 Mutagenesis, Insertional
"Mutagenesis, Insertional" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.
| Descriptor ID |
D016254
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| MeSH Number(s) |
E05.393.420.601.550 G05.355.600.550 G05.365.590.575
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| Concept/Terms |
Sequence Insertion- Sequence Insertion
- Insertion, Sequence
- Insertions, Sequence
- Sequence Insertions
Gene Insertion- Gene Insertion
- Gene Insertions
- Insertion, Gene
- Insertions, Gene
Insertion Mutation- Insertion Mutation
- Insertion Mutations
- Mutation, Insertion
- Mutations, Insertion
Insertional Activation- Insertional Activation
- Activation, Insertional
- Activations, Insertional
- Insertional Activations
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Below are MeSH descriptors whose meaning is more general than "Mutagenesis, Insertional".
Below are MeSH descriptors whose meaning is more specific than "Mutagenesis, Insertional".
This graph shows the total number of publications written about "Mutagenesis, Insertional" by people in this website by year, and whether "Mutagenesis, Insertional" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 0 | 2 | 2 | | 1993 | 0 | 5 | 5 | | 1994 | 1 | 3 | 4 | | 1995 | 0 | 1 | 1 | | 1996 | 0 | 3 | 3 | | 1997 | 0 | 4 | 4 | | 1998 | 3 | 2 | 5 | | 1999 | 0 | 2 | 2 | | 2000 | 1 | 3 | 4 | | 2001 | 2 | 4 | 6 | | 2002 | 0 | 3 | 3 | | 2004 | 1 | 2 | 3 | | 2006 | 1 | 3 | 4 | | 2007 | 1 | 0 | 1 | | 2008 | 4 | 1 | 5 | | 2009 | 2 | 3 | 5 | | 2010 | 0 | 2 | 2 | | 2011 | 1 | 3 | 4 | | 2012 | 0 | 5 | 5 | | 2013 | 0 | 3 | 3 | | 2014 | 1 | 1 | 2 | | 2015 | 0 | 3 | 3 | | 2017 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 0 | 1 | 1 | | 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Mutagenesis, Insertional" by people in Profiles.
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Gerstung M, Jolly C, Leshchiner I, Dentro SC, Gonzalez S, Rosebrock D, Mitchell TJ, Rubanova Y, Anur P, Yu K, Tarabichi M, Deshwar A, Wintersinger J, Kleinheinz K, Vázquez-García I, Haase K, Jerman L, Sengupta S, Macintyre G, Malikic S, Donmez N, Livitz DG, Cmero M, Demeulemeester J, Schumacher S, Fan Y, Yao X, Lee J, Schlesner M, Boutros PC, Bowtell DD, Zhu H, Getz G, Imielinski M, Beroukhim R, Sahinalp SC, Ji Y, Peifer M, Markowetz F, Mustonen V, Yuan K, Wang W, Morris QD. The evolutionary history of 2,658 cancers. Nature. 2020 02; 578(7793):122-128.
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Bruellman R, Watanabe Y, Shareef R, Abdullah MA, Dumitrescu A, Strauss BS, Refetoff S, Weiss RE. Insertion of an Alu Element in Thyroglobulin Gene as a Novel Cause of Congenital Hypothyroidism. Thyroid. 2020 05; 30(5):780-782.
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Jung HJ, Littmann ER, Seok R, Leiner IM, Taur Y, Peled J, van den Brink M, Ling L, Chen L, Kreiswirth BN, Goodman AL, Pamer EG. Genome-Wide Screening for Enteric Colonization Factors in Carbapenem-Resistant ST258 Klebsiella pneumoniae. mBio. 2019 03 12; 10(2).
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Çatli G, Fujisawa H, Kirbiyik Ö, Mimoto MS, Gençpinar P, Özdemir TR, Dündar BN, Dumitrescu AM. A Novel Homozygous Selenocysteine Insertion Sequence Binding Protein 2 (SECISBP2, SBP2) Gene Mutation in a Turkish Boy. Thyroid. 2018 09; 28(9):1221-1223.
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Chatzidaki-Livanis M, Coyne MJ, Roelofs KG, Gentyala RR, Caldwell JM, Comstock LE. Gut Symbiont Bacteroides fragilis Secretes a Eukaryotic-Like Ubiquitin Protein That Mediates Intraspecies Antagonism. mBio. 2017 11 28; 8(6).
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Gebhardt MJ, Gallagher LA, Jacobson RK, Usacheva EA, Peterson LR, Zurawski DV, Shuman HA. Joint Transcriptional Control of Virulence and Resistance to Antibiotic and Environmental Stress in Acinetobacter baumannii. mBio. 2015 Nov 10; 6(6):e01660-15.
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Zhong R, Bao R, Faber PW, Bindokas VP, Bechill J, Lingen MW, Spiotto MT. Notch1 Activation or Loss Promotes HPV-Induced Oral Tumorigenesis. Cancer Res. 2015 Sep 15; 75(18):3958-3969.
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Quintero-Rivera F, Xi QJ, Keppler-Noreuil KM, Lee JH, Higgins AW, Anchan RM, Roberts AE, Seong IS, Fan X, Lage K, Lu LY, Tao J, Hu X, Berezney R, Gelb BD, Kamp A, Moskowitz IP, Lacro RV, Lu W, Morton CC, Gusella JF, Maas RL. MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus. Hum Mol Genet. 2015 Apr 15; 24(8):2375-89.
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Schneewind O, Missiakas D. Genetic manipulation of Staphylococcus aureus. Curr Protoc Microbiol. 2014 Feb 06; 32:Unit 9C.3..
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Tam C, Demke O, Hermanas T, Mitchell A, Hendrickx AP, Schneewind O. YfbA, a Yersinia pestis regulator required for colonization and biofilm formation in the gut of cat fleas. J Bacteriol. 2014 Mar; 196(6):1165-73.
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