"Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (Dorland, 28th ed) EC 6.
| Descriptor ID |
D008025
|
| MeSH Number(s) |
D08.811.464
|
| Concept/Terms |
Ligases- Ligases
- Synthetases
- Synthetase
|
Below are MeSH descriptors whose meaning is more general than "Ligases".
Below are MeSH descriptors whose meaning is more specific than "Ligases".
This graph shows the total number of publications written about "Ligases" by people in this website by year, and whether "Ligases" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 1 | 2 |
| 1994 | 1 | 1 | 2 |
| 1995 | 1 | 0 | 1 |
| 1996 | 1 | 1 | 2 |
| 1999 | 1 | 0 | 1 |
| 2000 | 2 | 1 | 3 |
| 2001 | 4 | 2 | 6 |
| 2002 | 3 | 2 | 5 |
| 2003 | 3 | 1 | 4 |
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2012 | 1 | 1 | 2 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ligases" by people in Profiles.
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Structural basis of lipopolysaccharide maturation by the O-antigen ligase. Nature. 2022 04; 604(7905):371-376.
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The Enterococcal Cytolysin Synthetase Coevolves with Substrate for Stereoselective Lanthionine Synthesis. ACS Chem Biol. 2016 09 16; 11(9):2438-46.
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A New N-Acyl Homoserine Lactone Synthase in an Uncultured Symbiont of the Red Sea Sponge Theonella swinhoei. Appl Environ Microbiol. 2016 02 15; 82(4):1274-1285.
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The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold. Elife. 2015 Jul 30; 4.
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The capsular polysaccharide of Staphylococcus aureus is attached to peptidoglycan by the LytR-CpsA-Psr (LCP) family of enzymes. J Biol Chem. 2014 May 30; 289(22):15680-90.
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Development of a selective activity-based probe for adenylating enzymes: profiling MbtA Involved in siderophore biosynthesis from Mycobacterium tuberculosis. ACS Chem Biol. 2012 Oct 19; 7(10):1653-8.
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Structural and functional investigation of the intermolecular interaction between NRPS adenylation and carrier protein domains. Chem Biol. 2012 Feb 24; 19(2):188-98.
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A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination. Nat Struct Mol Biol. 2011 Jan; 18(1):100-6.
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Kinetic and inhibition studies of dihydroxybenzoate-AMP ligase from Escherichia coli. Biochemistry. 2010 May 04; 49(17):3648-57.
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Aryl acid adenylating enzymes involved in siderophore biosynthesis: fluorescence polarization assay, ligand specificity, and discovery of non-nucleoside inhibitors via high-throughput screening. Biochemistry. 2008 Nov 11; 47(45):11735-49.