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Tao Pan

TitleProfessor
InstitutionUniversity of Chicago
DepartmentBiochemistry and Molecular Biology
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    Our research focuses on (i) functional genomics and biology of tRNA including microbiomes and (ii) epitranscriptomics including microbiome-host interactions.

    tRNA biology: Translational regulation relies on the dynamic properties of tRNA that constantly change to facilitate response and adaptation to new environments and to control gene expression. We developed high throughput sequencing technologies that measure tRNA abundance, charging and modifications in one single sequencing library. We are investigating the roles of tRNA in translational control and extra-translational functions in mammalian cells.

    Microbiome: We also developed tRNA-seq as another approach for microbiome characterization. Standard microbiome characterizations include 16S-seq or shotgun metagenomics. Although powerful, these DNA-based methods do not directly report the microbiome activity such as dynamic gene expression which requires the studies of RNA in the microbiome. Our microbiome tRNA-seq results show extensive variations of tRNA abundance and modification patterns in microbiomes from different sources. We also show that tRNA modification dynamics in the microbiome correlates with tuning the expression of specific microbial proteins, indicating that tRNA-seq can provide new insights in microbiome biology. We are further developing this approach to explore the potentials of tRNA-seq to study microbiomes from humans and from the oceans.

    Epitranscriptomics: Over 100 types of post-transcriptional RNA modifications have been identified in thousands of sites in the transcriptome. They include methylation of bases and the ribose backbone, rotation and reduction of uridine, base deamination, addition of ring structures and carbohydrate moieties, and so on. mRNA modifications are involved in cell differentiation, proliferation, and many other cellular functions and human diseases. Some mRNA modifications can also be removed by cellular enzymes, resulting in the dynamic regulation of their functions. We are investigating the function and mechanisms of mRNA modifications such as N6-methyladenosine (m6A) in the regulation of gene expression. For example, we discovered that m6A modification can alter the local mRNA structure to regulate binding of mRNA binding proteins transcriptome-wide (m6A switch), resulting in changes in mRNA abundance and alternative splicing.

    Microbiome-host interactions through epitranscriptomics: We are working on elucidating the function of mammalian host mRNA and tRNA modifications in response to the gut microbiome. We found that microbiome reprograms the host m6A modifications transcriptome-wide in a tissue-dependent manner, suggesting that this dynamic epitranscriptomic mark is used in yet unknown ways in microbiome response. We also found that a microbiome dependent, host tRNA modification alters the cellular small RNA pool, suggesting yet another pathway of microbiome response through RNA modifications.
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    Collapse Biography 
    Collapse education and training
    University des Saarlands, GermanyBS/MS06/1986Chemistry
    Yale University, New Haven, CTPh.D.08/1990Biophysics/Biochemistry
    University of Colorado at Boulder, Boulder, COpostdoctoral12/1993Biochemistry
    Collapse awards and honors
    1991 - 1993Damon Runyon-Walter Winchell Cancer Research Fund
    1994Cancer Research Foundation, Raymond F. Zelko Young Investigator
    1995 - 1997American Cancer Society, Junior Faculty Research Award
    2009 - 2013NIH EUREKA award
    2011 - 2016NIH Director’s Pioneer award
    2015American Association for the Advancement of Science (AAAS) Fellow

    Collapse Research 
    Collapse research activities and funding
    R56AI141343     (SIMON, VIVIANA A)Aug 1, 2019 - Jul 31, 2020
    NIH
    Defining the role of pseudouridine modifications in HIV biology
    Role: Co-Principal Investigator

    R21AI125236     (SIMON, VIVIANA A)Jun 25, 2016 - May 31, 2018
    NIH
    N6-methyladenosine and the biology of HIV
    Role: Co-Principal Investigator

    R01GM113194     (PAN, TAO)Sep 1, 2015 - Jun 30, 2023
    NIH
    Recognition and mechanism of N6-methyl adenosine modifications
    Role: Principal Investigator

    DP1GM105386     (PAN, TAO)Sep 30, 2011 - Jul 31, 2017
    NIH
    Mis-translation as a new mechanism of stress response in biology
    Role: Principal Investigator

    DP1OD008169     (PAN, TAO)Sep 30, 2011 - Jul 31, 2012
    NIH
    Mis-translation as a new mechanism of stress response in biology
    Role: Principal Investigator

    R01GM088599     (PAN, TAO)Aug 1, 2009 - Jul 31, 2014
    NIH
    Discovering the epigenetics of RNA modifications
    Role: Principal Investigator

    R21GM073747     (PAN, TAO)Apr 1, 2005 - Mar 31, 2008
    NIH
    Studies of RNA modifications on the genomic scale
    Role: Principal Investigator

    R01GM057880     (PAN, TAO)Aug 1, 1998 - Apr 30, 2013
    NIH
    Kinetic/Thermodynamic/Structural studies of RNA folding
    Role: Principal Investigator

    R56GM057880     (PAN, TAO)Aug 1, 1998 - Apr 30, 2008
    NIH
    Kinetic/Thermodynamic/Structural Studies of RNA Folding
    Role: Principal Investigator

