 Mutagenesis, Insertional
"Mutagenesis, Insertional" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.
| Descriptor ID |
D016254
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| MeSH Number(s) |
E05.393.420.601.550 G05.355.600.550 G05.365.590.575
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| Concept/Terms |
Sequence Insertion- Sequence Insertion
- Insertion, Sequence
- Insertions, Sequence
- Sequence Insertions
Gene Insertion- Gene Insertion
- Gene Insertions
- Insertion, Gene
- Insertions, Gene
Insertion Mutation- Insertion Mutation
- Insertion Mutations
- Mutation, Insertion
- Mutations, Insertion
Insertional Activation- Insertional Activation
- Activation, Insertional
- Activations, Insertional
- Insertional Activations
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Below are MeSH descriptors whose meaning is more general than "Mutagenesis, Insertional".
Below are MeSH descriptors whose meaning is more specific than "Mutagenesis, Insertional".
This graph shows the total number of publications written about "Mutagenesis, Insertional" by people in this website by year, and whether "Mutagenesis, Insertional" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 0 | 2 | 2 | | 1992 | 0 | 2 | 2 | | 1993 | 0 | 5 | 5 | | 1994 | 1 | 3 | 4 | | 1995 | 0 | 2 | 2 | | 1996 | 0 | 3 | 3 | | 1997 | 0 | 5 | 5 | | 1998 | 3 | 2 | 5 | | 1999 | 0 | 2 | 2 | | 2000 | 1 | 3 | 4 | | 2001 | 2 | 4 | 6 | | 2002 | 0 | 3 | 3 | | 2004 | 1 | 2 | 3 | | 2005 | 0 | 1 | 1 | | 2006 | 1 | 3 | 4 | | 2007 | 1 | 0 | 1 | | 2008 | 4 | 1 | 5 | | 2009 | 2 | 3 | 5 | | 2010 | 0 | 3 | 3 | | 2011 | 1 | 3 | 4 | | 2012 | 0 | 6 | 6 | | 2013 | 0 | 3 | 3 | | 2014 | 1 | 1 | 2 | | 2015 | 0 | 3 | 3 | | 2016 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 0 | 2 | 2 | | 2020 | 1 | 1 | 2 | | 2021 | 3 | 0 | 3 |
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Below are the most recent publications written about "Mutagenesis, Insertional" by people in Profiles.
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Le X, Cornelissen R, Garassino M, Clarke JM, Tchekmedyian N, Goldman JW, Leu SY, Bhat G, Lebel F, Heymach JV, Socinski MA. Poziotinib in Non-Small-Cell Lung Cancer Harboring HER2 Exon 20 Insertion Mutations After Prior Therapies: ZENITH20-2 Trial. J Clin Oncol. 2022 03 01; 40(7):710-718.
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Rücker FG, Du L, Luck TJ, Benner A, Krzykalla J, Gathmann I, Voso MT, Amadori S, Prior TW, Brandwein JM, Appelbaum FR, Medeiros BC, Tallman MS, Savoie L, Sierra J, Pallaud C, Sanz MA, Jansen JH, Niederwieser D, Fischer T, Ehninger G, Heuser M, Ganser A, Bullinger L, Larson RA, Bloomfield CD, Stone RM, Döhner H, Thiede C, Döhner K. Molecular landscape and prognostic impact of FLT3-ITD insertion site in acute myeloid leukemia: RATIFY study results. Leukemia. 2022 01; 36(1):90-99.
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Prelaj A, Bottiglieri A, Proto C, Lo Russo G, Signorelli D, Ferrara R, Galli G, De Toma A, Viscardi G, Brambilla M, Lobefaro R, Nichetti F, Manglaviti S, Occhipinti M, Labianca A, Ganzinelli M, Gallucci R, Zilembo N, Greco GF, Torri V, de Braud F, Garassino MC. Poziotinib for EGFR and HER2 exon 20 insertion mutation in advanced NSCLC: Results from the expanded access program. Eur J Cancer. 2021 05; 149:235-248.
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Gerstung M, Jolly C, Leshchiner I, Dentro SC, Gonzalez S, Rosebrock D, Mitchell TJ, Rubanova Y, Anur P, Yu K, Tarabichi M, Deshwar A, Wintersinger J, Kleinheinz K, Vázquez-García I, Haase K, Jerman L, Sengupta S, Macintyre G, Malikic S, Donmez N, Livitz DG, Cmero M, Demeulemeester J, Schumacher S, Fan Y, Yao X, Lee J, Schlesner M, Boutros PC, Bowtell DD, Zhu H, Getz G, Imielinski M, Beroukhim R, Sahinalp SC, Ji Y, Peifer M, Markowetz F, Mustonen V, Yuan K, Wang W, Morris QD. The evolutionary history of 2,658 cancers. Nature. 2020 02; 578(7793):122-128.
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Bruellman R, Watanabe Y, Shareef R, Abdullah MA, Dumitrescu A, Strauss BS, Refetoff S, Weiss RE. Insertion of an Alu Element in Thyroglobulin Gene as a Novel Cause of Congenital Hypothyroidism. Thyroid. 2020 05; 30(5):780-782.
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Jung HJ, Littmann ER, Seok R, Leiner IM, Taur Y, Peled J, van den Brink M, Ling L, Chen L, Kreiswirth BN, Goodman AL, Pamer EG. Genome-Wide Screening for Enteric Colonization Factors in Carbapenem-Resistant ST258 Klebsiella pneumoniae. mBio. 2019 03 12; 10(2).
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Hershey DM, Fiebig A, Crosson S. A Genome-Wide Analysis of Adhesion in Caulobacter crescentus Identifies New Regulatory and Biosynthetic Components for Holdfast Assembly. mBio. 2019 02 12; 10(1).
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Çatli G, Fujisawa H, Kirbiyik Ö, Mimoto MS, Gençpinar P, Özdemir TR, Dündar BN, Dumitrescu AM. A Novel Homozygous Selenocysteine Insertion Sequence Binding Protein 2 (SECISBP2, SBP2) Gene Mutation in a Turkish Boy. Thyroid. 2018 09; 28(9):1221-1223.
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Chatzidaki-Livanis M, Coyne MJ, Roelofs KG, Gentyala RR, Caldwell JM, Comstock LE. Gut Symbiont Bacteroides fragilis Secretes a Eukaryotic-Like Ubiquitin Protein That Mediates Intraspecies Antagonism. mBio. 2017 11 28; 8(6).
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Stoddart A, Qian Z, Fernald AA, Bergerson RJ, Wang J, Karrison T, Anastasi J, Bartom ET, Sarver AL, McNerney ME, Largaespada DA, Le Beau MM. Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms. Haematologica. 2016 06; 101(6):e232-6.
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