"Protein Phosphatase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A eukayrotic protein serine-threonine phosphatase subtype that dephosphorylates a wide variety of cellular proteins. The enzyme is comprised of a catalytic subunit and regulatory subunit. Several isoforms of the protein phosphatase catalytic subunit exist due to the presence of multiple genes and the alternative splicing of their mRNAs. A large number of proteins have been shown to act as regulatory subunits for this enzyme. Many of the regulatory subunits have additional cellular functions.
| Descriptor ID |
D054645
|
| MeSH Number(s) |
D08.811.277.352.650.625.687
|
| Concept/Terms |
Protein Phosphatase 1- Protein Phosphatase 1
- Protein Phosphatase-1
- Type 1 Serine Threonine Protein Phosphatase
- PP1c Enzyme
|
Below are MeSH descriptors whose meaning is more general than "Protein Phosphatase 1".
Below are MeSH descriptors whose meaning is more specific than "Protein Phosphatase 1".
This graph shows the total number of publications written about "Protein Phosphatase 1" by people in this website by year, and whether "Protein Phosphatase 1" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 4 | 4 |
| 2004 | 0 | 3 | 3 |
| 2005 | 0 | 3 | 3 |
| 2006 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2010 | 1 | 1 | 2 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Phosphatase 1" by people in Profiles.
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Protein phosphatase 1 regulates reactive oxygen species-dependent degradation of histone deacetylase 5 by intermittent hypoxia. Am J Physiol Cell Physiol. 2022 08 01; 323(2):C423-C431.
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Knockdown of GADD34 in neonatal mutant SOD1 mice ameliorates ALS. Neurobiol Dis. 2020 03; 136:104702.
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Activation of the Integrated Stress Response and Metabolic Dysfunction in a Murine Model of Sleep Apnea. Am J Respir Cell Mol Biol. 2017 10; 57(4):477-486.
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Integrated stress response activation by sleep fragmentation during late gestation in mice leads to emergence of adverse metabolic phenotype in offspring. Metabolism. 2017 04; 69:188-198.
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A novel rasopathy caused by recurrent de novo missense mutations in PPP1CB closely resembles Noonan syndrome with loose anagen hair. Am J Med Genet A. 2016 09; 170(9):2237-47.
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Intravenous Lipid Infusion Induces Endoplasmic Reticulum Stress in Endothelial Cells and Blood Mononuclear Cells of Healthy Adults. J Am Heart Assoc. 2016 Jan 11; 5(1).
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Antagonism of the phosphatase PP1 by the measles virus V protein is required for innate immune escape of MDA5. Cell Host Microbe. 2014 Jul 09; 16(1):19-30.
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Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases. Cell Host Microbe. 2014 Jul 09; 16(1):31-42.
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c-Src kinase inhibition reduces arrhythmia inducibility and connexin43 dysregulation after myocardial infarction. J Am Coll Cardiol. 2014 Mar 11; 63(9):928-34.
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An enhanced integrated stress response ameliorates mutant SOD1-induced ALS. Hum Mol Genet. 2014 May 15; 23(10):2629-38.