"Leptin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
| Descriptor ID |
D020738
|
| MeSH Number(s) |
D06.472.699.042.500 D12.644.276.024.500 D12.644.548.011.500 D12.776.467.024.500 D23.529.024.500
|
| Concept/Terms |
Leptin- Leptin
- Obese Protein
- Obese Gene Product
- Gene Product, Obese
- Ob Gene Product
- Gene Product, Ob
- Ob Protein
|
Below are MeSH descriptors whose meaning is more general than "Leptin".
Below are MeSH descriptors whose meaning is more specific than "Leptin".
This graph shows the total number of publications written about "Leptin" by people in this website by year, and whether "Leptin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 3 | 3 |
| 1999 | 2 | 0 | 2 |
| 2000 | 4 | 0 | 4 |
| 2001 | 1 | 0 | 1 |
| 2002 | 2 | 1 | 3 |
| 2004 | 2 | 1 | 3 |
| 2005 | 4 | 0 | 4 |
| 2006 | 1 | 4 | 5 |
| 2008 | 1 | 1 | 2 |
| 2009 | 4 | 2 | 6 |
| 2010 | 3 | 3 | 6 |
| 2011 | 3 | 2 | 5 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 5 | 6 |
| 2014 | 3 | 4 | 7 |
| 2015 | 1 | 3 | 4 |
| 2016 | 0 | 1 | 1 |
| 2017 | 3 | 1 | 4 |
| 2018 | 1 | 2 | 3 |
| 2020 | 1 | 1 | 2 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Leptin" by people in Profiles.
-
Late isocaloric eating increases hunger, decreases energy expenditure, and modifies metabolic pathways in adults with overweight and obesity. Cell Metab. 2022 10 04; 34(10):1486-1498.e7.
-
Leptin-mediated neural targets in obesity hypoventilation syndrome. Sleep. 2022 09 08; 45(9).
-
NTS Prlh overcomes orexigenic stimuli and ameliorates dietary and genetic forms of obesity. Nat Commun. 2021 08 30; 12(1):5175.
-
Leptin Potentiates BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells Through the Activation of JAK/STAT Signaling. Stem Cells Dev. 2020 04 15; 29(8):498-510.
-
Circadian Misalignment of the 24-hour Profile of Endocannabinoid 2-Arachidonoylglycerol (2-AG) in Obese Adults. J Clin Endocrinol Metab. 2020 03 01; 105(3).
-
Activating Leptin Receptors in the Central Nervous System Using Intranasal Leptin. A Novel Therapeutic Target for Sleep-disordered Breathing. Am J Respir Crit Care Med. 2019 Mar 15; 199(6):689-691.
-
Blood Levels of Tumor Necrosis Factor Alpha and Its Type 2 Receptor Are Elevated in Patients with Boston Type I Keratoprosthesis. Curr Eye Res. 2019 06; 44(6):599-606.
-
Lateral Hypothalamic Area Neurotensin Neurons Are Required for Control of Orexin Neurons and Energy Balance. Endocrinology. 2018 09 01; 159(9):3158-3176.
-
A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer. Cell Metab. 2018 Jul 03; 28(1):118-129.e5.
-
Essential Role for Hypothalamic Calcitonin Receptor?Expressing Neurons in the Control of Food Intake by Leptin. Endocrinology. 2018 04 01; 159(4):1860-1872.