Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia.

Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):3070-5.

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subject areas

Adult
Aged
Binding Sites
Child
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 8
Cloning, Molecular
Core Binding Factor Alpha 2 Subunit
Deoxyribonuclease I
DNA Topoisomerases, Type II
DNA, Neoplasm
DNA-Binding Proteins
Female
Humans
Leukemia, Myeloid
Male
Middle Aged
Multigene Family
Neoplasm Proteins
Proto-Oncogene Proteins
RUNX1 Translocation Partner 1 Protein
Transcription Factors
Translocation, Genetic
Tumor Cells, Cultured

authors with profiles

Richard A. Larson