Lymphoid Enhancer-Binding Factor 1
"Lymphoid Enhancer-Binding Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A T-cell factor that plays an essential role in EMBRYONIC DEVELOPMENT.
| Descriptor ID |
D051821
|
| MeSH Number(s) |
D12.776.260.730.500 D12.776.660.235.400.800.500 D12.776.664.235.400.800.500 D12.776.930.875.500
|
| Concept/Terms |
Lymphoid Enhancer-Binding Factor 1- Lymphoid Enhancer-Binding Factor 1
- Lymphoid Enhancer Binding Factor 1
- LEF-1 Transcription Factor
- LEF 1 Transcription Factor
- Transcription Factor, LEF-1
- T Cell-Specific Transcription Factor 1-alpha
- T Cell Specific Transcription Factor 1 alpha
|
Below are MeSH descriptors whose meaning is more general than "Lymphoid Enhancer-Binding Factor 1".
Below are MeSH descriptors whose meaning is more specific than "Lymphoid Enhancer-Binding Factor 1".
This graph shows the total number of publications written about "Lymphoid Enhancer-Binding Factor 1" by people in this website by year, and whether "Lymphoid Enhancer-Binding Factor 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 1 | 1 | 2 |
| 2018 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Lymphoid Enhancer-Binding Factor 1" by people in Profiles.
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Oncogenic and Tumor Suppressor Functions for Lymphoid Enhancer Factor 1 in E2a-/- T Acute Lymphoblastic Leukemia. Front Immunol. 2022; 13:845488.
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Wnt signaling pathway involvement in genotypic and phenotypic variations in Waardenburg syndrome type 2 with MITF mutations. J Hum Genet. 2018 May; 63(5):639-646.
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The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation. J Exp Med. 2015 May 04; 212(5):793-807.
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ß-catenin regulates c-Myc and CDKN1A expression in breast cancer cells. Mol Carcinog. 2016 May; 55(5):431-9.
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Nanowire-mediated delivery enables functional interrogation of primary immune cells: application to the analysis of chronic lymphocytic leukemia. Nano Lett. 2012 Dec 12; 12(12):6498-504.
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Marked downregulation of the granulopoiesis regulator LEF1 is associated with disease progression in the myelodysplastic syndromes. Br J Haematol. 2009 Jun; 146(1):86-90.
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Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas. Blood. 2007 Oct 01; 110(7):2650-8.
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Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells. J Biol Chem. 2004 Feb 20; 279(8):6840-6.
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The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6064-9.
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Interactions between Wnt and Vg1 signalling pathways initiate primitive streak formation in the chick embryo. Development. 2001 Aug; 128(15):2915-27.