Proto-Oncogene Proteins c-raf
"Proto-Oncogene Proteins c-raf" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously expressed raf kinase subclass that plays an important role in SIGNAL TRANSDUCTION. The c-raf Kinases are MAP kinase kinase kinases that have specificity for MAP KINASE KINASE 1 and MAP KINASE KINASE 2.
| Descriptor ID |
D019908
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| MeSH Number(s) |
D08.811.913.696.620.682.700.559.842.500 D12.644.360.400.842.500 D12.776.476.400.842.500 D12.776.624.664.700.204.500
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| Concept/Terms |
Proto-Oncogene Proteins c-raf- Proto-Oncogene Proteins c-raf
- Proteins c-raf, Proto-Oncogene
- Proto Oncogene Proteins c raf
- c-raf, Proto-Oncogene Proteins
- Proto-Oncogene Protein c-raf
- Protein c-raf, Proto-Oncogene
- Proto Oncogene Protein c raf
- c-raf, Proto-Oncogene Protein
- c-raf Kinases
- Kinases, c-raf
- c raf Kinases
- Kinase Raf-1
- Kinase Raf 1
- Raf-1, Kinase
- cRaf1 Kinase
- Kinase, cRaf1
- raf-1 Kinase
- Kinase, raf-1
- raf 1 Kinase
- c-raf Proteins
- Proteins, c-raf
- c raf Proteins
- Kinase p74(raf-1)
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Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-raf".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-raf".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-raf" by people in this website by year, and whether "Proto-Oncogene Proteins c-raf" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 0 | 4 | 4 |
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 7 | 7 |
| 1998 | 2 | 1 | 3 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 1 | 2 |
| 2001 | 2 | 0 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 2 | 0 | 2 |
| 2005 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Proto-Oncogene Proteins c-raf" by people in Profiles.
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Three distinct regions of cRaf kinase domain interact with membrane. Sci Rep. 2019 02 14; 9(1):2057.
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TSC1 controls macrophage polarization to prevent inflammatory disease. Nat Commun. 2014 Sep 01; 5:4696.
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RKIP structure drives its function: a three-state model for regulation of RKIP. Crit Rev Oncog. 2014; 19(6):483-8.
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A cardiac-enriched microRNA, miR-378, blocks cardiac hypertrophy by targeting Ras signaling. J Biol Chem. 2013 Apr 19; 288(16):11216-32.
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RKIP regulates MAP kinase signaling in cells with defective B-Raf activity. Cell Signal. 2013 May; 25(5):1156-65.
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Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. Diabetes. 2010 Apr; 59(4):967-77.
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Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration. PLoS One. 2009 Jun 24; 4(6):e6028.
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TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB. J Biol Chem. 2008 Oct 24; 283(43):29485-94.
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Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation. J Biol Chem. 2005 Jul 01; 280(26):24931-40.
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Delivery of a liposomal c-raf-1 antisense oligonucleotide by weekly bolus dosing in patients with advanced solid tumors: a phase I study. Clin Cancer Res. 2004 Nov 01; 10(21):7244-51.