Click Chemistry
"Click Chemistry" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
Descriptor ID |
D057930
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MeSH Number(s) |
E05.916.039.124 E05.916.079 G02.607.750.155.124 J01.897.836.249.124
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Concept/Terms |
Click Chemistry- Click Chemistry
- Chemistries, Click
- Chemistry, Click
- Click Chemistries
- Click Chemical Techniques
- Chemical Technique, Click
- Chemical Techniques, Click
- Click Chemical Technique
- Technique, Click Chemical
- Techniques, Click Chemical
Click Chemical Reactions- Click Chemical Reactions
- Chemical Reaction, Click
- Chemical Reactions, Click
- Click Chemical Reaction
- Reaction, Click Chemical
- Reactions, Click Chemical
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Below are MeSH descriptors whose meaning is more general than "Click Chemistry".
- Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
- Investigative Techniques [E05]
- Technology, Pharmaceutical [E05.916]
- Chemistry Techniques, Synthetic [E05.916.039]
- Click Chemistry [E05.916.039.124]
- Click Chemistry [E05.916.079]
- Biological Sciences [G]
- Chemical Phenomena [G02]
- Organic Chemistry Phenomena [G02.607]
- Organic Chemistry Processes [G02.607.750]
- Chemistry Techniques, Synthetic [G02.607.750.155]
- Click Chemistry [G02.607.750.155.124]
- Technology, Industry, Agriculture [J]
- Technology, Industry, and Agriculture [J01]
- Technology [J01.897]
- Technology, Pharmaceutical [J01.897.836]
- Chemistry Techniques, Synthetic [J01.897.836.249]
- Click Chemistry [J01.897.836.249.124]
Below are MeSH descriptors whose meaning is more specific than "Click Chemistry".
This graph shows the total number of publications written about "Click Chemistry" by people in this website by year, and whether "Click Chemistry" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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2011 | 0 | 1 | 1 | 2020 | 1 | 0 | 1 | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Click Chemistry" by people in Profiles.
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Weiss AM, Ajit J, Albin TJ, Kapoor N, Maroju S, Berges A, Pill L, Fairman J, Esser-Kahn AP. Site-specific antigen-adjuvant conjugation using cell-free protein synthesis enhances antigen presentation and CD8+ T-cell response. Sci Rep. 2021 03 18; 11(1):6267.
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Shields EP, Weber SG. A crosslinked, low pH-stable, mixed-mode cation-exchange like stationary phase made using the thiol-yne click reaction. J Chromatogr A. 2020 May 10; 1618:460851.
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Spitale RC, Flynn RA, Zhang QC, Crisalli P, Lee B, Jung JW, Kuchelmeister HY, Batista PJ, Torre EA, Kool ET, Chang HY. Structural imprints in vivo decode RNA regulatory mechanisms. Nature. 2015 Mar 26; 519(7544):486-90.
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Yu Z, Koirala D, Cui Y, Easterling LF, Zhao Y, Mao H. Click chemistry assisted single-molecule fingerprinting reveals a 3D biomolecular folding funnel. J Am Chem Soc. 2012 Aug 01; 134(30):12338-41.
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Song CX, He C. Bioorthogonal labeling of 5-hydroxymethylcytosine in genomic DNA and diazirine-based DNA photo-cross-linking probes. Acc Chem Res. 2011 Sep 20; 44(9):709-17.
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