Zinc Finger E-box-Binding Homeobox 1
"Zinc Finger E-box-Binding Homeobox 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcription factor characterized by N-terminal and C-terminal CYS2-HIS2 ZINC FINGERS separated by a homeobox. It represses the expression of E-CADHERIN to induce the EPITHELIAL-MESENCHYMAL TRANSITION. It also represses PROTO-ONCOGENE PROTEINS C-BCL-6; regulates the cell type-specific expression of SODIUM-POTASSIUM-EXCHANGING ATPASE; and promotes neuronal differentiation.
| Descriptor ID |
D000071799
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| MeSH Number(s) |
D12.776.260.400.906 D12.776.260.703.800 D12.776.930.780.945
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| Concept/Terms |
Zinc Finger E-box-Binding Homeobox 1- Zinc Finger E-box-Binding Homeobox 1
- Zinc Finger E box Binding Homeobox 1
- NIL-2-A Zinc Finger Protein
- NIL 2 A Zinc Finger Protein
- TCF8 Protein
- Zeb1 Transcription Factor
- Transcription Factor, Zeb1
- Transcription Factor 8
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Below are MeSH descriptors whose meaning is more general than "Zinc Finger E-box-Binding Homeobox 1".
Below are MeSH descriptors whose meaning is more specific than "Zinc Finger E-box-Binding Homeobox 1".
This graph shows the total number of publications written about "Zinc Finger E-box-Binding Homeobox 1" by people in this website by year, and whether "Zinc Finger E-box-Binding Homeobox 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Zinc Finger E-box-Binding Homeobox 1" by people in Profiles.
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Breast Cancer Risk-Associated SNPs in the mTOR Promoter Form De Novo KLF5- and ZEB1-Binding Sites that Influence the Cellular Response to Paclitaxel. Mol Cancer Res. 2019 11; 17(11):2244-2256.
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Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma. Cell Rep. 2017 01 24; 18(4):961-976.
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DAB2IP regulates cancer stem cell phenotypes through modulating stem cell factor receptor and ZEB1. Oncogene. 2015 May 21; 34(21):2741-52.
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Detection of primary cilia in human glioblastoma. J Neurooncol. 2014 Mar; 117(1):15-24.
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Reduced expression of miR-200 family members contributes to antiestrogen resistance in LY2 human breast cancer cells. PLoS One. 2013; 8(4):e62334.
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Complete reversal of epithelial to mesenchymal transition requires inhibition of both ZEB expression and the Rho pathway. BMC Cell Biol. 2009 Dec 21; 10:94.
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The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev. 2008 Apr 01; 22(7):894-907.