 Proto-Oncogene Proteins c-raf
"Proto-Oncogene Proteins c-raf" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously expressed raf kinase subclass that plays an important role in SIGNAL TRANSDUCTION. The c-raf Kinases are MAP kinase kinase kinases that have specificity for MAP KINASE KINASE 1 and MAP KINASE KINASE 2.
| Descriptor ID |
D019908
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| MeSH Number(s) |
D08.811.913.696.620.682.700.559.842.500 D12.644.360.400.842.500 D12.776.476.400.842.500 D12.776.624.664.700.204.500
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| Concept/Terms |
Proto-Oncogene Proteins c-raf- Proto-Oncogene Proteins c-raf
- Proteins c-raf, Proto-Oncogene
- Proto Oncogene Proteins c raf
- c-raf, Proto-Oncogene Proteins
- c-raf Proteins
- Proteins, c-raf
- c raf Proteins
- cRaf1 Kinase
- Kinase, cRaf1
- Kinase Raf-1
- Kinase Raf 1
- Raf-1, Kinase
- Proto-Oncogene Protein c-raf
- Protein c-raf, Proto-Oncogene
- Proto Oncogene Protein c raf
- c-raf, Proto-Oncogene Protein
- raf-1 Kinase
- Kinase, raf-1
- raf 1 Kinase
- c-raf Kinases
- Kinases, c-raf
- c raf Kinases
- Kinase p74(raf-1)
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Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-raf".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-raf".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-raf" by people in this website by year, and whether "Proto-Oncogene Proteins c-raf" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1989 | 0 | 1 | 1 | | 1994 | 0 | 2 | 2 | | 1995 | 0 | 4 | 4 | | 1996 | 0 | 2 | 2 | | 1997 | 0 | 7 | 7 | | 1998 | 2 | 1 | 3 | | 1999 | 0 | 1 | 1 | | 2000 | 1 | 1 | 2 | | 2001 | 2 | 0 | 2 | | 2002 | 0 | 1 | 1 | | 2003 | 1 | 1 | 2 | | 2004 | 2 | 0 | 2 | | 2005 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2013 | 0 | 2 | 2 | | 2014 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Proto-Oncogene Proteins c-raf" by people in Profiles.
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Prakash P, Hancock JF, Gorfe AA. Three distinct regions of cRaf kinase domain interact with membrane. Sci Rep. 2019 02 14; 9(1):2057.
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Zhu L, Yang T, Li L, Sun L, Hou Y, Hu X, Zhang L, Tian H, Zhao Q, Peng J, Zhang H, Wang R, Yang Z, Zhang L, Zhao Y. TSC1 controls macrophage polarization to prevent inflammatory disease. Nat Commun. 2014 Sep 01; 5:4696.
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Skinner JJ, Rosner MR. RKIP structure drives its function: a three-state model for regulation of RKIP. Crit Rev Oncog. 2014; 19(6):483-8.
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Nagalingam RS, Sundaresan NR, Gupta MP, Geenen DL, Solaro RJ, Gupta M. A cardiac-enriched microRNA, miR-378, blocks cardiac hypertrophy by targeting Ras signaling. J Biol Chem. 2013 Apr 19; 288(16):11216-32.
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Zeng L, Ehrenreiter K, Menon J, Menard R, Kern F, Nakazawa Y, Bevilacqua E, Imamoto A, Baccarini M, Rosner MR. RKIP regulates MAP kinase signaling in cells with defective B-Raf activity. Cell Signal. 2013 May; 25(5):1156-65.
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Kowluru A, Veluthakal R, Rhodes CJ, Kamath V, Syed I, Koch BJ. Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. Diabetes. 2010 Apr; 59(4):967-77.
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Shemon AN, Eves EM, Clark MC, Heil G, Granovsky A, Zeng L, Imamoto A, Koide S, Rosner MR. Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration. PLoS One. 2009 Jun 24; 4(6):e6028.
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Edelblum KL, Goettel JA, Koyama T, McElroy SJ, Yan F, Polk DB. TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB. J Biol Chem. 2008 Oct 24; 283(43):29485-94.
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Trakul N, Menard RE, Schade GR, Qian Z, Rosner MR. Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation. J Biol Chem. 2005 Jul 01; 280(26):24931-40.
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Rudin CM, Marshall JL, Huang CH, Kindler HL, Zhang C, Kumar D, Gokhale PC, Steinberg J, Wanaski S, Kasid UN, Ratain MJ. Delivery of a liposomal c-raf-1 antisense oligonucleotide by weekly bolus dosing in patients with advanced solid tumors: a phase I study. Clin Cancer Res. 2004 Nov 01; 10(21):7244-51.
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