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Vytautas Bindokas

TitleResearch Associate Professor
InstitutionUniversity of Chicago
DepartmentPhysiology & Pharmacology
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Efimova EV, Appelbe OK, Ricco N, Lee SS, Liu Y, Wolfgeher DJ, Collins TN, Flor AC, Ramamurthy A, Warrington S, Bindokas VP, Kron SJ. O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors. Mol Cancer Res. 2019 Jun; 17(6):1338-1350. PMID: 30885991.
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    2. Lee SS, Bindokas VP, Lingen MW, Kron SJ. Nondestructive, multiplex three-dimensional mapping of immune infiltrates in core needle biopsy. Lab Invest. 2019 Sep; 99(9):1400-1413. PMID: 30401959.
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    3. Lee SS, Bindokas VP, Kron SJ. Multiplex Three-Dimensional Mapping of Macromolecular Drug Distribution in the Tumor Microenvironment. Mol Cancer Ther. 2019 01; 18(1):213-226. PMID: 30322947.
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    4. Lee SS, Bindokas VP, Kron SJ. Multiplex three-dimensional optical mapping of tumor immune microenvironment. Sci Rep. 2017 12 05; 7(1):17031. PMID: 29208908.
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    5. Wang JC, Bindokas VP, Skinner M, Emrick T, Marks JD. Mitochondrial mechanisms of neuronal rescue by F-68, a hydrophilic Pluronic block co-polymer, following acute substrate deprivation. Neurochem Int. 2017 Oct; 109:126-140. PMID: 28433663.
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    6. Zaborin A, Krezalek M, Hyoju S, Defazio JR, Setia N, Belogortseva N, Bindokas VP, Guo Q, Zaborina O, Alverdy JC. Critical role of microbiota within cecal crypts on the regenerative capacity of the intestinal epithelium following surgical stress. Am J Physiol Gastrointest Liver Physiol. 2017 Feb 01; 312(2):G112-G122. PMID: 27979825.
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    7. Arina A, Idel C, Hyjek EM, Alegre ML, Wang Y, Bindokas VP, Weichselbaum RR, Schreiber H. Tumor-associated fibroblasts predominantly come from local and not circulating precursors. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):7551-6. PMID: 27317748.
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    8. Singer BF, Bubula N, Li D, Przybycien-Szymanska MM, Bindokas VP, Vezina P. Drug-Paired Contextual Stimuli Increase Dendritic Spine Dynamics in Select Nucleus Accumbens Neurons. Neuropsychopharmacology. 2016 07; 41(8):2178-87. PMID: 26979294.
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    9. Riazanski V, Gabdoulkhakova AG, Boynton LS, Eguchi RR, Deriy LV, Hogarth DK, Loaëc N, Oumata N, Galons H, Brown ME, Shevchenko P, Gallan AJ, Yoo SG, Naren AP, Villereal ML, Beacham DW, Bindokas VP, Birnbaumer L, Meijer L, Nelson DJ. TRPC6 channel translocation into phagosomal membrane augments phagosomal function. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):E6486-95. PMID: 26604306.
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    10. Zhong R, Bao R, Faber PW, Bindokas VP, Bechill J, Lingen MW, Spiotto MT. Notch1 Activation or Loss Promotes HPV-Induced Oral Tumorigenesis. Cancer Res. 2015 Sep 15; 75(18):3958-3969. PMID: 26294213.
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    11. Buggia-Prévot V, Fernandez CG, Riordan S, Vetrivel KS, Roseman J, Waters J, Bindokas VP, Vassar R, Thinakaran G. Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase. Mol Neurodegener. 2014 Jan 04; 9:1. PMID: 24386896.
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    12. Buggia-Prévot V, Fernandez CG, Udayar V, Vetrivel KS, Elie A, Roseman J, Sasse VA, Lefkow M, Meckler X, Bhattacharyya S, George M, Kar S, Bindokas VP, Parent AT, Rajendran L, Band H, Vassar R, Thinakaran G. A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aß production. Cell Rep. 2013 Dec 26; 5(6):1552-63. PMID: 24373286.
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    13. Cortes CJ, Qin K, Norstrom EM, Green WN, Bindokas VP, Mastrianni JA. Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy. Int J Cell Biol. 2013; 2013:560421. PMID: 24454378.
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    14. Kawada I, Hasina R, Lennon FE, Bindokas VP, Usatyuk P, Tan YH, Krishnaswamy S, Arif Q, Carey G, Hseu RD, Robinson M, Tretiakova M, Brand TM, Iida M, Ferguson MK, Wheeler DL, Husain AN, Natarajan V, Vokes EE, Singleton PA, Salgia R. Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: relevance to lung cancer. Cancer Biol Ther. 2013 Jul; 14(7):679-91. PMID: 23792636.
