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Matthew J. Brady

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Endocrinology
AddressChicago IL 60637
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ha CWY, Martin A, Sepich-Poore GD, Shi B, Wang Y, Gouin K, Humphrey G, Sanders K, Ratnayake Y, Chan KSL, Hendrick G, Caldera JR, Arias C, Moskowitz JE, Ho Sui SJ, Yang S, Underhill D, Brady MJ, Knott S, Kaihara K, Steinbaugh MJ, Li H, McGovern DPB, Knight R, Fleshner P, Devkota S. Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans. Cell. 2020 Oct 29; 183(3):666-683.e17. PMID: 32991841.
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    2. Mustafi D, Valek R, Fitch M, Werner V, Fan X, Markiewicz E, Fernandez S, Zamora M, Mueller J, Olopade OI, Conzen SD, Brady MJ, Karczmar GS. Magnetic resonance angiography reveals increased arterial blood supply and tumorigenesis following high fat feeding in a mouse model of triple-negative breast cancer. NMR Biomed. 2020 10; 33(10):e4363. PMID: 32881124.
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    3. Rossi RM, Brady MJ, Hall ES, Warshak CR. Effect of Needle Exchange Program on Maternal Hepatitis C Virus Prevalence. Am J Perinatol. 2020 07; 37(9):881-889. PMID: 31962347.
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    4. Casimiro I, Hanlon EC, White J, De Leon A, Ross R, Moise K, Piron M, Brady MJ. Reduction of IL-6 gene expression in human adipose tissue after sleeve gastrectomy surgery. Obes Sci Pract. 2020 Apr; 6(2):215-224. PMID: 32313680.
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    5. White JM, Piron MJ, Rangaraj VR, Hanlon EC, Cohen RN, Brady MJ. Reference Gene Optimization for Circadian Gene Expression Analysis in Human Adipose Tissue. J Biol Rhythms. 2020 02; 35(1):84-97. PMID: 31668115.
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    6. Dybala MP, Brady MJ, Hara M. Disparity in Adiposity among Adults with Normal Body Mass Index and Waist-to-Height Ratio. iScience. 2019 Nov 22; 21:612-623. PMID: 31731199.
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    7. Strober JW, Brady MJ. Dietary Fructose Consumption and Triple-Negative Breast Cancer Incidence. Front Endocrinol (Lausanne). 2019; 10:367. PMID: 31244777.
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    8. Casimiro I, Sam S, Brady MJ. Endocrine implications of bariatric surgery: a review on the intersection between incretins, bone, and sex hormones. Physiol Rep. 2019 05; 7(10):e14111. PMID: 31134746.
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    9. Johnson MB, Hoffmann JN, You HM, Lastra RR, Fernandez S, Strober JW, Allaw AB, Brady MJ, Conzen SD, McClintock MK. Psychosocial Stress Exposure Disrupts Mammary Gland Development. J Mammary Gland Biol Neoplasia. 2018 06; 23(1-2):59-73. PMID: 29687293.
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    10. He D, Mustafi D, Fan X, Fernandez S, Markiewicz E, Zamora M, Mueller J, Sachleben JR, Brady MJ, Conzen SD, Karczmar GS. Magnetic resonance spectroscopy detects differential lipid composition in mammary glands on low fat, high animal fat versus high fructose diets. PLoS One. 2018; 13(1):e0190929. PMID: 29324859.
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    11. Coats BR, Schoenfelt KQ, Barbosa-Lorenzi VC, Peris E, Cui C, Hoffman A, Zhou G, Fernandez S, Zhai L, Hall BA, Haka AS, Shah AM, Reardon CA, Brady MJ, Rhodes CJ, Maxfield FR, Becker L. Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity. Cell Rep. 2017 Sep 26; 20(13):3149-3161. PMID: 28954231.
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    12. Mustafi D, Fernandez S, Markiewicz E, Fan X, Zamora M, Mueller J, Brady MJ, Conzen SD, Karczmar GS. MRI reveals increased tumorigenesis following high fat feeding in a mouse model of triple-negative breast cancer. NMR Biomed. 2017 Oct; 30(10). PMID: 28661075.