    R01GM052993     (PAN, TAO)Aug 4, 1995 - Jul 31, 2004
    NIH
    FOLDING AND CATALYSIS OF THE RIBOZYME FROM RNASE P
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yuan L, Chen X, Huang Y, Chen J, Pan T. Spectral separation degree method for Vis-NIR spectroscopic discriminant analysis of milk powder adulteration. Spectrochim Acta A Mol Biomol Spectrosc. 2023 Nov 15; 301:122975. PMID: 37301030.
      Citations:    Fields:    Translation:AnimalsPHPublic Health
    2. Tian Y, Ran H, Wen X, Fu G, Zhou X, Liu R, Pan T. Probiotics improve symptoms of patients with COVID-19 through gut-lung axis: a systematic review and meta-analysis. Front Nutr. 2023; 10:1179432. PMID: 37284648; PMCID: PMC10239816.
      Citations: 1     
    3. Li W, Fan G, Sun K, Liu J, Liu J, Wang Y, Li E, Wu X, Shen L, Pan T. Microbial community structure dynamics of invasive bullfrog with meningitis-like infectious disease. Front Microbiol. 2023; 14:1126195. PMID: 36992930; PMCID: PMC10040567.
      Citations:    
    4. Huang Y, Zhang L, Li Y, Ren C, Pan T, Zhang W, Zhang F, Li C, Gu J, Liu J. Characteristics of the Northern Hemisphere cold regions changes from 1901 to 2019. Sci Rep. 2023 Mar 08; 13(1):3879. PMID: 36890155; PMCID: PMC9995312.
      Citations:    Fields:    
    5. Lu Z, Pan T, Wang Y, Xie Y. [Surgical issues and managements in cochlear reimplantation in 32 children]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2023 Mar; 37(3):218-221. PMID: 36843522; PMCID: PMC10320666.
      Citations:    Translation:Humans
    6. Hernandez-Alias X, Katanski CD, Zhang W, Assari M, Watkins CP, Schaefer MH, Serrano L, Pan T. Single-read tRNA-seq analysis reveals coordination of tRNA modification and aminoacylation and fragmentation. Nucleic Acids Res. 2023 02 22; 51(3):e17. PMID: 36537222; PMCID: PMC9943672.
      Citations: 1     Fields:    Translation:Cells
    7. Kiefl E, Esen OC, Miller SE, Kroll KL, Willis AD, Pan T, Eren AM, Rappé MS. Structure-informed microbial population genetics elucidate selective pressures that shape protein evolution. Sci Adv. 2023 02 22; 9(8):eabq4632. PMID: 36812328.
      Citations: 4     Fields:    Translation:Cells
    8. Tian Y, Pan T, Wen X, Ao G, Ma Y, Liu X, Liu R, Ran H. Efficacy and Safety of Direct Oral Anticoagulants Compared With Heparin for Preventing Thromboembolism in Hospitalized Patients With COVID-19: A Systematic Review and Meta-Analysis. Clin Appl Thromb Hemost. 2023 Jan-Dec; 29:10760296231164355. PMID: 37131319; PMCID: PMC10170187.
      Citations:    Fields:    Translation:Humans
    9. Xie Y, Wang Y, Pan T, Tyler RS. Validation of the Chinese Translation of the "Meaning of Life" in Patients with Hearing Loss or Tinnitus. J Am Acad Audiol. 2022 Dec 10. PMID: 36495866.
      Citations:    Fields:    
    10. Su M, Pan T, Chen QZ, Zhou WW, Gong Y, Xu G, Yan HY, Li S, Shi QZ, Zhang Y, He X, Jiang CJ, Fan SC, Li X, Cairns MJ, Wang X, Li YS. Data analysis guidelines for single-cell RNA-seq in biomedical studies and clinical applications. Mil Med Res. 2022 12 02; 9(1):68. PMID: 36461064.
      Citations: 6     Fields:    Translation:Humans
    11. Wang X, Liu Y, Lu Y, Chen S, Xing Y, Yang H, Wang X, Zhang Y, Pan T, Li J, Wang M, Zhang N, Liang M, Zhou F. Clinical impact of Fn-induced high expression of KIR2DL1 in CD8 T lymphocytes in oesophageal squamous cell carcinoma. Ann Med. 2022 Dec; 54(1):51-62. PMID: 34935568; PMCID: PMC8725851.
      Citations: 5     Fields:    Translation:HumansCells
    12. Katanski CD, Alshammary H, Watkins CP, Huang S, Gonzales-Reiche A, Sordillo EM, van Bakel H, Mount Sinai PSP study group, Lolans K, Simon V, Pan T. tRNA abundance, modification and fragmentation in nasopharyngeal swabs as biomarkers for COVID-19 severity. Front Cell Dev Biol. 2022; 10:999351. PMID: 36393870; PMCID: PMC9664364.
      Citations: 2     
    13. Fan Z, Yu B, Pan T, Li F, Li J, Hou J, Liu W, Su L, Zhu Z, Yan C, Liu B. DKK1 as a robust predictor for adjuvant platinum chemotherapy benefit in resectable pStage II-III gastric cancer. Transl Oncol. 2022 Nov 01; 27:101577. PMID: 36332599; PMCID: PMC9636483.
      Citations:    
    14. Dai Q, Zhang LS, Sun HL, Pajdzik K, Yang L, Ye C, Ju CW, Liu S, Wang Y, Zheng Z, Zhang L, Harada BT, Dou X, Irkliyenko I, Feng X, Zhang W, Pan T, He C. Quantitative sequencing using BID-seq uncovers abundant pseudouridines in mammalian mRNA at base resolution. Nat Biotechnol. 2023 03; 41(3):344-354. PMID: 36302989; PMCID: PMC10017504.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    15. Katanski CD, Watkins CP, Zhang W, Reyer M, Miller S, Pan T. Analysis of queuosine and 2-thio tRNA modifications by high throughput sequencing. Nucleic Acids Res. 2022 09 23; 50(17):e99. PMID: 35713550; PMCID: PMC9508811.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    16. Wang L, Wu J, Liu R, Chen W, Pang Z, Zhou F, Xia L, Huang J, Pan T, Su XZ, Wang X. Epitranscriptome profiling of spleen mRNA m6A methylation reveals pathways of host responses to malaria parasite infection. Front Immunol. 2022; 13:998756. PMID: 36203583; PMCID: PMC9531237.
      Citations:    Fields:    Translation:AnimalsCells
    17. Gao L, Gao D, Zhang J, Li C, Wu M, Xiao Y, Yang L, Ma T, Wang X, Zhang M, Yang D, Pan T, Zhang H, Wang A, Jin Y, Chen H. Age-related endoplasmic reticulum stress represses testosterone synthesis via attenuation of the circadian clock in Leydig cells. Theriogenology. 2022 Sep 01; 189:137-149. PMID: 35753227.
      Citations: 2     Fields:    Translation:AnimalsCells
    18. Zou H, Pan T, Gao Y, Chen R, Li S, Guo J, Tian Z, Xu G, Xu J, Ma Y, Li Y. Pan-cancer assessment of mutational landscape in intrinsically disordered hotspots reveals potential driver genes. Nucleic Acids Res. 2022 05 20; 50(9):e49. PMID: 35061901; PMCID: PMC9122534.
      Citations: 4     Fields:    Translation:Humans
    19. Watkins CP, Zhang W, Wylder AC, Katanski CD, Pan T. A multiplex platform for small RNA sequencing elucidates multifaceted tRNA stress response and translational regulation. Nat Commun. 2022 05 05; 13(1):2491. PMID: 35513407; PMCID: PMC9072684.
      Citations: 9     Fields:    Translation:HumansCells
    20. Xiong S, Jiang L, Wang Y, Pan T, Ma F. The Role of the P1 Latency in Auditory and Speech Performance Evaluation in Cochlear Implanted Children. Neural Plast. 2022; 2022:6894794. PMID: 35422857; PMCID: PMC9005287.
      Citations: 1     Fields:    Translation:Humans
    21. Zhang W, Watkins C, Halucha M, Alshammary H, Hernandez MM, Liu WC, Albrecht RA, Garcia-Sastre A, Simon V, Katanski C, Pan T, Peña N. Profiling Selective Packaging of Host RNA and Viral RNA Modification in SARS-CoV-2 Viral Preparations. Front Cell Dev Biol. 2022; 10:768356. PMID: 35186917; PMCID: PMC8851031.
      Citations: 1     
    22. Zhang W, Foo M, Eren AM, Pan T. tRNA modification dynamics from individual organisms to metaepitranscriptomics of microbiomes. Mol Cell. 2022 03 03; 82(5):891-906. PMID: 35032425; PMCID: PMC8897278.
      Citations: 10     Fields:    Translation:HumansCells
    23. Huang S, Zhang W, Katanski CD, Dersh D, Dai Q, Lolans K, Yewdell J, Eren AM, Pan T. Interferon inducible pseudouridine modification in human mRNA by quantitative nanopore profiling. Genome Biol. 2021 12 06; 22(1):330. PMID: 34872593; PMCID: PMC8646010.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    24. Jiang T, Zhou W, Chang Z, Zou H, Bai J, Sun Q, Pan T, Xu J, Li Y, Li X. ImmReg: the regulon atlas of immune-related pathways across cancer types. Nucleic Acids Res. 2021 12 02; 49(21):12106-12118. PMID: 34755873; PMCID: PMC8643631.
      Citations: 5     Fields:    Translation:Humans
    25. Lu Z, Pan T, Wang Y. [Postoperative hearing in tympanoplasty preserving the manubrium of malleus and tensor tympani muscle tendon]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Nov; 35(11):981-987. PMID: 34886600; PMCID: PMC10128360.
      Citations:    Translation:Humans
    26. Wang J, Liu S, Pan T, Wang M, Li L, Weng X, Jia P, Li Q, Zhou X. Long non-coding RNA ZNF674-AS1 regulates miR-23a/E-cadherin axis to suppress the migration and invasion of non-small cell lung cancer cells. Transl Cancer Res. 2021 Sep; 10(9):4116-4124. PMID: 35116709; PMCID: PMC8798196.
      Citations: 2     
    27. Yang L, Ma T, Zhao L, Jiang H, Zhang J, Liu D, Zhang L, Wang X, Pan T, Zhang H, Wang A, Chao HW, Jin Y, Chen H. Circadian regulation of apolipoprotein gene expression affects testosterone production in mouse testis. Theriogenology. 2021 Oct 15; 174:9-19. PMID: 34416563.
