 Leptin
"Leptin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
| Descriptor ID |
D020738
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| MeSH Number(s) |
D06.472.699.042.500 D12.644.276.024.500 D12.644.548.011.500 D12.776.467.024.500 D23.529.024.500
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| Concept/Terms |
Leptin- Leptin
- Obese Protein
- Obese Gene Product
- Gene Product, Obese
- Ob Gene Product
- Gene Product, Ob
- Ob Protein
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Below are MeSH descriptors whose meaning is more general than "Leptin".
Below are MeSH descriptors whose meaning is more specific than "Leptin".
This graph shows the total number of publications written about "Leptin" by people in this website by year, and whether "Leptin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 | | 1997 | 0 | 3 | 3 | | 1999 | 2 | 0 | 2 | | 2000 | 4 | 0 | 4 | | 2001 | 1 | 0 | 1 | | 2002 | 2 | 1 | 3 | | 2004 | 2 | 1 | 3 | | 2005 | 4 | 0 | 4 | | 2006 | 3 | 4 | 7 | | 2007 | 1 | 4 | 5 | | 2008 | 1 | 2 | 3 | | 2009 | 6 | 3 | 9 | | 2010 | 3 | 3 | 6 | | 2011 | 3 | 2 | 5 | | 2012 | 0 | 2 | 2 | | 2013 | 1 | 5 | 6 | | 2014 | 3 | 4 | 7 | | 2015 | 1 | 2 | 3 | | 2016 | 0 | 1 | 1 | | 2017 | 3 | 2 | 5 | | 2018 | 1 | 2 | 3 | | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Leptin" by people in Profiles.
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Ip MSM, Mokhlesi B. Activating Leptin Receptors in the Central Nervous System Using Intranasal Leptin. A Novel Therapeutic Target for Sleep-disordered Breathing. Am J Respir Crit Care Med. 2019 Mar 15; 199(6):689-691.
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Brown J, Sagante A, Mayer T, Wright A, Bugescu R, Fuller PM, Leinninger G. Lateral Hypothalamic Area Neurotensin Neurons Are Required for Control of Orexin Neurons and Energy Balance. Endocrinology. 2018 09 01; 159(9):3158-3176.
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Borniger JC, Walker Ii WH. A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer. Cell Metab. 2018 Jul 03; 28(1):118-129.e5.
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Pan W, Adams JM, Allison MB, Patterson C, Flak JN, Jones J, Strohbehn G, Trevaskis J, Rhodes CJ, Olson DP, Myers MG. Essential Role for Hypothalamic Calcitonin Receptor?Expressing Neurons in the Control of Food Intake by Leptin. Endocrinology. 2018 04 01; 159(4):1860-1872.
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Lee JW, Kim WY, Cho BR, Vezina P, Kim JH. Leptin in the nucleus accumbens core disrupts acute cocaine effects: Implications for GSK3ß connections. Behav Brain Res. 2018 Jan 30; 337:46-52.
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Gozal D, Khalyfa A, Qiao Z, Akbarpour M, Maccari R, Ottanà R. Protein-Tyrosine Phosphatase-1B Mediates Sleep Fragmentation-Induced Insulin Resistance and Visceral Adipose Tissue Inflammation in Mice. Sleep. 2017 09 01; 40(9).
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Cho BR, Yoon HS, Kim WY, Vezina P, Kim JH. Cocaine inhibits leptin-induced increase of the cocaine- and amphetamine-regulated transcript peptide in the nucleus accumbens in rats. Neuroreport. 2017 Aug 02; 28(11):701-704.
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Wang T, Zhang Z, Wang K, Wang J, Jiang Y, Xia J, Gou L, Liu M, Zhou L, He T, Zhang Y. Inhibitory effects of BMP9 on breast cancer cells by regulating their interaction with pre-adipocytes/adipocytes. Oncotarget. 2017 May 30; 8(22):35890-35901.
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Brown JA, Bugescu R, Mayer TA, Gata-Garcia A, Kurt G, Woodworth HL, Leinninger GM. Loss of Action via Neurotensin-Leptin Receptor Neurons Disrupts Leptin and Ghrelin-Mediated Control of Energy Balance. Endocrinology. 2017 05 01; 158(5):1271-1288.
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Dolezelova E, Stein E, Derosa G, Maffioli P, Nachtigal P, Sahebkar A. Effect of ezetimibe on plasma adipokines: a systematic review and meta-analysis. Br J Clin Pharmacol. 2017 07; 83(7):1380-1396.
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