 Mice, Inbred MRL lpr
"Mice, Inbred MRL lpr" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents.
| Descriptor ID |
D019463
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| MeSH Number(s) |
B01.050.050.157.520.555 B01.050.050.199.520.520.555 B01.050.150.900.649.865.635.505.500.400.555
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| Concept/Terms |
Mice, Inbred MRL lpr- Mice, Inbred MRL lpr
- Mice, MRL lpr
- MRL lpr Mice
- lpr Mice, MRL
- Mouse, MRL lpr
- MRL lpr Mouse
- lpr Mouse, MRL
- Mouse, Inbred MRL lpr
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Below are MeSH descriptors whose meaning is more general than "Mice, Inbred MRL lpr".
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This graph shows the total number of publications written about "Mice, Inbred MRL lpr" by people in this website by year, and whether "Mice, Inbred MRL lpr" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1997 | 0 | 2 | 2 | | 1999 | 0 | 2 | 2 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 3 | 3 | | 2004 | 0 | 3 | 3 | | 2005 | 0 | 4 | 4 | | 2006 | 0 | 2 | 2 | | 2007 | 0 | 2 | 2 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 3 | 3 | | 2011 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mice, Inbred MRL lpr" by people in Profiles.
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Mahajan SD, Tutino VM, Redae Y, Meng H, Siddiqui A, Woodruff TM, Jarvis JN, Hennon T, Schwartz S, Quigg RJ, Alexander JJ. C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupus. Immunology. 2016 08; 148(4):407-19.
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Foxley S, Zamora M, Hack B, Alexander RR, Roman B, Quigg RJ, Alexander JJ. Curcumin aggravates CNS pathology in experimental systemic lupus erythematosus. Brain Res. 2013 Apr 04; 1504:85-96.
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Gay D, Saunders T, Camper S, Weigert M. Receptor editing: an approach by autoreactive B cells to escape tolerance. The Journal of Experimental Medicine. 1993. 177: 999-1008. J Immunol. 2011 Feb 01; 186(3):1303-12.
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Bao L, Haas M, Quigg RJ. Complement factor H deficiency accelerates development of lupus nephritis. J Am Soc Nephrol. 2011 Feb; 22(2):285-95.
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Jacob A, Hack B, Bai T, Brorson JR, Quigg RJ, Alexander JJ. Inhibition of C5a receptor alleviates experimental CNS lupus. J Neuroimmunol. 2010 Apr 15; 221(1-2):46-52.
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Jacob A, Hack B, Chiang E, Garcia JG, Quigg RJ, Alexander JJ. C5a alters blood-brain barrier integrity in experimental lupus. FASEB J. 2010 Jun; 24(6):1682-8.
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Jacob A, Bao L, Brorson J, Quigg RJ, Alexander JJ. C3aR inhibition reduces neurodegeneration in experimental lupus. Lupus. 2010 Jan; 19(1):73-82.
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Alexander JJ, Zwingmann C, Jacob A, Quigg R. Alteration in kidney glucose and amino acids are implicated in renal pathology in MRL/lpr mice. Biochim Biophys Acta. 2007 Oct; 1772(10):1143-9.
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Alexander JJ, Jacob A, Vezina P, Sekine H, Gilkeson GS, Quigg RJ. Absence of functional alternative complement pathway alleviates lupus cerebritis. Eur J Immunol. 2007 Jun; 37(6):1691-701.
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Sekiguchi DR, Yunk L, Gary D, Charan D, Srivastava B, Allman D, Weigert MG, Prak ET. Development and selection of edited B cells in B6.56R mice. J Immunol. 2006 Jun 01; 176(11):6879-87.
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