Suppressor of Cytokine Signaling 1 Protein
"Suppressor of Cytokine Signaling 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS1 functions as a negative regulator of CYTOKINES that signal through the JANUS KINASES-STAT 3 TRANSCRIPTION FACTOR (JAK/STAT3) pathway by inhibiting the activity of JANUS KINASES.
| Descriptor ID |
D000071222
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| MeSH Number(s) |
D12.644.360.024.374.500 D12.776.157.057.249.500 D12.776.476.024.437.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Suppressor of Cytokine Signaling 1 Protein".
Below are MeSH descriptors whose meaning is more specific than "Suppressor of Cytokine Signaling 1 Protein".
This graph shows the total number of publications written about "Suppressor of Cytokine Signaling 1 Protein" by people in this website by year, and whether "Suppressor of Cytokine Signaling 1 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Suppressor of Cytokine Signaling 1 Protein" by people in Profiles.
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N6-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation. Dev Cell. 2020 12 21; 55(6):737-753.e7.
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1,25-Dihydroxyvitamin D promotes negative feedback regulation of TLR signaling via targeting microRNA-155-SOCS1 in macrophages. J Immunol. 2013 Apr 01; 190(7):3687-95.
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The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. J Exp Med. 2011 May 09; 208(5):1001-13.
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Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma. Am J Respir Cell Mol Biol. 2007 Apr; 36(4):491-6.
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Suppressor of cytokine signaling 1 expression protects oligodendrocytes from the deleterious effects of interferon-gamma. J Neurosci. 2006 May 10; 26(19):5143-52.
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IFN-gamma-induced SOCS-1 regulates STAT6-dependent eotaxin production triggered by IL-4 and TNF-alpha. Biochem Biophys Res Commun. 2004 Feb 06; 314(2):468-75.