      Citations: 5     Fields:    Translation:Animals
    28. Zhang W, Pan T. Quantitative probing of glycosylated queuosine modifications in tRNA. Methods Enzymol. 2021; 658:73-82. PMID: 34517960.
      Citations: 2     Fields:    Translation:HumansCells
    29. Zhang LS, Xiong QP, Liu C, Wei J, Le C, Zhang L, Harada BT, Dai Q, Feng X, Hao Z, Wang Y, Dong X, Hu L, Wang ED, Pan T, Klungland A, Liu RJ, He C, Peña Perez S. ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing. Nat Cell Biol. 2021 07; 23(7):684-691. PMID: 34253897; PMCID: PMC8716185.
      Citations: 18     Fields:    Translation:HumansCells
    30. Pan T, Dan Y, Guo D, Jiang J, Ran D, Zhang L, Tian B, Yuan J, Yu Y, Gan Z. Discovery of 2,4-pyrimidinediamine derivatives as potent dual inhibitors of ALK and HDAC. Eur J Med Chem. 2021 Nov 15; 224:113672. PMID: 34237620.
      Citations: 5     Fields:    Translation:HumansCells
    31. Zhang W, Pan T. Pseudouridine RNA modification detection and quantification by RT-PCR. Methods. 2022 07; 203:1-4. PMID: 34020036; PMCID: PMC8599501.
      Citations: 4     Fields:    Translation:Cells
    32. Huang J, Chen W, Zhou F, Pang Z, Wang L, Pan T, Wang X. Tissue-specific reprogramming of host tRNA transcriptome by the microbiome. Genome Res. 2021 06; 31(6):947-957. PMID: 33858843; PMCID: PMC8168588.
      Citations: 4     Fields:    Translation:AnimalsCells
    33. Sun L, Wei N, Kuhle B, Blocquel D, Novick S, Matuszek Z, Zhou H, He W, Zhang J, Weber T, Horvath R, Latour P, Pan T, Schimmel P, Griffin PR, Yang XL. CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS. Proc Natl Acad Sci U S A. 2021 03 30; 118(13). PMID: 33753480; PMCID: PMC8020758.
      Citations: 11     Fields:    Translation:HumansCells
    34. Wang Y, Katanski CD, Watkins C, Pan JN, Dai Q, Jiang Z, Pan T. A high-throughput screening method for evolving a demethylase enzyme with improved and new functionalities. Nucleic Acids Res. 2021 03 18; 49(5):e30. PMID: 33337498; PMCID: PMC7968990.
      Citations: 3     Fields:    Translation:Cells
    35. Zhang S, Zhang L, Chen Q, Zhang Y, Cai D, Luo W, Chen K, Pan T, Gao Z. Management of magnetic foreign body ingestion in children. Medicine (Baltimore). 2021 Jan 15; 100(2):e24055. PMID: 33466161; PMCID: PMC7808496.
      Citations: 4     Fields:    Translation:Humans
    36. Huang Y, Pan T, Lu Z, Wang Y, Ma F. [Clinical analysis of 21 cases of cholesteatoma recidivism after canal-wall-up mastoidectomy with tympanoplasty]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 01 05; 35(1):66-69. PMID: 33540978; PMCID: PMC10128542.
      Citations:    Translation:Humans
    37. Wang Y, Wu Y, Yu Y, Pan T, Li D, Lambropoulou D, Yang X. Natural polyphenols enhanced the Cu(II)/peroxymonosulfate (PMS) oxidation: The contribution of Cu(III) and HO•. Water Res. 2020 Nov 01; 186:116326. PMID: 32854031.
      Citations: 6     Fields:    Translation:Cells
    38. Wang Y, Pan T, Yu Y, Wu Y, Pan Y, Yang X. A novel peroxymonosulfate (PMS)-enhanced iron coagulation process for simultaneous removal of trace organic pollutants in water. Water Res. 2020 Oct 15; 185:116136. PMID: 32818738.
      Citations: 4     Fields:    Translation:CellsPHPublic Health
    39. Pan C, Duan H, Wu Y, Zhu C, Yi C, Duan Y, Lu D, Guo C, Wu D, Wang Y, Fu X, Xu J, Chen Y, Luo M, Tian W, Pan T, Xu W, Zhang S, Huang J. Inhibition of DNA-PK by gefitinib causes synergism between gefitinib and cisplatin in NSCLC. Int J Oncol. 2020 10; 57(4):939-955. PMID: 32945394; PMCID: PMC7473755.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    40. Chen M, Kuhle B, Diedrich J, Liu Z, Moresco JJ, Yates Iii JR, Pan T, Yang XL. Cross-editing by a tRNA synthetase allows vertebrates to abundantly express mischargeable tRNA without causing mistranslation. Nucleic Acids Res. 2020 07 09; 48(12):6445-6457. PMID: 32484512; PMCID: PMC7337962.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    41. Eckwahl M, Xu R, Michalkiewicz J, Zhang W, Patel P, Cai Z, Pan T. 5-Methylcytosine RNA Modifications Promote Retrovirus Replication in an ALYREF Reader Protein-Dependent Manner. J Virol. 2020 06 16; 94(13). PMID: 32321818; PMCID: PMC7307164.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    42. Zhang W, Xu R, Matuszek Z, Cai Z, Pan T. Detection and quantification of glycosylated queuosine modified tRNAs by acid denaturing and APB gels. RNA. 2020 09; 26(9):1291-1298. PMID: 32439717; PMCID: PMC7430669.
      Citations: 5     Fields:    Translation:HumansCells
    43. Zhang J, Lu R, Zhang Y, Matuszek Z, Zhang W, Xia Y, Pan T, Sun J. tRNA Queuosine Modification Enzyme Modulates the Growth and Microbiome Recruitment to Breast Tumors. Cancers (Basel). 2020 Mar 09; 12(3). PMID: 32182756; PMCID: PMC7139606.
      Citations: 14     
    44. Jurczyszak D, Zhang W, Terry SN, Kehrer T, McGregor E, Mulder LCF, Eckwahl MJ, Pan T, Simon V, Bermúdez González MC. HIV protease cleaves the antiviral m6A reader protein YTHDF3 in the viral particle. PLoS Pathog. 2020 02; 16(2):e1008305. PMID: 32053707; PMCID: PMC7043784.
      Citations: 25     Fields:    Translation:HumansCells
    45. Zhang W, Pan T. A dual function PUS enzyme. Nat Chem Biol. 2020 02; 16(2):107-108. PMID: 31974524.
      Citations: 1     Fields:    Translation:Humans
    46. Wu Y, Wang Y, Pan T, Yang X. Oxidation of tetrabromobisphenol A (TBBPA) by peroxymonosulfate: The role of in-situ formed HOBr. Water Res. 2020 Feb 01; 169:115202. PMID: 31669899.
      Citations:    Fields:    Translation:Cells
    47. Blocquel D, Sun L, Matuszek Z, Li S, Weber T, Kuhle B, Kooi G, Wei N, Baets J, Pan T, Schimmel P, Yang XL. CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells. Proc Natl Acad Sci U S A. 2019 09 24; 116(39):19440-19448. PMID: 31501329; PMCID: PMC6765236.
      Citations: 18     Fields:    Translation:HumansCells
    48. Zhou KI, Shi H, Lyu R, Wylder AC, Matuszek Z, Pan JN, He C, Pan T, Parisien M. Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG. Mol Cell. 2019 10 03; 76(1):70-81.e9. PMID: 31445886; PMCID: PMC6778029.
      Citations: 143     Fields:    Translation:HumansCells
    49. Yu Y, Ran D, Jiang J, Pan T, Dan Y, Tang Q, Li W, Zhang L, Gan L, Gan Z. Discovery of novel 9H-purin derivatives as dual inhibitors of HDAC1 and CDK2. Bioorg Med Chem Lett. 2019 08 15; 29(16):2136-2140. PMID: 31272794.
      Citations: 2     Fields:    Translation:HumansCells
    50. Liu R, Wang L, Gan T, Pan T, Huang J, Bai M. Long noncoding RNA LINC00511 promotes cell growth and invasion in triple-negative breast cancer by interacting with Snail. Cancer Manag Res. 2019; 11:5691-5699. PMID: 31417312; PMCID: PMC6600316.
      Citations: 5     
    51. Zhang W, Eckwahl MJ, Zhou KI, Pan T. Sensitive and quantitative probing of pseudouridine modification in mRNA and long noncoding RNA. RNA. 2019 09; 25(9):1218-1225. PMID: 31227565; PMCID: PMC6800517.
      Citations: 22     Fields:    Translation:HumansCells
    52. Matuszek Z, Pan T. Quantification of Queuosine Modification Levels in tRNA from Human Cells Using APB Gel and Northern Blot. Bio Protoc. 2019 Mar 20; 9(6):e3191. PMID: 33654991; PMCID: PMC7854232.
      Citations: 3     
    53. Wang Y, Pan T, Ma FR, Wang JJ, Zhang K, Pan WW, Zhang JH, Yi ZM, Ying YQ. Ceftriaxone-induced immune hemolytic anemia in a case with large vestibular aqueduct syndrome after cochlear implant. Chin Med J (Engl). 2019 Jan 05; 132(1):100-102. PMID: 30628967; PMCID: PMC6629315.
      Citations:    Fields:    Translation:Humans
    54. Schwartz MH, Wang H, Pan JN, Clark WC, Cui S, Eckwahl MJ, Pan DW, Parisien M, Owens SM, Cheng BL, Martinez K, Xu J, Chang EB, Pan T, Eren AM. Microbiome characterization by high-throughput transfer RNA sequencing and modification analysis. Nat Commun. 2018 12 17; 9(1):5353. PMID: 30559359; PMCID: PMC6297222.
      Citations: 28     Fields:    Translation:AnimalsCells
    55. Wang X, Li Y, Chen W, Shi H, Eren AM, Morozov A, He C, Luo GZ, Pan T. Transcriptome-wide reprogramming of N6-methyladenosine modification by the mouse microbiome. Cell Res. 2019 02; 29(2):167-170. PMID: 30559439; PMCID: PMC6355850.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    56. Ma H, Wang X, Cai J, Dai Q, Lv R, Chen K, Lu Z, Chen H, Shi YG, Lan F, Fan J, Pan T, Shi Y, He C, Natchiar SK, Klaholz BP. N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation. Nat Chem Biol. 2019 01; 15(1):88-94. PMID: 30531910; PMCID: PMC6463480.
