Mice, Inbred MRL lpr
"Mice, Inbred MRL lpr" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents.
Descriptor ID |
D019463
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MeSH Number(s) |
B01.050.050.157.520.555 B01.050.050.199.520.520.555 B01.050.150.900.649.865.635.505.500.400.555
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Concept/Terms |
Mice, Inbred MRL lpr- Mice, Inbred MRL lpr
- Mice, MRL lpr
- MRL lpr Mice
- lpr Mice, MRL
- Mouse, MRL lpr
- MRL lpr Mouse
- lpr Mouse, MRL
- Mouse, Inbred MRL lpr
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Below are MeSH descriptors whose meaning is more general than "Mice, Inbred MRL lpr".
Below are MeSH descriptors whose meaning is more specific than "Mice, Inbred MRL lpr".
This graph shows the total number of publications written about "Mice, Inbred MRL lpr" by people in this website by year, and whether "Mice, Inbred MRL lpr" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1997 | 0 | 2 | 2 | 1999 | 0 | 2 | 2 | 2002 | 0 | 2 | 2 | 2003 | 0 | 3 | 3 | 2004 | 0 | 3 | 3 | 2005 | 0 | 4 | 4 | 2006 | 0 | 2 | 2 | 2007 | 0 | 2 | 2 | 2009 | 0 | 1 | 1 | 2010 | 0 | 3 | 3 | 2011 | 0 | 1 | 1 | 2013 | 0 | 1 | 1 | 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mice, Inbred MRL lpr" by people in Profiles.
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Mahajan SD, Tutino VM, Redae Y, Meng H, Siddiqui A, Woodruff TM, Jarvis JN, Hennon T, Schwartz S, Quigg RJ, Alexander JJ. C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupus. Immunology. 2016 08; 148(4):407-19.
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Foxley S, Zamora M, Hack B, Alexander RR, Roman B, Quigg RJ, Alexander JJ. Curcumin aggravates CNS pathology in experimental systemic lupus erythematosus. Brain Res. 2013 Apr 04; 1504:85-96.
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Gay D, Saunders T, Camper S, Weigert M. Receptor editing: an approach by autoreactive B cells to escape tolerance. The Journal of Experimental Medicine. 1993. 177: 999-1008. J Immunol. 2011 Feb 01; 186(3):1303-12.
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Bao L, Haas M, Quigg RJ. Complement factor H deficiency accelerates development of lupus nephritis. J Am Soc Nephrol. 2011 Feb; 22(2):285-95.
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Jacob A, Hack B, Bai T, Brorson JR, Quigg RJ, Alexander JJ. Inhibition of C5a receptor alleviates experimental CNS lupus. J Neuroimmunol. 2010 Apr 15; 221(1-2):46-52.
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Jacob A, Hack B, Chiang E, Garcia JG, Quigg RJ, Alexander JJ. C5a alters blood-brain barrier integrity in experimental lupus. FASEB J. 2010 Jun; 24(6):1682-8.
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Jacob A, Bao L, Brorson J, Quigg RJ, Alexander JJ. C3aR inhibition reduces neurodegeneration in experimental lupus. Lupus. 2010 Jan; 19(1):73-82.
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Alexander JJ, Zwingmann C, Jacob A, Quigg R. Alteration in kidney glucose and amino acids are implicated in renal pathology in MRL/lpr mice. Biochim Biophys Acta. 2007 Oct; 1772(10):1143-9.
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Alexander JJ, Jacob A, Vezina P, Sekine H, Gilkeson GS, Quigg RJ. Absence of functional alternative complement pathway alleviates lupus cerebritis. Eur J Immunol. 2007 Jun; 37(6):1691-701.
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Sekiguchi DR, Yunk L, Gary D, Charan D, Srivastava B, Allman D, Weigert MG, Prak ET. Development and selection of edited B cells in B6.56R mice. J Immunol. 2006 Jun 01; 176(11):6879-87.
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