"Click Chemistry" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
| Descriptor ID |
D057930
|
| MeSH Number(s) |
E05.197.124 J01.897.836.249.124
|
| Concept/Terms |
Click Chemistry- Click Chemistry
- Chemistries, Click
- Chemistry, Click
- Click Chemistries
- Click Chemical Techniques
- Chemical Technique, Click
- Chemical Techniques, Click
- Click Chemical Technique
- Technique, Click Chemical
- Techniques, Click Chemical
Click Chemical Reactions- Click Chemical Reactions
- Chemical Reaction, Click
- Chemical Reactions, Click
- Click Chemical Reaction
- Reaction, Click Chemical
- Reactions, Click Chemical
|
Below are MeSH descriptors whose meaning is more general than "Click Chemistry".
Below are MeSH descriptors whose meaning is more specific than "Click Chemistry".
This graph shows the total number of publications written about "Click Chemistry" by people in this website by year, and whether "Click Chemistry" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Click Chemistry" by people in Profiles.
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KAS-seq: genome-wide sequencing of single-stranded DNA by N3-kethoxal-assisted labeling. Nat Protoc. 2022 Feb; 17(2):402-420.
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Site-specific antigen-adjuvant conjugation using cell-free protein synthesis enhances antigen presentation and CD8+ T-cell response. Sci Rep. 2021 03 18; 11(1):6267.
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A crosslinked, low pH-stable, mixed-mode cation-exchange like stationary phase made using the thiol-yne click reaction. J Chromatogr A. 2020 May 10; 1618:460851.
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Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation. Bioorg Med Chem. 2018 05 01; 26(8):1939-1949.
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Structural imprints in vivo decode RNA regulatory mechanisms. Nature. 2015 Mar 26; 519(7544):486-90.
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Click chemistry assisted single-molecule fingerprinting reveals a 3D biomolecular folding funnel. J Am Chem Soc. 2012 Aug 01; 134(30):12338-41.
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Bioorthogonal labeling of 5-hydroxymethylcytosine in genomic DNA and diazirine-based DNA photo-cross-linking probes. Acc Chem Res. 2011 Sep 20; 44(9):709-17.