      Citations: 161     Fields:    Translation:HumansAnimalsCells
    57. Richter U, Evans ME, Clark WC, Marttinen P, Shoubridge EA, Suomalainen A, Wredenberg A, Wedell A, Pan T, Battersby BJ. RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis. Nat Commun. 2018 09 27; 9(1):3966. PMID: 30262910; PMCID: PMC6160436.
      Citations: 32     Fields:    Translation:HumansCells
    58. Wang X, Matuszek Z, Huang Y, Dai Q, Clark W, Schwartz MH, Pan T, Parisien M. Queuosine modification protects cognate tRNAs against ribonuclease cleavage. RNA. 2018 10; 24(10):1305-1313. PMID: 29970597; PMCID: PMC6140461.
      Citations: 55     Fields:    Translation:HumansCells
    59. Zhou KI, Clark WC, Pan DW, Eckwahl MJ, Dai Q, Pan T. Pseudouridines have context-dependent mutation and stop rates in high-throughput sequencing. RNA Biol. 2018; 15(7):892-900. PMID: 29683381; PMCID: PMC6161689.
      Citations: 18     Fields:    Translation:HumansCells
    60. Zhou KI, Pan T. An additional class of m6A readers. Nat Cell Biol. 2018 03; 20(3):230-232. PMID: 29476150; PMCID: PMC5831501.
      Citations: 19     Fields:    Translation:Cells
    61. Pan T. Modifications and functional genomics of human transfer RNA. Cell Res. 2018 Apr; 28(4):395-404. PMID: 29463900; PMCID: PMC5939049.
      Citations: 148     Fields:    Translation:HumansAnimalsCells
    62. Xu J, Wang Z, Jin X, Li L, Pan T. Methods for Identification of Protein-RNA Interaction. Adv Exp Med Biol. 2018; 1094:117-126. PMID: 30191493.
      Citations: 2     Fields:    Translation:Humans
    63. Chen Q, Gao Z, Zhang L, Zhang Y, Pan T, Cai D, Xiong Q, Shu Q, Qian Y. Multifaceted behavior of Meckel's diverticulum in children. J Pediatr Surg. 2018 Apr; 53(4):676-681. PMID: 29331260.
      Citations: 15     Fields:    Translation:Humans
    64. Evans ME, Clark WC, Zheng G, Pan T. Determination of tRNA aminoacylation levels by high-throughput sequencing. Nucleic Acids Res. 2017 Aug 21; 45(14):e133. PMID: 28586482; PMCID: PMC5737633.
      Citations: 48     Fields:    Translation:HumansCells
    65. Roundtree IA, Evans ME, Pan T, He C. Dynamic RNA Modifications in Gene Expression Regulation. Cell. 2017 Jun 15; 169(7):1187-1200. PMID: 28622506; PMCID: PMC5657247.
      Citations: 1179     Fields:    Translation:HumansAnimalsCells
    66. Liu N, Zhou KI, Dai Q, Pan T, Parisien M, Diatchenko L. N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein. Nucleic Acids Res. 2017 Jun 02; 45(10):6051-6063. PMID: 28334903; PMCID: PMC5449601.
      Citations: 358     Fields:    Translation:HumansCells
    67. Peterlin BM, Liu P, Wang X, Cary D, Shao W, Leoz M, Hong T, Pan T, Fujinaga K. Hili Inhibits HIV Replication in Activated T Cells. J Virol. 2017 06 01; 91(11). PMID: 28331090; PMCID: PMC5432865.
      Citations: 10     Fields:    Translation:HumansCells
    68. Zhou KI, Liu N, Pan T. Identification of N6-methyladenosine reader proteins. Methods. 2017 08 15; 126:105-111. PMID: 28454774; PMCID: PMC5583020.
      Citations: 2     Fields:    Translation:HumansCells
    69. Dai Q, Zheng G, Schwartz MH, Clark WC, Pan T. Selective Enzymatic Demethylation of N2 ,N2 -Dimethylguanosine in RNA and Its Application in High-Throughput tRNA Sequencing. Angew Chem Int Ed Engl. 2017 04 24; 56(18):5017-5020. PMID: 28371071; PMCID: PMC5497677.
      Citations: 18     Fields:    Translation:Cells
    70. Lewis CJ, Pan T, Kalsotra A. RNA modifications and structures cooperate to guide RNA-protein interactions. Nat Rev Mol Cell Biol. 2017 03; 18(3):202-210. PMID: 28144031; PMCID: PMC5542016.
      Citations: 126     Fields:    Translation:Cells
    71. Schwartz MH, Pan T. Function and origin of mistranslation in distinct cellular contexts. Crit Rev Biochem Mol Biol. 2017 Apr; 52(2):205-219. PMID: 28075177; PMCID: PMC5548284.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    72. Schwartz MH, Pan T. tRNA Misacylation with Methionine in the Mouse Gut Microbiome in Situ. Microb Ecol. 2017 07; 74(1):10-14. PMID: 28070678; PMCID: PMC5466836.
      Citations: 5     Fields:    Translation:AnimalsCells
    73. Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q, Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T, He C. ALKBH1-Mediated tRNA Demethylation Regulates Translation. Cell. 2016 Oct 20; 167(3):816-828.e16. PMID: 27745969; PMCID: PMC5119773.
      Citations: 188     Fields:    Translation:HumansCells
    74. Schwartz MH, Waldbauer JR, Zhang L, Pan T. Global tRNA misacylation induced by anaerobiosis and antibiotic exposure broadly increases stress resistance in Escherichia coli. Nucleic Acids Res. 2016 Dec 01; 44(21):10292-10303. PMID: 27672035; PMCID: PMC5137444.
      Citations: 21     Fields:    Translation:Cells
    75. Sun L, Gomes AC, He W, Zhou H, Wang X, Pan DW, Schimmel P, Pan T, Yang XL. Evolutionary Gain of Alanine Mischarging to Noncognate tRNAs with a G4:U69 Base Pair. J Am Chem Soc. 2016 10 05; 138(39):12948-12955. PMID: 27622773; PMCID: PMC5356932.
      Citations: 20     Fields:    Translation:Cells
    76. Schwartz MH, Pan T. Determining the fidelity of tRNA aminoacylation via microarrays. Methods. 2017 01 15; 113:27-33. PMID: 27639882; PMCID: PMC5253240.
      Citations: 9     Fields:    Translation:AnimalsCells
    77. Saikia M, Wang X, Mao Y, Wan J, Pan T, Qian SB. Codon optimality controls differential mRNA translation during amino acid starvation. RNA. 2016 11; 22(11):1719-1727. PMID: 27613579; PMCID: PMC5066624.
      Citations: 23     Fields:    Translation:Cells
    78. Clark WC, Evans ME, Dominissini D, Zheng G, Pan T. tRNA base methylation identification and quantification via high-throughput sequencing. RNA. 2016 11; 22(11):1771-1784. PMID: 27613580; PMCID: PMC5066629.
      Citations: 93     Fields:    Translation:HumansCells
    79. Zhou KI, Pan T. Structures of the m(6)A Methyltransferase Complex: Two Subunits with Distinct but Coordinated Roles. Mol Cell. 2016 07 21; 63(2):183-185. PMID: 27447983; PMCID: PMC5109923.
      Citations: 20     Fields:    
    80. Wang X, Pan T. Stress Response and Adaptation Mediated by Amino Acid Misincorporation during Protein Synthesis. Adv Nutr. 2016 07; 7(4):773S-9S. PMID: 27422514; PMCID: PMC4942860.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    81. Wang X, Chow CR, Ebine K, Lee J, Rosner MR, Pan T, Munshi HG. Interaction of tRNA with MEK2 in pancreatic cancer cells. Sci Rep. 2016 06 15; 6:28260. PMID: 27301426; PMCID: PMC4908586.
      Citations: 5     Fields:    Translation:HumansCells
    82. Frye M, Jaffrey SR, Pan T, Rechavi G, Suzuki T. RNA modifications: what have we learned and where are we headed? Nat Rev Genet. 2016 06; 17(6):365-72. PMID: 27140282.
      Citations: 116     Fields:    Translation:HumansAnimalsCells
    83. Dominissini D, Nachtergaele S, Moshitch-Moshkovitz S, Peer E, Kol N, Ben-Haim MS, Dai Q, Di Segni A, Salmon-Divon M, Clark WC, Zheng G, Pan T, Solomon O, Eyal E, Hershkovitz V, Han D, Amariglio N, Rechavi G, He C, Doré LC. The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA. Nature. 2016 Feb 25; 530(7591):441-6. PMID: 26863196; PMCID: PMC4842015.
      Citations: 418     Fields:    Translation:HumansAnimalsCells
    84. Liu N, Pan T. N6-methyladenosine–encoded epitranscriptomics. Nat Struct Mol Biol. 2016 Feb; 23(2):98-102. PMID: 26840897.
      Citations: 151     Fields:    Translation:HumansAnimalsCells
    85. Wang X, Pan T. Correction: Methionine Mistranslation Bypasses the Restraint of the Genetic Code to Generate Mutant Proteins with Distinct Activities. PLoS Genet. 2016 01; 12(1):e1005832. PMID: 26808153; PMCID: PMC4726583.
      Citations:    Fields:    
    86. Gomes AC, Kordala AJ, Strack R, Wang X, Geslain R, Delaney K, Clark WC, Keenan R, Pan T. A dual fluorescent reporter for the investigation of methionine mistranslation in live cells. RNA. 2016 Mar; 22(3):467-76. PMID: 26729921; PMCID: PMC4748823.
      Citations: 11     Fields:    Translation:HumansCells
    87. Liu N, Pan T. Probing N6-methyladenosine (m6A) RNA Modification in Total RNA with SCARLET. Methods Mol Biol. 2016; 1358:285-92. PMID: 26463390.
      Citations: 11     Fields:    Translation:HumansCells