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    15. Gong P, Roseman J, Fernandez CG, Vetrivel KS, Bindokas VP, Zitzow LA, Kar S, Parent AT, Thinakaran G. Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice. Mol Neurodegener. 2011 Dec 28; 6:87. PMID: 22204304.
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    16. Efimova EV, Mauceri HJ, Golden DW, Labay E, Bindokas VP, Darga TE, Chakraborty C, Barreto-Andrade JC, Crawley C, Sutton HG, Kron SJ, Weichselbaum RR. Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors. Cancer Res. 2010 Aug 01; 70(15):6277-82. PMID: 20610628.
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    17. Deriy LV, Gomez EA, Zhang G, Beacham DW, Hopson JA, Gallan AJ, Shevchenko PD, Bindokas VP, Nelson DJ. Disease-causing mutations in the cystic fibrosis transmembrane conductance regulator determine the functional responses of alveolar macrophages. J Biol Chem. 2009 Dec 18; 284(51):35926-38. PMID: 19837664.
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    18. Deriy LV, Gomez EA, Jacobson DA, Wang X, Hopson JA, Liu XY, Zhang G, Bindokas VP, Philipson LH, Nelson DJ. The granular chloride channel ClC-3 is permissive for insulin secretion. Cell Metab. 2009 Oct; 10(4):316-23. PMID: 19808024.
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    19. Jiao J, Nakajima A, Janssen WG, Bindokas VP, Xiong X, Morrison JH, Brorson JR, Tang YP. Expression of NR2B in cerebellar granule cells specifically facilitates effect of motor training on motor learning. PLoS One. 2008 Feb 27; 3(2):e1684. PMID: 18301761.
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    20. Wang XQ, Deriy LV, Foss S, Huang P, Lamb FS, Kaetzel MA, Bindokas V, Marks JD, Nelson DJ. CLC-3 channels modulate excitatory synaptic transmission in hippocampal neurons. Neuron. 2006 Oct 19; 52(2):321-33. PMID: 17046694.
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    21. Kataoka Y, Bindokas VP, Duggan RC, Murley JS, Grdina DJ. Flow cytometric analysis of phosphorylated histone H2AX following exposure to ionizing radiation in human microvascular endothelial cells. J Radiat Res. 2006 Nov; 47(3-4):245-57. PMID: 16960336.
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    22. Di A, Brown ME, Deriy LV, Li C, Szeto FL, Chen Y, Huang P, Tong J, Naren AP, Bindokas V, Palfrey HC, Nelson DJ. CFTR regulates phagosome acidification in macrophages and alters bactericidal activity. Nat Cell Biol. 2006 Sep; 8(9):933-44. PMID: 16921366.
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    23. Roe MW, Fiekers JF, Philipson LH, Bindokas VP. Visualizing calcium signaling in cells by digitized wide-field and confocal fluorescent microscopy. Methods Mol Biol. 2006; 319:37-66. PMID: 16719350.
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    24. Hara M, Dizon RF, Glick BS, Lee CS, Kaestner KH, Piston DW, Bindokas VP. Imaging pancreatic beta-cells in the intact pancreas. Am J Physiol Endocrinol Metab. 2006 May; 290(5):E1041-7. PMID: 16368785.
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    25. Tamarina NA, Kuznetsov A, Rhodes CJ, Bindokas VP, Philipson LH. Inositol (1,4,5)-trisphosphate dynamics and intracellular calcium oscillations in pancreatic beta-cells. Diabetes. 2005 Nov; 54(11):3073-81. PMID: 16249428.
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    26. Kuznetsov A, Bindokas VP, Marks JD, Philipson LH. FRET-based voltage probes for confocal imaging: membrane potential oscillations throughout pancreatic islets. Am J Physiol Cell Physiol. 2005 Jul; 289(1):C224-9. PMID: 15758044.
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    27. Ma L, Bindokas VP, Kuznetsov A, Rhodes C, Hays L, Edwardson JM, Ueda K, Steiner DF, Philipson LH. Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion. Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9266-71. PMID: 15197259.
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    28. Hara M, Bindokas V, Lopez JP, Kaihara K, Landa LR, Harbeck M, Roe MW. Imaging endoplasmic reticulum calcium with a fluorescent biosensor in transgenic mice. Am J Physiol Cell Physiol. 2004 Oct; 287(4):C932-8. PMID: 15163621.
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    29. Zhou YP, Sreenan S, Pan CY, Currie KP, Bindokas VP, Horikawa Y, Lee JP, Ostrega D, Ahmed N, Baldwin AC, Cox NJ, Fox AP, Miller RJ, Bell GI, Polonsky KS. A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin. Metabolism. 2003 May; 52(5):528-34. PMID: 12759879.
