"Clonal Deletion" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Removal, via CELL DEATH, of immature lymphocytes that interact with antigens during maturation. For T-lymphocytes this occurs in the thymus and ensures that mature T-lymphocytes are self tolerant. B-lymphocytes may also undergo clonal deletion.
| Descriptor ID |
D017637
|
| MeSH Number(s) |
G12.535.425.120
|
| Concept/Terms |
Clonal Deletion- Clonal Deletion
- Clonal Deletions
- Deletion, Clonal
- Deletions, Clonal
Clonal Abortion- Clonal Abortion
- Abortion, Clonal
- Abortions, Clonal
- Clonal Abortions
|
Below are MeSH descriptors whose meaning is more general than "Clonal Deletion".
Below are MeSH descriptors whose meaning is more specific than "Clonal Deletion".
This graph shows the total number of publications written about "Clonal Deletion" by people in this website by year, and whether "Clonal Deletion" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1997 | 1 | 1 | 2 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 1 | 2 |
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 1 | 2 |
| 2016 | 0 | 2 | 2 |
| 2020 | 0 | 2 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Clonal Deletion" by people in Profiles.
-
B cells as antigen-presenting cells in transplantation rejection and tolerance. Cell Immunol. 2020 03; 349:104061.
-
Regulatory T Cell Development. Annu Rev Immunol. 2020 04 26; 38:421-453.
-
Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage. Immunity. 2016 05 17; 44(5):1102-13.
-
Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns. Nat Immunol. 2016 Feb; 17(2):187-95.
-
CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b-/- mice favoring autoimmune cholangitis. Oncotarget. 2015 Oct 06; 6(30):28588-606.
-
I spy alloreactive T cells. Sci Transl Med. 2015 Jan 28; 7(272):272fs3.
-
Elevated T cell receptor signaling identifies a thymic precursor to the TCRaß(+)CD4(-)CD8ß(-) intraepithelial lymphocyte lineage. Immunity. 2014 Aug 21; 41(2):219-29.
-
Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7847-52.
-
The VDAC2-BAK rheostat controls thymocyte survival. Sci Signal. 2009 Aug 25; 2(85):ra48.
-
Peripheral deletion of mature alloreactive B cells induced by costimulation blockade. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12093-8.