Mitogen-Activated Protein Kinase 1
"Mitogen-Activated Protein Kinase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.
| Descriptor ID |
D019950
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.567.249.500 D12.644.360.450.169.500 D12.776.476.450.169.500
|
| Concept/Terms |
Mitogen-Activated Protein Kinase 1- Mitogen-Activated Protein Kinase 1
- Mitogen Activated Protein Kinase 1
- p42 MAPK
- p42(Mitogen-Activated Protein Kinase)
- p42(Mapk) Kinase
- p42 MAP Kinase
- MAP Kinase, p42
- MAPK2 Mitogen-Activated Protein Kinase
- MAPK2 Mitogen Activated Protein Kinase
- Extracellular Signal-Regulated Kinase 2
- Extracellular Signal Regulated Kinase 2
- Mitogen-Activated Protein Kinase 2
- Mitogen Activated Protein Kinase 2
- MAPK1 Mitogen-Activated Protein Kinase
- MAPK1 Mitogen Activated Protein Kinase
- p42(Mapk)
- MAP Kinase 2
|
Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinase 1".
Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinase 1".
This graph shows the total number of publications written about "Mitogen-Activated Protein Kinase 1" by people in this website by year, and whether "Mitogen-Activated Protein Kinase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 7 | 7 |
| 2000 | 2 | 0 | 2 |
| 2001 | 2 | 4 | 6 |
| 2002 | 1 | 4 | 5 |
| 2003 | 1 | 2 | 3 |
| 2004 | 0 | 3 | 3 |
| 2005 | 0 | 2 | 2 |
| 2006 | 2 | 4 | 6 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 5 | 5 |
| 2009 | 1 | 1 | 2 |
| 2010 | 1 | 2 | 3 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 1 | 1 | 2 |
| 2015 | 1 | 1 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mitogen-Activated Protein Kinase 1" by people in Profiles.
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A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis. Nat Commun. 2019 04 17; 10(1):1791.
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IL-1ß Inhibits Connexin 43 and Disrupts Decidualization of Human Endometrial Stromal Cells Through ERK1/2 and p38 MAP Kinase. Endocrinology. 2017 12 01; 158(12):4270-4285.
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Constitutive Expression of a Dominant-Negative TGF-ß Type II Receptor in the Posterior Left Atrium Leads to Beneficial Remodeling of Atrial Fibrillation Substrate. Circ Res. 2016 06 24; 119(1):69-82.
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Cardioprotective Signature of Short-Term Caloric Restriction. PLoS One. 2015; 10(6):e0130658.
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Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2. J Med Chem. 2015 Feb 26; 58(4):1976-91.
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Restoration of adiponectin expression via the ERK pathway in TNFa-treated 3T3-L1 adipocytes. Mol Med Rep. 2014 Aug; 10(2):905-10.
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Paxillin mediates stretch-induced Rho signaling and endothelial permeability via assembly of paxillin-p42/44MAPK-GEF-H1 complex. FASEB J. 2014 Jul; 28(7):3249-60.
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A novel p38 mitogen-activated protein kinase/Elk-1 transcription factor-dependent molecular mechanism underlying abnormal endothelial cell proliferation in plexogenic pulmonary arterial hypertension. J Biol Chem. 2013 Sep 06; 288(36):25701-25716.
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RKIP regulates MAP kinase signaling in cells with defective B-Raf activity. Cell Signal. 2013 May; 25(5):1156-65.
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Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation. J Biol Chem. 2012 Apr 27; 287(18):14937-49.