 PPAR gamma
"PPAR gamma" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR ALPHA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES. It is a target of THIAZOLIDINEDIONES for control of DIABETES MELLITUS.
| Descriptor ID |
D047495
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| MeSH Number(s) |
D12.776.260.698.239.588 D12.776.826.239.588 D12.776.930.669.239.588
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| Concept/Terms |
PPAR gamma- PPAR gamma
- Peroxisome Proliferator-Activated Receptor gamma
- Peroxisome Proliferator Activated Receptor gamma
- PPARgamma
- Thiazolidinedione Receptor
- Receptor, Thiazolidinedione
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Below are MeSH descriptors whose meaning is more general than "PPAR gamma".
Below are MeSH descriptors whose meaning is more specific than "PPAR gamma".
This graph shows the total number of publications written about "PPAR gamma" by people in this website by year, and whether "PPAR gamma" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 2 | 1 | 3 | | 2005 | 1 | 1 | 2 | | 2006 | 2 | 2 | 4 | | 2007 | 3 | 1 | 4 | | 2008 | 2 | 1 | 3 | | 2009 | 4 | 2 | 6 | | 2010 | 2 | 0 | 2 | | 2011 | 3 | 2 | 5 | | 2012 | 1 | 2 | 3 | | 2014 | 1 | 1 | 2 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 2 | 3 | | 2017 | 0 | 1 | 1 | | 2018 | 2 | 0 | 2 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "PPAR gamma" by people in Profiles.
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Philipson LH. Harnessing heterogeneity in type 2 diabetes mellitus. Nat Rev Endocrinol. 2020 02; 16(2):79-80.
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Kan B, Michalski C, Fu H, Au HHT, Lee K, Marchant EA, Cheng MF, Anderson-Baucum E, Aharoni-Simon M, Tilley P, Mirmira RG, Ross CJ, Luciani DS, Jan E, Lavoie PM. Cellular metabolism constrains innate immune responses in early human ontogeny. Nat Commun. 2018 11 16; 9(1):4822.
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Katafuchi T, Holland WL, Kollipara RK, Kittler R, Mangelsdorf DJ, Kliewer SA. PPAR?-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice. Proc Natl Acad Sci U S A. 2018 11 27; 115(48):12102-12111.
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Chang E, Kim Y. Vitamin D Insufficiency Exacerbates Adipose Tissue Macrophage Infiltration and Decreases AMPK/SIRT1 Activity in Obese Rats. Nutrients. 2017 Mar 29; 9(4).
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Maganti AV, Tersey SA, Syed F, Nelson JB, Colvin SC, Maier B, Mirmira RG. Peroxisome Proliferator-activated Receptor-? Activation Augments the ß-Cell Unfolded Protein Response and Rescues Early Glycemic Deterioration and ß Cell Death in Non-obese Diabetic Mice. J Biol Chem. 2016 Oct 21; 291(43):22524-22533.
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Sweis RF, Spranger S, Bao R, Paner GP, Stadler WM, Steinberg G, Gajewski TF. Molecular Drivers of the Non-T-cell-Inflamed Tumor Microenvironment in Urothelial Bladder Cancer. Cancer Immunol Res. 2016 07; 4(7):563-8.
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Park SE, Park CY, Choi JM, Chang E, Rhee EJ, Lee WY, Oh KW, Park SW, Kang ES, Lee HC, Cha BS. Depot-Specific Changes in Fat Metabolism with Aging in a Type 2 Diabetic Animal Model. PLoS One. 2016; 11(2):e0148141.
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Regnier SM, El-Hashani E, Kamau W, Zhang X, Massad NL, Sargis RM. Tributyltin differentially promotes development of a phenotypically distinct adipocyte. Obesity (Silver Spring). 2015 Sep; 23(9):1864-71.
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Cao Y, Gomes SA, Rangel EB, Paulino EC, Fonseca TL, Li J, Teixeira MB, Gouveia CH, Bianco AC, Kapiloff MS, Balkan W, Hare JM. S-nitrosoglutathione reductase-dependent PPAR? denitrosylation participates in MSC-derived adipogenesis and osteogenesis. J Clin Invest. 2015 Apr; 125(4):1679-91.
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Srivastava N, Kollipara RK, Singh DK, Sudderth J, Hu Z, Nguyen H, Wang S, Humphries CG, Carstens R, Huffman KE, DeBerardinis RJ, Kittler R. Inhibition of cancer cell proliferation by PPAR? is mediated by a metabolic switch that increases reactive oxygen species levels. Cell Metab. 2014 Oct 07; 20(4):650-61.
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