Esfandyari S, Ulin M, Bakir L, Aboalsoud A, Ali M, Ashour D, Igboeli P, Ismail N, McAllister J, Al-Hendy A. Mesenchymal stem cell therapy ameliorates metabolic dysfunction and restores fertility in a PCOS mouse model through interleukin-10. Stem Cell Res Ther. 2021 07 07; 12(1):388.
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Miyoshi J, Miyoshi S, Delmont TO, Cham C, Lee STM, Sakatani A, Yang K, Shan Y, Kennedy M, Kiefl E, Yousef M, Crosson S, Sogin M, Antonopoulos DA, Eren AM, Leone V, Chang EB. Early-Life Microbial Restitution Reduces Colitis Risk Promoted by Antibiotic-Induced Gut Dysbiosis in Interleukin 10-/- Mice. Gastroenterology. 2021 09; 161(3):940-952.e15.
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Schumacher MA, Dennis IC, Liu CY, Robinson C, Shang J, Bernard JK, Washington MK, Polk DB, Frey MR. NRG4-ErbB4 signaling represses proinflammatory macrophage activity. Am J Physiol Gastrointest Liver Physiol. 2021 06 01; 320(6):G990-G1001.
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Yuba E, Budina E, Katsumata K, Ishihara A, Mansurov A, Alpar AT, Watkins EA, Hosseinchi P, Reda JW, Lauterbach AL, Nguyen M, Solanki A, Kageyama T, Swartz MA, Ishihara J, Hubbell JA. Suppression of Rheumatoid Arthritis by Enhanced Lymph Node Trafficking of Engineered Interleukin-10 in Murine Models. Arthritis Rheumatol. 2021 05; 73(5):769-778.
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Surette FA, Guthmiller JJ, Li L, Sturtz AJ, Vijay R, Pope RL, McClellan BL, Pack AD, Zander RA, Shao P, Lan LY, Fernandez-Ruiz D, Heath WR, Wilson PC, Butler NS. Extrafollicular CD4 T cell-derived IL-10 functions rapidly and transiently to support anti-Plasmodium humoral immunity. PLoS Pathog. 2021 02; 17(2):e1009288.
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Dabitao D, Dembele M, Urbanowski M, Kone B, Wague M, Coulibaly N, Sarro YDS, Baya B, Goita D, Dao S, Belson M, Klein SL, Achenbach C, Holl JL, Diakite M, Doumbia S, Bream JH, Bishai WR, Diallo S, Murphy RL. Short Communication: Genetic Variation in Human IL10 Proximal Promoter and Susceptibility to HIV-1 Infection in Mali, West Africa. AIDS Res Hum Retroviruses. 2021 01; 37(1):57-61.
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Liu CY, Tam SS, Huang Y, Dubé PE, Alhosh R, Girish N, Punit S, Nataneli S, Li F, Bender JM, Washington MK, Polk DB. TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice. Cell Rep. 2020 10 20; 33(3):108275.
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Miyoshi J, Lee STM, Kennedy M, Puertolas M, Frith M, Koval JC, Miyoshi S, Antonopoulos DA, Leone V, Chang EB. Metagenomic Alterations in Gut Microbiota Precede and Predict Onset of Colitis in the IL10 Gene-Deficient Murine Model. Cell Mol Gastroenterol Hepatol. 2021; 11(2):491-502.
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Shu S, Matsuzaki J, Want MY, Conway A, Benjamin-Davalos S, Allen CL, Koroleva M, Battaglia S, Odunsi A, Minderman H, Ernstoff MS. An Immunosuppressive Effect of Melanoma-derived Exosomes on NY-ESO-1 Antigen-specific Human CD8+ T Cells is Dependent on IL-10 and Independent of BRAFV600E Mutation in Melanoma Cell Lines. Immunol Invest. 2020 Oct; 49(7):744-757.
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Goel G, Tye-Din JA, Qiao SW, Russell AK, Mayassi T, Ciszewski C, Sarna VK, Wang S, Goldstein KE, Dzuris JL, Williams LJ, Xavier RJ, Lundin KEA, Jabri B, Sollid LM, Anderson RP. Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease. Sci Adv. 2019 08; 5(8):eaaw7756.
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