Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia.
Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):3070-5.
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Adult
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Aged
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Binding Sites
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Child
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Chromosomes, Human, Pair 21
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Chromosomes, Human, Pair 8
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Cloning, Molecular
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Core Binding Factor Alpha 2 Subunit
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Deoxyribonuclease I
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DNA Topoisomerases, Type II
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DNA, Neoplasm
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DNA-Binding Proteins
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Female
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Humans
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Leukemia, Myeloid
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Male
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Middle Aged
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Multigene Family
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Neoplasm Proteins
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Proto-Oncogene Proteins
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RUNX1 Translocation Partner 1 Protein
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Transcription Factors
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Translocation, Genetic
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Tumor Cells, Cultured