 bcl-2-Associated X Protein
"bcl-2-Associated X Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. It regulates the release of CYTOCHROME C and APOPTOSIS INDUCING FACTOR from the MITOCHONDRIA. Several isoforms of BCL2-associated X protein occur due to ALTERNATIVE SPLICING of the mRNA for this protein.
| Descriptor ID |
D051028
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| MeSH Number(s) |
D12.644.360.075.718.400 D12.776.476.075.718.400
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| Concept/Terms |
bcl-2-Associated X Protein- bcl-2-Associated X Protein
- Protein, bcl-2-Associated X
- X Protein, bcl-2-Associated
- bcl 2 Associated X Protein
- Bax Protein
- bcl2-Associated X Protein
- bcl2 Associated X Protein
- Bax Apoptosis Regulator Protein
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Below are MeSH descriptors whose meaning is more general than "bcl-2-Associated X Protein".
Below are MeSH descriptors whose meaning is more specific than "bcl-2-Associated X Protein".
This graph shows the total number of publications written about "bcl-2-Associated X Protein" by people in this website by year, and whether "bcl-2-Associated X Protein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1997 | 0 | 1 | 1 | | 2000 | 0 | 4 | 4 | | 2002 | 0 | 4 | 4 | | 2003 | 0 | 5 | 5 | | 2004 | 0 | 2 | 2 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 2 | 2 | | 2007 | 1 | 4 | 5 | | 2008 | 0 | 8 | 8 | | 2009 | 1 | 4 | 5 | | 2010 | 1 | 3 | 4 | | 2011 | 0 | 4 | 4 | | 2012 | 0 | 4 | 4 | | 2013 | 0 | 4 | 4 | | 2016 | 1 | 1 | 2 | | 2017 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "bcl-2-Associated X Protein" by people in Profiles.
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Roychowdhury T, Lu H, Hornsby WE, Crone B, Wang GT, Guo DC, Sendamarai AK, Devineni P, Lin M, Zhou W, Graham SE, Wolford BN, Surakka I, Wang Z, Chang L, Zhang J, Mathis M, Brummett CM, Melendez TL, Shea MJ, Kim KM, Deeb GM, Patel HJ, Eliason J, Eagle KA, Yang B, Ganesh SK, Brumpton B, Åsvold BO, Skogholt AH, Hveem K. Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm. Am J Hum Genet. 2021 09 02; 108(9):1578-1589.
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Vazquez JM, Sulak M, Chigurupati S, Lynch VJ. A Zombie LIF Gene in Elephants Is Upregulated by TP53 to Induce Apoptosis in Response to DNA Damage. Cell Rep. 2018 08 14; 24(7):1765-1776.
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Skinner JJ, Wang S, Lee J, Ong C, Sommese R, Sivaramakrishnan S, Koelmel W, Hirschbeck M, Schindelin H, Kisker C, Lorenz K, Sosnick TR, Rosner MR. Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome. Proc Natl Acad Sci U S A. 2017 12 19; 114(51):13453-13458.
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Mañas A, Wang S, Nelson A, Li J, Zhao Y, Zhang H, Davis A, Xie B, Maltsev N, Xiang J. The functional domains for Bax?2 aggregate-mediated caspase 8-dependent cell death. Exp Cell Res. 2017 10 15; 359(2):342-355.
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Sun J, Mao LQ, Polonsky KS, Ren DC. Pancreatic ß-Cell Death due to Pdx-1 Deficiency Requires Multi-BH Domain Protein Bax but Not Bak. J Biol Chem. 2016 Jun 24; 291(26):13529-34.
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Bechill J, Zhong R, Zhang C, Solomaha E, Spiotto MT. A High-Throughput Cell-Based Screen Identified a 2-[(E)-2-Phenylvinyl]-8-Quinolinol Core Structure That Activates p53. PLoS One. 2016; 11(4):e0154125.
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Chen HC, Kanai M, Inoue-Yamauchi A, Tu HC, Huang Y, Ren D, Kim H, Takeda S, Reyna DE, Chan PM, Ganesan YT, Liao CP, Gavathiotis E, Hsieh JJ, Cheng EH. An interconnected hierarchical model of cell death regulation by the BCL-2 family. Nat Cell Biol. 2015 Oct; 17(10):1270-81.
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Wissing ER, Boyer JG, Kwong JQ, Sargent MA, Karch J, McNally EM, Otsu K, Molkentin JD. P38a MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism. Hum Mol Genet. 2014 Oct 15; 23(20):5452-63.
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Edwards AL, Gavathiotis E, LaBelle JL, Braun CR, Opoku-Nsiah KA, Bird GH, Walensky LD. Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3. Chem Biol. 2013 Jul 25; 20(7):888-902.
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Shelat PB, Plant LD, Wang JC, Lee E, Marks JD. The membrane-active tri-block copolymer pluronic F-68 profoundly rescues rat hippocampal neurons from oxygen-glucose deprivation-induced death through early inhibition of apoptosis. J Neurosci. 2013 Jul 24; 33(30):12287-99.
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