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    13. Kunze KN, Hanlon EC, Prachand VN, Brady MJ. Peripheral circadian misalignment: contributor to systemic insulin resistance and potential intervention to improve bariatric surgical outcomes. . 2016 09 01; 311(3):R558-63. PMID: 27465735.
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    14. Brady MJ. Coordinate mobilization and burning of lipid stores. Focus on "Protein kinase A induces UCP1 expression in specific adipose depots to increase energy expenditure and improve metabolic health". . 2016 07 01; 311(1):R10-1. PMID: 27225951.
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    15. Carmean CM, Huang YH, Brady MJ. Glycogen Repletion in Brown Adipose Tissue upon Refeeding Is Primarily Driven by Phosphorylation-Independent Mechanisms. PLoS One. 2016; 11(5):e0156148. PMID: 27213961.
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    16. Volden PA, Skor MN, Johnson MB, Singh P, Patel FN, McClintock MK, Brady MJ, Conzen SD. Mammary Adipose Tissue-Derived Lysophospholipids Promote Estrogen Receptor-Negative Mammary Epithelial Cell Proliferation. Cancer Prev Res (Phila). 2016 05; 9(5):367-78. PMID: 26862086.
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    17. Singh P, Brock CO, Volden PA, Hernandez K, Skor M, Kocherginsky M, Park JE, Brady MJ, Conzen SD. Glucocorticoid receptor ChIP-sequencing of subcutaneous fat reveals modulation of inflammatory pathways. Obesity (Silver Spring). 2015 Nov; 23(11):2286-93. PMID: 26408078.
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    18. Bailey KA, Savic D, Zielinski M, Park SY, Wang LJ, Witkowski P, Brady M, Hara M, Bell GI, Nobrega MA. Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice. Hum Mol Genet. 2015 Mar 15; 24(6):1646-54. PMID: 25398947.
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    19. Zhang SX, Khalyfa A, Wang Y, Carreras A, Hakim F, Neel BA, Brady MJ, Qiao Z, Hirotsu C, Gozal D. Sleep fragmentation promotes NADPH oxidase 2-mediated adipose tissue inflammation leading to insulin resistance in mice. Int J Obes (Lond). 2014 Apr; 38(4):619-24. PMID: 23897221.
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    20. Carmean CM, Bobe AM, Yu JC, Volden PA, Brady MJ. Refeeding-induced brown adipose tissue glycogen hyper-accumulation in mice is mediated by insulin and catecholamines. PLoS One. 2013; 8(7):e67807. PMID: 23861810.
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    21. Volden PA, Wonder EL, Skor MN, Carmean CM, Patel FN, Ye H, Kocherginsky M, McClintock MK, Brady MJ, Conzen SD. Chronic social isolation is associated with metabolic gene expression changes specific to mammary adipose tissue. Cancer Prev Res (Phila). 2013 Jul; 6(7):634-45. PMID: 23780289.
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    22. Carmean CM, Cohen RN, Brady MJ. Systemic regulation of adipose metabolism. Biochim Biophys Acta. 2014 Mar; 1842(3):424-30. PMID: 23774083.
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    23. Huang EY, Leone VA, Devkota S, Wang Y, Brady MJ, Chang EB. Composition of dietary fat source shapes gut microbiota architecture and alters host inflammatory mediators in mouse adipose tissue. JPEN J Parenter Enteral Nutr. 2013 Nov; 37(6):746-54. PMID: 23639897.
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    24. Neel BA, Brady MJ, Sargis RM. The endocrine disrupting chemical tolylfluanid alters adipocyte metabolism via glucocorticoid receptor activation. Mol Endocrinol. 2013 Mar; 27(3):394-406. PMID: 23340252.
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    25. Koshy AA, Bobe AM, Brady MJ. Potential mechanisms by which bariatric surgery improves systemic metabolism. Transl Res. 2013 Feb; 161(2):63-72. PMID: 23079469.