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    30. Di A, Nelson DJ, Bindokas V, Brown ME, Libunao F, Palfrey HC. Dynamin regulates focal exocytosis in phagocytosing macrophages. Mol Biol Cell. 2003 May; 14(5):2016-28. PMID: 12802072.
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    31. Bindokas VP, Kuznetsov A, Sreenan S, Polonsky KS, Roe MW, Philipson LH. Visualizing superoxide production in normal and diabetic rat islets of Langerhans. J Biol Chem. 2003 Mar 14; 278(11):9796-801. PMID: 12514170.
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    32. Kim S, Nollen EA, Kitagawa K, Bindokas VP, Morimoto RI. Polyglutamine protein aggregates are dynamic. Nat Cell Biol. 2002 Oct; 4(10):826-31. PMID: 12360295.
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    33. Lee JP, Gerin C, Bindokas VP, Miller R, Ghadge G, Roos RP. No correlation between aggregates of Cu/Zn superoxide dismutase and cell death in familial amyotrophic lateral sclerosis. J Neurochem. 2002 Sep; 82(5):1229-38. PMID: 12358770.
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    34. Li C, Fox CJ, Master SR, Bindokas VP, Chodosh LA, Thompson CB. Bcl-X(L) affects Ca(2+) homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9830-5. PMID: 12118121.
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    35. Bushell T, Endoh T, Simen AA, Ren D, Bindokas VP, Miller RJ. Molecular components of tolerance to opiates in single hippocampal neurons. Mol Pharmacol. 2002 Jan; 61(1):55-64. PMID: 11752206.
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    36. Simen AA, Lee CC, Simen BB, Bindokas VP, Miller RJ. The C terminus of the Ca channel alpha1B subunit mediates selective inhibition by G-protein-coupled receptors. J Neurosci. 2001 Oct 01; 21(19):7587-97. PMID: 11567049.
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    37. Nakamura K, Bindokas VP, Kowlessur D, Elas M, Milstien S, Marks JD, Halpern HJ, Kang UJ. Tetrahydrobiopterin scavenges superoxide in dopaminergic neurons. J Biol Chem. 2001 Sep 14; 276(37):34402-7. PMID: 11447224.
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    38. Vandenberghe W, Bindokas VP, Miller RJ, Robberecht W, Brorson JR. Subcellular localization of calcium-permeable AMPA receptors in spinal motoneurons. Eur J Neurosci. 2001 Jul; 14(2):305-14. PMID: 11553281.
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    39. Marks JD, Bindokas VP, Zhang XM. Maturation of vulnerability to excitotoxicity: intracellular mechanisms in cultured postnatal hippocampal neurons. Brain Res Dev Brain Res. 2000 Nov 30; 124(1-2):101-16. PMID: 11113517.
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    40. Nakamura K, Bindokas VP, Marks JD, Wright DA, Frim DM, Miller RJ, Kang UJ. The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: the role of mitochondrial complex I and reactive oxygen species revisited. Mol Pharmacol. 2000 Aug; 58(2):271-8. PMID: 10908294.
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    41. Zhou YP, Pena JC, Roe MW, Mittal A, Levisetti M, Baldwin AC, Pugh W, Ostrega D, Ahmed N, Bindokas VP, Philipson LH, Hanahan D, Thompson CB, Polonsky KS. Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion. Am J Physiol Endocrinol Metab. 2000 Feb; 278(2):E340-51. PMID: 10662719.
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    42. Lee JP, Palfrey HC, Bindokas VP, Ghadge GD, Ma L, Miller RJ, Roos RP. The role of immunophilins in mutant superoxide dismutase-1linked familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3251-6. PMID: 10077670.
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    43. Bindokas VP, Lee CC, Colmers WF, Miller RJ. Changes in mitochondrial function resulting from synaptic activity in the rat hippocampal slice. J Neurosci. 1998 Jun 15; 18(12):4570-87. PMID: 9614233.
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    44. Ghadge GD, Lee JP, Bindokas VP, Jordan J, Ma L, Miller RJ, Roos RP. Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection. J Neurosci. 1997 Nov 15; 17(22):8756-66. PMID: 9348345.
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    45. Glaum SR, Hara M, Bindokas VP, Lee CC, Polonsky KS, Bell GI, Miller RJ. Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus. Mol Pharmacol. 1996 Aug; 50(2):230-5. PMID: 8700128.
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    46. Bindokas VP, Ishida AT. Conotoxin-sensitive and conotoxin-resistant Ca2+ currents in fish retinal ganglion cells. J Neurobiol. 1996 Apr; 29(4):429-44. PMID: 8656209.
