(Volchenboum, S.L.)Jan 1, 2022 - Dec 3, 2025 Innovation in Cancer Informatics GEARBOx - a multisite clinical trial matching tool for children with relapsed or refractory cancer Role Description: Project Goal: The University of Chicago’s Pediatric Cancer Data Commons (PCDC) team has built a platform
called GEARBOx (Genomic Eligibility Algorithm at Relapse for Better Outcomes) that enables clinicians to match their acute myelogenous leukemia (AML) patients with open clinical trials for relapsed or refractory disease. In this grant, GEARBOx will be expanded to several other types of pediatric cancer and more efficient ways to extract criteria from trials using natural language processing will be developed. Connections to third parties, such as Foundation Medicine, Inc, will also be established to facilitate the automatic import of genomic biomarkers for faster and more accurate trial matching |
|
R21-CA259771 (Skapek, S)Apr 2, 2021 - Mar 31, 2023 NIH/NCI Identifying neuroblastoma drivers and bringing them to the clinic Role Description: Project Goals: The goal of this project is to identify drivers of aggressive neuroblastoma by integrating copy number and expression analysis. A second aim is to perform functional validation of in silico hits.
Specific Aims: 1. To uncover oncogenic drivers and tumor suppressors in neuroblastoma by using iExCN, a Bayesian-based, intregrative analysis algorithm; 2. To experimentally validate iExCN-predicted drivers and tumor suppressors in a panel neuroblastoma cell lines and PDX models; 3. To explore how CNVs and expression of iExCN genes correlate with clinical variables to improve risk stratification models and guide therapy for children with neuroblastoma. |
|
(Cohn, S.L.)Jul 1, 2020 - Jun 30, 2022 Hyundai Hope on Wheels Targeting DNA Double Strand Break (DSB) Repair Pathways Neuroblastoma Role Description: Project Goals: The overall goal of this study is to target proteins that promote efficient DNA damage repair in neuroblastoma to abrogate treatment resistance and improve the outcome of children with high-risk.
Specific Aims: 1) To functionally characterize how MELK, EZH2, and MYCN mediate competent HR DSB repair. 2) To investigate the activity of PARP inhibitors in neuroblastoma cells with HR deficiency due to
MELK, EZH2, or MYCN inhibition and treatment resistance in neuroblastoma cells: |
|
(Volchenboum, S.L.)Jul 1, 2019 - Jun 30, 2022 St. Baldrick's Foundation Pediatric Cancer Data Commons Role Description: Project Goals: The goal of this St. Baldrick’s Consortium Grant is to develop a comprehensive Pediatric Cancer Data Commons to advance pediatric oncology research by harmonizing, collecting, storing, and sharing large amounts of clinical trials data from studies of children with cancer.
Specific Aims: 1) Profile available sources of pediatric oncology clinical data and current data standards for
pediatric cancer. 2) Establish a data dictionary for pediatric cancer clinical data and harmonize existing data sets. 3) Provide cohort discovery, data access tools and processes, and education and training to the
pediatric oncology community. |
|
Dec 31, 2017 - Dec 30, 2019 Hyundai Hope on Wheels MELK, A New Therapeutic Target for Neuroblastoma Role: Principal Investigator |
|
Oct 1, 2017 - Sep 30, 2019 Alex's Lemonade Stand Foundation Genome-Wide 5hmC Profiling of Neuroblastoma Tumors and Patient Cell-free DNA Role: Principal Investigator |
|
UL1TR002389 (SOLWAY, JULIAN)Sep 6, 2017 - Jun 30, 2027 NIH The Institute for Translational Medicine Role: Co-Investigator |
|
R21CA173297 (COHN, SUSAN L.)Jul 1, 2013 - Jun 30, 2015 NIH Mechanisms of Pancreatic Cancer Inhibition by SPARC Role: Principal Investigator |
|
R21NS080120 (COHN, SUSAN L.)Mar 1, 2013 - Feb 28, 2015 NIH Mechanism of SPARC peptide FSEC inhibition of angiogenesis in neuroblastoma Role: Principal Investigator |
|
R01NS049814 (COHN, SUSAN L)Jul 1, 2004 - Apr 30, 2009 NIH The Role of SPARC in Neuroblastoma Angiogenesis Role: Principal Investigator |
|
R01CA074824 (COHN, SUSAN L)Aug 1, 1997 - May 31, 2002 NIH ELAV-LIKE PROTEINS IN NEUROBLASTOMA Role: Principal Investigator |
|
R03HS007846 (COHN, SUSAN E)Sep 30, 1992 - Sep 29, 1994 NIH VARIATIONS BETWEEN RURAL AND URBAN AIDS CARE Role: Principal Investigator |
|
R29CA051061 (COHN, SUSAN L)Jul 1, 1990 - Jun 30, 1995 NIH MOLECULAR MECHANISMS OF DIFFERENTIATION IN NEUROBLASTOMA Role: Principal Investigator |
|
U10CA007431 (COHN, SUSAN L)Dec 1, 1978 - Dec 31, 2002 NIH PEDIATRIC ONCOLOGY GROUP Role: Principal Investigator |