Early Growth Response Protein 2
"Early Growth Response Protein 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An early growth response transcription factor that controls the formation of the MYELIN SHEATH around peripheral AXONS by SCHWANN CELLS. Mutations in EGR2 transcription factor have been associated with HEREDITARY MOTOR AND SENSORY NEUROPATHIES such as CHARCOT-MARIE-TOOTH DISEASE.
| Descriptor ID |
D051767
|
| MeSH Number(s) |
D12.776.260.158.750 D12.776.460.525.750 D12.776.930.213.750
|
| Concept/Terms |
Early Growth Response Protein 2- Early Growth Response Protein 2
- Krox-20 Transcription Factor
- Krox 20 Transcription Factor
- Transcription Factor, Krox-20
- EGR2 Transcription Factor
- Transcription Factor, EGR2
- Krox20 Protein
|
Below are MeSH descriptors whose meaning is more general than "Early Growth Response Protein 2".
Below are MeSH descriptors whose meaning is more specific than "Early Growth Response Protein 2".
This graph shows the total number of publications written about "Early Growth Response Protein 2" by people in this website by year, and whether "Early Growth Response Protein 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2010 | 1 | 0 | 1 |
| 2012 | 2 | 0 | 2 |
| 2013 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Early Growth Response Protein 2" by people in Profiles.
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The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment. J Exp Med. 2017 02; 214(2):381-400.
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Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy. Mol Immunol. 2013 Oct; 55(3-4):283-91.
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Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo. J Exp Med. 2012 Nov 19; 209(12):2157-63.
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Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling. Nat Immunol. 2012 Feb 05; 13(3):264-71.
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Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus. Hum Mol Genet. 2010 Jun 01; 19(11):2313-20.
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A G-coupled receptor protein critical for peripheral nerve myelination. J Mol Cell Biol. 2010 Jun; 2(3):105-6.
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A two-step, PU.1-dependent mechanism for developmentally regulated chromatin remodeling and transcription of the c-fms gene. Mol Cell Biol. 2007 Feb; 27(3):878-87.
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Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell. 2006 Aug 25; 126(4):755-66.
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Neuronal and glial expression of the adhesion molecule TAG-1 is regulated after peripheral nerve lesion or central neurodegeneration of adult nervous system. Eur J Neurosci. 2005 Mar; 21(5):1169-80.
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Methylation at CpG islands in intron 1 of EGR2 confers enhancer-like activity. FEBS Lett. 2003 Nov 06; 554(1-2):67-72.