    88. Wang X, Pan T. Methionine Mistranslation Bypasses the Restraint of the Genetic Code to Generate Mutant Proteins with Distinct Activities. PLoS Genet. 2015 Dec; 11(12):e1005745. PMID: 26709516; PMCID: PMC4692448.
      Citations: 18     Fields:    Translation:HumansCells
    89. Pan T, Sun J, Hu J, Hu Y, Zhou J, Chen Z, Xu D, Xu W, Zheng S, Zhang S. Correction: Cytohesins/ARNO: The Function in Colorectal Cancer Cells. PLoS One. 2015; 10(12):e0146204. PMID: 26709508; PMCID: PMC4692562.
      Citations:    Fields:    
    90. Schwartz MH, Pan T. Temperature dependent mistranslation in a hyperthermophile adapts proteins to lower temperatures. Nucleic Acids Res. 2016 Jan 08; 44(1):294-303. PMID: 26657639; PMCID: PMC4705672.
      Citations: 23     Fields:    Translation:Cells
    91. Wallace EW, Kear-Scott JL, Pilipenko EV, Schwartz MH, Laskowski PR, Rojek AE, Katanski CD, Riback JA, Dion MF, Franks AM, Airoldi EM, Pan T, Budnik BA, Drummond DA. Reversible, Specific, Active Aggregates of Endogenous Proteins Assemble upon Heat Stress. Cell. 2015 Sep 10; 162(6):1286-98. PMID: 26359986; PMCID: PMC4567705.
      Citations: 202     Fields:    Translation:AnimalsCells
    92. Zhou KI, Dai Q, Liu N, Sachleben JR, Pan T, Parisien M, Diatchenko L. N(6)-Methyladenosine Modification in a Long Noncoding RNA Hairpin Predisposes Its Conformation to Protein Binding. J Mol Biol. 2016 Feb 27; 428(5 Pt A):822-833. PMID: 26343757; PMCID: PMC4779075.
      Citations: 103     Fields:    Translation:HumansCells
    93. Zheng G, Qin Y, Clark WC, Dai Q, Yi C, He C, Lambowitz AM, Pan T. Efficient and quantitative high-throughput tRNA sequencing. Nat Methods. 2015 Sep; 12(9):835-837. PMID: 26214130; PMCID: PMC4624326.
      Citations: 249     Fields:    Translation:HumansCells
    94. Liu N, Pan T. Probing RNA Modification Status at Single-Nucleotide Resolution in Total RNA. Methods Enzymol. 2015; 560:149-59. PMID: 26253970.
      Citations: 20     Fields:    Translation:HumansCells
    95. Wang Y, Pan T, Deshpande SB, Ma F. The Relationship Between EABR and Auditory Performance and Speech Intelligibility Outcomes in Pediatric Cochlear Implant Recipients. Am J Audiol. 2015 Jun; 24(2):226-34. PMID: 25677645.
      Citations: 5     Fields:    Translation:Humans
    96. Pan T. My adventure in tRNA biology, so far. RNA. 2015 Apr; 21(4):707-8. PMID: 25780201; PMCID: PMC4371343.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    97. Liu N, Dai Q, Zheng G, He C, Parisien M, Pan T. N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. Nature. 2015 Feb 26; 518(7540):560-4. PMID: 25719671; PMCID: PMC4355918.
      Citations: 908     Fields:    Translation:HumansCells
    98. Zaborske JM, DuMont VL, Wallace EW, Pan T, Aquadro CF, Drummond DA. A nutrient-driven tRNA modification alters translational fidelity and genome-wide protein coding across an animal genus. PLoS Biol. 2014 Dec; 12(12):e1002015. PMID: 25489848; PMCID: PMC4260829.
      Citations: 69     Fields:    Translation:AnimalsCells
    99. Chen K, Lu Z, Wang X, Fu Y, Luo GZ, Liu N, Han D, Dominissini D, Dai Q, Pan T, He C. High-resolution N(6) -methyladenosine (m(6) A) map using photo-crosslinking-assisted m(6) A sequencing. Angew Chem Int Ed Engl. 2015 Jan 26; 54(5):1587-90. PMID: 25491922; PMCID: PMC4396828.
      Citations: 172     Fields:    Translation:HumansCells
    100. Saikia M, Jobava R, Parisien M, Putnam A, Krokowski D, Gao XH, Guan BJ, Yuan Y, Jankowsky E, Feng Z, Hu GF, Pusztai-Carey M, Gorla M, Sepuri NB, Pan T, Hatzoglou M. Angiogenin-cleaved tRNA halves interact with cytochrome c, protecting cells from apoptosis during osmotic stress. Mol Cell Biol. 2014 Jul; 34(13):2450-63. PMID: 24752898; PMCID: PMC4054315.
      Citations: 152     Fields:    Translation:AnimalsCells
    101. Liu N, Pan T. RNA epigenetics. Transl Res. 2015 Jan; 165(1):28-35. PMID: 24768686; PMCID: PMC4190089.
      Citations: 52     Fields:    Translation:HumansAnimals
    102. Parisien M, Wang X, Pan T. Diversity of human tRNA genes from the 1000-genomes project. RNA Biol. 2013 Dec; 10(12):1853-67. PMID: 24448271; PMCID: PMC3917988.
      Citations: 57     Fields:    Translation:HumansCells
    103. Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, Fu Y, Parisien M, Dai Q, Jia G, Ren B, Pan T, He C. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 02; 505(7481):117-20. PMID: 24284625; PMCID: PMC3877715.
      Citations: 1780     Fields:    Translation:HumansCells
    104. Liu N, Parisien M, Dai Q, Zheng G, He C, Pan T. Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA. RNA. 2013 Dec; 19(12):1848-56. PMID: 24141618; PMCID: PMC3884656.
      Citations: 224     Fields:    Translation:HumansCells
    105. Czech A, Wende S, Pan T, Ignatova Z, Mörl M. Reversible and rapid transfer-RNA deactivation as a mechanism of translational repression in stress. PLoS Genet. 2013 Aug; 9(8):e1003767. PMID: 24009533; PMCID: PMC3757041.
      Citations: 57     Fields:    Translation:Cells
    106. Pan T. Adaptive translation as a mechanism of stress response and adaptation. Annu Rev Genet. 2013; 47:121-37. PMID: 23988117; PMCID: PMC4109725.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    107. Huang X, Zhang L, Pan T, Zhang B. Mitochondrial genome of Protobothrops dabieshanensis (Squamata: Viperidae: Crotalinae). Mitochondrial DNA. 2014 Oct; 25(5):337-8. PMID: 23841609.
      Citations: 1     Fields:    Translation:Animals
    108. Fan B, Zhang L, Li XC, Song YS, Guo EZ, Pan T, Shen L, Xin SY, Song XS, Wang JB. [Effects of neoadjuvant chemotherapy on the prognostic mortality risk of invasive transitional bladder cancer: a meta-analysis]. Zhonghua Yi Xue Za Zhi. 2013 Jun 11; 93(22):1705-10. PMID: 24124676.
      Citations:    Fields:    Translation:Humans
    109. Parisien M, Wang X, Perdrizet G, Lamphear C, Fierke CA, Maheshwari KC, Wilde MJ, Sosnick TR, Pan T. Discovering RNA-protein interactome by using chemical context profiling of the RNA-protein interface. Cell Rep. 2013 May 30; 3(5):1703-13. PMID: 23665222; PMCID: PMC3769137.
      Citations: 18     Fields:    Translation:HumansCells
    110. Krokowski D, Han J, Saikia M, Majumder M, Yuan CL, Guan BJ, Bevilacqua E, Bussolati O, Arvan P, Snider MD, Puchowicz M, Croniger CM, Kimball SR, Pan T, Koromilas AE, Kaufman RJ, Hatzoglou M, Bröer S, Tchórzewski M. A self-defeating anabolic program leads to ß-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux. J Biol Chem. 2013 Jun 14; 288(24):17202-13. PMID: 23645676; PMCID: PMC3682525.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    111. Vilfan ID, Tsai YC, Clark TA, Wegener J, Dai Q, Yi C, Pan T, Turner SW, Korlach J. Analysis of RNA base modification and structural rearrangement by single-molecule real-time detection of reverse transcription. J Nanobiotechnology. 2013 Apr 03; 11:8. PMID: 23552456; PMCID: PMC3623877.
      Citations: 64     Fields:    Translation:Cells
    112. Pavon-Eternod M, Gomes S, Rosner MR, Pan T. Overexpression of initiator methionine tRNA leads to global reprogramming of tRNA expression and increased proliferation in human epithelial cells. RNA. 2013 Apr; 19(4):461-6. PMID: 23431330; PMCID: PMC3677255.
      Citations: 78     Fields:    Translation:HumansCells
    113. Pan T. N6-methyl-adenosine modification in messenger and long non-coding RNA. Trends Biochem Sci. 2013 Apr; 38(4):204-9. PMID: 23337769; PMCID: PMC3608796.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    114. Wang Y, Pan T, Zhou N, Ma F. [Electrophysiological characteristics of EABR and its value assessment of cochlear implant]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Jan; 27(1):8-12. PMID: 23646423.
      Citations: 1     Fields:    Translation:Humans
    115. Subramaniam AR, Pan T, Cluzel P. Environmental perturbations lift the degeneracy of the genetic code to regulate protein levels in bacteria. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2419-24. PMID: 23277573; PMCID: PMC3568297.
      Citations: 47     Fields:    Translation:Cells
    116. Pavon-Eternod M, David A, Dittmar K, Berglund P, Pan T, Bennink JR, Yewdell JW. Vaccinia and influenza A viruses select rather than adjust tRNAs to optimize translation. Nucleic Acids Res. 2013 Feb 01; 41(3):1914-21. PMID: 23254333; PMCID: PMC3561966.
      Citations: 26     Fields:    Translation:HumansCells
    117. Pan T, Sun J, Zhou J, Fu Z, Hu Y, Zheng S, Zhang S. Function and mode of action of cytohesins in the epidermal growth factor pathway in colorectal cancer cells. Oncol Lett. 2013 Feb; 5(2):521-526. PMID: 23420529; PMCID: PMC3573086.
