 Clonal Deletion
"Clonal Deletion" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Removal, via CELL DEATH, of immature lymphocytes that interact with antigens during maturation. For T-lymphocytes this occurs in the thymus and ensures that mature T-lymphocytes are self tolerant. B-lymphocytes may also undergo clonal deletion.
| Descriptor ID |
D017637
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| MeSH Number(s) |
G12.425.746.425.120
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| Concept/Terms |
Clonal Deletion- Clonal Deletion
- Clonal Deletions
- Deletion, Clonal
- Deletions, Clonal
Clonal Abortion- Clonal Abortion
- Abortion, Clonal
- Abortions, Clonal
- Clonal Abortions
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Below are MeSH descriptors whose meaning is more general than "Clonal Deletion".
Below are MeSH descriptors whose meaning is more specific than "Clonal Deletion".
This graph shows the total number of publications written about "Clonal Deletion" by people in this website by year, and whether "Clonal Deletion" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 | | 1995 | 0 | 1 | 1 | | 1997 | 1 | 1 | 2 | | 1999 | 0 | 1 | 1 | | 2001 | 0 | 2 | 2 | | 2002 | 1 | 0 | 1 | | 2003 | 1 | 1 | 2 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 1 | 1 | 2 | | 2016 | 0 | 2 | 2 | | 2020 | 0 | 2 | 2 |
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Below are the most recent publications written about "Clonal Deletion" by people in Profiles.
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Chong AS. B cells as antigen-presenting cells in transplantation rejection and tolerance. Cell Immunol. 2020 03; 349:104061.
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Savage PA, Klawon DEJ, Miller CH. Regulatory T Cell Development. Annu Rev Immunol. 2020 04 26; 38:421-453.
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Malchow S, Leventhal DS, Lee V, Nishi S, Socci ND, Savage PA. Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage. Immunity. 2016 05 17; 44(5):1102-13.
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Malhotra D, Linehan JL, Dileepan T, Lee YJ, Purtha WE, Lu JV, Nelson RW, Fife BT, Orr HT, Anderson MS, Hogquist KA, Jenkins MK. Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns. Nat Immunol. 2016 Feb; 17(2):187-95.
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Concepcion AR, Salas JT, S?ez E, Sarvide S, Ferrer A, Portu A, Uriarte I, Herv?s-Stubbs S, Oude Elferink RP, Prieto J, Medina JF. CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b-/- mice favoring autoimmune cholangitis. Oncotarget. 2015 Oct 06; 6(30):28588-606.
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Alegre ML. I spy alloreactive T cells. Sci Transl Med. 2015 Jan 28; 7(272):272fs3.
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McDonald BD, Bunker JJ, Ishizuka IE, Jabri B, Bendelac A. Elevated T cell receptor signaling identifies a thymic precursor to the TCRa?(+)CD4(-)CD8?(-) intraepithelial lymphocyte lineage. Immunity. 2014 Aug 21; 41(2):219-29.
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Taniguchi RT, DeVoss JJ, Moon JJ, Sidney J, Sette A, Jenkins MK, Anderson MS. Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7847-52.
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Ren D, Kim H, Tu HC, Westergard TD, Fisher JK, Rubens JA, Korsmeyer SJ, Hsieh JJ, Cheng EH. The VDAC2-BAK rheostat controls thymocyte survival. Sci Signal. 2009 Aug 25; 2(85):ra48.
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Li Y, Ma L, Shen J, Chong AS. Peripheral deletion of mature alloreactive B cells induced by costimulation blockade. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12093-8.
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