"DNA Cleavage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A reaction that severs one of the covalent sugar-phosphate linkages between NUCLEOTIDES that compose the sugar phosphate backbone of DNA. It is catalyzed enzymatically, chemically or by radiation. Cleavage may be exonucleolytic - removing the end nucleotide, or endonucleolytic - splitting the strand in two.
| Descriptor ID |
D053837
|
| MeSH Number(s) |
G02.111.210 G05.193
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "DNA Cleavage".
Below are MeSH descriptors whose meaning is more specific than "DNA Cleavage".
This graph shows the total number of publications written about "DNA Cleavage" by people in this website by year, and whether "DNA Cleavage" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2018 | 0 | 2 | 2 |
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Below are the most recent publications written about "DNA Cleavage" by people in Profiles.
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Mechanisms of improved specificity of engineered Cas9s revealed by single-molecule FRET analysis. Nat Struct Mol Biol. 2018 04; 25(4):347-354.
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Evolved Cas9 variants with broad PAM compatibility and high DNA specificity. Nature. 2018 04 05; 556(7699):57-63.
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Arginine as a general acid catalyst in serine recombinase-mediated DNA cleavage. J Biol Chem. 2013 Oct 04; 288(40):29206-14.
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Accurate inference of transcription factor binding from DNA sequence and chromatin accessibility data. Genome Res. 2011 Mar; 21(3):447-55.
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Identification of a potential general acid/base in the reversible phosphoryl transfer reactions catalyzed by tyrosine recombinases: Flp H305. Chem Biol. 2007 Feb; 14(2):121-9.