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    26. Broussard JL, Ehrmann DA, Van Cauter E, Tasali E, Brady MJ. Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study. Ann Intern Med. 2012 Oct 16; 157(8):549-57. PMID: 23070488.
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    27. Zhang W, Sargis RM, Volden PA, Carmean CM, Sun XJ, Brady MJ. PCB 126 and other dioxin-like PCBs specifically suppress hepatic PEPCK expression via the aryl hydrocarbon receptor. PLoS One. 2012; 7(5):e37103. PMID: 22615911.
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    28. Glick D, Zhang W, Beaton M, Marsboom G, Gruber M, Simon MC, Hart J, Dorn GW, Brady MJ, Macleod KF. BNip3 regulates mitochondrial function and lipid metabolism in the liver. Mol Cell Biol. 2012 Jul; 32(13):2570-84. PMID: 22547685.
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    29. Sargis RM, Neel BA, Brock CO, Lin Y, Hickey AT, Carlton DA, Brady MJ. The novel endocrine disruptor tolylfluanid impairs insulin signaling in primary rodent and human adipocytes through a reduction in insulin receptor substrate-1 levels. Biochim Biophys Acta. 2012 Jun; 1822(6):952-60. PMID: 22387882.
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    30. Wong KE, Kong J, Zhang W, Szeto FL, Ye H, Deb DK, Brady MJ, Li YC. Targeted expression of human vitamin D receptor in adipocytes decreases energy expenditure and induces obesity in mice. J Biol Chem. 2011 Sep 30; 286(39):33804-10. PMID: 21840998.
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    31. Brady MJ. Allosteric trumps covalent in the control of glycogen synthesis. Cell Metab. 2010 Nov 03; 12(5):428-30. PMID: 21035754.
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    32. Broussard J, Brady MJ. The impact of sleep disturbances on adipocyte function and lipid metabolism. Best Pract Res Clin Endocrinol Metab. 2010 Oct; 24(5):763-73. PMID: 21112024.
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    33. Markan KR, Jurczak MJ, Allison MB, Ye H, Sutanto MM, Cohen RN, Brady MJ. Enhanced glycogen metabolism in adipose tissue decreases triglyceride mobilization. Am J Physiol Endocrinol Metab. 2010 Jul; 299(1):E117-25. PMID: 20424138.
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    34. Sutanto MM, Ferguson KK, Sakuma H, Ye H, Brady MJ, Cohen RN. The silencing mediator of retinoid and thyroid hormone receptors (SMRT) regulates adipose tissue accumulation and adipocyte insulin sensitivity in vivo. J Biol Chem. 2010 Jun 11; 285(24):18485-95. PMID: 20371609.
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    35. Jurczak MJ, Zapater JL, Greenberg CC, Brady MJ. Generation of a dominant-negative glycogen targeting subunit for protein phosphatase-1. Obesity (Silver Spring). 2010 Oct; 18(10):1881-7. PMID: 20203631.
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    36. Sargis RM, Brady MJ. Making fat work. Perspect Biol Med. 2010; 53(4):630-47. PMID: 21037416.
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    37. Sargis RM, Johnson DN, Choudhury RA, Brady MJ. Environmental endocrine disruptors promote adipogenesis in the 3T3-L1 cell line through glucocorticoid receptor activation. Obesity (Silver Spring). 2010 Jul; 18(7):1283-8. PMID: 19927138.
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    38. Markan KR, Jurczak MJ, Brady MJ. Stranger in a strange land: roles of glycogen turnover in adipose tissue metabolism. Mol Cell Endocrinol. 2010 Apr 29; 318(1-2):54-60. PMID: 19703517.
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    39. Danos AM, Osmanovic S, Brady MJ. Differential regulation of glycogenolysis by mutant protein phosphatase-1 glycogen-targeting subunits. J Biol Chem. 2009 Jul 17; 284(29):19544-53. PMID: 19487702.
