"Founder Effect" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phenomenon that is observed when a small subgroup of a larger POPULATION establishes itself as a separate and isolated entity. The subgroup's GENE POOL carries only a fraction of the genetic diversity of the parental population resulting in an increased frequency of certain diseases in the subgroup, especially those diseases known to be autosomal recessive.
- Founder Effect
- Effect, Founder
- Effects, Founder
- Founder Effects
Below are MeSH descriptors whose meaning is more general than "Founder Effect".
Below are MeSH descriptors whose meaning is more specific than "Founder Effect".
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Below are the most recent publications written about "Founder Effect" by people in Profiles.
Founder Effects of Spinocerebellar Ataxias in the American Continents and the Caribbean. Cerebellum. 2020 Jun; 19(3):446-458.
Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions. PLoS One. 2018; 13(9):e0203906.
Cancer Susceptibility Genetic Testing in a High-Risk Cohort of Urban Ashkenazi Jewish Individuals. J Genet Couns. 2018 12; 27(6):1405-1410.
Terminal Pleistocene Alaskan genome reveals first founding population of Native Americans. Nature. 2018 01 11; 553(7687):203-207.
Rare non-coding variants are associated with plasma lipid traits in a founder population. Sci Rep. 2017 11 27; 7(1):16415.
The promise of discovering population-specific disease-associated genes in South Asia. Nat Genet. 2017 Sep; 49(9):1403-1407.
Ocular biometry and determinants of refractive error in a founder population of European ancestry. Ophthalmic Genet. 2018 Jan-Feb; 39(1):11-16.
BMP9 induces osteogenesis and adipogenesis in the immortalized human cranial suture progenitors from the patent sutures of craniosynostosis patients. J Cell Mol Med. 2017 Nov; 21(11):2782-2795.
Haplotype analyses of the c.1027C>T and c.2167_2168delAT recurrent truncating mutations in the breast cancer-predisposing gene PALB2. Breast Cancer Res Treat. 2016 11; 160(1):121-129.
Disease Variant Landscape of a Large Multiethnic Population of Moyamoya Patients by Exome Sequencing. G3 (Bethesda). 2015 Nov 03; 6(1):41-9.