"Tight Junctions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cell-cell junctions that seal adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. (Alberts et al., Molecular Biology of the Cell, 2nd ed, p22)
| Descriptor ID |
D019108
|
| MeSH Number(s) |
A11.284.149.165.420.820
|
| Concept/Terms |
Tight Junctions- Tight Junctions
- Junction, Tight
- Junctions, Tight
- Tight Junction
- Zonula Occludens
- Occluden, Zonula
- Occludens, Zonula
- Zonula Occluden
- Occluding Junctions
- Junction, Occluding
- Junctions, Occluding
- Occluding Junction
|
Below are MeSH descriptors whose meaning is more general than "Tight Junctions".
Below are MeSH descriptors whose meaning is more specific than "Tight Junctions".
This graph shows the total number of publications written about "Tight Junctions" by people in this website by year, and whether "Tight Junctions" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 1 | 2 |
| 2005 | 4 | 0 | 4 |
| 2006 | 2 | 0 | 2 |
| 2007 | 1 | 3 | 4 |
| 2008 | 4 | 0 | 4 |
| 2009 | 2 | 3 | 5 |
| 2010 | 5 | 4 | 9 |
| 2011 | 6 | 4 | 10 |
| 2012 | 5 | 3 | 8 |
| 2013 | 3 | 2 | 5 |
| 2014 | 3 | 1 | 4 |
| 2015 | 4 | 6 | 10 |
| 2016 | 1 | 0 | 1 |
| 2017 | 3 | 5 | 8 |
| 2018 | 0 | 2 | 2 |
| 2019 | 1 | 1 | 2 |
| 2020 | 2 | 1 | 3 |
| 2021 | 1 | 0 | 1 |
| 2022 | 3 | 2 | 5 |
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Below are the most recent publications written about "Tight Junctions" by people in Profiles.
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Molecular mechanism of claudin-15 strand flexibility: A computational study. J Gen Physiol. 2022 12 05; 154(12).
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Serine 408 phosphorylation is a molecular switch that regulates structure and function of the occludin a-helical bundle. Proc Natl Acad Sci U S A. 2022 08 23; 119(34):e2204618119.
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Computational Assessment of Different Structural Models for Claudin-5 Complexes in Blood-Brain Barrier Tight Junctions. ACS Chem Neurosci. 2022 07 20; 13(14):2140-2153.
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Computational study of ion permeation through claudin-4 paracellular channels. Ann N Y Acad Sci. 2022 10; 1516(1):162-174.
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Confluence and tight junction dependence of volume regulation in epithelial tissue. Mol Biol Cell. 2022 09 15; 33(11):ar98.
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T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling. J Clin Invest. 2021 09 01; 131(17).
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Idiopathic pulmonary fibrosis is associated with tight junction protein alterations. Biochim Biophys Acta Biomembr. 2020 05 01; 1862(5):183205.
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Computational Modeling of Claudin Structure and Function. Int J Mol Sci. 2020 Jan 23; 21(3).
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Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation. Int J Mol Sci. 2020 Jan 20; 21(2).
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Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis. Nat Med. 2019 04; 25(4):690-700.