"Zinc Finger Protein Gli3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.
Descriptor ID |
D000074290
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MeSH Number(s) |
D12.776.260.522.875 D12.776.260.703.900 D12.776.930.375.875 D12.776.930.780.972
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Concept/Terms |
Zinc Finger Protein Gli3- Zinc Finger Protein Gli3
- Glioma-Associated Oncogene Family Zinc Finger 3 Protein
- Glioma Associated Oncogene Family Zinc Finger 3 Protein
- GLI-Kruppel Family Member 3 Protein
- GLI Kruppel Family Member 3 Protein
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Below are MeSH descriptors whose meaning is more general than "Zinc Finger Protein Gli3".
Below are MeSH descriptors whose meaning is more specific than "Zinc Finger Protein Gli3".
This graph shows the total number of publications written about "Zinc Finger Protein Gli3" by people in this website by year, and whether "Zinc Finger Protein Gli3" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1998 | 0 | 1 | 1 |
2000 | 0 | 1 | 1 |
2011 | 0 | 1 | 1 |
2014 | 0 | 1 | 1 |
2017 | 0 | 1 | 1 |
2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Zinc Finger Protein Gli3" by people in Profiles.
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The Shh/Gli3 gene regulatory network precedes the origin of paired fins and reveals the deep homology between distal fins and digits. Proc Natl Acad Sci U S A. 2021 11 16; 118(46).
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Noncanonical Hox, Etv4, and Gli3 gene activities give insight into unique limb patterning in salamanders. J Exp Zool B Mol Dev Evol. 2018 05; 330(3):138-147.
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Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects. Am J Hum Genet. 2017 Oct 05; 101(4):552-563.
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Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation. PLoS Genet. 2014 Oct; 10(10):e1004604.
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Shh and Gli3 regulate formation of the telencephalic-diencephalic junction and suppress an isthmus-like signaling source in the forebrain. Dev Biol. 2011 Nov 15; 359(2):242-50.
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Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J). Dev Biol. 2000 Jan 15; 217(2):254-65.
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The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice. Development. 1998 Jun; 125(12):2315-25.