      Citations: 4     
    118. Geslain R, Uddin S, Liu H, Jiang H, van Besien K, Pan T, Wickrema A. Distinct functions of erythropoietin and stem cell factor are linked to activation of mTOR kinase signaling pathway in human erythroid progenitors. Cytokine. 2013 Jan; 61(1):329-35. PMID: 23148990.
      Citations: 7     Fields:    Translation:HumansCells
    119. Saikia M, Krokowski D, Guan BJ, Ivanov P, Parisien M, Hu GF, Anderson P, Pan T, Hatzoglou M. Genome-wide identification and quantitative analysis of cleaved tRNA fragments induced by cellular stress. J Biol Chem. 2012 Dec 14; 287(51):42708-25. PMID: 23086926; PMCID: PMC3522271.
      Citations: 128     Fields:    Translation:AnimalsCells
    120. Li M, Kao E, Gao X, Sandig H, Limmer K, Pavon-Eternod M, Jones TE, Landry S, Pan T, Weitzman MD, David M. Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Nature. 2012 Nov 01; 491(7422):125-8. PMID: 23000900; PMCID: PMC3705913.
      Citations: 184     Fields:    Translation:HumansCells
    121. Zhou DH, Lee J, Frankenberger C, Geslain R, Rosner M, Pan T. Anti-tumor effects of an engineered "killer" transfer RNA. Biochem Biophys Res Commun. 2012 Oct 12; 427(1):148-53. PMID: 22989754.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    122. Sun J, Li J, Wang J, Pan T, Zhou J, Fu X, Zhang S. Meta-analysis of randomized controlled trials on laparoscopic gastrectomy vs. open gastrectomy for distal gastric cancer. Hepatogastroenterology. 2012 Sep; 59(118):1699-705. PMID: 22626787.
      Citations: 16     Fields:    Translation:Humans
    123. Wiltrout E, Goodenbour JM, Pan T, Fréchin M. Misacylation of tRNA with methionine in Saccharomyces cerevisiae. Nucleic Acids Res. 2012 Nov 01; 40(20):10494-506. PMID: 22941646; PMCID: PMC3488245.
      Citations: 43     Fields:    Translation:AnimalsCells
    124. Starck SR, Jiang V, Pavon-Eternod M, Prasad S, McCarthy B, Pan T, Shastri N. Leucine-tRNA initiates at CUG start codons for protein synthesis and presentation by MHC class I. Science. 2012 Jun 29; 336(6089):1719-23. PMID: 22745432.
      Citations: 123     Fields:    Translation:HumansAnimalsCells
    125. Novoa EM, Pavon-Eternod M, Pan T, Ribas de Pouplana L. A role for tRNA modifications in genome structure and codon usage. Cell. 2012 Mar 30; 149(1):202-13. PMID: 22464330.
      Citations: 129     Fields:    Translation:HumansAnimalsCells
    126. Perdrizet GA, Artsimovitch I, Furman R, Sosnick TR, Pan T. Transcriptional pausing coordinates folding of the aptamer domain and the expression platform of a riboswitch. Proc Natl Acad Sci U S A. 2012 Feb 28; 109(9):3323-8. PMID: 22331895; PMCID: PMC3295289.
      Citations: 51     Fields:    Translation:Cells
    127. Parisien M, Yi C, Pan T. Rationalization and prediction of selective decoding of pseudouridine-modified nonsense and sense codons. RNA. 2012 Mar; 18(3):355-67. PMID: 22282339; PMCID: PMC3285925.
      Citations: 16     Fields:    Translation:Cells
    128. Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG, He C. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol. 2011 Oct 16; 7(12):885-7. PMID: 22002720; PMCID: PMC3218240.
      Citations: 1642     Fields:    Translation:HumansCells
    129. Geslain R, Pan T. tRNA: Vast reservoir of RNA molecules with unexpected regulatory function. Proc Natl Acad Sci U S A. 2011 Oct 04; 108(40):16489-90. PMID: 21933958; PMCID: PMC3189024.
      Citations: 11     Fields:    Translation:HumansCells
    130. Yi C, Pan T. Cellular dynamics of RNA modification. Acc Chem Res. 2011 Dec 20; 44(12):1380-8. PMID: 21615108; PMCID: PMC3179539.
      Citations: 54     Fields:    Translation:HumansCells
    131. Dai Q, Song CX, Pan T, He C. Syntheses of two 5-hydroxymethyl-2'-deoxycytidine phosphoramidites with TBDMS as the 5-hydroxymethyl protecting group and their incorporation into DNA. J Org Chem. 2011 May 20; 76(10):4182-8. PMID: 21462947; PMCID: PMC4031239.
      Citations: 11     Fields:    
    132. Jones TE, Alexander RW, Pan T. Misacylation of specific nonmethionyl tRNAs by a bacterial methionyl-tRNA synthetase. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):6933-8. PMID: 21482813; PMCID: PMC3084089.
      Citations: 39     Fields:    Translation:Cells
    133. Fu Y, Dai Q, Zhang W, Ren J, Pan T, He C. The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA. Angew Chem Int Ed Engl. 2010 Nov 15; 49(47):8885-8. PMID: 20583019; PMCID: PMC3134247.
      Citations: 79     Fields:    Translation:HumansCells
    134. Reiter NJ, Osterman A, Torres-Larios A, Swinger KK, Pan T, Mondragón A. Structure of a bacterial ribonuclease P holoenzyme in complex with tRNA. Nature. 2010 Dec 09; 468(7325):784-9. PMID: 21076397; PMCID: PMC3058908.
      Citations: 155     Fields:    Translation:Cells
    135. Baird NJ, Ludtke SJ, Khant H, Chiu W, Pan T, Sosnick TR. Discrete structure of an RNA folding intermediate revealed by cryo-electron microscopy. J Am Chem Soc. 2010 Nov 24; 132(46):16352-3. PMID: 21038867; PMCID: PMC2988076.
      Citations: 12     Fields:    Translation:Cells
    136. Zaborske JM, Wu X, Wek RC, Pan T. Selective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae. BMC Biochem. 2010 Aug 04; 11:29. PMID: 20684782; PMCID: PMC2921344.
      Citations: 22     Fields:    Translation:Animals
    137. Zaborske J, Pan T. Genome-wide analysis of aminoacylation (charging) levels of tRNA using microarrays. J Vis Exp. 2010 Jun 18; (40). PMID: 20567214; PMCID: PMC3153904.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    138. Saikia M, Fu Y, Pavon-Eternod M, He C, Pan T. Genome-wide analysis of N1-methyl-adenosine modification in human tRNAs. RNA. 2010 Jul; 16(7):1317-27. PMID: 20484468; PMCID: PMC2885681.
      Citations: 68     Fields:    Translation:HumansCells
    139. Tuller T, Carmi A, Vestsigian K, Navon S, Dorfan Y, Zaborske J, Pan T, Dahan O, Furman I, Pilpel Y. An evolutionarily conserved mechanism for controlling the efficiency of protein translation. Cell. 2010 Apr 16; 141(2):344-54. PMID: 20403328.
      Citations: 430     Fields:    Translation:AnimalsCells
    140. Staschke KA, Dey S, Zaborske JM, Palam LR, McClintick JN, Pan T, Edenberg HJ, Wek RC. Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast. J Biol Chem. 2010 May 28; 285(22):16893-911. PMID: 20233714; PMCID: PMC2878067.
      Citations: 61     Fields:    Translation:AnimalsCells
    141. Baird NJ, Gong H, Zaheer SS, Freed KF, Pan T, Sosnick TR. Extended structures in RNA folding intermediates are due to nonnative interactions rather than electrostatic repulsion. J Mol Biol. 2010 Apr 16; 397(5):1298-306. PMID: 20188108; PMCID: PMC2873146.
      Citations: 12     Fields:    Translation:Cells
    142. Geslain R, Pan T. Functional analysis of human tRNA isodecoders. J Mol Biol. 2010 Feb 26; 396(3):821-31. PMID: 20026070; PMCID: PMC2822071.
      Citations: 45     Fields:    Translation:HumansCells
    143. Pavon-Eternod M, Wei M, Pan T, Kleiman L. Profiling non-lysyl tRNAs in HIV-1. RNA. 2010 Feb; 16(2):267-73. PMID: 20007329; PMCID: PMC2811655.
      Citations: 41     Fields:    Translation:HumansCells
    144. Netzer N, Goodenbour JM, David A, Dittmar KA, Jones RB, Schneider JR, Boone D, Eves EM, Rosner MR, Gibbs JS, Embry A, Dolan B, Das S, Hickman HD, Berglund P, Bennink JR, Yewdell JW, Pan T. Innate immune and chemically triggered oxidative stress modifies translational fidelity. Nature. 2009 Nov 26; 462(7272):522-6. PMID: 19940929; PMCID: PMC2785853.
      Citations: 176     Fields:    Translation:HumansAnimalsCells
    145. Pavon-Eternod M, Gomes S, Geslain R, Dai Q, Rosner MR, Pan T. tRNA over-expression in breast cancer and functional consequences. Nucleic Acids Res. 2009 Nov; 37(21):7268-80. PMID: 19783824; PMCID: PMC2790902.
      Citations: 174     Fields:    Translation:HumansCells
    146. Zaborske JM, Narasimhan J, Jiang L, Wek SA, Dittmar KA, Freimoser F, Pan T, Wek RC. Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p. J Biol Chem. 2009 Sep 11; 284(37):25254-67. PMID: 19546227; PMCID: PMC2757228.
      Citations: 72     Fields:    Translation:Cells
    147. Zhou Y, Goodenbour JM, Godley LA, Wickrema A, Pan T. High levels of tRNA abundance and alteration of tRNA charging by bortezomib in multiple myeloma. Biochem Biophys Res Commun. 2009 Jul 24; 385(2):160-4. PMID: 19450555; PMCID: PMC2774282.