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    47. Bindokas VP, Jordán J, Lee CC, Miller RJ. Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine. J Neurosci. 1996 Feb 15; 16(4):1324-36. PMID: 8778284.
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    48. Prehn JH, Bindokas VP, Jordán J, Galindo MF, Ghadge GD, Roos RP, Boise LH, Thompson CB, Krajewski S, Reed JC, Miller RJ. Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons. Mol Pharmacol. 1996 Feb; 49(2):319-28. PMID: 8632765.
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    49. Zhang H, Weir B, Marton LS, Macdonald RL, Bindokas V, Miller RJ, Brorson JR. Mechanisms of hemolysate-induced [Ca2+]i elevation in cerebral smooth muscle cells. Am J Physiol. 1995 Dec; 269(6 Pt 2):H1874-90. PMID: 8594895.
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    50. Bindokas VP, Miller RJ. Excitotoxic degeneration is initiated at non-random sites in cultured rat cerebellar neurons. J Neurosci. 1995 Nov; 15(11):6999-7011. PMID: 7472456.
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    51. Brorson JR, Bindokas VP, Iwama T, Marcuccilli CJ, Chisholm JC, Miller RJ. The Ca2+ influx induced by beta-amyloid peptide 25-35 in cultured hippocampal neurons results from network excitation. J Neurobiol. 1995 Mar; 26(3):325-38. PMID: 7775966.
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    52. Prehn JH, Bindokas VP, Marcuccilli CJ, Krajewski S, Reed JC, Miller RJ. Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12599-603. PMID: 7809085.
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    53. Bindokas VP, Yoshikawa M, Ishida AT. Na(+)-Ca2+ exchanger-like immunoreactivity and regulation of intracellular Ca2+ levels in fish retinal ganglion cells. J Neurophysiol. 1994 Jul; 72(1):47-55. PMID: 7965029.
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    54. Bindokas VP, Brorson JR, Miller RJ. Characteristics of voltage sensitive calcium channels in dendrites of cultured rat cerebellar neurons. Neuropharmacology. 1993 Nov; 32(11):1213-20. PMID: 8107975.
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    55. Toth PT, Bindokas VP, Bleakman D, Colmers WF, Miller RJ. Mechanism of presynaptic inhibition by neuropeptide Y at sympathetic nerve terminals. Nature. 1993 Aug 12; 364(6438):635-9. PMID: 8394510.
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    56. Foucart S, Bleakman D, Bindokas VP, Miller RJ. Neuropeptide Y and pancreatic polypeptide reduce calcium currents in acutely dissociated neurons from adult rat superior cervical ganglia. J Pharmacol Exp Ther. 1993 May; 265(2):903-9. PMID: 8098766.
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    57. Bindokas VP, Ishida AT. (-)-baclofen and gamma-aminobutyric acid inhibit calcium currents in isolated retinal ganglion cells. Proc Natl Acad Sci U S A. 1991 Dec 01; 88(23):10759-63. PMID: 1660149.
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    58. Bindokas VP, Venema VJ, Adams ME. Differential antagonism of transmitter release by subtypes of omega-agatoxins. J Neurophysiol. 1991 Aug; 66(2):590-601. PMID: 1685511.
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    59. Scott RH, Dolphin AC, Bindokas VP, Adams ME. Inhibition of neuronal Ca2+ channel currents by the funnel web spider toxin omega-Aga-IA. Mol Pharmacol. 1990 Nov; 38(5):711-8. PMID: 2172777.
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    60. Adams ME, Bindokas VP, Hasegawa L, Venema VJ. Omega-agatoxins: novel calcium channel antagonists of two subtypes from funnel web spider (Agelenopsis aperta) venom. J Biol Chem. 1990 Jan 15; 265(2):861-7. PMID: 2295621.
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    61. Bindokas VP, Adams ME. omega-Aga-I: a presynaptic calcium channel antagonist from venom of the funnel web spider, Agelenopsis aperta. J Neurobiol. 1989 Jun; 20(4):171-88. PMID: 2787835.
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    62. Bindokas VP, Gauger JR, Greenberg B. Laboratory investigations of the electrical characteristics of honey bees and their exposure to intense electric fields. Bioelectromagnetics. 1989; 10(1):1-12. PMID: 2712835.
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    63. Bindokas VP, Gauger JR, Greenberg B. Mechanism of biological effects observed in honey bees (Apis mellifera, L.) hived under extra-high-voltage transmission lines: implications derived from bee exposure to simulated intense electric fields and shocks. Bioelectromagnetics. 1988; 9(3):285-301. PMID: 3178903.
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    64. Bindokas VP, Gauger JR, Greenberg B. Exposure scheme separates effects of electric shock and electric field for honey bees, Apis mellifera L. Bioelectromagnetics. 1988; 9(3):275-84. PMID: 3178902.
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