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    40. Brady MJ, Thomas J, Wong TZ, Franklin KM, Ho LM, Paulson EK. Adrenal nodules at FDG PET/CT in patients known to have or suspected of having lung cancer: a proposal for an efficient diagnostic algorithm. Radiology. 2009 Feb; 250(2):523-30. PMID: 19188319.
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    41. Samarasinghe SP, Sutanto MM, Danos AM, Johnson DN, Brady MJ, Cohen RN. Altering PPARgamma ligand selectivity impairs adipogenesis by thiazolidinediones but not hormonal inducers. Obesity (Silver Spring). 2009 May; 17(5):965-72. PMID: 19165156.
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    42. Ho LM, Paulson EK, Brady MJ, Wong TZ, Schindera ST. Lipid-poor adenomas on unenhanced CT: does histogram analysis increase sensitivity compared with a mean attenuation threshold? AJR Am J Roentgenol. 2008 Jul; 191(1):234-8. PMID: 18562751.
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    43. Jurczak MJ, Danos AM, Rehrmann VR, Brady MJ. The role of protein translocation in the regulation of glycogen metabolism. J Cell Biochem. 2008 May 15; 104(2):435-43. PMID: 18022842.
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    44. Kim J, Temple KA, Jones SA, Meredith KN, Basko JL, Brady MJ. Differential modulation of 3T3-L1 adipogenesis mediated by 11beta-hydroxysteroid dehydrogenase-1 levels. J Biol Chem. 2007 Apr 13; 282(15):11038-46. PMID: 17311922.
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    45. Temple KA, Basko X, Allison MB, Brady MJ. Uncoupling of 3T3-L1 gene expression from lipid accumulation during adipogenesis. FEBS Lett. 2007 Feb 06; 581(3):469-74. PMID: 17239864.
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    46. Jurczak MJ, Danos AM, Rehrmann VR, Allison MB, Greenberg CC, Brady MJ. Transgenic overexpression of protein targeting to glycogen markedly increases adipocytic glycogen storage in mice. Am J Physiol Endocrinol Metab. 2007 Mar; 292(3):E952-63. PMID: 17132821.
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    47. Arden C, Green AR, Hampson LJ, Aiston S, Härndahl L, Greenberg CC, Brady MJ, Freeman S, Poucher SM, Agius L. Increased sensitivity of glycogen synthesis to phosphorylase-a and impaired expression of the glycogen-targeting protein R6 in hepatocytes from insulin-resistant Zucker fa/fa rats. FEBS J. 2006 May; 273(9):1989-99. PMID: 16640562.
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    48. Greenberg CC, Jurczak MJ, Danos AM, Brady MJ. Glycogen branches out: new perspectives on the role of glycogen metabolism in the integration of metabolic pathways. Am J Physiol Endocrinol Metab. 2006 Jul; 291(1):E1-8. PMID: 16478770.
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    49. Greenberg CC, Danos AM, Brady MJ. Central role for protein targeting to glycogen in the maintenance of cellular glycogen stores in 3T3-L1 adipocytes. Mol Cell Biol. 2006 Jan; 26(1):334-42. PMID: 16354703.
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    50. Ou H, Yan L, Mustafi D, Makinen MW, Brady MJ. The vanadyl (VO2+) chelate bis(acetylacetonato)oxovanadium(IV) potentiates tyrosine phosphorylation of the insulin receptor. J Biol Inorg Chem. 2005 Dec; 10(8):874-86. PMID: 16235045.
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    51. Dunn KJ, Brady M, Ochsenbauer-Jambor C, Snyder S, Incao A, Pavan WJ. WNT1 and WNT3a promote expansion of melanocytes through distinct modes of action. Pigment Cell Res. 2005 Jun; 18(3):167-80. PMID: 15892713.
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    52. Yu C, Markan K, Temple KA, Deplewski D, Brady MJ, Cohen RN. The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis. J Biol Chem. 2005 Apr 08; 280(14):13600-5. PMID: 15691842.