      Citations: 38     Fields:    Translation:HumansCells
    148. Dai Q, Saikia M, Li NS, Pan T, Piccirilli JA. Efficient chemical synthesis of AppDNA by adenylation of immobilized DNA-5'-monophosphate. Org Lett. 2009 Mar 05; 11(5):1067-70. PMID: 19191584.
      Citations: 5     Fields:    Translation:Cells
    149. Wong TN, Pan T. RNA folding during transcription: protocols and studies. Methods Enzymol. 2009; 468:167-93. PMID: 20946770.
      Citations: 20     Fields:    Translation:Cells
    150. Qu X, Smith GJ, Lee KT, Sosnick TR, Pan T, Scherer NF. Single-molecule nonequilibrium periodic Mg2+-concentration jump experiments reveal details of the early folding pathways of a large RNA. Proc Natl Acad Sci U S A. 2008 May 06; 105(18):6602-7. PMID: 18448679; PMCID: PMC2373323.
      Citations: 19     Fields:    Translation:Cells
    151. Smith GJ, Lee KT, Qu X, Xie Z, Pesic J, Sosnick TR, Pan T, Scherer NF. A large collapsed-state RNA can exhibit simple exponential single-molecule dynamics. J Mol Biol. 2008 May 09; 378(4):943-53. PMID: 18402978.
      Citations: 7     Fields:    Translation:Cells
    152. Wong TN, Sosnick TR, Pan T. Folding of noncoding RNAs during transcription facilitated by pausing-induced nonnative structures. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):17995-8000. PMID: 17986617; PMCID: PMC2084285.
      Citations: 66     Fields:    Translation:Cells
    153. Baird NJ, Fang XW, Srividya N, Pan T, Sosnick TR. Folding of a universal ribozyme: the ribonuclease P RNA. Q Rev Biophys. 2007 May; 40(2):113-61. PMID: 17931443.
      Citations: 15     Fields:    Translation:Cells
    154. Dai Q, Fong R, Saikia M, Stephenson D, Yu YT, Pan T, Piccirilli JA. Identification of recognition residues for ligation-based detection and quantitation of pseudouridine and N6-methyladenosine. Nucleic Acids Res. 2007; 35(18):6322-9. PMID: 17881375; PMCID: PMC2094055.
      Citations: 52     Fields:    Translation:AnimalsCells
    155. Song XY, Yuan XM, Chen WJ, Pan T, Xie SD, Qin C, Lou C, Jin M, Wang LB, Wu JM. Different criteria for radioactive sentinel lymph nodes has different impact on sentinel node biopsy in breast cancer patients. J Surg Oncol. 2007 Jun 15; 95(8):635-9. PMID: 17252554.
      Citations: 4     Fields:    Translation:Humans
    156. Dittmar KA, Goodenbour JM, Pan T. Tissue-specific differences in human transfer RNA expression. PLoS Genet. 2006 Dec; 2(12):e221. PMID: 17194224; PMCID: PMC1713254.
      Citations: 315     Fields:    Translation:HumansAnimalsCells
    157. Goodenbour JM, Pan T. Diversity of tRNA genes in eukaryotes. Nucleic Acids Res. 2006; 34(21):6137-46. PMID: 17088292; PMCID: PMC1693877.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    158. Saikia M, Dai Q, Decatur WA, Fournier MJ, Piccirilli JA, Pan T. A systematic, ligation-based approach to study RNA modifications. RNA. 2006 Nov; 12(11):2025-33. PMID: 16963711; PMCID: PMC1624908.
      Citations: 17     Fields:    Translation:AnimalsCells
    159. Torres-Larios A, Swinger KK, Pan T, Mondragón A. Structure of ribonuclease P--a universal ribozyme. Curr Opin Struct Biol. 2006 Jun; 16(3):327-35. PMID: 16650980.
      Citations: 36     Fields:    Translation:Cells
    160. Baird NJ, Srividya N, Krasilnikov AS, Sosnick TR, Pan T, Mondragón A. Structural basis for altering the stability of homologous RNAs from a mesophilic and a thermophilic bacterium. RNA. 2006 Apr; 12(4):598-606. PMID: 16581805; PMCID: PMC1421087.
      Citations: 13     Fields:    Translation:Cells
    161. Pan T, Sosnick T. RNA folding during transcription. Annu Rev Biophys Biomol Struct. 2006; 35:161-75. PMID: 16689632.
      Citations: 129     Fields:    Translation:Cells
    162. Pan T, Chang B, Wong P, Li C, Li R, Kang SC, Robinson JD, Thompsett AR, Tein P, Yin S, Barnard G, McConnell I, Brown DR, Wisniewski T, Sy MS. An aggregation-specific enzyme-linked immunosorbent assay: detection of conformational differences between recombinant PrP protein dimers and PrP(Sc) aggregates. J Virol. 2005 Oct; 79(19):12355-64. PMID: 16160162; PMCID: PMC1211538.
      Citations: 21     Fields:    Translation:AnimalsCells
    163. Baird NJ, Westhof E, Qin H, Pan T, Sosnick TR. Structure of a folding intermediate reveals the interplay between core and peripheral elements in RNA folding. J Mol Biol. 2005 Sep 23; 352(3):712-22. PMID: 16115647.
      Citations: 30     Fields:    Translation:Cells
    164. Torres-Larios A, Swinger KK, Krasilnikov AS, Pan T, Mondragón A. Crystal structure of the RNA component of bacterial ribonuclease P. Nature. 2005 Sep 22; 437(7058):584-7. PMID: 16113684.
      Citations: 107     Fields:    Translation:Cells
    165. Le TT, Guet CC, Dittmar K, Emonet T, Pan T, Cluzel P, Harlepp S. Real-time RNA profiling within a single bacterium. Proc Natl Acad Sci U S A. 2005 Jun 28; 102(26):9160-4. PMID: 15967986; PMCID: PMC1166617.
      Citations: 29     Fields:    Translation:Cells
    166. Wong T, Sosnick TR, Pan T. Mechanistic insights on the folding of a large ribozyme during transcription. Biochemistry. 2005 May 24; 44(20):7535-42. PMID: 15895996.
      Citations: 8     Fields:    Translation:Cells
    167. Dittmar KA, Elf J, Pan T, Sørensen MA, Ehrenberg M. Selective charging of tRNA isoacceptors induced by amino-acid starvation. EMBO Rep. 2005 Feb; 6(2):151-7. PMID: 15678157; PMCID: PMC1299251.
      Citations: 122     Fields:    Translation:Cells
    168. Pan T, Wong P, Chang B, Li C, Li R, Kang SC, Wisniewski T, Sy MS. Biochemical fingerprints of prion infection: accumulations of aberrant full-length and N-terminally truncated PrP species are common features in mouse prion disease. J Virol. 2005 Jan; 79(2):934-43. PMID: 15613322; PMCID: PMC538529.
      Citations: 18     Fields:    Translation:AnimalsCells
    169. Smith GJ, Sosnick TR, Scherer NF, Pan T. Efficient fluorescence labeling of a large RNA through oligonucleotide hybridization. RNA. 2005 Feb; 11(2):234-9. PMID: 15613536; PMCID: PMC1370712.
      Citations: 15     Fields:    Translation:Cells
    170. Sosnick TR, Pan T. Reduced contact order and RNA folding rates. J Mol Biol. 2004 Oct 01; 342(5):1359-65. PMID: 15364565.
      Citations: 14     Fields:    Translation:Cells
    171. Krasilnikov AS, Xiao Y, Pan T, Mondragón A. Basis for structural diversity in homologous RNAs. Science. 2004 Oct 01; 306(5693):104-7. PMID: 15459389.
      Citations: 69     Fields:    Translation:Cells
    172. Dittmar KA, Mobley EM, Radek AJ, Pan T. Exploring the regulation of tRNA distribution on the genomic scale. J Mol Biol. 2004 Mar 12; 337(1):31-47. PMID: 15001350.
      Citations: 59     Fields:    Translation:AnimalsCells
    173. Barrera A, Pan T. Interaction of the Bacillus subtilis RNase P with the 30S ribosomal subunit. RNA. 2004 Mar; 10(3):482-92. PMID: 14970393; PMCID: PMC1370943.
      Citations: 11     Fields:    Translation:Cells
    174. Wang L, Shen J, Song X, Chen W, Pan T, Zhang W, Sun X, He C, Wu J. A study of the lengthening and contractility of the surgical margins in digestive tract cancer. Am J Surg. 2004 Mar; 187(3):452-5. PMID: 15006583.
      Citations: 12     Fields:    Translation:Humans
    175. Song X, Wang L, Chen W, Pan T, Zhu H, Xu J, Jin M, Finley RK, Wu J. Lymphatic mapping and sentinel node biopsy in gastric cancer. Am J Surg. 2004 Feb; 187(2):270-3. PMID: 14769318.
      Citations: 16     Fields:    Translation:Humans
    176. Xie Z, Srividya N, Sosnick TR, Pan T, Scherer NF. Single-molecule studies highlight conformational heterogeneity in the early folding steps of a large ribozyme. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):534-9. PMID: 14704266; PMCID: PMC327182.
      Citations: 47     Fields:    Translation:Cells
    177. Fang XW, Srividya N, Golden BL, Sosnick TR, Pan T. Stepwise conversion of a mesophilic to a thermophilic ribozyme. J Mol Biol. 2003 Jul 04; 330(2):177-83. PMID: 12823959.
      Citations: 5     Fields:    Translation:Cells
    178. Sosnick TR, Pan T. RNA folding: models and perspectives. Curr Opin Struct Biol. 2003 Jun; 13(3):309-16. PMID: 12831881.
      Citations: 56     Fields:    Translation:Cells
    179. Krasilnikov AS, Yang X, Pan T, Mondragón A. Crystal structure of the specificity domain of ribonuclease P. Nature. 2003 Feb 13; 421(6924):760-4. PMID: 12610630.
      Citations: 105     Fields:    Translation:Cells
