RUNX1 Translocation Partner 1 Protein
"RUNX1 Translocation Partner 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcriptional co-repressor that contains a MYND-type zinc finger (MYND DOMAIN) at its C-terminal and functions as a homo-oligomer. It associates with DNA-binding transcription factors, other repressor proteins, and HISTONE ACETYLTRANSFERASES to repress expression of genes involved in cell growth and differentiation such as MATRIX METALLOPROTEINASE 7 and TCF12. A CHROMOSOMAL TRANSLOCATION involving the RUNX1T1 and CORE BINDING FACTOR ALPHA 2 SUBUNIT (RUNX1) genes frequently occurs in cells of leukemia patients; the resulting fusion protein (AML1-ETO or RUNX1-RUNX1T1) plays a critical role in leukemogenesis.
| Descriptor ID |
D000075142
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| MeSH Number(s) |
D12.776.624.664.700.936 D12.776.930.780.625.575
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "RUNX1 Translocation Partner 1 Protein".
Below are MeSH descriptors whose meaning is more specific than "RUNX1 Translocation Partner 1 Protein".
This graph shows the total number of publications written about "RUNX1 Translocation Partner 1 Protein" by people in this website by year, and whether "RUNX1 Translocation Partner 1 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "RUNX1 Translocation Partner 1 Protein" by people in Profiles.
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ABL1 kinase as a tumor suppressor in AML1-ETO and NUP98-PMX1 leukemias. Blood Cancer J. 2023 03 23; 13(1):42.
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Mouse models of human AML accurately predict chemotherapy response. Genes Dev. 2009 Apr 01; 23(7):877-89.
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A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis. Nat Med. 2006 Aug; 12(8):945-9.
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Prenatal origin of childhood AML occurs less frequently than in childhood ALL. BMC Cancer. 2006 Apr 21; 6:100.
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Prognostic significance of the AML1-ETO fusion transcript expression in children and young adults with t(8;21) acute myeloid leukemia. Haematologica. 2003 Sep; 88(9):1078-9.
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The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia. Nat Med. 2002 Jul; 8(7):743-50.
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Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):3070-5.
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Comparison of cytogenetic and molecular genetic detection of t(8;21) and inv(16) in a prospective series of adults with de novo acute myeloid leukemia: a Cancer and Leukemia Group B Study. J Clin Oncol. 2001 May 01; 19(9):2482-92.
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Inhibition of the transforming growth factor beta 1 signaling pathway by the AML1/ETO leukemia-associated fusion protein. J Biol Chem. 2000 Dec 22; 275(51):40282-7.
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Lineage specificity of CBFA2 fusion transcripts. Leuk Res. 2000 Jan; 24(1):11-7.