 Leptin
"Leptin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
| Descriptor ID |
D020738
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| MeSH Number(s) |
D06.472.699.042.500 D12.644.276.024.500 D12.644.548.011.500 D12.776.467.024.500 D23.529.024.500
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| Concept/Terms |
Leptin- Leptin
- Obese Protein
- Obese Gene Product
- Gene Product, Obese
- Ob Gene Product
- Gene Product, Ob
- Ob Protein
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Below are MeSH descriptors whose meaning is more general than "Leptin".
Below are MeSH descriptors whose meaning is more specific than "Leptin".
This graph shows the total number of publications written about "Leptin" by people in this website by year, and whether "Leptin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 | | 1997 | 0 | 3 | 3 | | 1999 | 2 | 0 | 2 | | 2000 | 4 | 0 | 4 | | 2001 | 1 | 0 | 1 | | 2002 | 2 | 1 | 3 | | 2004 | 2 | 1 | 3 | | 2005 | 4 | 0 | 4 | | 2006 | 3 | 4 | 7 | | 2007 | 1 | 4 | 5 | | 2008 | 1 | 1 | 2 | | 2009 | 6 | 3 | 9 | | 2010 | 3 | 3 | 6 | | 2011 | 3 | 2 | 5 | | 2012 | 0 | 2 | 2 | | 2013 | 1 | 5 | 6 | | 2014 | 3 | 4 | 7 | | 2015 | 1 | 3 | 4 | | 2016 | 0 | 1 | 1 | | 2017 | 3 | 2 | 5 | | 2018 | 1 | 2 | 3 | | 2019 | 1 | 1 | 2 | | 2020 | 1 | 1 | 2 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Leptin" by people in Profiles.
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Cheng W, Ndoka E, Maung JN, Pan W, Rupp AC, Rhodes CJ, Olson DP, Myers MG. NTS Prlh overcomes orexigenic stimuli and ameliorates dietary and genetic forms of obesity. Nat Commun. 2021 08 30; 12(1):5175.
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Zhang B, Yang L, Zeng Z, Feng Y, Wang X, Wu X, Luo H, Zhang J, Zhang M, Pakvasa M, Wagstaff W, He F, Mao Y, Qin K, Ding H, Zhang Y, Niu C, Wu M, Zhao X, Wang H, Huang L, Shi D, Liu Q, Ni N, Fu K, Athiviraham A, Moriatis Wolf J, Lee MJ, Hynes K, Strelzow J, El Dafrawy M, Xia Y, He TC. Leptin Potentiates BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells Through the Activation of JAK/STAT Signaling. Stem Cells Dev. 2020 04 15; 29(8):498-510.
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Hanlon EC, Leproult R, Stuhr KL, Doncheck EM, Hillard CJ, Van Cauter E. Circadian Misalignment of the 24-hour Profile of Endocannabinoid 2-Arachidonoylglycerol (2-AG) in Obese Adults. J Clin Endocrinol Metab. 2020 03 01; 105(3).
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Ip MSM, Mokhlesi B. Activating Leptin Receptors in the Central Nervous System Using Intranasal Leptin. A Novel Therapeutic Target for Sleep-disordered Breathing. Am J Respir Crit Care Med. 2019 Mar 15; 199(6):689-691.
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Paschalis EI, Taniguchi EV, Chodosh J, Pasquale LR, Colby K, Dohlman CH, Shen LQ. Blood Levels of Tumor Necrosis Factor Alpha and Its Type 2 Receptor Are Elevated in Patients with Boston Type I Keratoprosthesis. Curr Eye Res. 2019 06; 44(6):599-606.
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Brown J, Sagante A, Mayer T, Wright A, Bugescu R, Fuller PM, Leinninger G. Lateral Hypothalamic Area Neurotensin Neurons Are Required for Control of Orexin Neurons and Energy Balance. Endocrinology. 2018 09 01; 159(9):3158-3176.
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Borniger JC, Walker Ii WH. A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer. Cell Metab. 2018 Jul 03; 28(1):118-129.e5.
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Pan W, Adams JM, Allison MB, Patterson C, Flak JN, Jones J, Strohbehn G, Trevaskis J, Rhodes CJ, Olson DP, Myers MG. Essential Role for Hypothalamic Calcitonin Receptor?Expressing Neurons in the Control of Food Intake by Leptin. Endocrinology. 2018 04 01; 159(4):1860-1872.
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Lee JW, Kim WY, Cho BR, Vezina P, Kim JH. Leptin in the nucleus accumbens core disrupts acute cocaine effects: Implications for GSK3ß connections. Behav Brain Res. 2018 Jan 30; 337:46-52.
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Gozal D, Khalyfa A, Qiao Z, Akbarpour M, Maccari R, Ottanà R. Protein-Tyrosine Phosphatase-1B Mediates Sleep Fragmentation-Induced Insulin Resistance and Visceral Adipose Tissue Inflammation in Mice. Sleep. 2017 09 01; 40(9).
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