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    53. Ou H, Yan L, Osmanovic S, Greenberg CC, Brady MJ. Spatial reorganization of glycogen synthase upon activation in 3T3-L1 adipocytes. Endocrinology. 2005 Jan; 146(1):494-502. PMID: 15486231.
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    54. Brady MJ. IRS2 takes center stage in the development of type 2 diabetes. J Clin Invest. 2004 Oct; 114(7):886-8. PMID: 15467824.
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    55. Green AR, Aiston S, Greenberg CC, Freeman S, Poucher SM, Brady MJ, Agius L. The glycogenic action of protein targeting to glycogen in hepatocytes involves multiple mechanisms including phosphorylase inactivation and glycogen synthase translocation. J Biol Chem. 2004 Nov 05; 279(45):46474-82. PMID: 15322104.
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    56. Zhou XY, Shibusawa N, Naik K, Porras D, Temple K, Ou H, Kaihara K, Roe MW, Brady MJ, Wondisford FE. Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein. Nat Med. 2004 Jun; 10(6):633-7. PMID: 15146178.
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    57. Lerín C, Montell E, Nolasco T, Clark C, Brady MJ, Newgard CB, Gómez-Foix AM. Regulation and function of the muscle glycogen-targeting subunit of protein phosphatase 1 (GM) in human muscle cells depends on the COOH-terminal region and glycogen content. Diabetes. 2003 Sep; 52(9):2221-6. PMID: 12941760.
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    58. Greenberg CC, Meredith KN, Yan L, Brady MJ. Protein targeting to glycogen overexpression results in the specific enhancement of glycogen storage in 3T3-L1 adipocytes. J Biol Chem. 2003 Aug 15; 278(33):30835-42. PMID: 12805359.
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    59. Yan L, Nairn AC, Palfrey HC, Brady MJ. Glucose regulates EF-2 phosphorylation and protein translation by a protein phosphatase-2A-dependent mechanism in INS-1-derived 832/13 cells. J Biol Chem. 2003 May 16; 278(20):18177-83. PMID: 12644453.
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    60. Brady MJ. Measurement of glycogen synthesis and glycogen synthase activity in 3T3-L1 adipocytes. Methods Mol Med. 2003; 83:155-61. PMID: 12619727.
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    61. Lin Y, Brady MJ, Wolanske K, Holbert R, Ruderman NB, Yaney GC. Alterations of nPKC distribution, but normal Akt/PKB activation in denervated rat soleus muscle. Am J Physiol Endocrinol Metab. 2002 Aug; 283(2):E318-25. PMID: 12110537.
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    62. Makinen MW, Brady MJ. Structural origins of the insulin-mimetic activity of bis(acetylacetonato)oxovanadium(IV). J Biol Chem. 2002 Apr 05; 277(14):12215-20. PMID: 11815612.
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    63. Yang R, Cao L, Gasa R, Brady MJ, Sherry AD, Newgard CB. Glycogen-targeting subunits and glucokinase differentially affect pathways of glycogen metabolism and their regulation in hepatocytes. J Biol Chem. 2002 Jan 11; 277(2):1514-23. PMID: 11600496.
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    64. Rosen A, Isaacson D, Brady M, Corey JP. Hypersensitivity to latex in health care workers: report of five cases. Otolaryngol Head Neck Surg. 1993 Oct; 109(4):731-4. PMID: 8233512.
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    65. Brady MJ, Palfrey HC. Rapid and sustained phosphorylation of a calmodulin-binding protein (CaM-BP100) in NGF-treated PC12 cells. J Biol Chem. 1993 Aug 25; 268(24):17951-8. PMID: 8394355.
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    66. Brady MJ, Nairn AC, Wagner JA, Palfrey HC. Nerve growth factor-induced down-regulation of calmodulin-dependent protein kinase III in PC12 cells involves cyclic AMP-dependent protein kinase. J Neurochem. 1990 Mar; 54(3):1034-9. PMID: 1689374.
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