    180. Sosnick TR, Pan T, Sosnick TR, Pan T. Getting hotter with RNA. Nat Struct Biol. 2002 Nov; 9(11):795-6. PMID: 12402034.
      Citations: 1     Fields:    Translation:AnimalsCells
    181. Barrera A, Fang X, Jacob J, Casey E, Thiyagarajan P, Pan T, Barrera A, Fang X, Jacob J, Casey E, Thiyagarajan P, Pan T. Dimeric and monomeric Bacillus subtilis RNase P holoenzyme in the absence and presence of pre-tRNA substrates. Biochemistry. 2002 Oct 29; 41(43):12986-94. PMID: 12390025.
      Citations: 12     Fields:    Translation:Cells
    182. Fang XW, Thiyagarajan P, Sosnick TR, Pan T. The rate-limiting step in the folding of a large ribozyme without kinetic traps. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8518-23. PMID: 12084911; PMCID: PMC124294.
      Citations: 32     Fields:    Translation:Cells
    183. Wang L, Song X, Chen W, Pan T, Zhang W, Sun X, He C, Wu J. [The extensibility and retractility of surgical margins in digestive tract cancer]. Zhonghua Wai Ke Za Zhi. 2002 Apr; 40(4):271-3. PMID: 12133357.
      Citations:    Fields:    Translation:Humans
    184. Qin H, Sosnick TR, Pan T. Modular construction of a tertiary RNA structure: the specificity domain of the Bacillus subtilis RNase P RNA. Biochemistry. 2001 Sep 18; 40(37):11202-10. PMID: 11551219.
      Citations: 13     Fields:    Translation:Cells
    185. Loria A, Pan T. Modular construction for function of a ribonucleoprotein enzyme: the catalytic domain of Bacillus subtilis RNase P complexed with B. subtilis RNase P protein. Nucleic Acids Res. 2001 May 01; 29(9):1892-7. PMID: 11328872; PMCID: PMC37254.
      Citations: 12     Fields:    Translation:Cells
    186. Pan T. Probing RNA structure by lead cleavage. Curr Protoc Nucleic Acid Chem. 2001 May; Chapter 6:Unit 6.3. PMID: 18428864.
      Citations: 3     Fields:    Translation:AnimalsCells
    187. Fang XW, Golden BL, Littrell K, Shelton V, Thiyagarajan P, Pan T, Sosnick TR. The thermodynamic origin of the stability of a thermophilic ribozyme. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4355-60. PMID: 11296284; PMCID: PMC31839.
      Citations: 33     Fields:    Translation:Cells
    188. Shelton VM, Sosnick TR, Pan T. Altering the intermediate in the equilibrium folding of unmodified yeast tRNAPhe with monovalent and divalent cations. Biochemistry. 2001 Mar 27; 40(12):3629-38. PMID: 11297430.
      Citations: 18     Fields:    Translation:AnimalsCells
    189. Fang XW, Yang XJ, Littrell K, Niranjanakumari S, Thiyagarajan P, Fierke CA, Sosnick TR, Pan T. The Bacillus subtilis RNase P holoenzyme contains two RNase P RNA and two RNase P protein subunits. RNA. 2001 Feb; 7(2):233-41. PMID: 11233980; PMCID: PMC1370081.
      Citations: 20     Fields:    Translation:Cells
    190. Loria A, Pan T. The 3' substrate determinants for the catalytic efficiency of the Bacillus subtilis RNase P holoenzyme suggest autolytic processing of the RNase P RNA in vivo. RNA. 2000 Oct; 6(10):1413-22. PMID: 11073217; PMCID: PMC1370012.
      Citations: 11     Fields:    Translation:AnimalsCells
    191. Fang X, Littrell K, Yang XJ, Henderson SJ, Siefert S, Thiyagarajan P, Pan T, Sosnick TR. Mg2+-dependent compaction and folding of yeast tRNAPhe and the catalytic domain of the B. subtilis RNase P RNA determined by small-angle X-ray scattering. Biochemistry. 2000 Sep 12; 39(36):11107-13. PMID: 10998249.
      Citations: 46     Fields:    Translation:AnimalsCells
    192. Pan T. Probing RNA structure and function, by circular permutation. Methods Enzymol. 2000; 317:313-30. PMID: 10829288.
      Citations: 4     Fields:    Translation:Cells
    193. Fang X, Pan T, Sosnick TR. A thermodynamic framework and cooperativity in the tertiary folding of a Mg2+-dependent ribozyme. Biochemistry. 1999 Dec 21; 38(51):16840-6. PMID: 10606517.
      Citations: 42     Fields:    Translation:Cells
    194. Shelton VM, Sosnick TR, Pan T. Applicability of urea in the thermodynamic analysis of secondary and tertiary RNA folding. Biochemistry. 1999 Dec 21; 38(51):16831-9. PMID: 10606516.
      Citations: 43     Fields:    Translation:AnimalsCells
    195. Fang XW, Pan T, Sosnick TR. Mg2+-dependent folding of a large ribozyme without kinetic traps. Nat Struct Biol. 1999 Dec; 6(12):1091-5. PMID: 10581546.
      Citations: 49     Fields:    Translation:AnimalsCells
    196. Mobley EM, Pan T. Design and isolation of ribozyme-substrate pairs using RNase P-based ribozymes containing altered substrate binding sites. Nucleic Acids Res. 1999 Nov 01; 27(21):4298-304. PMID: 10518624; PMCID: PMC148707.
      Citations: 6     Fields:    Translation:AnimalsCells
    197. Pan T, Artsimovitch I, Fang XW, Landick R, Sosnick TR. Folding of a large ribozyme during transcription and the effect of the elongation factor NusA. Proc Natl Acad Sci U S A. 1999 Aug 17; 96(17):9545-50. PMID: 10449729; PMCID: PMC22245.
      Citations: 77     Fields:    Translation:Cells
    198. Loria A, Pan T. The cleavage step of ribonuclease P catalysis is determined by ribozyme-substrate interactions both distal and proximal to the cleavage site. Biochemistry. 1999 Jul 06; 38(27):8612-20. PMID: 10393536.
      Citations: 23     Fields:    Translation:Cells
    199. Pan T, Fang X, Sosnick T. Pathway modulation, circular permutation and rapid RNA folding under kinetic control. J Mol Biol. 1999 Feb 26; 286(3):721-31. PMID: 10024446.
      Citations: 38     Fields:    Translation:Cells
    200. Loria A, Niranjanakumari S, Fierke CA, Pan T. Recognition of a pre-tRNA substrate by the Bacillus subtilis RNase P holoenzyme. Biochemistry. 1998 Nov 03; 37(44):15466-73. PMID: 9799509.
      Citations: 28     Fields:    Translation:Cells
    201. Odell L, Huang V, Jakacka M, Pan T. Interaction of structural modules in substrate binding by the ribozyme from Bacillus subtilis RNase P. Nucleic Acids Res. 1998 Aug 15; 26(16):3717-23. PMID: 9685487; PMCID: PMC147761.
      Citations: 10     Fields:    Translation:Cells
    202. Loria A, Pan T. Recognition of the 5' leader and the acceptor stem of a pre-tRNA substrate by the ribozyme from Bacillus subtilis RNase P. Biochemistry. 1998 Jul 14; 37(28):10126-33. PMID: 9665718.
      Citations: 22     Fields:    Translation:Cells
    203. Pan T, Sosnick TR. Intermediates and kinetic traps in the folding of a large ribozyme revealed by circular dichroism and UV absorbance spectroscopies and catalytic activity. Nat Struct Biol. 1997 Nov; 4(11):931-8. PMID: 9360610.
      Citations: 70     Fields:    Translation:Cells
    204. Pan T. Novel and variant ribozymes obtained through in vitro selection. Curr Opin Chem Biol. 1997 Jun; 1(1):17-25. PMID: 9667827.
      Citations: 4     Fields:    Translation:Cells
    205. Loria A, Pan T. Recognition of the T stem-loop of a pre-tRNA substrate by the ribozyme from Bacillus subtilis ribonuclease P. Biochemistry. 1997 May 27; 36(21):6317-25. PMID: 9174346.
      Citations: 39     Fields:    Translation:Cells
    206. Loria A, Pan T. Domain structure of the ribozyme from eubacterial ribonuclease P. RNA. 1996 Jun; 2(6):551-63. PMID: 8718684; PMCID: PMC1369394.
      Citations: 61     Fields:    Translation:Cells
    207. Pan T, Jakacka M. Multiple substrate binding sites in the ribozyme from Bacillus subtilis RNase P. EMBO J. 1996 May 01; 15(9):2249-55. PMID: 8641290; PMCID: PMC450150.
      Citations: 15     Fields:    Translation:Cells
    208. Pan T, Loria A, Zhong K. Probing of tertiary interactions in RNA: 2'-hydroxyl-base contacts between the RNase P RNA and pre-tRNA. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26):12510-4. PMID: 8618931; PMCID: PMC40387.
      Citations: 40     Fields:    Translation:Cells
    209. Pan T. Novel RNA substrates for the ribozyme from Bacillus subtilis ribonuclease P identified by in vitro selection. Biochemistry. 1995 Jul 04; 34(26):8458-64. PMID: 7541243.
      Citations: 5     Fields:    Translation:Cells
    210. Pan T. Higher order folding and domain analysis of the ribozyme from Bacillus subtilis ribonuclease P. Biochemistry. 1995 Jan 24; 34(3):902-9. PMID: 7827048.
      Citations: 42     Fields:    Translation:Cells
    211. Pan T, Zhong K. Selection of circularly permuted ribozymes from Bacillus subtilis RNAse P by substrate binding. Biochemistry. 1994 Nov 29; 33(47):14207-12. PMID: 7524672.
      Citations: 8     Fields:    Translation:Cells
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